Mesacol 1 gm Suppository 7's

Written By Veda Maddala , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MRP ₹455

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Whats That

About Mesacol 1 gm Suppository

Mesacol 1 gm Suppository belongs to a class of anti-inflammatory drugs used to treat ulcerative colitis. Ulcerative colitis is a chronic inflammatory bowel disease that causes inflammation of the large intestine lining (colon). It produces ulcers on the colon's lining, which may cause bleeding and discharge of pus and mucus. Ulcerative proctitis is a condition in which ulcerative colitis solely affects the rear channel (rectum). Mesacol 1 gm Suppository used for the treatment of ulcerative proctitis and is exclusively designed for rectal usage.

Mesacol 1 gm Suppository contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (redness and swelling) in the intestines and provides relief from symptoms such as stomach pain or bleeding.

Use Mesacol 1 gm Suppository as directed by your physician. Sometimes, you may experience diarrhoea, stomach pain, headache or nausea. Most of these side effects of Mesacol 1 gm Suppository do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic to Mesalazine, aspirin, or other medicines. Mesacol 1 gm Suppository should be used with caution in the elderly. If pregnant or breastfeeding, please inform your doctor before using the Mesacol 1 gm Suppository. Avoid taking Mesacol 1 gm Suppository if you have severe kidney failure. Avoid taking Mesacol 1 gm Suppository if you have blood abnormalities or kidney problems caused by other medicines such as Sulphasalazine.

Uses of Mesacol 1 gm Suppository

Ulcerative colitis, Ulcerative proctitis

Directions for Use

Suppository: Empty your bowels if required. Wash your hands thoroughly before and after use. Lie down on your left side and raise your right knee to the chest. Remove the wrapper and insert the pointed end of the suppository into the rectum. If necessary, grease the suppository tip with petroleum jelly.Enema: Use it as advised by the doctor. Shake the bottle well and remove the protective shield from the tip. Lie down on your left side, raise your right knee to the chest, or kneel and lean forward so that the head and chest are resting comfortably. Insert the enema bottle into the rectum with the tip pointing towards the navel. Squeeze the bottle gently until it is empty. Remove the bottle from the rectum and wash your hands thoroughly.Rectal foam: Mesacol 1 gm Suppository should be used as directed by your doctor. It is exclusively intended for rectal usage. Before using, empty your bowels (if necessary) and wash your hands. Shake the bottle vigorously for at least 30 seconds. Remove the applicator's protective cap and hold the bottle by its top end. Lie on your left side, your left leg extended and your right leg bent. Insert the applicator (lubricant-coated) for easier entry into the rectum. Squeeze the bottle gently while holding it directed towards your navel. When the bottle is empty, remove the applicator from the rectum. Allow the drug to spread throughout the lower section of the large intestine for at least 30 minutes by remaining in this posture. Wash your hands (after usage) and wait till the next morning to empty your bowels. Your doctor will choose the appropriate amount and duration for you based on your age, body weight, and medical state.

Medicinal Benefits

Mesacol 1 gm Suppository contains Mesalazine, an anti-inflammatory drug used to treat ulcerative colitis, ulcerative proctitis and Crohn’s disease. It works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thereby helping reduce inflammation (redness and swelling) in the intestines and providing relief from symptoms such as stomach pain or bleeding. Also, Mesacol 1 gm Suppository may prevent further episodes of ulcerative colitis. It is especially useful when ulcerative colitis symptoms affect the rectum.

Storage

Keep Mesacol 1 gm Suppository out of reach and sight of children.

Side effects of Mesacol 1 gm Suppository

Burps

Eating and drinking slowly can help swallow less air, which reduces burps.
Avoid consuming foods like gum and hard candy and drinking carbonated drinks as they release carbon dioxide gas in your body.
Prevent smoking as it can impact your whole body.
Seek medical help to treat gastric problems and heart burn that may lead to frequent burps.
Check your dentures because if they are loosely fit, excess air can be swallowed that causes burbs more frequently.

Bowel Inflammation

If you have bowel inflammation, eat smaller quantities and more frequent meals.
Eat slowly and chew your food thoroughly to help digestion.
Eat fiber-rich foods such as fruits, whole grains, and vegetables to promote regular bowel movements.
Avoid gas-producing foods like cabbage, beans, broccoli and carbonated drinks.
Drink lots of water throughout the day to prevent dehydration and aid digestion.
Do regular exercise to enhance digestion and reduce bloating.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Pain

Apply a hot/cold pack to the affected area.
Doing gentle exercises can help cope with pain by stretching muscles.
Get enough sleep. It helps enhance mood and lower pain sensitivity.
Avoid alcohol, smoking and tobacco as they can increase pain.
Follow a well-balanced meal.
Meditation and massages may also help with pain.

