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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition

IBRUTINIB-140MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Ibronza 140Mg Capsule 30'S

Ibronza 140Mg Capsule 30'S belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma (cancer affecting the lymph nodes), chronic lymphocytic leukaemia (cancer affecting white blood cells and lymph nodes), and waldenström's macroglobulinaemia (cancer affecting white blood cells).
 
Ibronza 140Mg Capsule 30'S contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.
 
In some cases, Ibronza 140Mg Capsule 30'S may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
 
Do not take Ibronza 140Mg Capsule 30'S if you are pregnant or breastfeeding. Consult the doctor immediately if you become pregnant during treatment with Ibronza 140Mg Capsule 30'S. This medicine is not recommended for children as safety and effectiveness have not been established. Inform the doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Ibronza 140Mg Capsule 30'S

Mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia.

Directions for Use

Swallow the medicine as a whole with water; do not crush or chew it.

Medicinal Benefits

Ibronza 140Mg Capsule 30'S belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia. This medicine may also be used to treat marginal zone lymphoma (cancer that begins in a type of white blood cells that normally fights infection) and chronic graft vs host disease (a complication of hematopoietic stem-cell transplant). Ibronza 140Mg Capsule 30'S contains Ibrutinib, which works by blocking Bruton's tyrosine kinase (a protein in the body that helps cancer cells grow and survive). Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Ibronza 140Mg Capsule 30'S

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Fatigue
  • Dizziness
  • Mouth sores

Drug Warnings

Do not take Ibronza 140Mg Capsule 30'S if you are allergic to any of its components, if you are taking St. John's wort (herbal medicine) or if you are pregnant/breastfeeding. Inform the doctor if you have/had unusual bruising or bleeding, irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, kidney problems, or if you are due to undergo any surgery. Seek immediate medical attention if you experience symptoms of progressive multifocal leukoencephalopathy, a serious brain infection (trouble thinking, memory loss, sight loss, or difficulty walking), stroke (sudden confusion, numbness or weakness, trouble speaking, sight loss, loss of balance, or sudden severe headache), heart failure (breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs), rupture of the spleen (left abdominal pain, pain below the left rib cage or at the tip of left shoulder), infection (chills, fever, weakness, body aches, cold, flu symptoms, or confusion), or haemophagocytic lymphohistiocytosis, an inflammatory disorder (fever, bruising, swollen glands, or skin rash).

Drug-Drug Interactions

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IbrutinibAbciximab
Severe
IbrutinibImatinib
Severe

Drug-Drug Interactions

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IbrutinibAbciximab
Severe
How does the drug interact with Ibronza 140Mg Capsule:
When Ibronza 140Mg Capsule and Abciximab are taken together, there is a chance that bleeding and haemorrhage risk or severity will rise.

How to manage the interaction:
Taking Abciximab with Ibronza 140Mg Capsule together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that resembles coffee grounds, severe headache, and weakness, consult a doctor. Do not discontinue any medications without a doctor's advice.
IbrutinibImatinib
Severe
How does the drug interact with Ibronza 140Mg Capsule:
Taking Ibronza 140Mg Capsule with imatinib may increase the levels of Ibronza 140Mg Capsule.

How to manage the interaction:
Taking Ibronza 140Mg Capsule with Imatinib together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or inflamed skin, body sores, or discomfort or burning when urinating, nausea, vomiting, loss of appetite, fluid retention, swelling, irregular heartbeat, you should consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IbrutinibReteplase
Severe
How does the drug interact with Ibronza 140Mg Capsule:
Co-administration of Ibronza 140Mg Capsule with Reteplase can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibronza 140Mg Capsule with Reteplase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibUrokinase
Severe
How does the drug interact with Ibronza 140Mg Capsule:
Co-administration of Ibronza 140Mg Capsule with Urokinase can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibronza 140Mg Capsule with Urokinase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibMitotane
Severe
How does the drug interact with Ibronza 140Mg Capsule:
Co-administration of Mitotane may decrease the blood levels of Ibronza 140Mg Capsule, which may make Ibronza 140Mg Capsule less effective in treating your condition.

