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  3. Acabrunat 100 Capsule 30's

Acabrunat 100 Capsule 30's, Pack of 1 Capsule
Acabrunat 100 Capsule 30's, Pack of 1 Capsule
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Whats That

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Composition :

ACALABRUTINIB-100MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Acabrunat 100 Capsule

Acabrunat 100 Capsule is a tyrosine kinase inhibitor or cancer growth inhibitor that is primarily used to treat people with mantle cell lymphoma (MCL) who have had at least one prior treatment for their malignancy (cancer), as well as adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). Cancer is caused by a genetic mutation that causes our cells to divide uncontrollably and spread into neighbouring tissues.

Acabrunat 100 Capsule contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that transmit signals to cells, telling them to grow and divide. Acalabrutinib inhibits these signals to cancer cells. Cells die when their signals are disrupted. This could help to slow the progression of the cancer.

To treat your condition effectually, continue using Acabrunat 100 Capsule for as long as your doctor has prescribed it. The most common adverse reactions are anaemia (lack of blood), neutropenia (low count of neutrophils), upper respiratory tract infection, thrombocytopenia (Low platelet level), headache, diarrhoea, and musculoskeletal pain. You should talk to your doctor if you persistently experience these side effects.

It is recommended not to use if you are hypersensitive to any component present in Acabrunat 100 Capsule and suffer from Severe Hepatic Impairment. Acabrunat 100 Capsule can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant or get pregnant while undergoing therapy and for several months after the treatment. Using effective contraceptive methods is recommended while on therapy with Acabrunat 100 Capsule . Contact your doctor immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment. Alcohol should be avoided during treatment with this medicine. Safety and effectiveness in children have not been established.

Uses of Acabrunat 100 Capsule

Mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL)

Directions for Use

Acabrunat 100 Capsule should be swallowed as a whole with a glass of water. Do not crush, chew, or break the tablets. The doctor determines the dose and duration based on your health condition.

Medicinal Benefits

Acabrunat 100 Capsule is primarily used to treat people with mantle cell lymphoma (MCL) who have had at least one prior treatment for their malignancy, as well as adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). Acabrunat 100 Capsule contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that send signals to cells, directing them to grow and divide. Acalabrutinib blocks these signals to cancer cells. Cancer cells die when their signals are interrupted. This could help to delay the progression of the cancer.

Storage

Store in a cool and dry place away from sunlight
Side effects of Acabrunat 100 Capsule
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Avoid taking raw fruits, nuts and vegetables.
  • Do not share your personal things with others like toothbrushes.
  • Clean the wounds and cuts using soap and water.
  • Wash your hands thoroughly and frequently and maintain hygiene.
  • Get a good quality of sleep.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Drug Warnings

Before taking the Acabrunat 100 Capsule , inform your doctor about all your medical conditions, sensitivities, and medications you are using. If you are a woman capable of having children, you should use an effective method of contraception during Acalabrutinib treatment and for at least one week after the last dose. If you are a man, you should use a barrier method of contraception to prevent your partner from becoming pregnant while taking Acalabrutinib and for at least one week after the last dose. Unless the doctor suggests, do not use any other medicine, including herbal or vitamin supplements.

Drug-Drug Interactions

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AcalabrutinibErythromycin
Severe
AcalabrutinibFosaprepitant
Severe

Drug-Drug Interactions

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AcalabrutinibErythromycin
Severe
How does the drug interact with Acabrunat 100 Capsule:
When Acabrunat 100 Capsule is taken with Erythromycin, the amount of Acabrunat 100 Capsule in the blood can increase.

How to manage the interaction:
Taking Erythromycin with Acabrunat 100 Capsule together can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs and symptoms - feeling sick, diarrhea, stomach pain, bleeding, feeling weak, dizzy, faint, fever, sore throat, muscle pain, trouble breathing, or pain while urinating - make sure to call your doctor immediately. Do not discontinue any medications without first consulting your doctor.
AcalabrutinibFosaprepitant
Severe
How does the drug interact with Acabrunat 100 Capsule:
Coadministration of Fosaprepitant with Acabrunat 100 Capsule can reduce the metabolism and increase the levels of Acabrunat 100 Capsule in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Fosaprepitant with Acabrunat 100 Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcalabrutinibRabeprazole
Severe
How does the drug interact with Acabrunat 100 Capsule:
Taking Rabeprazole together with Acabrunat 100 Capsule results in a decreased effectiveness of Acabrunat 100 Capsule.

