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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Composition :

OLAPARIB-100MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Lupiparp 100 Tablet 60's

Lupiparp 100 Tablet 60's belongs to a group of medicines known as 'anti-cancer' drugs used to treat various cancers, including Ovarian, breast, pancreatic, and prostate. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can attack and destroy surrounding healthy tissue, including organs.

Lupiparp 100 Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

Use this medicine as directed by your doctor. You may sometimes experience shortness of breath (dyspnoea), feeling very tired, pale skin or fast heartbeat, anaemia, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.

To treat your condition effectually, continue taking Lupiparp 100 Tablet 60's for as long as your doctor has prescribed. Do not stop using the Lupiparp 100 Tablet 60's midway. Talk to your doctor before taking Lupiparp 100 Tablet 60's if you have severe allergic reactions to Lupiparp 100 Tablet 60's or other medicines or suffer from severe infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Lupiparp 100 Tablet 60's if you are pregnant or breastfeeding because this Lupiparp 100 Tablet 60's can cause harmful effects on the unborn baby. Both women and men using this Lupiparp 100 Tablet 60's should use birth control to avoid pregnancy. While on Lupiparp 100 Tablet 60's treatment, you should avoid eating grapefruit, Seville oranges or consuming grapefruit juice since it can affect how the medicine works.

Uses of Lupiparp 100 Tablet 60's

Cancer (Ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer)

Directions for Use

Swallow it as a whole with water; do not crush or chew it.

Medicinal Benefits

Lupiparp 100 Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage. Thus, it treats various cancers, including Ovarian, breast, pancreatic, and prostate. It can be used alone or with other chemotherapy drugs, depending on your type of cancer.

Storage

Keep Lupiparp 100 Tablet 60's out of reach and sight of children.
Side effects of Lupiparp 100 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.

Drug Warnings

Always take this medicine exactly as your doctor or healthcare professional has told you. To treat your condition effectually, continue taking Lupiparp 100 Tablet 60's for as long as your doctor has prescribed. Do not stop Lupiparp 100 Tablet 60's midway. Talk to your doctor before taking Lupiparp 100 Tablet 60's if you have severe allergic reactions to Lupiparp 100 Tablet 60's or other medicines or suffer from any medical illness. Avoid taking Lupiparp 100 Tablet 60's if you are pregnant or breastfeeding because this Lupiparp 100 Tablet 60's can cause harmful effects on the unborn baby. Both women and men using this Lupiparp 100 Tablet 60's should use birth control to avoid pregnancy. Do not start Lupiparp 100 Tablet 60's unless patients have recovered from haematological damage induced by previous chemotherapy (Grade 1). Check full blood count for cytopenia at baseline and monthly afterwards for clinically significant changes during treatment. For persistent haematological toxicity, discontinue Lupiparp 100 Tablet 60's and monitor blood count weekly until recovery. Do not receive any immunization or vaccination without your doctor's approval while taking the Lupiparp 100 Tablet 60's.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Lupiparp 100 Tablet:
Using Ciprofloxacin and Lupiparp 100 Tablet can increase the blood levels of Lupiparp 100 Tablet. This can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a interaction between ciprofloxacin and Lupiparp 100 Tablet, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lupiparp 100 Tablet:
Using Atazanavir and Lupiparp 100 Tablet can increase the blood levels of Lupiparp 100 Tablet. This can increase the risk and/or severity of side effects Lupiparp 100 Tablet.

How to manage the interaction:
Combining Atazanavir and Lupiparp 100 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
OlaparibMibefradil
Severe
How does the drug interact with Lupiparp 100 Tablet:
Using Mibefradil and Lupiparp 100 Tablet can increase the blood levels of Lupiparp 100 Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Mibefradil and Lupiparp 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Lupiparp 100 Tablet:
Using Diltiazem and Lupiparp 100 Tablet can increase the blood levels of Lupiparp 100 Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Diltiazem and Lupiparp 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Lupiparp 100 Tablet:
Taking Lupiparp 100 Tablet with rifampicin can decrease the blood levels of Lupiparp 100 Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Lupiparp 100 Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lupiparp 100 Tablet:
Taking Armodafinil and Lupiparp 100 Tablet may reduce the blood levels of Lupiparp 100 Tablet, which may reduce the effect of Lupiparp 100 Tablet.

How to manage the interaction:
Although there is a possible interaction between Armodafinil and Lupiparp 100 Tablet, you can take these medicines together if prescribed by a doctor. Contact a doctor if your symptoms do not improve. Do not stop using any medications without consulting a doctor.
How does the drug interact with Lupiparp 100 Tablet:
Combining Deferiprone and Lupiparp 100 Tablet can increase the risk of lowering white blood cell count and affect white blood cells or bone marrow function.

