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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Tykinax 5 Tablet 14's

Tykinax 5 Tablet 14's is an anti-cancer medicine used in the treatment of renal cell carcinoma. Renal cell carcinoma, also known as kidney cancer, is a disease in which the cancer or malignant cells grow uncontrollably in the kidney and form a tumour.

Tykinax 5 Tablet 14's contains Axitinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Tykinax 5 Tablet 14's may cause certain side effects such as diarrhea, rash, tiredness, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, chest pain, weakness, dizziness, hoarseness, and constipation. Inform your doctor if any of these side effects bother you. Tykinax 5 Tablet 14's should be taken as advised by your doctor.

Avoid taking Tykinax 5 Tablet 14's if you are allergic to it or any other components of it. Before taking Tykinax 5 Tablet 14's, inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, thyroid disorders, or blood disorders. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

rxMedicinePrescription drug

Whats That

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Non returnable*
COD available

Online payment accepted

Composition

AXITINIB-5MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

Uses of Tykinax 5 Tablet 14's

Renal Cell Carcinoma.

Medicinal Benefits

Tykinax 5 Tablet 14's contains Axitinib, which is used in treating advanced renal cell carcinoma after failure of prior systemic therapy. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Tykinax 5 Tablet 14's stops the body's production, spread and growth of cancerous cells.

Side Effects of Tykinax 5 Tablet 14's

  • Nausea
  • Vomiting
  • Diarrhoea
  • Loss of appetite
  • Skin rash
  • Increased blood pressure
  • Cough
  • Tiredness
  • Visual disturbances
  • Chest pain
  • Dizziness
  • Weakness
  • Hoarseness
  • Peeling of the skin.

Directions for Use

Take Tykinax 5 Tablet 14's as prescribed by the doctor. It can be taken with or without food in a 12-hour interval. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

To treat your condition effectually, continue taking Tykinax 5 Tablet 14's for the period that your doctor has prescribed. Avoid taking Tykinax 5 Tablet 14's if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Tykinax 5 Tablet 14's may cause hypertension, arterial and venous thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes in some patients. Hence, inform your doctor about your complete medication and medical history before taking Tykinax 5 Tablet 14's.

Therapeutic Class

ANTINEOPLASTIC

Drug-Drug Interactions

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AxitinibEnzalutamide
Severe
AxitinibAmprenavir
Severe

Drug-Drug Interactions

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AxitinibEnzalutamide
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Taking Enzalutamide with Tykinax 5 Tablet 14's, may decrease the blood levels of Tykinax 5 Tablet 14's, which may make Tykinax 5 Tablet 14's less effective in treating the condition.

How to manage the interaction:
Although taking Enzalutamide and Tykinax 5 Tablet 14's together can cause an interaction, it can be taken if a doctor has suggested it. Do not discontinue any medications without consulting a doctor.
AxitinibAmprenavir
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Co-administration of Tykinax 5 Tablet 14's with Amprenavir may cause Tykinax 5 Tablet 14's blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Tykinax 5 Tablet 14's and Amprenavir, you can take these medicines together if prescribed by a doctor. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without consulting a doctor.
AxitinibNelfinavir
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
When Tykinax 5 Tablet 14's is taken with Nelfinavir, the body's ability to break down Tykinax 5 Tablet 14's may be reduced.

How to manage the interaction:
There may be a possibility of interaction between Tykinax 5 Tablet 14's and Nelfinavir, but it can be taken if prescribed by a doctor. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
AxitinibMitotane
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Mitotane may decrease the blood levels of Tykinax 5 Tablet 14's, which may make Tykinax 5 Tablet 14's less effective in treating the condition.

How to manage the interaction:
Although taking Tykinax 5 Tablet 14's and Mitotane together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
AxitinibArmodafinil
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Armodafinil may reduce the blood levels of Tykinax 5 Tablet 14's, which may reduce the effect of Tykinax 5 Tablet 14's.

