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Written By aquibnaseer ,
Reviewed By Sunny S , MBBS
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Composition :

GLIMEPIRIDE-2MG

Manufacturer/Marketer :

Erinyle Pharma

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Gliminyle 2 mg Tablet

Gliminyle 2 mg Tablet belongs to a class of antidiabetic called 'sulfonylureas' used to lower raised blood sugar levels in Type 2 diabetes mellitus (non-insulin-dependent diabetes mellitus - NIDDM). Type 2 diabetes develops if the body does not produce enough insulin or when your body's insulin does not work as well as it should. Insulin is a substance that helps to lower the level of sugar in your blood, especially after meals.

The Gliminyle 2 mg Tablet contains Glimepiride which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells which lets insulin pass out of the cell. This insulin then makes each cell in the body take up glucose and utilize it, thus lowering raised blood glucose. Therefore, it prevents symptoms of type 2 diabetes.

Take Gliminyle 2 mg Tablet as prescribed by your doctor. Some people may experience an allergic reaction (skin rash, hives & sensitivity to sun rays), liver dysfunction (jaundice, bile duct blockage, and hepatitis), seizures, coma & low glucose levels. Most of these side effects of Gliminyle 2 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. 

Gliminyle 2 mg Tablet should not be stopped even if you feel better without consulting your doctor as the sugar level keeps changing. If you stop taking Gliminyle 2 mg Tablet abruptly, it may increase your sugar levels which could further increase the risk of eyesight loss (retinopathy), kidney (nephropathy) and nerve damage (neuropathy). Gliminyle 2 mg Tablet should not be taken if you have type 1 diabetes mellitus or severe kidney or liver disease. Please inform your doctor if you have any heart disease or plan to get pregnant or breastfeed.

Uses of Gliminyle 2 mg Tablet

Type 2 diabetes

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Gliminyle 2 mg Tablet is used in people with type 2 diabetes to minimize elevated blood sugar levels with a balanced diet and exercise in combination. Gliminyle 2 mg Tablet  can be combined with insulin or other forms of oral antidiabetic medication. Gliminyle 2 mg Tablet decreases blood sugar levels in a diabetic patient by increasing the production and secretion of insulin from the pancreas beta cells. Thus, it helps in controlling increased blood sugar levels after the meal.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Gliminyle 2 mg Tablet

  • Allergic reactions
  • Headache
  • Nausea
  • Blood pressure drop
  • Shock
  • Abnormal liver function
  • Including skin and eye yellowing (jaundice)
  • Bile flow issues (cholestasis)
  • Liver inflammation (hepatitis) or failure of the liver

Drug Warnings

Before taking Gliminyle 2 mg Tablet , inform your doctor if you are healing from injury, had or going to have surgery, have fever infections or other sources of stress, then contact your doctor as it might be appropriate to adjust care temporarily. If you have a serious kidney/liver disease, breastfeeding or pregnant, consult the doctor before using Gliminyle 2 mg Tablet . Do not take Gliminyle 2 mg Tablet if you are allergic to sulpha drugs, glimepiride, or any other antidiabetic medicines or have a deficiency of glucose 6-phosphate dehydrogenase (G6PD). A heart disease patient should consult a doctor before taking the Gliminyle 2 mg Tablet as it may worsen the heart disease's current conditions. Do not take Gliminyle 2 mg Tablet with oral contraceptives as it may increase blood sugar levels. On the other hand, taking Gliminyle 2 mg Tablet with pain killers like aspirin or ibuprofen can lower your blood sugar.

Drug-Drug Interactions

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GlimepirideClarithromycin
Severe
GlimepirideParoxetine
Severe

Drug-Drug Interactions

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GlimepirideClarithromycin
Severe
How does the drug interact with Gliminyle 2 mg Tablet:
Taking Clarithromycin with Gliminyle 2 mg Tablet may increase the effects of Gliminyle 2 mg Tablet on lowering blood sugar.

