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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition

AXITINIB-5MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Bexinib 5mg Tablet 14's

Bexinib 5mg Tablet 14's is an anti-cancer medicine used in the treatment of renal cell carcinoma. Renal cell carcinoma, also known as kidney cancer, is a disease in which the cancer or malignant cells grow uncontrollably in the kidney and form a tumour.

Bexinib 5mg Tablet 14's contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Bexinib 5mg Tablet 14's may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you. Bexinib 5mg Tablet 14's should be taken as advised by your doctor.

Avoid taking Bexinib 5mg Tablet 14's if you are allergic to it or any other components of it. Before taking Bexinib 5mg Tablet 14's, inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, thyroid disorders, or blood disorders. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Bexinib 5mg Tablet 14's

Renal Cell Carcinoma.

Directions for Use

Take Bexinib 5mg Tablet 14's as prescribed by the doctor. It can be taken with or without food in a 12-hour interval. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Medicinal Benefits

Bexinib 5mg Tablet 14's contains Axitinib, which is used in treating advanced renal cell carcinoma after failure of prior systemic therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Bexinib 5mg Tablet 14's stops the body's production, spread and growth of cancerous cells.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Bexinib 5mg Tablet 14's

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Skin rash
  • Increased blood pressure
  • Cough
  • Tiredness
  • Visual disturbances
  • Chest pain
  • Dizziness
  • Weakness
  • Hoarseness
  • Peeling of the skin.

Drug Warnings

To treat your condition effectually, continue taking Bexinib 5mg Tablet 14's for the period that your doctor has prescribed. Avoid taking Bexinib 5mg Tablet 14's if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Bexinib 5mg Tablet 14's may cause hypertension, arterial and venous thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes in some patients. Hence, inform your doctor about your complete medication and medical history before taking Bexinib 5mg Tablet 14's.

Drug-Drug Interactions

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AxitinibEtravirine
Severe
AxitinibMitotane
Severe

Drug-Drug Interactions

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AxitinibEtravirine
Severe
How does the drug interact with Bexinib 5mg Tablet:
Etravirine may decrease the blood levels of Bexinib 5mg Tablet, which may make Bexinib 5mg Tablet less effective in treating the condition.

How to manage the interaction:
Taking Bexinib 5mg Tablet with Etravirine together can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AxitinibMitotane
Severe
How does the drug interact with Bexinib 5mg Tablet:
Mitotane may decrease the blood levels of Bexinib 5mg Tablet, which may make Bexinib 5mg Tablet less effective in treating the condition.

How to manage the interaction:
Although taking Bexinib 5mg Tablet and Mitotane together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
AxitinibKetoconazole
Severe
How does the drug interact with Bexinib 5mg Tablet:
Coadministration of ketoconazole with Bexinib 5mg Tablet can increase the levels of Bexinib 5mg Tablet in the body. This may increase the risk or severity of side effects.

How to manage the interaction:
Although taking Ketoconazole and Bexinib 5mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
AxitinibLeflunomide
Severe
How does the drug interact with Bexinib 5mg Tablet:
When Bexinib 5mg Tablet is taken with Leflunomide, the risk of liver problems increases.

How to manage the interaction:
Although there is an interaction between leflunomide and Bexinib 5mg Tablet can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AxitinibFosphenytoin
Severe
How does the drug interact with Bexinib 5mg Tablet:
Fosphenytoin may decrease the blood levels of Bexinib 5mg Tablet, which may make Bexinib 5mg Tablet less effective in treating your condition

How to manage the interaction:
Co-administration of Bexinib 5mg Tablet with Fosphenytoin can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
AxitinibRitonavir
Severe
How does the drug interact with Bexinib 5mg Tablet:
Taking Bexinib 5mg Tablet with ritonavir may significantly increase the blood levels of Bexinib 5mg Tablet.

How to manage the interaction:
There may be a possibility of interaction between Bexinib 5mg Tablet and Ritonavir, but it can be taken if prescribed by a doctor. However, if you experience chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor. Do not discontinue any medications without consulting a doctor.
AxitinibModafinil
Severe
How does the drug interact with Bexinib 5mg Tablet:
Coadministration of Modafinil with Bexinib 5mg Tablet may decrease the blood levels of Bexinib 5mg Tablet, which may make Bexinib 5mg Tablet less effective in treating the condition.

How to manage the interaction:
Although there is a possible interaction between Bexinib 5mg Tablet and Modafinil, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AxitinibRifabutin
Severe
How does the drug interact with Bexinib 5mg Tablet:
Coadministration of Rifabutin may decrease the blood levels of Bexinib 5mg Tablet.

How to manage the interaction:
Although taking Bexinib 5mg Tablet and Rifabutin together can cause an interaction, it can be taken if a doctor has suggested it. If you experience any unusual side effects, consult a doctor. Do not stop using any medications without a doctor's advice.
AxitinibNelfinavir
Severe
How does the drug interact with Bexinib 5mg Tablet:
When Bexinib 5mg Tablet is taken with Nelfinavir, the body's ability to break down Bexinib 5mg Tablet may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Bexinib 5mg Tablet and Nelfinavir, but it can be taken if prescribed by a doctor. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
AxitinibTroleandomycin
Severe
How does the drug interact with Bexinib 5mg Tablet:
Co-administration of Bexinib 5mg Tablet with troleandomycin may cause Bexinib 5mg Tablet blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Bexinib 5mg Tablet and Troleandomycin, you can take these medicines together if prescribed by a doctor. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor’s advice.

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit or grapefruit juice might raise the medication's levels in the blood leading to side effects such as high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet. Avoid consuming grapefruit or grapefruit juice during treatment with Bexinib 5mg Tablet.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Bexinib 5mg Tablet 14's Substitute

Substitutes safety advice
  • Axpero 5 mg Tablet 14's

    by AYUR

    141.08per tablet
  • INLYTA 5MG TABLETLET 14'S

    by Others

    2444.59per tablet
  • Tykinax 5 Tablet 14's

    by Others

    96.40per tablet
  • Aximac 5 mg Tablet 14's

    by Others

    2429.10per tablet
  • Axzyb Tablet 30's

    by Others

    114.80per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • RITONAVIR
  • DILTIAZEM
  • CARBAMAZEPINE
  • PHENYTOIN
  • RIFAMPICIN
  • DEXAMETHASONE

Special Advise

  • Your doctor may suggest periodic liver function tests and urine test to monitor the function of the liver and presence of protein in urine due to the use of Bexinib 5mg Tablet 14's.
  • It is advised to use contraceptive pills while using Bexinib 5mg Tablet 14's to prevent pregnancy.
  • Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.

Disease/Condition Glossary

Renal Cell Carcinoma: Also known as kidney cancer. It is the most common type of cancer seen in adults. This condition occurs when cancer/ malignant cells grow uncontrollably in the kidney and form a tumor. Advanced kidney cancer (metastatic renal cell carcinoma) occurs when the malignant cells spread to other parts of the body. Symptoms include red, orange, or pink-coloured urine due to the presence of blood in the urine.

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