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Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
COD available

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Whats That

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Composition :

LAPATINIB-250MG

Manufacturer/Marketer :

Allieva Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Lapalieva 250 mg Tablet 30's

Lapalieva 250 mg Tablet 30's is an anti-cancer medicine used in the treatment of Breast cancer. The abnormal growth of cancer (malignant) cells in the breast is known as breast cancer. Lapalieva 250 mg Tablet 30's is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment, including anthracycline, taxane, and trastuzumab. This medicine is also used in combination with letrozole for the treatment of hormone receptor-positive metastatic breast cancer in patients with HER2-positive (human epidermal growth factor receptor 2) for whom hormonal therapy is indicated.

Lapalieva 250 mg Tablet 30's contains Lapatinib as an active ingredient which belongs to the class of kinase inhibitors. It works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Lapalieva 250 mg Tablet 30's may cause certain side effects such as diarrhea, fatigue, nausea, rash, indigestion, loss of appetite, headache, vomiting, weakness, mouth sores, hair loss, dry skin, myalgia, and allergic reactions. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. Lapalieva 250 mg Tablet 30's should be taken as advised by your doctor. Take the medicine around the same time daily. Do not skip any dose; if you forget any dose, try to take it as soon as you remember unless it is time for your next dose. Do not double the dose.

Lapalieva 250 mg Tablet 30's should be avoided if you are allergic to it or any other components of this medicine. Before starting the treatment, let your doctor know about your complete medical history and medication history, including vitamin and herbal supplements. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease before taking Lapalieva 250 mg Tablet 30's. Lapalieva 250 mg Tablet 30's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand. 

Uses of Lapalieva 250 mg Tablet 30's

Breast Cancer.

Directions for Use

Take Lapalieva 250 mg Tablet 30's as prescribed by your doctor. It should be taken one hour before or at least one hour after. Swallow the medicine as a whole with a glass of water. Do not chew, crush, or break the medicine.

Medicinal Benefits

Lapalieva 250 mg Tablet 30's contains Lapatinib as an active ingredient, which is used in combination with capecitabine for treating patients with HER2-positive advanced or metastatic breast cancer who have received prior treatment. This medicine works by inhibiting the excess production of a human epidermal growth factor receptor 2 (HER2) protein in the mammalian cells. This causes inhibition of the cancer cell growth and, finally, initiation of apoptosis.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lapalieva 250 mg Tablet 30's

  • Nausea
  • Vomiting
  • Diarrhoea
  • Myalgia
  • Dry skin
  • Hair loss
  • Tiredness
  • Weakness
  • Headache
  • Fatigue

Drug Warnings

Lapalieva 250 mg Tablet 30's should be avoided if you are allergic to it or any other components of this medicine. Inform your doctor if you have any cardiovascular conditions or liver/kidney disease, as it can cause adverse effects. Lapalieva 250 mg Tablet 30's may cause left ventricular ejection fraction, prolonged QT interval, hepatotoxicity, interstitial lung disease, pneumonitis, severe diarrhoea, and hypersensitivity reactions during the treatment. Hence, careful observation should be performed for any reactions in the patient. If any changes or hypersensitivity reactions occur, treatment should be discontinued. Lapalieva 250 mg Tablet 30's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Breastfeeding should be discontinued in nursing mothers during the treatment. Lapalieva 250 mg Tablet 30's should be given to children only if prescribed by the paediatrician. Lapalieva 250 mg Tablet 30's is not recommended for use in children as the safety and efficacy are not established. Avoid alcohol consumption and smoking, as it can lead to serious adverse effects.

Drug-Drug Interactions

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LapatinibAmiodarone
Severe
LapatinibEnzalutamide
Severe

Drug-Drug Interactions

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LapatinibAmiodarone
Severe
How does the drug interact with Lapalieva 250 mg Tablet:
Coadministration of Amiodarone together with Lapalieva 250 mg Tablet may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Lapalieva 250 mg Tablet interact, they can be used if prescribed by a doctor. If you have cardiac problems or electrolyte imbalances, you may be at greater risk. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical attention. Do not discontinue any medications without consulting a doctor.
LapatinibEnzalutamide
Severe
How does the drug interact with Lapalieva 250 mg Tablet:
When Lapalieva 250 mg Tablet is taken with Enzalutamide, this could reduce the effects of Lapalieva 250 mg Tablet and its blood levels. Additionally, taking these medications together may enhance enzalutamide's effects and blood levels.

How to manage the interaction:
Co-administration of Enzalutamide with Lapalieva 250 mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms - like Seizures, exhaustion, fatigue, constipation, discomfort in the muscles or bones, hot flushes, swelling, tingling or prickling, headaches, dizziness, sleeplessness, anxiety, and increased blood pressure, consult a doctor. Do not stop using any medications without talking to a doctor.
LapatinibCeritinib
Severe
How does the drug interact with Lapalieva 250 mg Tablet:
Taking Lapalieva 250 mg Tablet with ceritinib may significantly increase the blood levels of Lapalieva 250 mg Tablet. This can make you more likely to develop side effects such as diarrhea and liver problems.

