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Reviewed By Sunny S , MBBS
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Composition :

DOMPERIDONE-10MG

Manufacturer/Marketer :

Janssen Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Gastractiv Tablet

Gastractiv Tablet belongs to a class of medications known as 'dopamine antagonist' used to treat nausea (feeling sick) and vomit (being sick) in adults and adolescents 12 years or older. Besides this, it also helps in the treatment of indigestion. Nausea and vomiting are not diseases but are symptoms of many conditions like infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying).

Gastractiv Tablet contains domperidone, which prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps decrease stomach emptying time.

Take Gastractiv Tablet as prescribed by your doctor. Symptoms of nausea and vomiting may usually resolve within 3-4 days after taking Gastractiv Tablet . However, if it does not resolve even after this, stop taking this medicine and contact the doctor. Do not take Gastractiv Tablet for longer than seven days. The most common side effect of Gastractiv Tablet is dry mouth. This side effect is temporary and may resolve after some time; however, if this side persists, contact the doctor.

Do not consume Gastractiv Tablet if you are hypersensitive to any components present in Gastractiv Tablet . Before taking the Gastractiv Tablet , inform your doctor if you suffer from liver or kidney problems. Prolonged intake of Gastractiv Tablet may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking doses higher than 30 mg daily. Gastractiv Tablet is not usually recommended in pregnancy and breastfeeding. But in some cases, domperidone is used to increase milk supply. However, it should be used only during breastfeeding if your physician considers this necessary. Ask your doctor for advice before taking this medicine. Adolescents (children from 12-18 years of age) who weigh less than 35 kg should not be given the Gastractiv Tablet .

Uses of Gastractiv Tablet

Nausea, Vomiting.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Dispersible Tablet: Check the label for directions before use. Disperse the tablet in the prescribed amount of water and swallow the contents. Do not crush, chew or swallow as a whole.Oral Suspension/Syrup/Oral drops: Shake the bottle well before use. Check the label for directions and take Gastractiv Tablet in doses as prescribed by your doctor with the help of a measuring cup/dropper provided by the pack.

Medicinal Benefits

Gastractiv Tablet contains domperidone, a dopamine antagonist that helps by blocking certain vomiting-inducing receptors in the brain. Gastractiv Tablet also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and decreases gastric emptying time. Domperidone is occasionally used to boost milk production. If you're experiencing difficulty nursing, your doctor may prescribe it if nothing else has helped.

Storage

Store in a cool and dry place away from sunlight
Side effects of Gastractiv Tablet
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Regular activity including cardio and weightlifting can help in weight loss and breast tissue reduction.
  • Limit alcohol intake to lower your chances of gynecomastia and hormonal changes.
  • Eat a balanced diet and avoid foods high in estrogen-like compounds.
  • Follow your doctor's instructions take medication consistently to reduce breast enlargement and do not stop taking medication on your own.
  • Eat a balanced diet rich in fruits, vegetables, whole grains, and healthy fats.
  • Engage in regular moderate exercise, avoiding excessive strenuous activity.
  • Practice relaxation techniques like deep breathing, meditation, or yoga to manage stress.
  • Ensure adequate sleep and hydration.
  • Track your menstrual cycle to monitor patterns and symptoms.
  • Increase calorie intake and aim for a healthy energy balance.
  • Prioritize healthy fats annd take omega-3 rich foods like fatty fish, avocado, nuts, and seeds.
  • Eat complex carbohydrates like whole grains like brown rice, quinoa, whole wheat bread, and oats.
  • Ensure adequate protein intake like lean protein sources like chicken, fish, beans, lentils, and tofu.
  • Include calcium-rich foods such as dairy products like milk, yogurt, and fortified plant-based options.
  • Consume vitamin D sources like fortified milk, fatty fish, or consider supplementation.
  • Practice relaxation techniques like yoga, meditation, and deep breathing exercises to manage stress.
  • Do moderate exercise and reduce intensity or duration to prevent hormonal disruption.
  • Aim for 7-8 hours of restful sleep each night to help your body and mind recharge.
  • Stay hydrated by drinking plenty of water.
  • Maintain a healthy body weight through balanced diet and exercise.
  • Consult a healthcare professional before making significant dietary changes, especially if suspecting a medical cause for amenorrhea.

Drug Warnings

Do not consume Gastractiv Tablet if you are allergic to any components present in Gastractiv Tablet . Before taking the Gastractiv Tablet , contact your doctor if you suffer from liver or kidney problems (kidney function impairment or failure). Prolonged intake of Gastractiv Tablet may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking doses higher than 30 mg daily. Tell your doctor if you are using anti-fungal medicines and/or if you have heart problems or AIDS/HIV. If you experience heart rhythm disorders like palpitations, trouble breathing, or loss of consciousness after taking the Gastractiv Tablet , immediately contact your doctor. Domperidone is not usually recommended in pregnancy and breastfeeding. But in some cases, domperidone is used to increase milk supply. However, it should be used only during breastfeeding if your physician considers this necessary. Ask your doctor for advice before taking this medicine. Adolescents (children from 12-18 years of age) who weigh less than 35 kg should not be given the Gastractiv Tablet .

