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Written By Divya L , PharmaD
Reviewed By Sunny S , MBBS

About ZIVAST AM TABLET

ZIVAST AM TABLET is a combination of cholesterol-lowering agent and anti-hypertensive agent, primarily used to treat high blood pressure, chest pain (angina) and coronary artery disease (clogged arteries). It lower raised bad cholesterol levels (low-density lipoprotein - LDL), triglycerides (TG) and increases good cholesterol levels (high-density lipoprotein - HDL) in the body. A heart attack occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).

ZIVAST AM TABLET is composed of two medicines, namely: Atorvastatin and Amlodipine. Atorvastatin belongs to the class of drugs known as statins or HMG-CoA reductase inhibitor. It works by blocking liver enzymes, causing the liver to make less cholesterol. Amlodipine belongs to the class of 'calcium channel blockers' and is used to treat high blood pressure, Prinzmetal's or variant angina (chest pain) and other conditions caused by coronary artery disease. It relaxes blood vessels, so that blood passes through them easily, thereby lowers the blood pressure. Thus, ZIVAST AM TABLET lowers the risk of stroke and heart attack in people with diabetes and coronary heart disease with raised cholesterol level. 

Your doctor will advise you how often you take ZIVAST AM TABLET based on your medical condition. The common side effects of ZIVAST AM TABLET include nausea, stomach pain, headache, sleepiness, ankle swelling, flushing (warm sensation in the face, ears, neck and trunk), palpitations (pounding heartbeat), constipation, muscle pain and tiredness. These side effects do not occur in everyone using ZIVAST AM TABLET and may vary individually. If you notice any side effects that are not manageable, it is advised to consult your doctor.

Try not to stop taking this medicine of your own. Stopping ZIVAST AM TABLET may worsen your condition and increase the risk of a future heart attack. Let your doctor know if are sensitive to ZIVAST AM TABLET and have any kidney/liver diseases and heart problems like aortic/mitral stenosis (reduced blood flow from left atrium to the left ventricle due to narrowing of the mitral valve). ZIVAST AM TABLET is not recommended for use in pregnancy and breastfeeding. ZIVAST AM TABLET may cause dizziness, hence it is advised to drive only when you are mentally alert.

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Whats That

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Non returnable*
COD available

Online payment accepted

Synonym

ATORVASTATIN+S AMLODIPINE

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of ZIVAST AM TABLET

High blood pressure (hypertension), Chest pain (angina), and Coronary artery disease (clogged arteries).

Medicinal Benefits

ZIVAST AM TABLET is used to treat myocardial infarction (heart attack), stroke or coronary artery disease. It also lowers abnormally elevated bad cholesterol or fat levels and raises good cholesterol levels in the body. ZIVAST AM TABLET is composed of Atorvastatin and Amlodipine. Atorvastatin is a cholesterol-lowering agent and HMG-CoA reductase inhibitor. It works by blocking liver enzymes, causing the liver to make less cholesterol. Atorvastatin reduces the risk of coronary events, such as heart attack, stroke and angina (chest pain). Amlodipine is a calcium channel blocker that relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. It treats high blood pressure, Prinzmetal's or variant angina (chest pain) and coronary artery disease conditions. Amlodipine also improves blood supply to the heart muscle to receive more oxygen and thus preventing chest pain. ZIVAST AM TABLET helps lower cholesterol and blood pressure, thereby preventing a heart attack, stroke and other peripheral vascular diseases. 

Side Effects of ZIVAST AM TABLET

  • Nausea
  • Stomach pain
  • Headache
  • Sleepiness
  • Ankle swelling
  • Flushing (warm sensation in the face, ears, neck and trunk)
  • Palpitations (pounding heartbeat)
  • Constipation
  • Muscle pain
  • Tiredness

Directions for Use

Swallow ZIVAST AM TABLET as a whole with water; do not crush, break or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

It is important to tell your doctor if you have any kidney/liver diseases, muscle pain, diabetes, thyroid disorders, alcohol use, and heart problems (aortic/mitral stenosis) before using ZIVAST AM TABLET. The patient should inform the doctor if he/she is taking ZIVAST AM TABLET before any surgery is scheduled or any new medicine is taken. ZIVAST AM TABLET can have harmful effects on the baby when a pregnant mother uses it. Also, ZIVAST AM TABLET can pass into the breast milk and may affect the breastfed infants. ZIVAST AM TABLET is contraindicated during pregnancy and breastfeeding. ZIVAST AM TABLET may cause dizziness, headaches, nausea or tiredness that can affect your ability to drive; hence drive or operate machinery only when you are alert. Avoid alcohol intake while using ZIVAST AM TABLET since it may lead to increased blood pressure and further worsening of side effects. ZIVAST AM TABLET should be used in children only under a doctor's supervision. 

Therapeutic Class

CARDIOVASCULAR AGENTS

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
AtorvastatinPosaconazole
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with ZIVAST AM TABLET:
Using ZIVAST AM TABLET together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking ZIVAST AM TABLET with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
AtorvastatinPosaconazole
Critical
How does the drug interact with ZIVAST AM TABLET:
Taking ZIVAST AM TABLET with Posaconazole can increase the blood levels of ZIVAST AM TABLET. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between posaconazole with ZIVAST AM TABLET, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AmlodipineSirolimus
Severe
How does the drug interact with ZIVAST AM TABLET:
Co-administration of ZIVAST AM TABLET can make Sirolimus may increase the risk of angioedema (a condition associated with swelling of the face, eyes, lips, tongue, throat, and occasionally also the hands and feet).