How to manage the interaction:
Although taking Ibronza 140Mg Capsule and Mitotane together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
IbrutinibCiprofloxacin
Severe
How does the drug interact with Ibronza 140Mg Capsule:
Taking Ibronza 140Mg Capsule with Ciprofloxacin may increase the levels of Ibronza 140Mg Capsule. As a result, there may be an increased risk of kidney issues.

How to manage the interaction:
Although taking Ciprofloxacin and Ibronza 140Mg Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience paleness, tiredness, dizziness, fainting, unusual scaring or bleeding, fever, chills, diarrhea, sore throat, muscle pains, difficulty breathing, blood in your coughing fluid, weight loss, red or inflamed skin, body sores, or discomfort or burning when urinating, nausea, vomiting, loss of appetite, sudden weight gain or loss, fluid retention, swelling, or irregular heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IbrutinibAprepitant
Severe
How does the drug interact with Ibronza 140Mg Capsule:
Co-administration of Ibronza 140Mg Capsule together with Aprepitant may significantly increase the blood levels of Ibronza 140Mg Capsule.

How to manage the interaction:
Even though there is an interaction between Aprepitant and Ibronza 140Mg Capsule, it can be taken if a doctor prescribes it. However, doctor if you experience any of the following symptoms: paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in the phlegm, red or inflamed skin, body sores, increased or decreased urination, pain while urinating, nausea, vomiting or loss of hunger, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
IbrutinibDalteparin
Severe
How does the drug interact with Ibronza 140Mg Capsule:
Co-administration of Ibronza 140Mg Capsule with Dalteparin can increase the risk of bleeding.

How to manage the interaction:
Taking Ibronza 140Mg Capsule with Dalteparin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibLepirudin
Severe
How does the drug interact with Ibronza 140Mg Capsule:
Co-administration of Ibronza 140Mg Capsule with Lepirudin can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Ibronza 140Mg Capsule with Lepirudin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibEtanercept
Severe
How does the drug interact with Ibronza 140Mg Capsule:
When Etanercept is used with Ibronza 140Mg Capsule, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between Ibronza 140Mg Capsule and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, St. John’S Wort

How to manage the interaction:
Consumption of grape fruit or its products, St. John’S Wort during Ibronza 140Mg Capsule treatment may lead to an interaction. Avoid consumption of grape fruit or its products, St. John’S Wort while on therapy with Ibronza 140Mg Capsule.

Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Ibronza 140Mg Capsule 30'S Substitute

Substitutes safety advice
  • Ibrunat Capsule 30's

    by AYUR

    259.67per tablet
  • Nitib 140mg Tablet 30's

    by Others

    291.65per tablet
  • Imbruvica 140Mg Capsule 90'S

    by AYUR

    2988.44per tablet
  • Imbruvica 140Mg 120 Capsule

    by Others

    2979.33per tablet
  • Bdbrut Capsule 30's

    by Others

    196.80per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Special Advise

  • Women of childbearing potential should use highly effective contraception during treatment and for three months after receiving the last dose.
  • If you are due to undergo any surgery, including dental surgery, inform the doctor/dentist that you are on treatment with Ibronza 140Mg Capsule 30'S.
  • Your doctor may recommend tests to check liver function.
  • Drink plenty of water or other fluids while taking Ibronza 140Mg Capsule 30'S.

Disease/Condition Glossary

Mantle cell lymphoma (MCL): Mantle cell lymphoma is a type of cancer that affects the lymph nodes. Symptoms include swelling of lymph nodes, fever, night sweats, weight loss, fatigue, nausea, vomiting, pain, bloating, and indigestion.

Chronic lymphocytic leukaemia (CLL): Chronic lymphocytic leukaemia is a type of cancer affecting white blood cells called lymphocytes that also involves the lymph nodes. Symptoms include swollen lymph nodes, easy bruising, and fatigue.

Waldenström's macroglobulinaemia (WM): Waldenström's macroglobulinaemia is a type of cancer that affects white blood cells called lymphocytes. Symptoms include anaemia (lack of red blood cells), frequent infections due to lack of white blood cells, swelling of lymph nodes, pain and discomfort.

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