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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Composition

APIXABAN-5MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Apigat 5 Tablet 30's

Apigat 5 Tablet 30's belongs to a class of drugs called 'anticoagulants' (blood thinners) primarily used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, Apigat 5 Tablet 30's is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). Deep vein thrombosis is a condition in which blood clots form in deep veins usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs. Atrial fibrillation is a condition that causes irregular, often fast heartbeat.

Apigat 5 Tablet 30's contains Apixaban that works by inhibiting the action of blood clotting factor (X a) which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein) and helps in preventing blood clot formation.

Take Apigat 5 Tablet 30's as prescribed. Your doctor will advise you how often you take Apigat 5 Tablet 30's based on your medical condition. Some people may experience nausea, anemia (lack of blood), and unusual bleeding, including swelling and bruising. Most of these side effects of Apigat 5 Tablet 30's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Apigat 5 Tablet 30's or any other medicines, please tell your doctor. If you are pregnant or a nursing mother, it is advised to consult a doctor before using Apigat 5 Tablet 30's. If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure, or bleeding problems, inform your doctor before taking Apigat 5 Tablet 30's. Your doctor may suggest a blood test called 'international normalized ratio' (INR) to check how quickly your blood's clotting. This test result will help your doctor to decide exactly when you should start taking Apigat 5 Tablet 30's.

Uses of Apigat 5 Tablet 30's

Prevention of blood clot

Directions for Use

Take Apigat 5 Tablet 30's with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not chew or break it. If you have difficulty swallowing the whole tablet, crush it and mix with water, 5 % dextrose in water, apple puree, or juice.

Medicinal Benefits

Apigat 5 Tablet 30's is primarily used to prevent and treat blood clots in the body by inhibiting the action of clotting factor Xa which is important element of blood clotting. Thereby, prevents conversion of fibrinogen to fibrin (a protein that binds platelets together and forms a clot) and helps in preventing blood clots formation.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Apigat 5 Tablet 30's

  • Nausea
  • Anaemia (lack of blood)
  • Bleeding including swelling and bruising

Drug Warnings

Apigat 5 Tablet 30's should not be used in children. Blood tests are advised before and while taking Apigat 5 Tablet 30's to monitor kidney and liver functioning. If you are pregnant or breastfeeding, please inform your doctor before taking Apigat 5 Tablet 30's. If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure or bleeding problems, antiphospholipid syndrome (an immune system disorder that causes an increased risk of blood clots), inform your doctor before taking Apigat 5 Tablet 30's.

Drug-Drug Interactions

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ApixabanDefibrotide
Critical
ApixabanMifepristone
Critical

Drug-Drug Interactions

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ApixabanDefibrotide
Critical
How does the drug interact with Apigat 5 Tablet:
Coadministration of Defibrotide and Apigat 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Defibrotide and Apigat 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanMifepristone
Critical
How does the drug interact with Apigat 5 Tablet:
Mifepristone and Apigat 5 Tablet co-administration have been associated with more severe vaginal bleeding in women.

How to manage the interaction:
Taking Apigat 5 Tablet with Mifepristone together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
ApixabanOmacetaxine mepesuccinate
Severe
How does the drug interact with Apigat 5 Tablet:
Coadministration of Omacetaxine mepesuccinate and Apigat 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Omacetaxine mepesuccinate and Apigat 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanRifapentine
Severe
How does the drug interact with Apigat 5 Tablet:
Apigat 5 Tablet's blood levels can be considerably lowered by taking it along with Rifapentine.

How to manage the interaction:
Although Co-administration of Rifapentine and Apigat 5 Tablet can lead to an interaction, they can be taken in case a doctor advises it to. Rifapentine makes Apigat 5 Tablet less effective in treating and preventing blood clots. Never discontinue taking a medication without consulting a doctor.
ApixabanCobicistat
Severe
How does the drug interact with Apigat 5 Tablet:
Cobicistat may significantly increase the blood levels of Apigat 5 Tablet. This can increase the risk of serious bleeding complications.

How to manage the interaction:
Even though combining Cobicistat and Apigat 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanFenoprofen
Severe
How does the drug interact with Apigat 5 Tablet:
Coadministration of Fenoprofen and Apigat 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Fenoprofen and Apigat 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanDabigatran etexilate
Severe
How does the drug interact with Apigat 5 Tablet:
Coadministration of Dabigatran etexilate and Apigat 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Dabigatran etexilate and Apigat 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanTolmetin
Severe
How does the drug interact with Apigat 5 Tablet:
Coadministration of Tolmetin and Apigat 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Tolmetin and Apigat 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanWarfarin
Severe
How does the drug interact with Apigat 5 Tablet:
Coadministration of Warfarin and Apigat 5 Tablet may raise the risk of bleeding.