How to manage the interaction:
Combining Deferiprone and Lupiparp 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Lupiparp 100 Tablet:
Using Ketoconazole and Lupiparp 100 Tablet can increase the blood levels of Lupiparp 100 Tablet. This can increase the risk and/or severity of side effects (nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells).

How to manage the interaction:
Combining Ketoconazole and Lupiparp 100 Tablet can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
OlaparibBoceprevir
Severe
How does the drug interact with Lupiparp 100 Tablet:
Using Boceprevir and Lupiparp 100 Tablet can increase the blood levels of Lupiparp 100 Tablet.This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Boceprevir and Lupiparp 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Lupiparp 100 Tablet:
When Lupiparp 100 Tablet is taken with Voriconazole may significantly increase the blood levels of Lupiparp 100 Tablet which increases risk of side effects.

How to manage the interaction:
Although taking Voriconazole and Lupiparp 100 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience dizziness, fever, shortness of breath, and pain or burning during urination, contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs and added sugars.

Side Effects of Lupiparp 100 Tablet 60's

  • Feeling sick (nausea)
  • Being sick (vomiting)
  • Feeling tired or weak (fatigue)
  • Feeling very tired
  • Indigestion or heartburn (dyspepsia)
  • Loss of appetite
  • Headache
  • Changes in the taste of foods (dysgeusia)
  • Feeling dizzy
  • Cough
  • Shortness of breath (dyspnoea)
  • Diarrhoea
  • Low white blood cell count (leukopenia or neutropenia)
  • Rash
  • Sore mouth (stomatitis)
  • Upper abdominal pain (pain in the stomach area under the ribs)
  • Blood clot in a deep vein, usually in the leg (venous thrombosis)

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Lupiparp 100 Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

If you are allergic to Olaparib or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Lupiparp 100 Tablet 60's.

Yes, Lupiparp 100 Tablet 60's can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.

Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Yes, Olaparib was generally a well-tolerated medication. Take Lupiparp 100 Tablet 60's pills exactly as directed by your healthcare provider. Do not change your dose or stop taking Lupiparp 100 Tablet 60's unless your healthcare physician instructs you. If you encounter side symptoms, your healthcare provider may temporarily discontinue your Lupiparp 100 Tablet 60's therapy or adjust your Lupiparp 100 Tablet 60's dose.

Drug-Drug Interactions Checker List

  • AMPRENAVIR
  • DARUNAVIR
  • APREPITANT
  • BCG VACCINE
  • DENGUE VACCINE
  • MUMPS (LIVE ATTENUATED)
  • CIPROFLOXACIN
  • FLUCONAZOLE
  • ITRACONAZOLE

Special Advise

  • Pregnancy testing is recommended for females of reproductive potential prior to initiating treatment with Lupiparp 100 Tablet 60's.
  • Lupiparp 100 Tablet 60's should be taken under strict medical supervision. The doctor will regularly monitor your condition while taking Lupiparp 100 Tablet 60's.
  • Monitor complete blood count for cytopenia at baseline and monthly for clinically significant changes during treatment.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count in your blood.
  • Peripheral blood counts should be frequently monitored during Lupiparp 100 Tablet 60's treatment and, when appropriate, until recovery is achieved.
  • Do not donate sperm during treatment with Lupiparp 100 Tablet 60's for three months after your last dose.

Disease/Condition Glossary

Cancer: Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can invade and destroy surrounding healthy tissue, including organs. Cancer sometimes begins in one body part before spreading to other areas.

Ovarian cancer: Ovarian cancer begins in the ovaries (one of a pair of female reproductive glands in which the ova, or eggs, are formed).

Breast cancer: Breast cancer is a type of cancer that develops in breast cells stimulated by a female sex hormone called estrogen. Breast cancer may form in lobules (glands that produce milk), ducts of the breast (the pathway that brings milk from glands to the nipple), and the fatty tissue or the fibrous connective tissue within the breast. The tumour cells invade other healthy breast cells and travel to lymph nodes, a primary pathway for the cancer cells to move to other body parts. Symptoms of breast cancer include a lump in the breast or tissue thickening, which feels different than the normal surrounding tissues, breast pain, redness, swelling, and nipple discharge other than breast milk.

Prostate cancer: Prostate cancer is a type of cancer that only occurs in men and affects the prostate gland, a tiny gland under the bladder that produces semen. Inability to urinate easily, pain, numbness, or sexual issues are among the symptoms. For men, it is the most typical type of cancer. Although the exact cause of prostate cancer is unknown, it may be brought on by family history, chemical exposure, or both. Prostate cancer risk factors include a family history of the disease, advanced age, obesity, and genetic changes.

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