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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition :

AXITINIB-1MG

Manufacturer/Marketer :

Adley Oncology

Consume Type :

ORAL

Return Policy :

Not Returnable

About Bexinib 1 mg Tablet 14's

Bexinib 1 mg Tablet 14's is an anti-cancer medicine used in the treatment of renal cell carcinoma. Renal cell carcinoma, also known as kidney cancer, is a disease in which the cancer or malignant cells grow uncontrollably in the kidney and form a tumour.

Bexinib 1 mg Tablet 14's contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Bexinib 1 mg Tablet 14's may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you. Bexinib 1 mg Tablet 14's should be taken as advised by your doctor.

Avoid taking Bexinib 1 mg Tablet 14's if you are allergic to it or any other components of it. Before taking Bexinib 1 mg Tablet 14's, inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, thyroid disorders, or blood disorders. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Bexinib 1 mg Tablet 14's

Renal Cell Carcinoma.

Directions for Use

Take Bexinib 1 mg Tablet 14's as prescribed by the doctor. It can be taken with or without food in a 12-hour interval. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Medicinal Benefits

Bexinib 1 mg Tablet 14's contains Axitinib, which is used in treating advanced renal cell carcinoma after failure of prior systemic therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Bexinib 1 mg Tablet 14's stops the body's production, spread and growth of cancerous cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Bexinib 1 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug Warnings

To treat your condition effectually, continue taking Bexinib 1 mg Tablet 14's for the period that your doctor has prescribed. Avoid taking Bexinib 1 mg Tablet 14's if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Bexinib 1 mg Tablet 14's may cause hypertension, arterial and venous thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes in some patients. Hence, inform your doctor about your complete medication and medical history before taking Bexinib 1 mg Tablet 14's.

Drug-Drug Interactions

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AxitinibTroleandomycin
Severe
AxitinibLeflunomide
Severe

Drug-Drug Interactions

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AxitinibTroleandomycin
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Co-administration of Bexinib 1 mg Tablet with troleandomycin may cause Bexinib 1 mg Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Bexinib 1 mg Tablet and Troleandomycin, you can take these medicines together if prescribed by a doctor. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor’s advice.
AxitinibLeflunomide
Severe
How does the drug interact with Bexinib 1 mg Tablet:
When Bexinib 1 mg Tablet is taken with Leflunomide, the risk of liver problems increases.

How to manage the interaction:
Although there is an interaction between leflunomide and Bexinib 1 mg Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AxitinibFosamprenavir
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Co-administration of Bexinib 1 mg Tablet with fosamprenavir may cause Bexinib 1 mg Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Co-administration of Bexinib 1 mg Tablet with Fosamprenavir can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without consulting a doctor.
AxitinibPhenobarbital
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Phenobarbital can considerably lower Bexinib 1 mg Tablet levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Bexinib 1 mg Tablet can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
AxitinibTelaprevir
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Co-administration of Bexinib 1 mg Tablet with telaprevir may cause Bexinib 1 mg Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Co-administration of Bexinib 1 mg Tablet with Telaprevir can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor’s advice.
AxitinibMitotane
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Mitotane may decrease the blood levels of Bexinib 1 mg Tablet, which may make Bexinib 1 mg Tablet less effective in treating the condition.

How to manage the interaction:
Although taking Bexinib 1 mg Tablet and Mitotane together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
AxitinibRifabutin
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Coadministration of Rifabutin may decrease the blood levels of Bexinib 1 mg Tablet.

How to manage the interaction:
Although taking Bexinib 1 mg Tablet and Rifabutin together can cause an interaction, it can be taken if a doctor has suggested it. If you experience any unusual side effects, consult a doctor. Do not stop using any medications without a doctor's advice.
AxitinibDelavirdine
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Co-administration of Bexinib 1 mg Tablet with Delavirdine may cause Bexinib 1 mg Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Co-administration of Bexinib 1 mg Tablet with Delavirdine can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor's advice.
AxitinibDexamethasone
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Taking Dexamethasone may reduce the blood levels of Bexinib 1 mg Tablet, making the medication less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction, dexamethasone can be taken with Bexinib 1 mg Tablet if prescribed by the doctor. Do not discontinue any medications without consulting a doctor.
AxitinibModafinil
Severe
How does the drug interact with Bexinib 1 mg Tablet:
Coadministration of Modafinil with Bexinib 1 mg Tablet may decrease the blood levels of Bexinib 1 mg Tablet, which may make Bexinib 1 mg Tablet less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Bexinib 1 mg Tablet and Modafinil, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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AXITINIB-1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AXITINIB-1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit or grapefruit juice might raise the medication's levels in the blood leading to side effects such as high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet. Avoid consuming grapefruit or grapefruit juice during treatment with Bexinib 1 mg Tablet.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Bexinib 1 mg Tablet 14's Substitute

Substitutes safety advice
  • Axpero 1 mg Tablet 14's

    by AYUR

    35.01per tablet
  • Bdaxit 1mg Tablet

    by Others

    28.93per tablet
  • Axzyb Tablet 60's

    by Others

    31.50per tablet
  • Axzyb 1 Tablet 14's

    by Others

    35.00per tablet
  • Inlyta 1mg Tablet 28's

    by Others

    244.45per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Bexinib 1 mg Tablet 14's contains Axitinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

Bexinib 1 mg Tablet 14's is safe to be taken by a diabetic person. However, take Bexinib 1 mg Tablet 14's only after consulting with a doctor, as they may adjust the dosing according to your condition.

Bexinib 1 mg Tablet 14's may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • RITONAVIR
  • DILTIAZEM
  • CARBAMAZEPINE
  • PHENYTOIN
  • RIFAMPICIN
  • DEXAMETHASONE

Special Advise

  • Your doctor may suggest periodic liver function tests and urine test to monitor the function of the liver and presence of protein in urine due to the use of Bexinib 1 mg Tablet 14's.
  • It is advised to use contraceptive pills while using Bexinib 1 mg Tablet 14's to prevent pregnancy.
  • Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.

Disease/Condition Glossary

Renal Cell Carcinoma: Also known as kidney cancer. It is the most common type of cancer seen in adults. This condition occurs when cancer/ malignant cells grow uncontrollably in the kidney and form a tumor. Advanced kidney cancer (metastatic renal cell carcinoma) occurs when the malignant cells spread to other parts of the body. Symptoms include red, orange, or pink-coloured urine due to the presence of blood in the urine.

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