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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition :

SIMVASTATIN-20MG

Manufacturer/Marketer :

G R Healthcare Laboratories

Consume Type :

ORAL

Return Policy :

Not Returnable

About G Sim 20mg Tablet

G Sim 20mg Tablet belongs to a group of antilipemic medicines called 'lipid-lowering agents' used to lower the levels of increased cholesterol in the body. Additionally, G Sim 20mg Tablet is also used to lower the risk of heart diseases such as heart attack or stroke. High cholesterol levels might cause a build-up of cholesterol on the arteries walls, leading to blockage of blood flow to the heart and other body parts that could cause heart disease, heart attack or stroke.

G Sim 20mg Tablet contains 'Simvastatin' that works by blocking HMG-CoA reductase, an enzyme necessary for cholesterol production in the body. G Sim 20mg Tablet helps lower the levels of LDL (bad) cholesterol, and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, G Sim 20mg Tablet lowers the raised levels of fats, triglycerides and cholesterol, which lowers the risk of heart attack or stroke. 

You are advised to take G Sim 20mg Tablet for as long as your doctor has prescribed it for you depending on your medical condition. You may experience certain common side-effects such as headache, stomach pain, constipation, and nausea in some cases. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.

Do not take G Sim 20mg Tablet if you are pregnant, think you may be pregnant or if you are trying for pregnancy. Stop taking G Sim 20mg Tablet and consult a doctor immediately if you become pregnant while taking G Sim 20mg Tablet. G Sim 20mg Tablet may cause dizziness, so be cautious while driving. Avoid consuming alcohol with G Sim 20mg Tablet as it could lead to increased dizziness. G Sim 20mg Tablet is not recommended for children below 10 years as safety and effectiveness have not been established. Inform your doctor regarding your health condition and the medicines you are taking to rule out any side effects or interactions.

Uses of G Sim 20mg Tablet

Hyperlipidaemia (high cholesterol)

Directions for Use

Swallow G Sim 20mg Tablet a whole with a glass of water; do not chew, or break it.

Medicinal Benefits

G Sim 20mg Tablet contains 'Simvastatin', which belongs to a group of lipid-lowering agents called HMG-CoA reductase inhibitors to lower the increased levels of cholesterol or fat. G Sim 20mg Tablet works by blocking the HMG-CoA reductase enzyme, which is necessary for cholesterol production in the body. G Sim 20mg Tablet helps lower the levels of LDL (bad) cholesterol and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, G Sim 20mg Tablet lowers the blood level of fats and cholesterol and helps prevent a heart attack or stroke. G Sim 20mg Tablet as an adjunct to dietary measures is used to reduce the risk of having a heart event due to cardiovascular diseases, the incidence of non-fatal heart attack or stroke, the need for revascularisation procedures (restoration of blood flow to the heart), people with diabetes, pre-existing heart disease, and peripheral vascular disease.  

Storage

Store in a cool and dry place away from sunlight

Side Effects of G Sim 20mg Tablet

  • Headache
  • Stomach pain
  • Constipation
  • Nausea

Drug Warnings

Do not take G Sim 20mg Tablet if you are allergic to any of its contents; if you are taking fusidic acid or have taken it in the past 7 days. Inform your doctor if you are due to have surgery, drink large amounts of alcohol; if you have liver or kidney problems. Do not take G Sim 20mg Tablet if you are pregnant, breastfeeding, think you may be pregnant or if you are trying for pregnancy. Stop taking G Sim 20mg Tablet and consult a doctor immediately if you become pregnant while taking G Sim 20mg Tablet. G Sim 20mg Tablet may cause dizziness, so be cautious while driving. Avoid consuming alcohol with G Sim 20mg Tablet as it could lead to increased dizziness. G Sim 20mg Tablet is not recommended for children below 10 years as safety and effectiveness have not been established.

