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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Bdbrut Capsule 30's

Bdbrut Capsule 30's belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma (cancer affecting the lymph nodes), chronic lymphocytic leukaemia (cancer affecting white blood cells and lymph nodes), and waldenström's macroglobulinaemia (cancer affecting white blood cells).
 
Bdbrut Capsule 30's contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.
 
In some cases, Bdbrut Capsule 30's may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
 
Do not take Bdbrut Capsule 30's if you are pregnant or breastfeeding. Consult the doctor immediately if you become pregnant during treatment with Bdbrut Capsule 30's. This medicine is not recommended for children as safety and effectiveness have not been established. Inform the doctor about your health condition and medications to rule out any side effects/interactions.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

IBRUTINIB-140MG

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

Uses of Bdbrut Capsule 30's

Mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia.

Medicinal Benefits

Bdbrut Capsule 30's belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia. This medicine may also be used to treat marginal zone lymphoma (cancer that begins in a type of white blood cells that normally fights infection) and chronic graft vs host disease (a complication of hematopoietic stem-cell transplant). Bdbrut Capsule 30's contains Ibrutinib, which works by blocking Bruton's tyrosine kinase (a protein in the body that helps cancer cells grow and survive). Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer. 

Side Effects of Bdbrut Capsule 30's

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Fatigue
  • Dizziness
  • Mouth sores

Directions for Use

Swallow the medicine as a whole with water; do not crush or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Bdbrut Capsule 30's if you are allergic to any of its components, if you are taking St. John's wort (herbal medicine) or if you are pregnant/breastfeeding. Inform the doctor if you have/had unusual bruising or bleeding, irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, kidney problems, or if you are due to undergo any surgery. Seek immediate medical attention if you experience symptoms of progressive multifocal leukoencephalopathy, a serious brain infection (trouble thinking, memory loss, sight loss, or difficulty walking), stroke (sudden confusion, numbness or weakness, trouble speaking, sight loss, loss of balance, or sudden severe headache), heart failure (breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs), rupture of the spleen (left abdominal pain, pain below the left rib cage or at the tip of left shoulder), infection (chills, fever, weakness, body aches, cold, flu symptoms, or confusion), or haemophagocytic lymphohistiocytosis, an inflammatory disorder (fever, bruising, swollen glands, or skin rash).

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

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IbrutinibRivaroxaban
Severe
IbrutinibIndometacin
Severe

Drug-Drug Interactions

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IbrutinibRivaroxaban
Severe
How does the drug interact with Bdbrut Capsule 30's:
Co-administration of Bdbrut Capsule 30's and Rivaroxaban can increase the risk of bleeding problems.

How to manage the interaction:
Co-administration of Bdbrut Capsule 30's and Rivaroxaban can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IbrutinibIndometacin
Severe
How does the drug interact with Bdbrut Capsule 30's:
Co-administration of Indomethacin with Bdbrut Capsule 30's can increase the likelihood and seriousness of side effects.

How to manage the interaction:
Taking Indometacin with Bdbrut Capsule 30's together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibKetorolac
Severe
How does the drug interact with Bdbrut Capsule 30's:
Co-administration of Bdbrut Capsule 30's and Ketorolac may increase the risk of bleeding.

How to manage the interaction:
Although taking Ketorolac and Bdbrut Capsule 30's together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not discontinue any medications without consulting a doctor.
IbrutinibUrokinase
Severe
How does the drug interact with Bdbrut Capsule 30's:
Co-administration of Bdbrut Capsule 30's with Urokinase can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Bdbrut Capsule 30's with Urokinase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibMitotane
Severe
How does the drug interact with Bdbrut Capsule 30's:
Co-administration of Mitotane may decrease the blood levels of Bdbrut Capsule 30's, which may make Bdbrut Capsule 30's less effective in treating your condition.

How to manage the interaction:
Although taking Bdbrut Capsule 30's and Mitotane together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
IbrutinibKetoconazole
Severe
How does the drug interact with Bdbrut Capsule 30's:
If Ketoconazole and Bdbrut Capsule 30's are used together, the blood levels of Bdbrut Capsule 30's may be greatly raised.

How to manage the interaction:
Although taking Ketoconazole and Bdbrut Capsule 30's together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in your coughing fluid, sudden weight gain or loss, red or inflamed skin, body sores, increased or decreased urination, or discomfort or burning when urinating, nausea, vomiting, loss of appetite, swelling, confusion, or irregular heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IbrutinibDiclofenac
Severe
How does the drug interact with Bdbrut Capsule 30's:
Taking Diclofenac with Bdbrut Capsule 30's can increase the risk of bleeding tendencies.

How to manage the interaction:
There may be a possible interaction between Diclofenac and Bdbrut Capsule 30's, but they can be taken together if a doctor has prescribed them. However, consult a doctor immediately if you experience any unusual bleeding, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, or severe headaches. Do not discontinue any medications without consulting a doctor.
IbrutinibPhenobarbital
Severe
How does the drug interact with Bdbrut Capsule 30's:
Co-administration of Phenobarbital can significantly lower Bdbrut Capsule 30's levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Bdbrut Capsule 30's can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
IbrutinibBivalirudin
Severe
How does the drug interact with Bdbrut Capsule 30's:
Co-administration of Bdbrut Capsule 30's with Bivalirudin can increase the risk of bleeding.

How to manage the interaction:
Taking Bdbrut Capsule 30's with Bivalirudin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibDeferiprone
Severe
How does the drug interact with Bdbrut Capsule 30's:
Co-administration of Bdbrut Capsule 30's and Deferiprone can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Bdbrut Capsule 30's can be taken with Deferiprone, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, St. John’S Wort

How to manage the interaction:
Consumption of grape fruit or its products, St. John’S Wort during Bdbrut Capsule 30's treatment may lead to an interaction. Avoid consumption of grape fruit or its products, St. John’S Wort while on therapy with Bdbrut Capsule 30's.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water.

Habit Forming

No

Special Advise

  • Women of childbearing potential should use highly effective contraception during treatment and for three months after receiving the last dose.
  • If you are due to undergo any surgery, including dental surgery, inform the doctor/dentist that you are on treatment with Bdbrut Capsule 30's.
  • Your doctor may recommend tests to check liver function.
  • Drink plenty of water or other fluids while taking Bdbrut Capsule 30's.

Disease/Condition Glossary

Mantle cell lymphoma (MCL): Mantle cell lymphoma is a type of cancer that affects the lymph nodes. Symptoms include swelling of lymph nodes, fever, night sweats, weight loss, fatigue, nausea, vomiting, pain, bloating, and indigestion.

Chronic lymphocytic leukaemia (CLL): Chronic lymphocytic leukaemia is a type of cancer affecting white blood cells called lymphocytes that also involves the lymph nodes. Symptoms include swollen lymph nodes, easy bruising, and fatigue.

Waldenström's macroglobulinaemia (WM): Waldenström's macroglobulinaemia is a type of cancer that affects white blood cells called lymphocytes. Symptoms include anaemia (lack of red blood cells), frequent infections due to lack of white blood cells, swelling of lymph nodes, pain and discomfort.

Bdbrut Capsule 30's Substitute

Substitutes safety advice
  • Ibrunat Capsule 30's

    by AYUR

    259.67per tablet
  • Nitib 140mg Tablet 30's

    291.65per tablet
  • Ibronza 140Mg Capsule 30'S

    by AYUR

    227.47per tablet
  • Imbruvica 140Mg Capsule 90'S

    by AYUR

    2988.44per tablet
  • Imbruvica 140Mg 120 Capsule

    2979.33per tablet
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