How to manage the interaction:
Even though combining Warfarin and Apigat 5 Tablet may cause an interaction, it is still possible to take it if a doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanRivaroxaban
Severe
How does the drug interact with Apigat 5 Tablet:
Coadministration of Rivaroxaban and Apigat 5 Tablet co-administration may raise the risk of unusual bleeding.

How to manage the interaction:
Even though combining Rivaroxaban and Apigat 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid vitamin K rich foods such as coriander, cabbage, spinach, broccoli, collard greens, kale (leaf cabbage), black liquorice, turnip greens, avocados, Brussels sprouts as they may decrease the effectiveness of Apigat 5 Tablet 30's.
  • Do regular exercise as it helps to dissolve blood clots especially in obese people.
  • Do not consume more than 14 units of alcohol per week as excess alcohol intake may increase the risk of bleeding and quit smoking.

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

Apigat 5 Tablet 30's Substitute

Substitutes safety advice
  • Apixator 5 mg Tablet 10's

    by Others

    16.25per tablet
  • Elixaban 5 Tablet 10's

    by Others

    14.67per tablet
  • Abaxis 5 Tablet 10's

    by Others

    20.66per tablet
  • Apixapil 5 Tablet 10's

    by Others

    10.67per tablet
  • Apigy-5 Tablet 10's

    by Others

    18.81per tablet

Author Details

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Drug-Diseases Interactions

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APIXABAN-5MGHaemorrhage, not elsewhere classified
Severe
APIXABAN-5MGHepatic failure, not elsewhere classified
Moderate

Drug-Diseases Interactions

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APIXABAN-5MGHaemorrhage, not elsewhere classified
Severe
How does the disease interact with Apigat 5 Tablet:
Factor Xa inhibitors should not be used in individuals who have active pathological bleeding since they raise the risk of bleeding and have the potential to result in serious or fatal haemorrhages. Factor Xa inhibitors should only be prescribed with caution to patients who are at a higher risk of bleeding, such as those who are undergoing procedures where bleeding could result in life-threatening consequences.

How to manage the interaction:
Apigat 5 Tablet therapy is not recommended for patients with a history of bleeding disorder since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
APIXABAN-5MGHepatic failure, not elsewhere classified
Moderate
How does the disease interact with Apigat 5 Tablet:
In individuals with moderate or severe liver impairment (Child-Pugh B or C), the use of factor Xa inhibitors (including Apigat 5 Tablet and edoxaban) is not advised because these patients may have intrinsic coagulation problems.

How to manage the interaction:
Apigat 5 Tablet therapy is generally avoided in patients with a history of liver diseases since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, Skin and eyes that appear yellowish, abdominal pain and swelling, dizziness, lightheadedness, red or black tarry stools, dark urine, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
APIXABAN-5MGNonrheumatic aortic valve disorders
Moderate
How does the disease interact with Apigat 5 Tablet:
Patients who have artificial heart valves shouldn't use some factor Xa inhibitors, such as Apigat 5 Tablet, edoxaban, and rivaroxaban, as their safety and effectiveness have not been proven in this population.

How to manage the interaction:
Apigat 5 Tablet therapy is generally avoided in patients with a history of heart disease since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, palpitations, chest pain or discomfort, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
APIXABAN-5MGOther coagulation defects
Moderate
How does the disease interact with Apigat 5 Tablet:
In individuals with antiphospholipid syndrome (APS), direct-acting oral anticoagulants such as factor Xa inhibitors and some thrombin inhibitors like dabigatran are not advised. Increased rates of recurrent thrombotic events have been linked to the use of these medications, particularly in individuals with triple-positive APS.

How to manage the interaction:
Apigat 5 Tablet therapy is generally avoided in patients with a history of bleeding disorder since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, dark urine, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • CLOPIDOGREL
  • DILTIAZEM
  • HEPARIN
  • IBUPROFEN
  • NAPROXEN
  • RIVAROXABAN

Special Advise

Complete blood count (CBC), INR test, prothrombin tests are advised before and while taking Apigat 5 Tablet 30's.

Disease/Condition Glossary

Deep vein thrombosis (blood clots in legs) is a medical condition in which blood clots form in deep veins usually in legs. The symptoms include leg pain or swelling.

Pulmonary embolism (blood clots in lung) is a condition which occurs as the blood clots break and travel to lungs from deep veins in the legs or other parts of the body. The symptoms of pulmonary embolism include cough, chest pain and shortness of breath. Quick medication is advised to reduce the risk of serious conditions due to blood clots.

Atrial fibrillation is a condition that causes irregular, often fast heartbeat. In atrial fibrillation condition, blood clots are formed as blood is pooled in the upper chambers of heart.

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