Drug-Drug Interactions

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SimvastatinClarithromycin
Critical
SimvastatinNefazodone
Critical

Drug-Drug Interactions

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SimvastatinClarithromycin
Critical
How does the drug interact with G Sim 20mg Tablet:
Co-administration of Clarithromycin and G Sim 20mg Tablet can increase the blood levels and effects of G Sim 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis(which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Clarithromycin and G Sim 20mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinNefazodone
Critical
How does the drug interact with G Sim 20mg Tablet:
Combining Nefazodone and G Sim 20mg Tablet can increase the blood levels and effects of G Sim 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Nefazodone and G Sim 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinIndinavir
Critical
How does the drug interact with G Sim 20mg Tablet:
Combining Indinavir and G Sim 20mg Tablet can increase the blood levels and effects of G Sim 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Indinavir and G Sim 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinNelfinavir
Critical
How does the drug interact with G Sim 20mg Tablet:
Combining Nelfinavir and G Sim 20mg Tablet can increase the blood levels and effects of G Sim 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Nelfinavir and G Sim 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinSaquinavir
Critical
How does the drug interact with G Sim 20mg Tablet:
Combining Saquinavir and G Sim 20mg Tablet can increase the blood levels and effects of G Sim 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Saquinavir and G Sim 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinFosamprenavir
Critical
How does the drug interact with G Sim 20mg Tablet:
Combining Fosamprenavir and G Sim 20mg Tablet can increase the blood levels and effects of G Sim 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Fosamprenavir and G Sim 20mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinDanazol
Critical
How does the drug interact with G Sim 20mg Tablet:
Combining Danazol and G Sim 20mg Tablet can increase the blood levels and effects of G Sim 20mg Tablet.

How to manage the interaction:
Taking Danazol and G Sim 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
SimvastatinAmprenavir
Critical
How does the drug interact with G Sim 20mg Tablet:
Combining Amprenavir and G Sim 20mg Tablet can increase the blood levels and effects of G Sim 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Amprenavir and G Sim 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
SimvastatinTipranavir
Critical
How does the drug interact with G Sim 20mg Tablet:
Combining Tipranavir and G Sim 20mg Tablet can increase the blood levels and effects of G Sim 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Tipranavir and G Sim 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-coloured urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
SimvastatinBoceprevir
Critical
How does the drug interact with G Sim 20mg Tablet:
Combining Boceprevir and G Sim 20mg Tablet can increase the blood levels and effects of G Sim 20mg Tablet. This can increase the risk of side effects such as liver damage and rhabdomyolysis( involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Boceprevir and G Sim 20mg Tablet together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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SIMVASTATIN-20MGGrapefruit and Grapefruit Juice, Vitamin-K rich foods
Severe

Drug-Food Interactions

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SIMVASTATIN-20MGGrapefruit and Grapefruit Juice, Vitamin-K rich foods
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit, Green Tea

How to manage the interaction:
Taking grapefruit or grape juice and green tea or green tea extracts can increase the blood levels of G Sim 20mg Tablet and can increase the risk of liver damage and rhabdomyolysis (breakdown of skeletal muscle tissue). Taking grapefruit or grape juice and green tea or green tea extracts can lead to an interaction. However, if you experience any symptoms like muscle pain, tenderness, or weakness during treatment, fever or dark-colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, consult the doctor immediately. Avoid taking grapefruit or grape juice and green tea or green tea extracts.

Diet & Lifestyle Advise

  • Follow a cholesterol-lowering diet.
  • Exercise regularly. It helps in maintaining proper weight and lowers cholesterol.
  • Limit salt and sugar intake.
  • Avoid smoking and alcohol consumption. 
  • Choose healthy fats and cut down on trans-fat.
  • Include omega-3 fatty acids, fibre-rich food, fruits and vegetables.
  • Get active by doing any physical activity such as swimming, brisk walking or jogging. Take the stairs instead of elevators/lifts.

