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  3. Adside Injection 5 ml

Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

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Composition :

ETOPOSIDE-100MG

Manufacturer/Marketer :

Adley Formulations

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Adside Injection 5 ml

Adside Injection 5 ml belongs to a class of chemotherapy drugs used to treat various cancer conditions, including testicular tumours or cancer of the testicles, lung cancer (small cell lung cancer; SCLC). Besides this, it can also be used in treating Monoblastic leukaemia (AML M5) and acute myelomonoblastic leukaemia (AML M4). Cancer is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues.

Adside Injection 5 ml contains Etoposide, which is a podophyllotoxin derivative. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

Adside Injection 5 ml will be administered by a qualified healthcare professional. Sometimes, Adside Injection 5 ml may use certain side effects such as myelosuppression (bone marrow activity is decreased), leucopenia (reduction in the number of white cells in the blood), thrombocytopenia (deficiency of platelets), anaemia (deficiency of red cells), anorexia (lack or loss of appetite for food), fatigue (extreme tiredness), drowsiness, nausea, vomiting, alopecia, liver and kidney functional impairment, leukaemia, hypotension, haemorrhage, abdominal pain, diarrhoea, stomatitis (inflammation of the mucous membrane), hepatic dysfunction and increased bilirubin levels etc. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Inform your doctor if you are allergic or hypersensitive to any component present in the Adside Injection 5 ml or if you are pregnant, plan to have a baby or are breastfeeding. You should not become pregnant or breastfeed while receiving an etoposide injection. If you become pregnant while on treatment with etoposide, call your doctor. Before taking the Adside Injection 5 ml, inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions. Alcohol should be avoided during treatment with this medicine. You must not drive or operate machinery while receiving Adside Injection 5 ml.

Uses of Adside Injection 5 ml

Cancer [testicular cancer, small cell lung cancer, monoblastic leukaemia (AML M5) and acute myelomonoblastic leukaemia (AML M4)]

Directions for Use

Adside Injection 5 ml will be administered by a qualified healthcare professional; do not self-administer.

Medicinal Benefits

Adside Injection 5 ml is a chemotherapeutic medication that contains Etoposide. It is primarily used with other medications to treat testicular cancer that has not improved or worsened after treatment with other medications or radiation therapy. Etoposide injection is also used in conjunction with other drugs to treat a certain kind of lung cancer (small cell lung cancer; SCLC). It can also be used to treat monoblastic leukaemia (AML M5) and acute myelomonoblastic leukaemia (AML M4). Adside Injection 5 ml acts by blocking an enzyme that promotes cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are halted or inhibited.

Storage

Store in a cool and dry place away from sunlight
Side effects of Adside Injection 5 ml
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Focus on consuming whole, nutrient-dense foods to promote healthy, radiant skin.
  • Eat a variety of colourful fruits and vegetables, including citrus fruits, bell peppers, and broccoli.
  • Wear protective clothing, such as long-sleeved shirts and pants, during peak sun hours.
  • Drink plenty of water throughout the day to keep your skin moisturized and plump.
  • Practice mindfulness techniques, such as meditation, deep breathing, or yoga, to reduce stress and promote skin health.
  • Use gentle, fragrance-free skincare products that nourish and protect your skin.
  • Avoid prolonged sun exposure, especially during peak hours, to prevent skin damage and premature aging.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

Drug Warnings

Adside Injection 5 ml is not recommended to use if you are allergic to etoposide, podophyllotoxines or podophyllotoxin-derivatives or any other ingredients of this medicine; If your liver is not working properly; If your bone marrow does not produce enough blood cells; If you are breast-feeding; If you have a weak immune system and you are being vaccinated against yellow fever at the same time. So, inform your doctor about your medical history and ongoing therapies. Etoposide can significantly reduce the number of blood cells in your bone marrow. Before and during your therapy, your doctor will prescribe laboratory testing on a regular basis. A decrease in the number of blood cells in your body might produce symptoms and raise your chance of developing a serious infection or bleeding. If you notice any of the following symptoms, contact your doctor immediately.

Drug-Drug Interactions

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EtoposideRotavirus vaccine
Critical
EtoposideIdelalisib
Severe

Drug-Drug Interactions

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EtoposideRotavirus vaccine
Critical
How does the drug interact with Adside Injection 5 ml:
When the Rotavirus vaccine is used together with Adside Injection 5 ml, it may not work as well.

How to manage the interaction:
Taking Adside Injection 5 ml with the Rotavirus vaccine can cause an, please consult doctor before taking it. You may be at risk of acquiring an infection from the vaccination or having a decreased response of the vaccine depending on the dose and length of time you have been on Adside Injection 5 ml. Do not discontinue any medications without a doctor's advice.
EtoposideIdelalisib
Severe
How does the drug interact with Adside Injection 5 ml:
When Adside Injection 5 ml is used with Idelalisib, Idelalisib may increase the blood levels and effects of Adside Injection 5 ml.

