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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Imbruvica 140Mg 120 Capsule

Imbruvica 140Mg 120 Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma (cancer affecting the lymph nodes), chronic lymphocytic leukaemia (cancer affecting white blood cells and lymph nodes), and waldenström's macroglobulinaemia (cancer affecting white blood cells).
 
Imbruvica 140Mg 120 Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase, a protein in the body that helps cancer cells grow and survive. Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer.
 
In some cases, Imbruvica 140Mg 120 Capsule may cause side effects such as nausea, vomiting, diarrhoea, constipation, indigestion, and fatigue. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
 
Do not take Imbruvica 140Mg 120 Capsule if you are pregnant or breastfeeding. Consult the doctor immediately if you become pregnant during treatment with Imbruvica 140Mg 120 Capsule. This medicine is not recommended for children as safety and effectiveness have not been established. Inform the doctor about your health condition and medications to rule out any side effects/interactions.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

IBRUTINIB-140MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Imbruvica 140Mg 120 Capsule

Mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia.

Medicinal Benefits

Imbruvica 140Mg 120 Capsule belongs to the group of anti-cancer medicines called protein kinase inhibitors used to treat the following blood cancers in adults- mantle cell lymphoma, chronic lymphocytic leukaemia, and waldenström's macroglobulinaemia. This medicine may also be used to treat marginal zone lymphoma (cancer that begins in a type of white blood cells that normally fights infection) and chronic graft vs host disease (a complication of hematopoietic stem-cell transplant). Imbruvica 140Mg 120 Capsule contains Ibrutinib, which works by blocking Bruton's tyrosine kinase (a protein in the body that helps cancer cells grow and survive). Thereby, it kills and reduces the number of cancer cells. It also slows down the worsening of cancer. 

Side Effects of Imbruvica 140Mg 120 Capsule

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Headache
  • Fatigue
  • Dizziness
  • Mouth sores

Directions for Use

Swallow the medicine as a whole with water; do not crush or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Imbruvica 140Mg 120 Capsule if you are allergic to any of its components, if you are taking St. John's wort (herbal medicine) or if you are pregnant/breastfeeding. Inform the doctor if you have/had unusual bruising or bleeding, irregular heartbeat, heart failure, hepatitis B infection, liver problems, high blood pressure, kidney problems, or if you are due to undergo any surgery. Seek immediate medical attention if you experience symptoms of progressive multifocal leukoencephalopathy, a serious brain infection (trouble thinking, memory loss, sight loss, or difficulty walking), stroke (sudden confusion, numbness or weakness, trouble speaking, sight loss, loss of balance, or sudden severe headache), heart failure (breathlessness, difficulty breathing when lying down, weakness/tiredness, or swelling of the feet, ankles, or legs), rupture of the spleen (left abdominal pain, pain below the left rib cage or at the tip of left shoulder), infection (chills, fever, weakness, body aches, cold, flu symptoms, or confusion), or haemophagocytic lymphohistiocytosis, an inflammatory disorder (fever, bruising, swollen glands, or skin rash).

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

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IbrutinibAnistreplase
Severe
IbrutinibDeferiprone
Severe

Drug-Drug Interactions

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IbrutinibAnistreplase
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Imbruvica 140Mg 120 Capsule with Anistreplase can increase the risk of bleeding.

How to manage the interaction:
Taking Imbruvica 140Mg 120 Capsule with Anistreplase together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibDeferiprone
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Imbruvica 140Mg 120 Capsule and Deferiprone can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Imbruvica 140Mg 120 Capsule can be taken with Deferiprone, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
IbrutinibOxaprozin
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Imbruvica 140Mg 120 Capsule with Oxaprozin can increase the risk of bleeding.

How to manage the interaction:
Taking Imbruvica 140Mg 120 Capsule with Oxaprozin together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibTicagrelor
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Taking Ticagrelor with Imbruvica 140Mg 120 Capsule can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Imbruvica 140Mg 120 Capsule with Ticagrelor together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without consulting a doctor.
IbrutinibFenoprofen
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Imbruvica 140Mg 120 Capsule with Fenoprofen can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Imbruvica 140Mg 120 Capsule with Fenoprofen together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
IbrutinibRotavirus vaccine
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
When Rotavirus vaccine is used together with Imbruvica 140Mg 120 Capsule, its effectiveness may be reduced.

How to manage the interaction:
Taking Imbruvica 140Mg 120 Capsule with the Rotavirus vaccine together can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact the doctor right away. Do not discontinue any medications without consulting the doctor.
IbrutinibNaproxen
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Naproxen and Imbruvica 140Mg 120 Capsule can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Naproxen and Imbruvica 140Mg 120 Capsule together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without consulting a doctor.
IbrutinibAtazanavir
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Co-administration of Imbruvica 140Mg 120 Capsule with Atazanavir may significantly raise the blood levels of Imbruvica 140Mg 120 Capsule.

How to manage the interaction:
Taking Imbruvica 140Mg 120 Capsule with Atazanavir together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult the doctor. Do not discontinue any medications without a doctor's advice.
IbrutinibPosaconazole
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Taking Imbruvica 140Mg 120 Capsule with posaconazole may increase the levels of Imbruvica 140Mg 120 Capsule in the blood.

How to manage the interaction:
Although there is an interaction between posaconazole and Imbruvica 140Mg 120 Capsule, they can be taken together if advised by a doctor. However, contact a doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not stop taking any medications without consulting a doctor.
IbrutinibConivaptan
Severe
How does the drug interact with Imbruvica 140Mg 120 Capsule:
Taking Imbruvica 140Mg 120 Capsule with Conivaptan may increase the levels of Imbruvica 140Mg 120 Capsule.

How to manage the interaction:
Although taking Imbruvica 140Mg 120 Capsule and Conivaptan together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines

Drug-Food Interactions

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IBRUTINIB-140MGGrapefruit and Grapefruit Juice, Herbal products/medicines
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, St. John’S Wort

How to manage the interaction:
Consumption of grape fruit or its products, St. John’S Wort during Imbruvica 140Mg 120 Capsule treatment may lead to an interaction. Avoid consumption of grape fruit or its products, St. John’S Wort while on therapy with Imbruvica 140Mg 120 Capsule.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water.

Habit Forming

No

Special Advise

  • Women of childbearing potential should use highly effective contraception during treatment and for three months after receiving the last dose.
  • If you are due to undergo any surgery, including dental surgery, inform the doctor/dentist that you are on treatment with Imbruvica 140Mg 120 Capsule.
  • Your doctor may recommend tests to check liver function.
  • Drink plenty of water or other fluids while taking Imbruvica 140Mg 120 Capsule.

Disease/Condition Glossary

Mantle cell lymphoma (MCL): Mantle cell lymphoma is a type of cancer that affects the lymph nodes. Symptoms include swelling of lymph nodes, fever, night sweats, weight loss, fatigue, nausea, vomiting, pain, bloating, and indigestion.

Chronic lymphocytic leukaemia (CLL): Chronic lymphocytic leukaemia is a type of cancer affecting white blood cells called lymphocytes that also involves the lymph nodes. Symptoms include swollen lymph nodes, easy bruising, and fatigue.

Waldenström's macroglobulinaemia (WM): Waldenström's macroglobulinaemia is a type of cancer that affects white blood cells called lymphocytes. Symptoms include anaemia (lack of red blood cells), frequent infections due to lack of white blood cells, swelling of lymph nodes, pain and discomfort.

Imbruvica 140Mg 120 Capsule Substitute

Substitutes safety advice
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