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  1. Home
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  3. Zybiraa-500Mg Tablet 60'S

Zybiraa-500Mg Tablet 60'S, Pack of 1 TABLET
Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Composition :

ABIRATERONE ACETATE-500MG

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Zybiraa-500Mg Tablet

Zybiraa-500Mg Tablet is an anti-androgen medicine used in the treatment of prostate cancer. It is used to treat metastatic castration-resistant prostate cancer (a condition where cancer does not get controlled with hormonal therapy) and metastatic castration-sensitive prostate cancer (a condition where cancer has spread to other parts of the body but can be controlled) in men. Prostate cancer is a condition that occurs when the prostate gland cells increase abnormally. Symptoms may include difficulty in urinating, pain, numbness, etc.

Zybiraa-500Mg Tablet contains Abiraterone acetate, which belongs to the class of androgen biosynthesis inhibitors. Testosterone is a natural hormone produced by the body. This causes an increase in cancer cells in the prostate gland. Zybiraa-500Mg Tablet works by inhibiting the production of the testosterone hormone and thus stops the growth and spread of cancer. 

Zybiraa-500Mg Tablet may cause certain side effects such as nausea, dizziness, heartburn, headache, diarrhoea, muscle weakness, joint pain, confusion, hot flushes, loss of appetite and groin pain. These side effects usually disappear without any medical attention. However, if these side effects persist, inform your doctor. Take this medicine as advised by your doctor. It should be taken on an empty stomach at least 2 hours before or after meals. Your doctor will decide the dose of the medicine based on the severity of your disease.

Zybiraa-500Mg Tablet should be avoided if you are allergic to it. Inform your doctor if you have any pre-existing or a history of liver/kidney disease, cardiovascular disease, adrenocortical insufficiency, hypokalemia, hypoglycaemia, fluid retention before taking Zybiraa-500Mg Tablet . Zybiraa-500Mg Tablet is not recommended for use in women and children as the safety and efficacy of this medicine are not established. Inform your doctor of all your ongoing medications to avoid interactions. This medicine is used in combination with prednisolone for the treatment of prostate cancer. 

Uses of Zybiraa-500Mg Tablet

Prostate Cancer

Directions for Use

Zybiraa-500Mg Tablet should be taken on an empty stomach at least two hours before or after a meal. It is advised not to take more than the recommended dose of medicine. Swallow the medicine as a whole with a glass of water. Do not chew or crush or break the medicine.

Medicinal Benefits

Zybiraa-500Mg Tablet contains Abiraterone acetate, which belongs to the class of androgen biosynthesis inhibitors. Testosterone is a natural hormone produced by the body. This causes increase of cancer cells in prostate gland. Zybiraa-500Mg Tablet works by inhibiting the production of the testosterone hormone and thus stops the growth and spread of cancer. Zybiraa-500Mg Tablet is used in combination with prednisolone for the treatment of prostate cancer. It is mainly intended for use in men only.

Storage

Store in a cool and dry place away from sunlight
Side effects of Zybiraa-500Mg Tablet
  • If you have discomfort, illness, or unease after taking medication, seek medical attention.
  • Your treatment plan may be modified, including adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage discomfort, follow your doctor's advice, like getting plenty of rest, or staying hydrated, and practising stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to manage the discomfort effectively.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Drug Warnings

Zybiraa-500Mg Tablet should be avoided if you are allergic to it or any other components present in it. Inform your doctor if you have/had any conditions like liver/kidney disease, cardiovascular disease, adrenocortical insufficiency, hypokalemia, hypoglycaemia, fluid retention or taking any other medicines before taking Zybiraa-500Mg Tablet as it may cause serious side effects. Zybiraa-500Mg Tablet is not recommended for use in women and children as the safety and efficacy of this medicine are not established. This medicine is used in combination with prednisolone for the treatment of prostate cancer.

Drug-Drug Interactions

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AbirateroneThioridazine
Critical
AbirateroneEliglustat
Critical