How to manage the interaction:
There may be a possibility of interaction between ZIVAST AM TABLET and Sirolimus, but it can be taken if prescribed by a doctor. However, consult the doctor if you notice any swelling of the face, eyes, lips, tongue, throat, hands and feet or have trouble breathing or swallowing. Do not stop using any medications without a doctor's advice.
AmlodipineDolasetron
Severe
How does the drug interact with ZIVAST AM TABLET:
Using dolasetron together with ZIVAST AM TABLET can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between ZIVAST AM TABLET and Dolasetron, but it can be taken if prescribed by a doctor. If you have any of these symptoms, like feeling dizzy, lightheaded, or your heart beating irregularly, it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipinePhenobarbital
Severe
How does the drug interact with ZIVAST AM TABLET:
Using phenobarbital and ZIVAST AM TABLET may drastically lower ZIVAST AM TABLET blood levels, which makes the medicine less effective.

How to manage the interaction:
Although co-administration of phenobarbital with ZIVAST AM TABLET can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineEnzalutamide
Severe
How does the drug interact with ZIVAST AM TABLET:
Using a combination of ZIVAST AM TABLET and enzalutamide may drastically lower ZIVAST AM TABLET blood levels, making the medicine less effective.

How to manage the interaction:
Taking ZIVAST AM TABLET with enzalutamide can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineRifabutin
Severe
How does the drug interact with ZIVAST AM TABLET:
Using ZIVAST AM TABLET and rifabutin together may lower ZIVAST AM TABLET blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between ZIVAST AM TABLET with rifabutin, but it can be taken if a doctor has advised it. Consult the doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
AmlodipinePhenytoin
Severe
How does the drug interact with ZIVAST AM TABLET:
Using ZIVAST AM TABLET and phenytoin together may drastically lower ZIVAST AM TABLET blood levels, which makes the medicine less effective.

How to manage the interaction:
Although ZIVAST AM TABLET with phenytoin can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineSimvastatin
Severe
How does the drug interact with ZIVAST AM TABLET:
Taking simvastatin with ZIVAST AM TABLET may result in considerably higher blood levels of simvastatin and may increase the risk of side effects (liver damage and rhabdomyolysis - an uncommon but serious illness characterized by the breakdown of skeletal muscle tissue).

How to manage the interaction:
Although taking ZIVAST AM TABLET with simvastatin can result in an interaction, it can be taken if a doctor has advised it. If you have unexplained muscular pain, soreness, or weakness while using simvastatin, especially if these symptoms are accompanied by fever or dark-colored urine, consult the doctor immediately. However, if you develop a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, consult the doctor. Do not stop using any medications without a doctor's advice.
AmlodipineLemborexant
Severe
How does the drug interact with ZIVAST AM TABLET:
Coadministration of lemborexant and ZIVAST AM TABLET may increase the blood levels of lemborexant.

How to manage the interaction:
Although co-administration of ZIVAST AM TABLET with Lemborexant can result in an interaction, it can be taken if a doctor has advised it. However, consult your doctor if you experience abnormal sleep patterns, worsening of depression, changes in heartbeat, or headache. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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AMLODIPINE-5MG+ATORVASTATIN-10MGFruit juices
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+ATORVASTATIN-10MGFruit juices
Moderate
Common Foods to Avoid:
Grapefruit Juice, Pineapple Juice, Pomegranate Juice, Noni Juice, Orange Juice, Cranberry Juice

How to manage the interaction:
Consumption of grape juice can increase the blood levels of atorvastatin and causes side effects. Avoid taking grape juice with atorvastatin as it can lead to an interaction, You should also seek immediate medical attention if you develop fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes, Do not stop using any medications without a doctor's advice.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • GEMFIBROZIL
  • DAPTOMYCIN
  • TELITHROMYCIN
  • CYCLOSPORINE
  • GLECAPREVIR+PIBRENTASVIR
  • TELAPREVIR
  • RITONAVIR
  • IBUPROFEN
  • NAPROXEN

Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals. Do not use other over the counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take ZIVAST AM TABLET.
  • Low cholesterol diet and regular exercise regime are found to complement treatment with ZIVAST AM TABLET effectively. 
  • Keep your cholesterol and triglyceride levels under control.
  • Eat at regular intervals and maintain a healthy diet that includes fresh fruits, vegetables.
  • High-fat meal should be avoided as it may further increase the risk of heart attack and instead eat heart-healthy foods.
  • Limit alcohol intake since it raises blood pressure and increases the risk of heart diseases.
  • Keep a check on your weight and exercise regularly to keep your heart healthy.
  • Your doctor also guides you on noticing and managing the early symptoms of detecting heart diseases. 

Habit Forming

No

Special Advise

  • Please consult your doctor and mention that you are using ZIVAST AM TABLET before undergoing a dental procedure or any surgery. 
  • Monitoring your heart health with an occasional ECG will be helpful.
  • Please keep a check on your cholesterol levels (HDL, LDL) in blood with timely blood examinations.
  • Your doctor may advice regular monitoring of blood glucose levels.

Author Details

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Disease/Condition Glossary

Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack.

Heart attack: It occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries). During a heart attack (myocardial infarction), the blood supply which nourishes the heart with oxygen is cut off. Heart attack signs include chest pain, upper body pain, sweating, nausea, fatigue and trouble breathing.

Stroke: It occurs when there is a blockage of blood supply to part of the brain that prevents brain tissues from getting enough oxygen and nutrients.

Hyperlipidaemia or dyslipidemia: It occurs when there is an excess of the unhealthy balance of cholesterol in the blood. When there is a high cholesterol level in the blood, your arteries get narrowed and clogged that finally contributes to heart diseases, like stroke and heart attack. Eating high-fat or high-cholesterol containing food/drinks and genetic factors are the primary causes of high cholesterol.

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