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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Gufisome 50 mg Injection

Gufisome 50 mg Injection belongs to a class of medication called 'antifungal' used to treat severe fungal infections like leishmaniasis. A fungal infection is a disease in which fungi attack the tissue and cause infection. Fungi are commonly present in nature but do not cause infections normally. However, if the person has a weak immune system, certain types of fungi may infect them. 

Gufisome 50 mg Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Gufisome 50 mg Injection is given by a doctor or nurse. In some cases, you may experience fever, chills, irregular heartbeat, high or low blood pressure, breathing problems, nausea, vomiting, headache, shaking, muscle cramps or pain. Most of these side effects of Gufisome 50 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Gufisome 50 mg Injection or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Gufisome 50 mg Injection . Gufisome 50 mg Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Gufisome 50 mg Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain or difficulty in breathing, or encephalopathy (a brain disease which may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help.

Uses of Gufisome 50 mg Injection

Severe fungal infections

Directions for Use

Gufisome 50 mg Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Gufisome 50 mg Injection contains Amphotericin B, an antifungal used to treat severe fungal infections. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Gufisome 50 mg Injection damages fungal cell membranes and kills fungi. Gufisome 50 mg Injection is used to treat infections such as blood infection with candida, cryptococcus, fusarium, zygomycetes, aspergillus, coccidiodes or blastomycetes, or cryptococcal meningitis (inflammation of the brain).

Storage

Store in a cool and dry place away from sunlight

Side Effects of Gufisome 50 mg Injection

  • Fever
  • Chills
  • Irregular heartbeat
  • High or low blood pressure
  • Breathing problems
  • Nausea
  • Vomiting
  • Headache
  • Shaking
  • Muscle cramps or pain

Drug Warnings

If you are allergic to Amphotericin B or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Gufisome 50 mg Injection . Gufisome 50 mg Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Gufisome 50 mg Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain, difficulty breathing, or encephalopathy (a brain disease that may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help. If you have diabetes, electrolyte imbalance (low magnesium or potassium levels in the blood), kidney, liver or heart problems, inform your doctor before taking Gufisome 50 mg Injection .

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
Amphotericin bIopamidol
Severe

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
How does the drug interact with Gufisome 50 mg Injection :
Taking Gufisome 50 mg Injection and streptozocin together can enhance kidney injury and can cause damage to the ear.

How to manage the interaction:
Taking Streptozocin with Gufisome 50 mg Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it.
Amphotericin bIopamidol
Severe
How does the drug interact with Gufisome 50 mg Injection :
Coadministration of Gufisome 50 mg Injection and Iopamidol may increase the risk of kidney problem.

How to manage the interaction:
Taking Gufisome 50 mg Injection with Iopamidol together can result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on how much you pee. If you notice any changes like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bMetrizamide
Severe
How does the drug interact with Gufisome 50 mg Injection :
Coadministration of Gufisome 50 mg Injection and Metrizamide may increase the risk of kidney damage.

How to manage the interaction:
Co-administration of Gufisome 50 mg Injection with Metrizamide can result in an interaction, but it can be taken if a doctor has advised it. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, let the doctor know. Do not stop using any medications without talking to a doctor.
Amphotericin bDroperidol
Severe
How does the drug interact with Gufisome 50 mg Injection :
Using droperidol together with Gufisome 50 mg Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Gufisome 50 mg Injection and Droperidol together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms - an irregular heart rhythm, a heart condition, a condition called congenital long qt syndrome, problems with your heart's conduction, severe or long-lasting diarrhea, vomiting, complications, sudden dizziness, feeling lightheaded, fainting, difficulty breathing, heart palpitations, feeling weak, feeling sleepy, feeling confused, muscle pain, feeling nauseous or vomiting - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bIodamide
Severe
How does the drug interact with Gufisome 50 mg Injection :
Coadministration of Gufisome 50 mg Injection and Iodamide may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Gufisome 50 mg Injection and Iodamide, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. If you notice any changes, let the doctor know. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Amphotericin bIoversol
Severe
How does the drug interact with Gufisome 50 mg Injection :
Coadministration of Gufisome 50 mg Injection and Ioversol may increase the risk of kidney damage.

How to manage the interaction:
There may be a possibility of interaction between Gufisome 50 mg Injection and Ioversol, but it can be taken if prescribed by a doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to a doctor.
Amphotericin bFoscarnet
Severe
How does the drug interact with Gufisome 50 mg Injection :
Using foscarnet together with Gufisome 50 mg Injection can cause serious side effects to the kidneys. Using these drugs together can also increase the risks of seizures (fits) and an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Gufisome 50 mg Injection and Foscarnet, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: seizures, an irregular heart rhythm, feeling sick, swelling, sudden weight gain or loss, severe pain in your upper stomach that spreads, strong heartbeats, feeling dizzy, or chest pain. Do not discontinue any medications without consulting a doctor.
Amphotericin bIotalamic acid
Severe
How does the drug interact with Gufisome 50 mg Injection :
Coadministration of Gufisome 50 mg Injection and Iotalamic acid may decrease the excretion rate of Iothalamic acid which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Gufisome 50 mg Injection and Iotalamic acid, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
Amphotericin bIodixanol
Severe
How does the drug interact with Gufisome 50 mg Injection :
Coadministration of Gufisome 50 mg Injection and Iodixanol can cause higher levels of Iodixanol in the blood by reducing its excretion rate.

How to manage the interaction:
There may be a possibility of interaction between Gufisome 50 mg Injection and Iodixanol, but it can be taken if prescribed by a doctor. It's important to keep an eye on how much you pee. If you notice any changes, like peeing more or less than usual, it's a good idea to let the doctor know right away. These changes could be a sign of different health issues, like problems with your kidneys, diabetes, or dehydration. Other symptoms to watch out for include feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, or having trouble breathing. Do not stop using any medications without talking to a doctor.
Amphotericin bDronedarone
Severe
How does the drug interact with Gufisome 50 mg Injection :
Dronedarone used with Gufisome 50 mg Injection may raise the chance of a significantly abnormal heart rhythm, although it is a rare side effect.

How to manage the interaction:
Although there is a possible interaction between Gufisome 50 mg Injection and Dronedarone, you can take these medicines together if prescribed by a doctor. You should also notify a doctor if you suffer any of the following symptoms: weakness, weariness, sleepiness, disorientation, muscular pain, cramps, dizziness, nausea, or vomiting. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Wash your hands regularly and keep your hands clean to prevent the spread of germs.
  • Avoid dusty activities and digging in the soil.
  • Wear shoes, a long-sleeved t-shirt and long pants while doing outdoor activities such as yard work, gardening or visiting wooded areas to protect from fungus commonly present in the environment.
  • Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Gufisome 50 mg Injection Substitute

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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • ZIDOVUDINE
  • CICLOSPORIN
  • FLUCYTOSINE
  • FUROSEMIDE
  • METHOTREXATE

Special Advise

  • Regular blood tests are recommended while taking Gufisome 50 mg Injection to monitor blood, liver or kidney functioning and potassium levels.

Disease/Condition Glossary

Fungal infection is a disease in which fungi attack the tissue and cause infection. Fungi are commonly present in nature but do not cause infections normally. However, if the person has a weak immune system, certain types of fungi may infect them. Cryptococcal meningitis is a fungal infection of tissues covering the spinal cord (meninges) and brain. The symptoms include headache, hallucinations, fever, stiff neck, sensitivity to light, nausea and vomiting. Fungal infections in the lungs may be more serious and life-threatening and often cause symptoms similar to tuberculosis or bacterial pneumonia.

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