How to manage the interaction:
Taking Adside Injection 5 ml with Idelalisib together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
EtoposideIvacaftor
Severe
How does the drug interact with Adside Injection 5 ml:
When Fenofibrate is used in combination with Ivacaftor, the blood levels of Fenofibrate might be raised.

How to manage the interaction:
Taking Adside Injection 5 ml with Ivacaftor together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Adside Injection 5 ml:
When Adside Injection 5 ml is used with Leflunomide, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Leflunomide and Adside Injection 5 ml, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Adside Injection 5 ml:
When Adside Injection 5 ml is used with Adalimumab, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Adside Injection 5 ml and Adalimumab together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Adside Injection 5 ml:
When Infliximab is taken with Adside Injection 5 ml, it can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Adside Injection 5 ml with Infliximab can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Adside Injection 5 ml:
When Adside Injection 5 ml is used with Fingolimod, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Adside Injection 5 ml with Fingolimod together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Adside Injection 5 ml:
Taking Adside Injection 5 ml with natalizumab, especially taking both simultaneously with little to no time in between, may raise the risk of serious infections.

How to manage the interaction:
Although taking Adside Injection 5 ml and Natalizumab together can cause an interaction, it can be taken if a doctor has suggested it. However, consult a doctor immediately, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. progressive weakening on one side of your body, clumsiness of limbs, visual disturbance, disorientation, or changes in your thinking, memory, or personality. Do not stop using any medications without talking to a doctor.
EtoposideVoclosporin
Severe
How does the drug interact with Adside Injection 5 ml:
When Adside Injection 5 ml is used with Voclosporin, the risk of severe infections, as well as certain cancers including skin cancer and cancer of the lymph glands (lymphoma), increases.

How to manage the interaction:
Although taking Adside Injection 5 ml and Voclosporin together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, If you experience a fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Adside Injection 5 ml:
Coadministration of baricitinib and Adside Injection 5 ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Adside Injection 5 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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ETOPOSIDE-100MGHerbal products/medicines
Moderate

Drug-Food Interactions

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ETOPOSIDE-100MGHerbal products/medicines
Moderate
Common Foods to Avoid:
St. John’S Wort

How to manage the interaction:
St. John's wort should be used with caution.This plant stimulates metabolism, which might lower Adside Injection 5 ml levels in the blood. Avoid the use of St. John's wort while taking Adside Injection 5 ml.

Diet & Lifestyle Advise

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, and high fibre content. Also, eat small and frequent meals for a speedy recovery.
  • Avoid smoking and alcohol consumption. Also, avoid high fat and cholesterol diet.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Adside Injection 5 ml contains Etoposide, which is used to treat various types of cancers. It works by inhibiting an enzyme responsible for cancer cell proliferation and induces cell death (apoptosis). As a result, the growth and spread of cancer cells are stopped or slowed down.

While taking Adside Injection 5 ml, make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and urine tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Adside Injection 5 ml.

Do not stop taking Adside Injection 5 ml on your own. Take Adside Injection 5 ml for as long as your doctor prescribes it, depending on your medical condition. Do not hesitate to speak with your doctor if you experience difficulty while taking Adside Injection 5 ml.

Adside Injection 5 ml can make you more likely to get infections or may worsen any current infections. Avoid contact with people with infections that may spread to others (such as chickenpox, measles, or flu). Consult your doctor if you have been exposed to an infection or for more details.

The live vaccine may not work while on treatment with Adside Injection 5 ml. Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Etoposide can cause a significant decrease in the number of blood cells in your bone marrow. Your doctor will order laboratory testing on a regular basis before and during your therapy.

Drug-Drug Interactions Checker List

  • WARFARIN
  • CYCLOSPORINE
  • CISPLATIN
  • YELLOW FEVER VACCINE
  • PHENYTOIN
  • PHENYLBUTAZONE
  • SODIUM SALICYCLATE
  • ACETYLSALICYLIC ACID

Special Advise

  • A blood test is required to monitor liver function and blood cells while taking Adside Injection 5 ml.
  • Do not have immunizations with live vaccines (for mumps, rubella, measles and BCG, yellow fever and shingles or pox chicken) while you’re having treatment and for up to 12 months afterwards.
  • Contact your doctor immediately if you experience any infection signs, including a temperature above 37.5 C or below 36 C.

Disease/Condition Glossary

Cancer: Cancer is a genetic change in which our cells divide uncontrollably and spread into surrounding tissues. There are two types of cancer: benign (localized) and metastatic (spread to the whole body). Types of cancer include blood, lung, breast, etc. Cancer growth can be prevented by chemotherapy, radiation, and stem cell therapy.

Small-cell lung cancer: Small-cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung.

Leukaemia: Leukaemia is a type of blood cancer that affects blood cells in your bone marrow, usually white blood cells. Many types exist, such as monoblastic leukaemia (AML M5) and acute myelomonoblastic leukaemia (AML M4).

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