How to manage the interaction:
Although taking Rabeprazole and Acabrunat 100 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
AcalabrutinibDiclofenac
Severe
How does the drug interact with Acabrunat 100 Capsule:
Taking Acabrunat 100 Capsule together with diclofenac may increase the risk of bleeding.

How to manage the interaction:
Co-administration of Diclofenac and Acabrunat 100 Capsule can lead to an interaction; it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult your doctor immediately. Do not stop using any medications without a doctor's advice.
AcalabrutinibAprepitant
Severe
How does the drug interact with Acabrunat 100 Capsule:
Coadministration of Aprepitant can significantly increase the blood levels of Acabrunat 100 Capsule.

How to manage the interaction:
Although there is an interaction between Aprepitant and Acabrunat 100 Capsule, it can be taken if prescribed by a doctor. A doctor should be consulted if you experience any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in the phlegm, red or irritated skin, body sores, and discomfort when urinating. Without consulting a doctor, never stop taking medicines.
AcalabrutinibPrasugrel
Severe
How does the drug interact with Acabrunat 100 Capsule:
Co-administration of Prasugrel with Acabrunat 100 Capsule can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Prasugrel with Acabrunat 100 Capsule together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AcalabrutinibCarbamazepine
Severe
How does the drug interact with Acabrunat 100 Capsule:
When Acabrunat 100 Capsule is taken with Carbamazepine, it may decrease the blood levels of Acabrunat 100 Capsule, which may make Acabrunat 100 Capsule less effective in treating your condition.

How to manage the interaction:
There may be a possibility of interaction between Acabrunat 100 Capsule and Carbamazepine, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
AcalabrutinibVerapamil
Severe
How does the drug interact with Acabrunat 100 Capsule:
Taking Verapamil with Acabrunat 100 Capsule can significantly increase the blood levels of Acabrunat 100 Capsule.

How to manage the interaction:
Although taking verapamil and Acabrunat 100 Capsule together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, headache, shortness of breath, chest pain or tightness, rapid heartbeat, fever, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AcalabrutinibDiclofenac Diethylamine
Severe
How does the drug interact with Acabrunat 100 Capsule:
The combined use of Acabrunat 100 Capsule and Diclofenac Diethylamine can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Acabrunat 100 Capsule and Diclofenac Diethylamine can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, tarry stools, coughing up or vomiting blood, severe headache, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
AcalabrutinibCiprofloxacin
Severe
How does the drug interact with Acabrunat 100 Capsule:
Taking Ciprofloxacin with Acabrunat 100 Capsule may increase your risk of acquiring irregular heart rhythm, anemia, bleeding issues, or infections.

How to manage the interaction:
Co-administration of Ciprofloxacin with Acabrunat 100 Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience paleness, exhaustion, dizziness, fainting, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, pain in the muscles, breathing difficulty, blood in the phlegm, weight loss, red or irritated skin, body sores, and discomfort or burning when urinating, consult the doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS

Acabrunat 100 Capsule Substitute

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:49 AM IST

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Acabrunat 100 Capsule contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that send signals to cells, directing them to grow and divide. Acalabrutinib blocks these signals to cancer cells. Cancer cells die when their signals are interrupted. This could help to delay the progression of the cancer.

While taking Acabrunat 100 Capsule , make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Acabrunat 100 Capsule .

Mantle cell lymphoma (MCL) is diagnosed by taking a biopsy of tumour tissue and examining the cells under a microscope.

You can take the missed dose if you forget to take your acalabrutinib, which is less than 3 hours after your usual time. Then, take the next dose at the regular time. Do not take your missed dose if more than 3 hours have passed. Wait and take the next dose at the regular time. Do not take a double dose to make up for a missing one.

Drug-Drug Interactions Checker List

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Special Advise

  • Keep all of your doctor's and laboratory appointments.
  • Pregnancy testing is recommended prior to starting treatment with Acabrunat 100 Capsule .

Disease/Condition Glossary

Cancer: Cancer is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer: benign (localized) and metastatic (spread to the whole body). Types of cancer include blood, lung, breast, etc. Cancer growth can be prevented by chemotherapy, radiation, and stem cell therapy.

Mantle Cell lymphoma (MCL): Mantle Cell lymphoma (MCL) is an aggressive, rare form of non-Hodgkin lymphoma (NHL) that arises from cells originating in the “mantle zone.” The mantle zone is the outer ring of small lymphocytes surrounding the centre of a lymphatic nodule.

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