Habit Forming

No

Therapeutic Class

ANTILIPEMICS

G Sim 20mg Tablet Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

G Sim 20mg Tablet works by blocking HMG-CoA reductase, an enzyme necessary for the production of cholesterol in the body. G Sim 20mg Tablet helps lower the levels of LDL (bad) cholesterol and triglycerides and raises the levels of HDL (good) cholesterol. Thereby, G Sim 20mg Tablet lowers the blood level of raised fats and cholesterol and helps prevent a heart attack or stroke.

Do not discontinue G Sim 20mg Tablet without consulting your doctor as it could lead to the rise of cholesterol. To treat your condition effectually, continue taking G Sim 20mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking G Sim 20mg Tablet.

Constipation could be a side-effect of G Sim 20mg Tablet. Drink plenty of fluids and eat fibre-rich food if you experience constipation. Consult your doctor if you have severe constipation.

G Sim 20mg Tablet can be taken by diabetes patients if prescribed by the doctor. Your doctor will monitor your condition closely if you have diabetes. Regular monitoring of blood sugar levels is advised.

G Sim 20mg Tablet should not be taken with antibiotics such as fusidic acid as it could lead to a serious muscle problem called rhabdomyolysis (the breakdown of muscle tissue). Inform the doctor that you are taking G Sim 20mg Tablet if your doctor has prescribed fusidic acid, the doctor may ask you to temporarily stop taking G Sim 20mg Tablet to treat your infection. Your doctor will decide when it is safe to restart treatment with G Sim 20mg Tablet.

G Sim 20mg Tablet might cause muscle problems, particularly when taken at high doses. In rare conditions, G Sim 20mg Tablet might cause serious muscle problems such as rhabdomyolysis (muscle tissue breakdown). Consult your doctor immediately if you experience muscle pain, weakness, and tenderness, especially if associated with fever or tiredness.

Drug-Drug Interactions Checker List

  • FUSIDIC ACID
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • TELITHROMYCIN
  • INDINAVIR
  • SAQUINAVIR
  • RITONAVIR
  • NELFINAVIR
  • ITRACONAZOLE
  • KETOCONAZOLE
  • POSACONAZOLE
  • VORICONAZOLE
  • BOCEPREVIR
  • TELAPREVIR
  • NEFAZODONE
  • GEMFIBROZIL
  • CYCLOSPORINE
  • DANAZOL
  • COBICISTAT

Special Advise

  • Regular blood tests are advised to determine the effect of G Sim 20mg Tablet on lipids. 
  • Consult your doctor immediately if you experience muscle pain, weakness, or tenderness, especially if associated with fever or tiredness.
  • Your doctor may recommend blood tests to monitor liver function prior to the start of treatment and during the treatment with G Sim 20mg Tablet. Inform your doctor if you notice yellowing of skin or eyes, unusually dark urine, and tiredness.
  • G Sim 20mg Tablet might affect test results for liver function and muscle enzyme (creatin-kinase). Inform the person doing the tests that you are taking G Sim 20mg Tablet.
  • It is advisable to have complete cholesterol tests (lipid profile test) at least once a year. It will help you to closely monitor your heart health and risk of heart attack and stroke. 

Disease/Condition Glossary

Hyperlipidaemia: Hyperlipidaemia is commonly known as high cholesterol. Cholesterol is a fatty substance that is naturally produced in the liver because every cell uses it. Cholesterol is also found in fatty foods such as cheese, red meat, and eggs. High cholesterol levels might cause a build-up of fat on the arteries' walls, leading to blockage of blood flow to the heart and other body parts that could cause heart disease, heart attack or stroke. Cholesterol is mainly of two types, namely 'bad cholesterol' and 'good cholesterol'. Bad cholesterol comprises low-density lipoprotein (LDL) and triglycerides (TG) which deposit fat in the arteries leading to their blockage. Good cholesterol consists of high-density lipoprotein (HDL), which prevents the deposition of fats. Risk factors of high cholesterol are a high-fat diet, obesity, lack of physical exercise, and smoking. Usually, there are no specific symptoms of raised or high cholesterol levels, so it is advisable to have complete cholesterol tests (lipid profile tests) at least once a year. It will help monitor your heart health and risk of heart attack or stroke. 

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