ZIVAST AM TABLET

ZIVAST AM TABLET is a combination of cholesterol-lowering agent and anti-hypertensive agent, primarily used to treat high blood pressure, chest pain (angina) and coronary artery disease (clogged arteries). It lower raised bad cholesterol levels (low-density lipoprotein - LDL), triglycerides (TG) and increases good cholesterol levels (high-density lipoprotein - HDL) in the body. A heart attack occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).

ZIVAST AM TABLET is composed of two medicines, namely: Atorvastatin and Amlodipine. Atorvastatin belongs to the class of drugs known as statins or HMG-CoA reductase inhibitor. It works by blocking liver enzymes, causing the liver to make less cholesterol. Amlodipine belongs to the class of 'calcium channel blockers' and is used to treat high blood pressure, Prinzmetal's or variant angina (chest pain) and other conditions caused by coronary artery disease. It relaxes blood vessels, so that blood passes through them easily, thereby lowers the blood pressure. Thus, ZIVAST AM TABLET lowers the risk of stroke and heart attack in people with diabetes and coronary heart disease with raised cholesterol level. 

Your doctor will advise you how often you take ZIVAST AM TABLET based on your medical condition. The common side effects of ZIVAST AM TABLET include nausea, stomach pain, headache, sleepiness, ankle swelling, flushing (warm sensation in the face, ears, neck and trunk), palpitations (pounding heartbeat), constipation, muscle pain and tiredness. These side effects do not occur in everyone using ZIVAST AM TABLET and may vary individually. If you notice any side effects that are not manageable, it is advised to consult your doctor.

Try not to stop taking this medicine of your own. Stopping ZIVAST AM TABLET may worsen your condition and increase the risk of a future heart attack. Let your doctor know if are sensitive to ZIVAST AM TABLET and have any kidney/liver diseases and heart problems like aortic/mitral stenosis (reduced blood flow from left atrium to the left ventricle due to narrowing of the mitral valve). ZIVAST AM TABLET is not recommended for use in pregnancy and breastfeeding. ZIVAST AM TABLET may cause dizziness, hence it is advised to drive only when you are mentally alert.

ZIVAST AM TABLET is used to treat myocardial infarction (heart attack), stroke or coronary artery disease. It also lowers abnormally elevated bad cholesterol or fat levels and raises good cholesterol levels in the body. ZIVAST AM TABLET is composed of Atorvastatin and Amlodipine. Atorvastatin is a cholesterol-lowering agent and HMG-CoA reductase inhibitor. It works by blocking liver enzymes, causing the liver to make less cholesterol. Atorvastatin reduces the risk of coronary events, such as heart attack, stroke and angina (chest pain). Amlodipine is a calcium channel blocker that relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. It treats high blood pressure, Prinzmetal's or variant angina (chest pain) and coronary artery disease conditions. Amlodipine also improves blood supply to the heart muscle to receive more oxygen and thus preventing chest pain. ZIVAST AM TABLET helps lower cholesterol and blood pressure, thereby preventing a heart attack, stroke and other peripheral vascular diseases. 

• Nausea
• Stomach pain
• Headache
• Sleepiness
• Ankle swelling
• Flushing (warm sensation in the face, ears, neck and trunk)
• Palpitations (pounding heartbeat)
• Constipation
• Muscle pain
• Tiredness

It is important to tell your doctor if you have any kidney/liver diseases, muscle pain, diabetes, thyroid disorders, alcohol use, and heart problems (aortic/mitral stenosis) before using ZIVAST AM TABLET. The patient should inform the doctor if he/she is taking ZIVAST AM TABLET before any surgery is scheduled or any new medicine is taken. ZIVAST AM TABLET can have harmful effects on the baby when a pregnant mother uses it. Also, ZIVAST AM TABLET can pass into the breast milk and may affect the breastfed infants. ZIVAST AM TABLET is contraindicated during pregnancy and breastfeeding. ZIVAST AM TABLET may cause dizziness, headaches, nausea or tiredness that can affect your ability to drive; hence drive or operate machinery only when you are alert. Avoid alcohol intake while using ZIVAST AM TABLET since it may lead to increased blood pressure and further worsening of side effects. ZIVAST AM TABLET should be used in children only under a doctor's supervision. 

Drug-Drug Interaction: ZIVAST AM TABLET may interact with cholesterol-lowering drugs (Gemfibrozil), antibiotics (daptomycin, telithromycin), immunosuppressants (cyclosporine), hepatitis C medications (glecaprevir+pibrentasvir, telaprevir), HIV/AIDS drugs (ritonavir), pain killers (ibuprofen, naproxen), birth control pills and heart-related medicines.

Drug-Food Interaction: Limit alcohol intake since it may cause a rise in blood pressure leading to heart diseases. Avoid fatty foods to help control your cholesterol and triglyceride levels. Exclude red yeast rice products, grapefruit and its products from your diet to prevent unwanted side effects while using ZIVAST AM TABLET. 

Drug-Disease Interaction: ZIVAST AM TABLET should be used with caution if you have any kidney/liver diseases, muscle pain, diabetes, thyroid disorders, alcohol use and heart problems (aortic/mitral stenosis). 

• GEMFIBROZIL
• DAPTOMYCIN
• TELITHROMYCIN
• CYCLOSPORINE
• GLECAPREVIR+PIBRENTASVIR
• TELAPREVIR
• RITONAVIR
• IBUPROFEN
• NAPROXEN

• Take the medication as directed by the doctor and at regular intervals. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take ZIVAST AM TABLET.
• Low cholesterol diet and regular exercise regime are found to complement treatment with ZIVAST AM TABLET effectively. 
• Keep your cholesterol and triglyceride levels under control.
• Eat at regular intervals and maintain a healthy diet that includes fresh fruits, vegetables.
• High-fat meal should be avoided as it may further increase the risk of heart attack and instead eat heart-healthy foods.
• Limit alcohol intake since it raises blood pressure and increases the risk of heart diseases.
• Keep a check on your weight and exercise regularly to keep your heart healthy.
• Your doctor also guides you on noticing and managing the early symptoms of detecting heart diseases. 

• Please consult your doctor and mention that you are using ZIVAST AM TABLET before undergoing a dental procedure or any surgery. 
• Monitoring your heart health with an occasional ECG will be helpful.
• Please keep a check on your cholesterol levels (HDL, LDL) in blood with timely blood examinations.
• Your doctor may advice regular monitoring of blood glucose levels.

Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack.

Heart attack: It occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries). During a heart attack (myocardial infarction), the blood supply which nourishes the heart with oxygen is cut off. Heart attack signs include chest pain, upper body pain, sweating, nausea, fatigue and trouble breathing.

Stroke: It occurs when there is a blockage of blood supply to part of the brain that prevents brain tissues from getting enough oxygen and nutrients.

Hyperlipidaemia or dyslipidemia: It occurs when there is an excess of the unhealthy balance of cholesterol in the blood. When there is a high cholesterol level in the blood, your arteries get narrowed and clogged that finally contributes to heart diseases, like stroke and heart attack. Eating high-fat or high-cholesterol containing food/drinks and genetic factors are the primary causes of high cholesterol.