Drug-Drug Interactions

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DomperidoneHalofantrine
Severe
DomperidoneNefazodone
Severe

Drug-Drug Interactions

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DomperidoneHalofantrine
Severe
How does the drug interact with Gastractiv Tablet:
Coadministration of Gastractiv Tablet with Halofantrine can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Gastractiv Tablet and Halofantrine together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneNefazodone
Severe
How does the drug interact with Gastractiv Tablet:
Coadministration of Gastractiv Tablet with Nefazodone can increase the blood levels of Gastractiv Tablet.

How to manage the interaction:
There may be a possibility of interaction between Gastractiv Tablet and Nefazodone, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneCitalopram
Severe
How does the drug interact with Gastractiv Tablet:
Coadministration of Gastractiv Tablet with Citalopram can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Gastractiv Tablet and Citalopram together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneToremifene
Severe
How does the drug interact with Gastractiv Tablet:
Coadministration of Gastractiv Tablet with Toremifene can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Gastractiv Tablet and Toremifene together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneMizolastine
Severe
How does the drug interact with Gastractiv Tablet:
Combining Mizolastine with Gastractiv Tablet can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Although taking Gastractiv Tablet and Mizolastine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DomperidoneClarithromycin
Severe
How does the drug interact with Gastractiv Tablet:
Coadministration of Gastractiv Tablet with Clarithromycin can increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Gastractiv Tablet and Clarithromycin, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
DomperidoneKetoconazole
Severe
How does the drug interact with Gastractiv Tablet:
Coadministration of Gastractiv Tablet with Ketoconazole can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Gastractiv Tablet and Ketoconazole together can cause an interaction, it can be taken if a doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneCisapride
Severe
How does the drug interact with Gastractiv Tablet:
Coadministration of Gastractiv Tablet with Cisapride can increase the blood levels of Gastractiv Tablet.

How to manage the interaction:
There may be a possibility of interaction between Gastractiv Tablet and Cisapride, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneRitonavir
Severe
How does the drug interact with Gastractiv Tablet:
Coadministration of Gastractiv Tablet with Ritonavir can increase the blood levels of Gastractiv Tablet.

How to manage the interaction:
There may be a possibility of interaction between Gastractiv Tablet and Ritonavir, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneMethadone
Severe
How does the drug interact with Gastractiv Tablet:
Coadministration of Gastractiv Tablet with Methadone can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Gastractiv Tablet and Methadone together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy low-fat diet, especially in small portions, as it will be easy to digest. Avoid eating over-sweet food and include more salty food, especially if you have been vomiting.
  • Also, if you like vomiting at a specific time, avoid eating your favourite food at that particular time, as your taste for that food may get turned off. 
  • Include more cool beverages in your food like clear soups, flavoured gelatin, and carbonated beverages. And also, when you drink with a stray, sip slowly to avoid swallowing air that may lead to gas or acidity.
  • Drink after or any other liquid at least 30 minutes after eating food. After eating food, lie down for at least after 2 hours.
  • If the smell of food makes you feel sick (vomit), do not cook food as it may worsen your condition. Let someone else cook food or use prepared food from the freezer.
  • Avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes).

Habit Forming

No

Therapeutic Class

ANTIEMETICS

Gastractiv Tablet Substitute

Substitutes safety advice
  • Aquris Domone-10 Tablet 10's

    by Others

    2.55per tablet
  • Domstal 10 Tablet 10's

    by Others

    2.30per tablet
  • Vomistop Tablet 10's

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    2.30per tablet
  • Dom-DT 10 Rapitab 10's

    by AYUR

    2.30per tablet
  • Domstal DT 10 Tablet 15's

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    2.31per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Gastractiv Tablet contains domperidone, which prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps decrease stomach emptying time.

If you are intolerant to sugars, please inform your doctor before starting Gastractiv Tablet as it contains lactose. So, to avoid any unpleasant side effects, do as your doctor advises.

Yes, Gastractiv Tablet can cause dry mouth. In case you feel excessively thirsty, please increase your fluid intake and do frequent mouth rinses.

If you miss a dose, take your medicine as soon as you remember. If it is almost time for your next dose, wait until that is due and continue as usual. Do not take a double dose to make up for a forgotten dose.

Domperidone should be used for the shortest time. It is commonly taken for up to a week. Domperidone can produce irregular heartbeats if taken for an extended time or at a high dose.

No, it is a prescribed medication; it should be used only if specified by the doctor.

Drug-Drug Interactions Checker List

  • AMIODARONE
  • MOXIFLOXACIN
  • ERYTHROMYCIN
  • DILTIAZEM
  • SOTALOL
  • ESCITALOPRAM
  • VERAPAMIL

Disease/Condition Glossary

Nausea is a feeling of stomach uneasiness that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth. In short, nausea and vomiting are not diseases but are symptoms of many conditions like infections, motion sickness, an early stage of pregnancy, and gastroparesis (slow stomach emptying). A receptor in our brain known as the chemoreceptor zone (CTZ) controls vomiting.

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