How to manage the interaction:
Although there is a possible interaction, Clarithromycin can be taken with Gliminyle 2 mg Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, hunger, weakness, dizziness, drowsiness, nervousness, sweating, confusion, and tremor. Do not discontinue the medications without consulting a doctor.
GlimepirideParoxetine
Severe
How does the drug interact with Gliminyle 2 mg Tablet:
Taking Gliminyle 2 mg Tablet with Paroxetine may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, Gliminyle 2 mg Tablet can be taken with paroxetine if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar like headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
GlimepirideFluconazole
Severe
How does the drug interact with Gliminyle 2 mg Tablet:
Co-administration of Fluconazole may increase the blood levels and effects of Gliminyle 2 mg Tablet may cause low blood glucose.

How to manage the interaction:
Although there is a possible interaction, Gliminyle 2 mg Tablet can be taken with fluconazole if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar like headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
GlimepirideCitalopram
Severe
How does the drug interact with Gliminyle 2 mg Tablet:
Taking Gliminyle 2 mg Tablet with Citalopram may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, Gliminyle 2 mg Tablet can be taken with Citalopram if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
GlimepirideIndometacin
Severe
How does the drug interact with Gliminyle 2 mg Tablet:
Taking indomethacin with Gliminyle 2 mg Tablet may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, Gliminyle 2 mg Tablet can be taken with indomethacin if prescribed by the doctor. Consult the doctor if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat.
GlimepirideVilazodone
Severe
How does the drug interact with Gliminyle 2 mg Tablet:
Taking Gliminyle 2 mg Tablet with Vilazodone may increase the risk of low blood sugar.

How to manage the interaction:
Although there is a possible interaction, Gliminyle 2 mg Tablet can be taken with Vilazodone if prescribed by the doctor. Consult the prescriber if you experience symptoms of low blood sugar such as headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. Do not discontinue the medications without consulting a doctor.
GlimepirideTrovafloxacin
Severe
How does the drug interact with Gliminyle 2 mg Tablet:
When Gliminyle 2 mg Tablet is taken with Trovafloxacin, it can affect blood glucose levels either hypoglycemia or hyperglycemia.

How to manage the interaction:
Taking Gliminyle 2 mg Tablet with Trovafloxacin together can possibly result in an interaction, but it can be taken if a doctor has advised it. It's important to be aware of symptoms like increased urination and thirst, and to contact your doctor if you experience any concerning symptoms. Your doctor may be able to suggest alternative medications that don't interact with your diabetes treatment. Do not stop using any medications without a doctor's advice.
GlimepirideDiethylstilbestrol
Severe
How does the drug interact with Gliminyle 2 mg Tablet:
Co-administration of Diethylstilbestrol may interfere with blood glucose control and reduce the effectiveness of Gliminyle 2 mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Gliminyle 2 mg Tablet and Diethylstilbestrol, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much urine you're producing. If you notice any of these signs - very high or very low blood sugar levels - make sure to contact a doctor right away. Do not stop using any medications without talking to a doctor.
GlimepirideIsoniazid
Severe
How does the drug interact with Gliminyle 2 mg Tablet:
Co-administration of Gliminyle 2 mg Tablet with Isoniazid may interfere with blood glucose control and reduce the effectiveness of Gliminyle 2 mg Tablet.

How to manage the interaction:
Although there is a possible interaction, Gliminyle 2 mg Tablet can be taken with Isoniazid if prescribed by the doctor. Regular monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
GlimepirideBisoprolol
Severe
How does the drug interact with Gliminyle 2 mg Tablet:
Concomitant use of bisoprolol with Gliminyle 2 mg Tablet may increase the risk, severity, and/or duration of hypoglycemia (low blood sugar). It may also mask some of the symptoms of hypoglycemia such as palpitation, tremor, and rapid heartbeat, making it more difficult to recognize an oncoming episode.

