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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

AP Serra Tablet 10's belongs to the class of drugs known as 'non-steroidal anti-inflammatory drug' (NSAID). It is a fixed-dose combination composed of aceclofenac, paracetamol and serratiopeptidase. AP Serra Tablet 10's is used in the reduction of pain and inflammation due to bone or soft tissue injury, resolution of postoperative inflammation, oedema (swollen tissue with fluid) and pain. Aceclofenac works by blocking the action of an enzyme known as cyclo-oxygenase (COX) which causes pain and swelling in the injured or damaged tissue. Paracetamol acts as a mild analgesic (pain reducer) and antipyretic (fever reducer) which enhances the pain relief action of aceclofenac. Serratiopeptidase is an enzyme which helps in the breakdown of a protein (fibrin) which is formed as a by-product of the clotted blood at the site of injury. It thus causes thinning of the fluids around the site of injury thereby making fluid drainage smoother in the swollen tissue.

Pain can be temporary (acute) or lifelong (chronic) in nature. Acute pain is for a short time caused by damage to the tissues of the muscle, bone or organs. While, chronic pain lasts for life long caused due to nerve damage, osteoarthritis and dental pain due to damage to the tooth nerve, infection, decay, extraction or injury. There are different types of musculoskeletal pain caused due to soft tissue (muscle, tendon and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains or trauma or post-surgery may require a prolonged amount of time to heal. 

You can take AP Serra Tablet 10's with food or without food. It should be swallowed whole with a glass of water. Do not chew, bite or break it. Your doctor will advise you on how often you take your tablets based on your medical condition.  Most of the side effects of AP Serra Tablet 10's do not require medical attention and gradually resolve over time. Common side effects include nausea, vomiting, indigestion, stomach pain etc. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Do not take AP Serra Tablet 10's if you are allergic to painkillers like aspirin, ibuprofen, naproxen, or diclofenac. It is not recommended for use in children. It is advisable not to exceed the recommended dose or duration of treatment.

Non returnable*
COD available

Online payment accepted

Prescription drug

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Non returnable*
COD available

Online payment accepted

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine
 Pain after any injury, Low back pain, Cervical pain, Spondylitis, Osteoarthritis, Rheumatoid arthritis, etc.

AP Serra Tablet 10's consists of aceclofenac, paracetamol and serratiopeptidase. Aceclofenac works by blocking the action of an enzyme known as cyclo-oxygenase (COX) which causes pain and swelling at the injured or damaged tissue. Paracetamol acts as mild analgesic (pain reducer) and antipyretic (fever reducer) which enhances the pain relief action of aceclofenac. Serratiopeptidase causes thinning of the fluids around the site of injury thereby making fluid drainage smoother in the swollen tissue. Together these not only reduce pain and inflammation but also help in faster healing.

  • Nausea

  • Stomach Pain

  • Loss of appetite

  • Diarrhoea

  • Stomach upset

  • Indigestion

Tablet: Swallow it as a whole with water; do not crush, break or chew it.
Store in a cool and dry place away from sunlight

Consumption of alcohol should be avoided during the treatment with AP Serra Tablet 10's as it may lead to an increase in the risk of liver damage. Patients with stomach ulcers, gastric bleeding, severe heart failure and liver or kidney disease should not take AP Serra Tablet 10's on their own. Besides this, it should be avoided during the last trimester of pregnancy, unless there are compelling reasons for doing so. If you have a severe allergy to painkillers like asthma, rhinitis, angioedema (swelling under the skin) or skin rashes, immediately stop taking AP Serra Tablet 10's. Use with caution in pregnancy and breastfeeding. Do not self-administer AP Serra Tablet 10's if you are pregnant or are nursing.

ANALGESIC AND ANTIPYRETIC AGENT
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AceclofenacAtenolol
Severe
ParacetamolKetoconazole
Severe

Drug-Drug Interactions

AceclofenacAtenolol
Severe
How does the drug interact with AP Serra Tablet 10's:
Co-administration of Atenolol with AP Serra Tablet 10's could increase the risk of low blood pressure.