Drug-Drug Interactions

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AbirateroneThioridazine
Critical
How does the drug interact with Zybiraa-500Mg Tablet:
Taking Zybiraa-500Mg Tablet with Thioridazine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zybiraa-500Mg Tablet and Thioridazine together is not recommended and can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneEliglustat
Critical
How does the drug interact with Zybiraa-500Mg Tablet:
Coadministration of Zybiraa-500Mg Tablet with Eliglustat can increase the levels of Eliglustat in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Zybiraa-500Mg Tablet with Eliglustat is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AbirateroneSaquinavir
Critical
How does the drug interact with Zybiraa-500Mg Tablet:
Taking Zybiraa-500Mg Tablet with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zybiraa-500Mg Tablet and Saquinavir together is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateroneZiprasidone
Critical
How does the drug interact with Zybiraa-500Mg Tablet:
Taking Zybiraa-500Mg Tablet with ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Zybiraa-500Mg Tablet and ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
AbirateroneMesoridazine
Critical
How does the drug interact with Zybiraa-500Mg Tablet:
Taking Zybiraa-500Mg Tablet with Mesoridazine can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Zybiraa-500Mg Tablet and Mesoridazine together is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneLeflunomide
Severe
How does the drug interact with Zybiraa-500Mg Tablet:
Coadministration of Zybiraa-500Mg Tablet with leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Zybiraa-500Mg Tablet and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience ever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AbirateroneHaloperidol
Severe
How does the drug interact with Zybiraa-500Mg Tablet:
Taking Zybiraa-500Mg Tablet with Haloperidol can increase the risk or severity of developing irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Zybiraa-500Mg Tablet and Haloperidol together can result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneVemurafenib
Severe
How does the drug interact with Zybiraa-500Mg Tablet:
Taking Zybiraa-500Mg Tablet with Vemurafenib can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zybiraa-500Mg Tablet with Vemurafenib together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateroneBrexpiprazole
Severe
How does the drug interact with Zybiraa-500Mg Tablet:
Coadministration of Zybiraa-500Mg Tablet with Brexpiprazole can increase the levels of Brexpiprazole in the body. This increases the risk or severity of side effects like abnormal muscle movements or low blood pressure.

How to manage the interaction:
Taking Zybiraa-500Mg Tablet with Brexpiprazole together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience confusion, convulsions, muscle spasms, uncontrolled movements, dizziness, lightheadedness, fainting, and increased pulse or heart rate, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AbirateroneVandetanib
Severe
How does the drug interact with Zybiraa-500Mg Tablet:
Taking Zybiraa-500Mg Tablet with Vandetanib can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Zybiraa-500Mg Tablet with Vandetanib together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to take vegetables like cauliflower, cabbage, broccoli, spinach and kale. This food slows the growth of prostate cancer and even reduces the risk of prostate cancer.
  • It is advised to consume fewer dairy products as these foods may increase the risk of prostate cancer. 
  • Physical activity helps in strengthening muscles, reduces fatigue, helps in weight loss and gives strength.
  • Maintain a healthy weight by doing regular simple exercises and yoga. 
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention. 
  • Avoid including red meat high amounts of meat in your diet. When meat is cooked, it may increase the risk of developing prostate cancer.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Zybiraa-500Mg Tablet Substitute

Substitutes safety advice

Product Substitutes

Author Details

Lakshmithulasi YarraguntaDoctor badge

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Zybiraa-500Mg Tablet contains Abiraterone acetate, which belongs to the class of androgen biosynthesis inhibitors. It works by inhibiting the production of the testosterone hormone and thus stops the growth and spread of cancer.

No, do not stop taking Zybiraa-500Mg Tablet without consulting your doctor. It is recommended to take this medicine for the entire prescribed duration, even when symptoms improve or resolve.

The common side-effects of Zybiraa-500Mg Tablet are nausea, dizziness, heartburn, headache, diarrhoea, muscle weakness, joint pain, confusion, hot flushes, loss of appetite, and groin pain. These side effects usually do not require any medical attention.

Take Zybiraa-500Mg Tablet as advised by your doctor. However, if you forget or miss any dose of Zybiraa-500Mg Tablet , take it as soon as you remember unless it is time for your next dose. But do not double the dose.

Inform your doctor if you have a pre-existing or a history of liver/kidney disease, hypoglycemia, hypokalemia, bone disorders, adrenocortical insufficiency, fluid retention and cardiovascular conditions before taking Zybiraa-500Mg Tablet .

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • ITRACONAZOLE
  • PHENYTOIN
  • PHENOBARBITAL
  • FLECAINIDE
  • VENLAFAXINE

Special Advise

  • Zybiraa-500Mg Tablet is not recommended for use in patients suffering from severe hepatotoxicity.
  • This medicine may cause the laboratory abnormalities like elevated alkaline phosphatase, hypercholesterolemia, hyperglycemia, and hypokalemia.
  • It is also advised to perform frequent checkups on your potassium, blood sugar, and blood pressure levels.

Disease/Condition Glossary

Prostate cancer: The prostate gland is a small walnut-sized gland present under the bladder which is responsible for the production of seminal fluid. Prostate cancer is a carcinogenic condition that occurs when the cells of the prostate gland increase out of control. The main cause of this condition is unknown. However, a few underlying reasons that increase the risk for this condition include age, family history, ethnic group, genetic factors, obesity, etc.

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