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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

APIXABAN-5MG

Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Cadiquis 5 Tablet

Cadiquis 5 Tablet belongs to a class of drugs called 'anticoagulants' (blood thinners) primarily used to prevent and treat deep vein thrombosis (blood clots in leg veins) and pulmonary embolism (blood clots in the lung). Additionally, Cadiquis 5 Tablet is used to prevent blood clots in patients with atrial fibrillation (irregular heartbeat). Deep vein thrombosis is a condition in which blood clots form in deep veins usually in the legs. Pulmonary embolism is a condition in which a blood clot blocks the arteries in the lungs. Atrial fibrillation is a condition that causes irregular, often fast heartbeat.

Cadiquis 5 Tablet contains Apixaban that works by inhibiting the action of blood clotting factor (X a) which is an important element of blood clotting. Thereby, it prevents the conversion of fibrinogen (soluble protein) to fibrin (insoluble protein) and helps in preventing blood clot formation.

Take Cadiquis 5 Tablet as prescribed. Your doctor will advise you how often you take Cadiquis 5 Tablet based on your medical condition. Some people may experience nausea, anemia (lack of blood), and unusual bleeding, including swelling and bruising. Most of these side effects of Cadiquis 5 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Cadiquis 5 Tablet or any other medicines, please tell your doctor. If you are pregnant or a nursing mother, it is advised to consult a doctor before using Cadiquis 5 Tablet . If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure, or bleeding problems, inform your doctor before taking Cadiquis 5 Tablet . Your doctor may suggest a blood test called 'international normalized ratio' (INR) to check how quickly your blood's clotting. This test result will help your doctor to decide exactly when you should start taking Cadiquis 5 Tablet .

Uses of Cadiquis 5 Tablet

Prevention of blood clot

Directions for Use

Take Cadiquis 5 Tablet with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not chew or break it. If you have difficulty swallowing the whole tablet, crush it and mix with water, 5 % dextrose in water, apple puree, or juice.

Medicinal Benefits

Cadiquis 5 Tablet is primarily used to prevent and treat blood clots in the body by inhibiting the action of clotting factor Xa which is important element of blood clotting. Thereby, prevents conversion of fibrinogen to fibrin (a protein that binds platelets together and forms a clot) and helps in preventing blood clots formation.

Storage

Store in a cool and dry place away from sunlight
Side effects of Cadiquis 5 Tablet
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.

Drug Warnings

Cadiquis 5 Tablet should not be used in children. Blood tests are advised before and while taking Cadiquis 5 Tablet to monitor kidney and liver functioning. If you are pregnant or breastfeeding, please inform your doctor before taking Cadiquis 5 Tablet . If you have a stomach ulcer, recent bleeding in the brain, kidney or liver problems, high blood pressure or bleeding problems, antiphospholipid syndrome (an immune system disorder that causes an increased risk of blood clots), inform your doctor before taking Cadiquis 5 Tablet .

Drug-Drug Interactions

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ApixabanDefibrotide
Critical

Drug-Drug Interactions

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How does the drug interact with Cadiquis 5 Tablet:
Mifepristone and Cadiquis 5 Tablet co-administration have been associated with more severe vaginal bleeding in women.

How to manage the interaction:
Taking Cadiquis 5 Tablet with Mifepristone together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
ApixabanDefibrotide
Critical
How does the drug interact with Cadiquis 5 Tablet:
Coadministration of Defibrotide and Cadiquis 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Defibrotide and Cadiquis 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanDiflunisal
Severe
How does the drug interact with Cadiquis 5 Tablet:
Coadministration of Diflunisal and Cadiquis 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Diflunisal and Cadiquis 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanDrotrecogin alfa (activated)
Severe
How does the drug interact with Cadiquis 5 Tablet:
Coadministration of Drotrecogin alfa (activated) and Cadiquis 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Drotrecogin alfa (activated) and Cadiquis 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. You must inform the doctor if you are taking or had recently taken Cadiquis 5 Tablet within past 7 days. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
How does the drug interact with Cadiquis 5 Tablet:
Co-administration of Ibrutinib and Cadiquis 5 Tablet may raise the risk of bleeding.

How to manage the interaction:
Even though combining Ibrutinib and Cadiquis 5 Tablet may cause an interaction, it is still possible if a doctor advises you to take it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Cadiquis 5 Tablet:
Coadministration of Cabozantinib and Cadiquis 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Cabozantinib and Cadiquis 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanOmacetaxine mepesuccinate
Severe
How does the drug interact with Cadiquis 5 Tablet:
Coadministration of Omacetaxine mepesuccinate and Cadiquis 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Omacetaxine mepesuccinate and Cadiquis 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanDicoumarol
Severe
How does the drug interact with Cadiquis 5 Tablet:
Coadministration of Dicoumarol and Cadiquis 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Dicoumarol and Cadiquis 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
ApixabanLepirudin
Severe
How does the drug interact with Cadiquis 5 Tablet:
Coadministration of Lepirudin and Cadiquis 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Lepirudin and Cadiquis 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
How does the drug interact with Cadiquis 5 Tablet:
Coadministration of Urokinase and Cadiquis 5 Tablet co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Urokinase and Cadiquis 5 Tablet may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid vitamin K rich foods such as coriander, cabbage, spinach, broccoli, collard greens, kale (leaf cabbage), black liquorice, turnip greens, avocados, Brussels sprouts as they may decrease the effectiveness of Cadiquis 5 Tablet .
  • Do regular exercise as it helps to dissolve blood clots especially in obese people.
  • Do not consume more than 14 units of alcohol per week as excess alcohol intake may increase the risk of bleeding and quit smoking.