How to manage the interaction:
Although there is a possible interaction between Atenolol and AP Serra Tablet 10's, you can take these medicines together if prescribed by a doctor. Consult a doctor if you experience excessive sweating, shortness of breath, palpitations, or chest discomfort. Do not discontinue any medications without consulting a doctor.
ParacetamolKetoconazole
Severe
How does the drug interact with AP Serra Tablet 10's:
Co-administration of AP Serra Tablet 10's and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between AP Serra Tablet 10's and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolLeflunomide
Severe
How does the drug interact with AP Serra Tablet 10's:
Co-administration of AP Serra Tablet 10's and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between AP Serra Tablet 10's and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolTeriflunomide
Severe
How does the drug interact with AP Serra Tablet 10's:
Co-administration of Teriflunomide with AP Serra Tablet 10's may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking AP Serra Tablet 10's with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with AP Serra Tablet 10's:
Co-administration of AP Serra Tablet 10's may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and AP Serra Tablet 10's, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolLomitapide
Severe
How does the drug interact with AP Serra Tablet 10's:
Co-administration of Lomitapide and AP Serra Tablet 10's may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between AP Serra Tablet 10's and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolValdecoxib
Severe
How does the drug interact with AP Serra Tablet 10's:
Co-administration of AP Serra Tablet 10's and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between AP Serra Tablet 10's and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolKetamine
Severe
How does the drug interact with AP Serra Tablet 10's:
Co-administration of ketamine and AP Serra Tablet 10's may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and AP Serra Tablet 10's together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolMipomersen
Severe
How does the drug interact with AP Serra Tablet 10's:
Co-administration of Mipomersen with AP Serra Tablet 10's may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between AP Serra Tablet 10's and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

  • NIMESULIDE
  • OXYPHENBUTAZONE
  • METAMIZOLE
  • WARFARIN
  • Include more glucosamine, chondroitin sulphate, Vitamin D, calcium-enriched supplements. Besides this, turmeric and fish oils can help in reducing inflammation in the tissue.

  • Do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do stretching, low impact aerobic exercises like walking on a treadmill, bike riding and swimming. You can also strengthen your muscle strength by lifting light weights.

  • In the chronic conditions of arthritis or joint pain try to include fish like salmon, trout, tuna and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.

  • Your sitting posture is important especially when have pain and inflammation conditions. Try to sit as little as possible, and only for short time (10-15 min). Use back support like rolled-up towel at the back of your curve to minimize pain. Keep your knees and hips at a right angle. Besides this, you can use a footrest if required.

No
  • Paracetamol is a component of AP Serra Tablet 10's which can cause liver injury when in taken in large doses (usually more than 4 g/day). Concomitant use of alcohol is best avoided as it aggravates the liver toxicity.
  • Although AP Serra Tablet 10's provides symptomatic relief in conditions like arthritis and may reduce the inflammation caused by these conditions, to achieve best results, it is strongly recommended remaining physically active as much as your condition allows. Adopting a healthy lifestyle coupled with healthy diet containing high proteins, is the mainstay of management of arthritic conditions.

Pain can be temporary (acute) or lifelong (chronic) in nature. Acute pain is for short time caused by damage to the tissues of the muscle, bone or organs. While, chronic pain lasts for life long caused due to nerve damage, osteoarthritis and dental pain due to damage of the tooth nerve, infection, decay, extraction or injury. There are different types of musculoskeletal pain caused due to soft tissues (muscle, tendon and ligaments) injury. Extreme tissue pain and inflammation caused due to sprains, strains or trauma or post-surgery may require a prolonged amount of time to heal.

AP Serra Tablet 10's Substitute

Substitutes safety advice
  • Zerodol-SP Tablet 10's

    12.51per tablet
  • Signoflam Tablet 10's

    13.28per tablet
  • Hifenac-SP Tablet 10's

    12.02per tablet
  • Hifenac-D Tablet 10's

    12.02per tablet
  • Enzoflam-SP Tablet 10's

    11.97per tablet
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