How to manage the interaction:
Co-administration of Ceritinib with Lapalieva 250 mg Tablet can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LapatinibPazopanib
Severe
How does the drug interact with Lapalieva 250 mg Tablet:
Taking Pazopanib with Lapalieva 250 mg Tablet may significantly increase the blood levels of pazopanib. This can make you more likely to develop serious side effects such as liver problems, irregular heart rhythm, bleeding and high blood pressure,

How to manage the interaction:
Taking Pazopanib with Lapalieva 250 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, fast or pounding heartbeats, chest pain or tightness, pain in your arms, back, neck, or jaw, shortness of breath, numbness or weakness on one side of your body, and difficulty speaking. Do not stop using any medications without a doctor's advice.
LapatinibNilotinib
Severe
How does the drug interact with Lapalieva 250 mg Tablet:
Combining Lapalieva 250 mg Tablet and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Lapalieva 250 mg Tablet and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
LapatinibClarithromycin
Severe
How does the drug interact with Lapalieva 250 mg Tablet:
Taking clarithromycin with Lapalieva 250 mg Tablet may increase the blood levels of Lapalieva 250 mg Tablet. This might make you more likely to develop side effects such as diarrhea, liver damage, and heart problems.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Lapalieva 250 mg Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of liver damage such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or fast or pounding heartbeats during treatment with Lapalieva 250 mg Tablet. Do not stop using any medications without a doctor's advice.
LapatinibKetoconazole
Severe
How does the drug interact with Lapalieva 250 mg Tablet:
Coadministration of Lapalieva 250 mg Tablet and ketoconazole may greatly increase Lapalieva 250 mg Tablet blood levels. This can increase the risk for side effects (diarrhea, liver damage, and heart problems like decreased heartbeat and irregular heartbeat).

How to manage the interaction:
Although taking Ketoconazole and Lapalieva 250 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor immediately if you experience any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, nausea, vomiting, dark urine, light stools, and/or yellowing of the skin or eyes, sudden dizziness, lightheadedness, fainting; shortness of breath, or rapid or pounding heartbeats. Do not discontinue any medication without consulting a doctor.
LapatinibColchicine
Severe
How does the drug interact with Lapalieva 250 mg Tablet:
Coadministration of colchicine with Lapalieva 250 mg Tablet results in increased colchicine levels in the blood, increasing the risk of serious side effects

How to manage the interaction:
Although taking Colchicine and Lapalieva 250 mg Tablet together may possibly result in an interaction, they can be taken together if your doctor prescribes it. However, if you experience abdominal pain, numbness or tingling in your hands and legs, muscle pain, or weakness, contact your doctor immediately. Do not discontinue any medication without consulting your doctor.
LapatinibDigoxin
Severe
How does the drug interact with Lapalieva 250 mg Tablet:
Co-administration of Digoxin and Lapalieva 250 mg Tablet may increase the blood levels and effects of Digoxin.

How to manage the interaction:
If you are supposed to take Digoxin and Lapalieva 250 mg Tablet together, a doctor may adjust the dose or monitor more frequently to safely use both medications. If you experience diarrhea, nausea, loss of appetite, vomiting, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, contact a doctor as these may be signs and symptoms of excessive digoxin levels. Do not discontinue the medication without consulting a doctor.
LapatinibDisopyramide
Severe
How does the drug interact with Lapalieva 250 mg Tablet:
The combined use of Lapalieva 250 mg Tablet and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Lapalieva 250 mg Tablet and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Lapalieva 250 mg Tablet 30's Substitute

Substitutes safety advice
  • Tykerb 250 mg Tablet 30's

    by AYUR

    300.30per tablet
  • Herduo Tablet 30's

    by Others

    164.00per tablet
  • Combinib 250Mg Tablet 30'S

    by AYUR

    224.90per tablet
  • Cadilap Tablet

    by Others

    234.29per tablet
  • Bretolap 250 mg Tablet 30's

    by Others

    163.73per tablet

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Lapalieva 250 mg Tablet 30's contains Lapatinib, which works by inhibiting the excess production of a protein called human epidermal growth factor receptor 2 (HER2) in mammalian cells. This causes inhibition of the cancer cell growth.

Inform your doctor whether you have received any other breast cancer treatment. Lapalieva 250 mg Tablet 30's may cause left ventricular ejection fraction, hypersensitivity reactions, hepatotoxicity, severe diarrhea, and embryo-fetal toxicity during the treatment. Hence, inform your oncologist if you have any cardiovascular conditions, liver/kidney disease, are pregnant, are planning to become pregnant, or are breastfeeding before taking Lapalieva 250 mg Tablet 30's.

Hepatotoxicity (liver toxicity) has been reported in clinical studies and postmarketing experience with Lapalieva 250 mg Tablet 30's. Hepatotoxicity can be fatal, and deaths have been reported. The cause of death is unknown. If you have upper stomach pain, itching, dark urine, clay-coloured faeces, or jaundice (yellowing of the skin or eyes), inform your doctor immediately.

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • ERYTHROMYCIN
  • KETOCONAZOLE
  • RITONAVIR
  • VERAMAPIL
  • DILTIAZEM
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE
  • ST JOHN'S WORT
  • INDINAVIR
  • EFAVIRENZ
  • ITRACONAZOLE

Special Advise

  • Avoid intercourse while on treatment with Lapalieva 250 mg Tablet 30's.
  • Regular, complete blood count monitoring is advised during the treatment.
  • All patients should be tested for HER2 test before starting the treatment regimen.
  • Liver function tests (LFT) should be performed before starting the treatment and every 4 to 6 weeks during the treatment.
  • This medicine should be taken only once daily as prescribed by the doctor. Do not divide the dose of the medicine.
  • Regular ECG and electrolytes should be monitored while taking the medicine.

Disease/Condition Glossary

Breast Cancer: Breast cancer is a type of cancer with abnormal growth in the cells of the breast. There are different kinds of breast cancer, such as cancer occurring in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast. Symptoms of breast cancer include a lump in the breast, breast pain, redness, swelling, nipple discharge other than breast milk, bloody discharge, a lump or swelling under the arm, unexplained change in shape, size or appearance of the breast, peeling, flaking or scaling of the skin. 

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