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

Author Details

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Drug-Diseases Interactions

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APIXABAN-5MGHaemorrhage, not elsewhere classified
Severe
APIXABAN-5MGHepatic failure, not elsewhere classified
Moderate

Drug-Diseases Interactions

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APIXABAN-5MGHaemorrhage, not elsewhere classified
Severe
How does the disease interact with Cadiquis 5 Tablet:
Factor Xa inhibitors should not be used in individuals who have active pathological bleeding since they raise the risk of bleeding and have the potential to result in serious or fatal haemorrhages. Factor Xa inhibitors should only be prescribed with caution to patients who are at a higher risk of bleeding, such as those who are undergoing procedures where bleeding could result in life-threatening consequences.

How to manage the interaction:
Cadiquis 5 Tablet therapy is not recommended for patients with a history of bleeding disorder since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
APIXABAN-5MGHepatic failure, not elsewhere classified
Moderate
How does the disease interact with Cadiquis 5 Tablet:
In individuals with moderate or severe liver impairment (Child-Pugh B or C), the use of factor Xa inhibitors (including Cadiquis 5 Tablet and edoxaban) is not advised because these patients may have intrinsic coagulation problems.

How to manage the interaction:
Cadiquis 5 Tablet therapy is generally avoided in patients with a history of liver diseases since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, Skin and eyes that appear yellowish, abdominal pain and swelling, dizziness, lightheadedness, red or black tarry stools, dark urine, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
APIXABAN-5MGNonrheumatic aortic valve disorders
Moderate
How does the disease interact with Cadiquis 5 Tablet:
Patients who have artificial heart valves shouldn't use some factor Xa inhibitors, such as Cadiquis 5 Tablet, edoxaban, and rivaroxaban, as their safety and effectiveness have not been proven in this population.

How to manage the interaction:
Cadiquis 5 Tablet therapy is generally avoided in patients with a history of heart disease since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, palpitations, chest pain or discomfort, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
APIXABAN-5MGOther coagulation defects
Moderate
How does the disease interact with Cadiquis 5 Tablet:
In individuals with antiphospholipid syndrome (APS), direct-acting oral anticoagulants such as factor Xa inhibitors and some thrombin inhibitors like dabigatran are not advised. Increased rates of recurrent thrombotic events have been linked to the use of these medications, particularly in individuals with triple-positive APS.

How to manage the interaction:
Cadiquis 5 Tablet therapy is generally avoided in patients with a history of bleeding disorder since it can worsen the condition, which can be fatal. It can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, dark urine, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

FAQs

No, you are not recommended to take ibuprofen with Cadiquis 5 Tablet as co-administration of these two medicines may increase the risk of bleeding more easily. However, if you notice blood in urine or stools, dizziness, unusual bleeding or bruising, red or black tarry stools, vomiting, weakness or headache, please consult a doctor immediately. If you are supposed to use these medicines together, you are advised to contact your doctor so that the dose may be adjusted appropriately to use safely.

No, you are usually not advised to have a tattoo or body piercing while taking Cadiquis 5 Tablet as it may increase the risk of bleeding and infection. If you still wish to proceed further, contact your doctor so that the dose may be adjusted or any antibiotics may be prescribed and let the piercer or tattooist know in advance that you are on treatment with a blood thinner.

Yes, you are advised to stop taking Cadiquis 5 Tablet a few days before surgery or procedure as Cadiquis 5 Tablet may increase the risk of bleeding. Therefore, before having any procedure or any surgery, please inform your doctor that you are taking Cadiquis 5 Tablet .

Yes, Cadiquis 5 Tablet helps in reducing the risk of stroke and heart attack by preventing blood clots. Stroke is caused as blood clots break off and travel to brain.

No, you are not recommended to stop taking Cadiquis 5 Tablet without consulting your doctor as it may worsen the condition. Therefore, take Cadiquis 5 Tablet for as long as your doctor has prescribed it.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • CLOPIDOGREL
  • DILTIAZEM
  • HEPARIN
  • IBUPROFEN
  • NAPROXEN
  • RIVAROXABAN

Special Advise

Complete blood count (CBC), INR test, prothrombin tests are advised before and while taking Cadiquis 5 Tablet .

Disease/Condition Glossary

Deep vein thrombosis (blood clots in legs) is a medical condition in which blood clots form in deep veins usually in legs. The symptoms include leg pain or swelling.

Pulmonary embolism (blood clots in lung) is a condition which occurs as the blood clots break and travel to lungs from deep veins in the legs or other parts of the body. The symptoms of pulmonary embolism include cough, chest pain and shortness of breath. Quick medication is advised to reduce the risk of serious conditions due to blood clots.

Atrial fibrillation is a condition that causes irregular, often fast heartbeat. In atrial fibrillation condition, blood clots are formed as blood is pooled in the upper chambers of heart.

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