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  3. Leuprolide Depot 3.75mg Injection 1's

Leuprolide Depot 3.75mg Injection 1's, Pack of 1 INJECTION
Written By Veda Maddala , M Pharmacy
Reviewed By Hari Kumar , MBBS
Non returnable*
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Whats That

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Composition :

LEUPRORELIN-3.75MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Leuprolide Depot 3.75mg Injection

Leuprolide Depot 3.75mg Injection belongs to the class of synthetic hormones used in the treatment of prostate cancer in men, endometriosis, and hormone-responsive breast cancer in women. Also, Leuprolide Depot 3.75mg Injection is used to treat premature puberty in children. Prostate cancer is cancer of the prostate gland (a small gland under the bladder that produces semen) found only in men. The symptoms include difficulty in urination, pain, numbness, or sexual problems.

Leuprolide Depot 3.75mg Injection contains Leuprorelin, a synthetic hormone that works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and estrogen in women. Thereby, Leuprolide Depot 3.75mg Injection is used in the treatment of prostate cancer by inhibiting the growth of the tumor or causing it to shrink.  

Use Leuprolide Depot 3.75mg Injection as prescribed by your doctor. You are advised to take Leuprolide Depot 3.75mg Injection for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience pain, redness, swelling, or skin hardening at the injection site, muscle weakness, bone pain, inability to have an erection, breast tenderness, headache, vaginal dryness, changes in breast size, acne, or mood swings. Most of these side effects of Leuprolide Depot 3.75mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Leuprolide Depot 3.75mg Injection or any other medicines, please tell your doctor. Leuprolide Depot 3.75mg Injection is contraindicated in pregnant and breastfeeding women. It is advised to use effective contraceptive measures to avoid pregnancy while taking Leuprolide Depot 3.75mg Injection as it may cause birth defects. Leuprolide Depot 3.75mg Injection should be used with caution in children. You are recommended to avoid or limit consumption of alcohol with Leuprolide Depot 3.75mg Injection as it may increase the risk of bone density loss. Drive only if you are alert as Leuprolide Depot 3.75mg Injection may cause dizziness, drowsiness, or vision disturbances.

Uses of Leuprolide Depot 3.75mg Injection

Prostate cancer, Breast cancer, Endometriosis, Premature puberty

Directions for Use

Leuprolide Depot 3.75mg Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Leuprolide Depot 3.75mg Injection contains Leuprorelin which works similarly to the natural hormone, gonadotropin-releasing hormone (GnRH), by acting on the pituitary gland and decreasing the levels of testosterone in men and oestrogen in women. Thereby, Leuprolide Depot 3.75mg Injection is used in the treatment of prostate cancer by inhibiting the growth of the tumour or causing it to shrink.  Also, Leuprolide Depot 3.75mg Injection is used to treat hormone-responsive breast cancer in pre and postmenopausal women. By reducing testosterone and oestrogen levels, Leuprolide Depot 3.75mg Injection delays the onset of puberty in children.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to Leuprolide Depot 3.75mg Injection or any other medicines, please tell your doctor. Leuprolide Depot 3.75mg Injection is contraindicated in pregnant and breastfeeding women. It is advised to use effective non-hormonal contraceptives such as condoms to avoid pregnancy while taking Leuprolide Depot 3.75mg Injection as it may cause birth defects. Leuprolide Depot 3.75mg Injection should be used with caution in children. You are advised to quit smoking as it may increase the risk of prostate cancer. You are recommended to avoid or limit consumption of alcohol with Leuprolide Depot 3.75mg Injection as it may increase the risk of bone density loss. Drive only if you are alert as Leuprolide Depot 3.75mg Injection may cause dizziness, drowsiness or vision disturbances.

Drug-Drug Interactions

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LeuprorelinEliglustat
Critical
LeuprorelinCitalopram
Critical

Drug-Drug Interactions

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LeuprorelinEliglustat
Critical
How does the drug interact with Leuprolide Depot 3.75mg Injection:
Taking Leuprolide and Eliglustat together can raise the risk of an abnormal heart rhythm that may be serious.