How to manage the interaction:
If you are supposed to take Armodafinil and Tykinax 5 Tablet 14's together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. If your symptoms worsen or your condition changes, contact your doctor.
AxitinibIndinavir
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
When Tykinax 5 Tablet 14's is taken with Indinavir, the body's ability to break down Tykinax 5 Tablet 14's may be reduced.

How to manage the interaction:
Although taking Tykinax 5 Tablet 14's and Indinavir together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience Chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and extreme stomach or abdominal pain, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
AxitinibPrimidone
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Coadministration of Tykinax 5 Tablet 14's with primidone may decrease the blood levels of Tykinax 5 Tablet 14's, which may make Tykinax 5 Tablet 14's less effective in treating the condition.

How to manage the interaction:
Although there is an interaction between primidone and Tykinax 5 Tablet 14's, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
AxitinibAtazanavir
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
When Tykinax 5 Tablet 14's is taken with Atazanavir, it can cause a decrease in the way the body processes Tykinax 5 Tablet 14's.

How to manage the interaction:
Although there is a possible interaction between Tykinax 5 Tablet 14's and Atazanavir, you can take these medicines together if prescribed by a doctor. However, if you experience chest pain or pressure, pain in the arms, back, neck, or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
AxitinibNefazodone
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Co-administration of Tykinax 5 Tablet 14's with nefazodone may cause Tykinax 5 Tablet 14's blood levels to rise significantly, leading to an increased risk of side effects.

How to manage the interaction:
Taking Tykinax 5 Tablet 14's with Nefazodone together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, rash, itching or peeling of skin on the hands and feet, chest pain or pressure, pain in the arms, back, neck or jaw, swelling, shortness of breath, numbness or weakness on one side of the body, headache, vision changes, seizures, unusual bleeding or bruising, red or black stools, coughing up or vomiting blood or blood clots, and severe stomach or abdominal pain, consult a doctor. Do not stop using any medications without a doctor’s advice.
AxitinibThalidomide
Severe
How does the drug interact with Tykinax 5 Tablet 14's:
Taking thalidomide together with Tykinax 5 Tablet 14's may increase the risk of blood clots and others complications.

How to manage the interaction:
Although taking Tykinax 5 Tablet 14's and thalidomide together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AXITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit or grapefruit juice might raise the medication's levels in the blood leading to side effects such as high blood pressure, diarrhea, nausea, vomiting, constipation, decreased appetite, weight loss, and rash, itching or peeling of skin on the hands and feet. Avoid consuming grapefruit or grapefruit juice during treatment with Tykinax 5 Tablet 14's.

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ITRACONAZOLE
  • KETOCONAZOLE
  • RITONAVIR
  • DILTIAZEM
  • CARBAMAZEPINE
  • PHENYTOIN
  • RIFAMPICIN
  • DEXAMETHASONE

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Special Advise

  • Your doctor may suggest periodic liver function tests and urine test to monitor the function of the liver and presence of protein in urine due to the use of Tykinax 5 Tablet 14's.
  • It is advised to use contraceptive pills while using Tykinax 5 Tablet 14's to prevent pregnancy.
  • Seek medical attention immediately if you have swelling in your lower legs, fast heartbeats, or trouble breathing as it may be a sign of a heart problem.

Disease/Condition Glossary

Renal Cell Carcinoma: Also known as kidney cancer. It is the most common type of cancer seen in adults. This condition occurs when cancer/ malignant cells grow uncontrollably in the kidney and form a tumor. Advanced kidney cancer (metastatic renal cell carcinoma) occurs when the malignant cells spread to other parts of the body. Symptoms include red, orange, or pink-coloured urine due to the presence of blood in the urine.

Tykinax 5 Tablet 14's Substitute

Substitutes safety advice
  • Axpero 5 mg Tablet 14's

    by AYUR

    141.08per tablet
  • INLYTA 5MG TABLETLET 14'S

    2444.59per tablet
  • Bexinib 5mg Tablet 14's

    357.58per tablet
  • Raxitinib 5 mg Tablet 14's

    148.11per tablet
  • Axzyb Tablet 30's

    114.80per tablet
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