How to manage the interaction:
Although there may be an interaction, bisoprolol can be taken with Gliminyle 2 mg Tablet if prescribed by the doctor. Consult the prescriber if you develop symptoms of low blood sugar like shakiness, dizziness, sweating, nausea, hunger, weakness, or lightheadedness.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise such as cycling, walking, jogging, dancing or swimming for a minimum of 30 minutes per day. Invest at least 150 minutes of your week in exercise.
  • Maintain healthy body weight as obesity is also related to the onset of diabetes.
  • Maintain a low fat and a low sugar diet. Replace carbohydrates containing foods with whole grains, fruits and vegetables as carbohydrates turn to sugars leading to high blood sugar.
  • Avoid consumption of alcohol and quit smoking.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS AND ANTIHYPERGLYCEMICS

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Author Details

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Drug-Diseases Interactions

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GLIMEPIRIDE-2MGHypertensive heart and renal disease
Severe
GLIMEPIRIDE-2MGUnspecified kidney failure
Severe

Drug-Diseases Interactions

Login/Sign Up

GLIMEPIRIDE-2MGHypertensive heart and renal disease
Severe
How does the disease interact with Gliminyle 2 mg Tablet:
When compared to diet alone or diet plus insulin, the use of oral hypoglycemic medications may be associated with an increased risk of cardiovascular mortality. This alert is based on the University Group Diabetes Programme (UGDP) project, a long-term prospective clinical investigation aimed to assess the efficacy of glucose-lowering medications in preventing or delaying vascular problems in non-insulin-dependent diabetes patients. Patients treated for 5 to 8 years with diet with a fixed dose of either tolbutamide (a sulfonylurea) or phenformin (a biguanide) had a cardiovascular death risk nearly 2.5 times that of patients treated with diet alone, resulting in the cessation of both therapies in the research. Regardless of how these findings are interpreted, doctors and patients should be aware of the possibility.

How to manage the interaction:
The use of oral hypoglycemic agents may be associated with an increased risk of heart problems. Let the doctor know if you have heart problems.
GLIMEPIRIDE-2MGUnspecified kidney failure
Severe
How does the disease interact with Gliminyle 2 mg Tablet:
Sulfonylureas are metabolised in the liver and eliminated in the urine and faeces as metabolites (some of which have pharmacologic activity). Patients with poor liver and/or renal function who are treated with sulfonylureas may be exposed to increased serum drug concentrations, increasing the risk of severe hypoglycemia episodes. In the context of hepatic impairment, gluconeogenic ability may be reduced, adding to the risk. Sulfonylurea therapy should be used with caution in people who have liver or kidney illness. It is possible that lower dosages and longer intervals between dosage adjustments will be required. If hypoglycemia occurs during treatment, it may be prolonged in these patients due to slower medication metabolism and/or excretion.

How to manage the interaction:
In patients with kidney problems, severe hypoglycemic episodes may occur. Therapy should be administered cautiously in patients with renal disease.
GLIMEPIRIDE-2MGOther disorders of adrenal gland
Moderate
How does the disease interact with Gliminyle 2 mg Tablet:
Hypoglycemia is a common side effect of insulin and/or oral hypoglycemic medications. Patients who are debilitated or malnourished, those with defective counterregulatory mechanisms (e.g., autonomic neuropathy and adrenal or pituitary insufficiency), and those receiving beta-adrenergic blocking agents should exercise caution when using these drugs.

How to manage the interaction:
Care should be taken in patients who may be particularly susceptible to the development of hypoglycemic episodes during treatment.
GLIMEPIRIDE-2MGAnaemia due to enzyme disorders
Moderate
How does the disease interact with Gliminyle 2 mg Tablet:
In patients with glucose 6-phosphate dehydrogenase (G6PD) impairment, sulfonylureas can cause hemolytic anaemia. In individuals with G6PD deficiency, these medicines should be administered with caution, and a non-sulfonylurea option should be considered. Postmarketing reports of hemolytic anaemia in patients receiving these medications who did not have known G6PD deficiency have been received.