How to manage the interaction:
Taking Leuprolide Depot 3.75mg Injection with Eliglustat together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LeuprorelinCitalopram
Critical
How does the drug interact with Leuprolide Depot 3.75mg Injection:
Coadministration of Leuprolide Depot 3.75mg Injection and citalopram can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Leuprolide Depot 3.75mg Injection and citalopram together can possibly result in an interaction; they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinCisapride
Critical
How does the drug interact with Leuprolide Depot 3.75mg Injection:
Taking leuprolide with cisapride can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Leuprolide Depot 3.75mg Injection with Cisapride is not recommended, it can be taken if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinSaquinavir
Critical
How does the drug interact with Leuprolide Depot 3.75mg Injection:
Taking leuprolide with Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Leuprolide Depot 3.75mg Injection with Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinIbutilide
Critical
How does the drug interact with Leuprolide Depot 3.75mg Injection:
Using ibutilide together with leuprolide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Leuprolide Depot 3.75mg Injection with Ibutilide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinPimozide
Critical
How does the drug interact with Leuprolide Depot 3.75mg Injection:
Taking Leuprolide Depot 3.75mg Injection with Pimozide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Leuprolide Depot 3.75mg Injection with Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinVandetanib
Critical
How does the drug interact with Leuprolide Depot 3.75mg Injection:
Taking Leuprolide Depot 3.75mg Injection with Vandetanib together can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Leuprolide Depot 3.75mg Injection with Vandetanib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinNilotinib
Critical
How does the drug interact with Leuprolide Depot 3.75mg Injection:
Using nilotinib together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Leuprolide Depot 3.75mg Injection with Nilotinib is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
LeuprorelinDofetilide
Critical
How does the drug interact with Leuprolide Depot 3.75mg Injection:
Taking leuprolide with dofetilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Leuprolide Depot 3.75mg Injection with Dofetilide together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
LeuprorelinCeritinib
Severe
How does the drug interact with Leuprolide Depot 3.75mg Injection:
Taking Leuprolide Depot 3.75mg Injection and Ceritinib together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Leuprolide Depot 3.75mg Injection and Ceritinib, you can take these medicines together if prescribed by your doctor. If you experience symptoms like irregular heart rhythm, dizziness, fainting, or difficulty breathing, you must contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include fish, soy, tomatoes, Brussels sprouts, kale, broccoli, and oils containing omega-3 fatty acids such as olive oil as these foods may reduce the risk of prostate cancer.
  • Avoid grilled meat, red meat, and saturated fat found in animal products, milk, and dairy products as they may increase the risk of prostate cancer.
  • Exercise regularly to lose weight as obesity is also considered a risk factor for prostate cancer.
  • Quit smoking to reduce the risk of prostate cancer.
  • Avoid fast food, fried food, processed meats, refined carbs, and added sugar.

Habit Forming

No

Therapeutic Class

GONADOTROPHIN-RELEASING HORMONE AGONIST

Leuprolide Depot 3.75mg Injection Substitute

Substitutes safety advice

Product Substitutes

Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Hari Kumar

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:39 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Leuprolide Depot 3.75mg Injection contains Leuprorelin, a synthetic hormone that works similar to the natural hormone, gonadotropin-releasing hormone (GnRH) by acting on the pituitary gland and decreases the levels of testosterone in men and oestrogen in women. Thereby, Leuprolide Depot 3.75mg Injection is used in the treatment of prostate cancer by inhibiting the growth of tumour or causing it to shrink.

Leuprolide Depot 3.75mg Injection may stop menstrual periods. However, after 7 to 12 weeks of taking the final dose of injection, periods will resume. Please consult a doctor if you have any concerns regarding this.

Leuprolide Depot 3.75mg Injection should be used with caution in diabetic patients as it may increase the risk of high blood sugar levels. Therefore, it is advised to regularly monitor blood sugar levels while taking Leuprolide Depot 3.75mg Injection and inform your doctor if you have diabetes before taking Leuprolide Depot 3.75mg Injection.

Leuprolide Depot 3.75mg Injection may be used to treat endometriosis (tissue lining the uterus known as endometrium grows outside the uterus). Leuprolide Depot 3.75mg Injection reduces oestrogen levels and causes menopause temporarily. Thereby, shrink the tissue outside the uterus or stop its growth.

Leuprolide Depot 3.75mg Injection may decrease bone density, especially when used for the treatment of premature puberty in children. Therefore, regular monitoring of bone density is recommended while taking Leuprolide Depot 3.75mg Injection.

Leuprolide Depot 3.75mg Injection should be used with extreme caution in patients suffering from depression as it may worsen the condition. Therefore, inform your doctor if you have any history of depression before taking Leuprolide Depot 3.75mg Injection.

Drug-Drug Interactions Checker List

  • MOXIFLOXACIN
  • PROCAINAMIDE
  • QUINIDINE
  • SOTALOL
  • AMIODARONE
  • METHADONE
  • CLOZAPINE

Special Advise

Leuprolide Depot 3.75mg Injection may cause changes in blood cholesterol levels or affect values in liver functioning tests. Therefore, inform your doctor that you are taking Leuprolide Depot 3.75mg Injection before undergoing any tests.

Disease/Condition Glossary

Prostate cancer: It is the cancer of the prostate gland (a small gland under the bladder that produces semen) found only in men. The symptoms include difficulty in urination, pain, numbness, or sexual problems. Certain factors increase the risk of prostate cancer, such as the family history of prostate cancer, older age, obesity, or genetic changes.

Breast cancer: It is a type of cancer that develops in breast cells that are stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and in the fatty tissue or the fibrous connective tissue within the breast.

Endometriosis: It is a disorder in which the tissue lining the uterus (endometrium) grows on the ovaries, bowel, or tissues lining the pelvis. The most common symptom is pelvic pain. Other symptoms of endometriosis include lower back pain, painful periods, heavy menstrual bleeding, pain following sexual intercourse, or discomfort with bowel movements.  

Premature puberty: It is a condition in which the signs of puberty (physical changes in which a child’s body matures into an adult body) start early in children, i.e., before 9 years in girls and before 10 years in boys.

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