How to manage the interaction:
Therapy should be used with caution in patients with glucose 6-phosphate dehydrogenase (G6PD) deficiency. The use of a non-sulfonylurea alternative should be considered.
GLIMEPIRIDE-2MGOther disorders of fluid, electrolyte and acid-base balance
Moderate
How does the disease interact with Gliminyle 2 mg Tablet:
Treatment with sulfonylureas may cause hyponatremia in individuals who are taking other drugs or have medical disorders that cause hyponatremia, or it may stimulate the secretion of antidiuretic hormone. Certain sulfonylureas have been linked to the syndrome of inappropriate antidiuretic hormone (SIADH) secretion, and these medications may enhance the peripheral (antidiuretic) action of ADH and/or increase ADH release. Caution should be exercised when treating individuals who have hyponatremia or are at increased risk of developing hyponatremia, such as the elderly, those using diuretics, or those who are volume-depleted.

How to manage the interaction:
Caution should be used when treating patients with low sodium or at greater risk of developing low sodium such as elderly patients, patients taking diuretics or those who are volume-depleted.

FAQs

The Gliminyle 2 mg Tablet contains Glimepiride which acts on insulin-secreting cells called beta cells inside the pancreas and activates calcium channels on cells which lets insulin pass out of the cell. This insulin then makes each cell in the body take up glucose and utilize it, thus lowering raised blood glucose. Therefore, it prevents symptoms of type 2 diabetes.

A patient is advised to take the missed dose as soon as possible or skip to the next dose if it's been too late. A patient should never attempt to take a double dose to compensate for the missed dose as it may prove harmful.

Gliminyle 2 mg Tablet is not recommended with warfarin as these two drugs are contraindicated with each other and hence may result in any harmful symptom when taken together in heart patients.

Avoid intake of Gliminyle 2 mg Tablet and consult a doctor if you have an allergy to sulfa drugs, diabetic ketoacidosis, heart disease, liver or kidney disease, an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).

Your blood sugar might get decreased, so regular blood glucose monitoring is required. Signs and symptoms of low blood sugar level are feeling very hungry, dizziness, irritability, confusion, anxiety or shakiness. Try to eat or drink a fast-acting sugar source (like fruit juice, hard candy, crackers, raisins or non-diet soda).

No, Gliminyle 2 mg Tablet is only prescribed to treat type 2 diabetes and not type 1 diabetes. If you are type 1 diabetic patient consult with a doctor so that insulin forms can be prescribed for the same.

The patient is advised to talk to a doctor before taking contraceptive pills if he/she is already taking Gliminyle 2 mg Tablet , then the doctor may change the dose of Gliminyle 2 mg Tablet . This is because oral contraceptive pills change body responds to the sugar.

Drug-Drug Interactions Checker List

  • ASPIRIN
  • ROSUVASTATIN
  • DULOXETINE
  • DAPAGLIFLOZIN
  • GLYBURIDE
  • INSULIN
  • CANAGLIFLOZIN
  • SITAGLIPTIN
  • EMPAGLIFLOZIN
  • FUROSEMIDE
  • ATORVASTATIN
  • PREGABALIN
  • METFORMIN
  • NAPROXEN
  • CLOPIDOGREL
  • IBUPROFEN
  • WARFARIN

Disease/Condition Glossary

Type 2 diabetes: It is a chronic (long-lasting) condition that keeps the body from properly utilizing insulin. Hence, people affected with type 2 diabetes either do not produce enough insulin, or there is resistance to the action of insulin. Middle-aged or older are most likely to suffer from type 2 diabetes, so it is also known as adult-onset diabetes. Symptoms of type 2 diabetes include increased thirst, frequent urination at night, slow wound healing, increased hunger, fatigue, and blurred vision. In some cases, there may be weight gain while in rare cases weight loss may be observed. The complication of type 2 diabetes also includes nerve problems, kidney problems, the damaged retina of eyes or blindness, loss of limbs, sexual dysfunction, and an increased chance of heart attack or stroke.

Side effects of Gliminyle 2 mg Tablet
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
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