Common Cold

Here are the steps to manage the medication-triggered Common Cold:

Inform your doctor about the common cold symptoms you're experiencing due to medication.
Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Itching

Here are the few steps for dealing with itching caused by drug use:

Report the itching to your doctor immediately; they may need to change your medication or dosage.
Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
Try not to scratch, as this can worsen the itching and irritate your skin.
If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Drug Warnings

Please tell your doctor if you are allergic to Mesalazine, aspirin, or sulfasalazine. Mesacol 1 gm Suppository should be used with caution in the elderly. If you are pregnant or breastfeeding, please inform your doctor before using the Mesacol 1 gm Suppository. Avoid taking Mesacol 1 gm Suppository if you have severe kidney failure. Avoid taking Mesacol 1 gm Suppository if you have had blood abnormalities or kidney problems while taking other medicines such as Sulphasalazine. Use Mesacol 1 gm Suppository in dose and duration as advised by a doctor only. Do not swallow Mesacol 1 gm Suppository. In case of accidental swallowing, drink plenty of water and consult a doctor immediately.

Drug-Drug Interactions

MesalazineCidofovir

Critical

MesalazineIomeprol

Severe

Drug-Drug Interactions

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MesalazineCidofovir

Critical

How does the drug interact with Mesacol 1 gm Suppository:
Co-administration of Mesacol 1 gm Suppository with Cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Mesacol 1 gm Suppository with Cidofovir is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or loss, shortness of breath, consult a doctor. Do not discontinue any medications without consulting a doctor.

MesalazineIomeprol

Severe

How does the drug interact with Mesacol 1 gm Suppository:
Co-administration of Iomeprol with Mesacol 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol 1 gm Suppository and Iomeprol they can be taken together if your doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.

MesalazineRanitidine

Severe

How does the drug interact with Mesacol 1 gm Suppository:
Co-administration of Ranitidine with Mesacol 1 gm Suppository can decrease the levels of Mesacol 1 gm Suppository, which may be less effective in treating a condition.

How to manage the interaction:
There may be a possible interaction between Mesacol 1 gm Suppository with Ranitidine, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.

MesalazineTenofovir alafenamide

Severe

How does the drug interact with Mesacol 1 gm Suppository:
Co-administration of Tenofovir alafenamide with Mesacol 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
There is a possibility of interaction between Mesacol 1 gm Suppository with Tenofovir alafenamide, but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience increased or decreased urination, swelling, shortness of breath, bone pain, cramping in the muscles. Do not discontinue the medication without consulting a doctor.

MesalazineIodamide

Severe

How does the drug interact with Mesacol 1 gm Suppository:
Co-administration of Iodamide with Mesacol 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesalamine with Iodamine they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, itchy skin, shortness of breath, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.

MesalazineMetrizamide

Severe

How does the drug interact with Mesacol 1 gm Suppository:
Co-administration of Metrizamide with Mesacol 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol 1 gm Suppository with Metrizamide they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, dry, itchy skin, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.

MesalazineNizatidine

Severe

How does the drug interact with Mesacol 1 gm Suppository:
Co-administration of Nizatidine with Mesacol 1 gm Suppository can decrease the level or effect of Mesalamine by increasing gastric pH.

How to manage the interaction:
Although there may be a possible interaction between Mesacol 1 gm Suppository with Nizatidine, they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.

MesalazineDeferasirox

Severe

How does the drug interact with Mesacol 1 gm Suppository:
Co-administration of Deferasirox with Mesacol 1 gm Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possibility of interaction between Mesacol 1 gm Suppository and Deferasirox but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as increased or decreased urination, abrupt weight gain or loss, weakness, or dizziness. Do not discontinue the medication without consulting a doctor.

MesalazineOmeprazole

Severe

How does the drug interact with Mesacol 1 gm Suppository:
Co-administration of omeprazole with Mesacol 1 gm Suppository can decrease the effects of Mesacol 1 gm Suppository.

How to manage the interaction:
There could be a possible interaction between Mesacol 1 gm Suppository and omeprazole, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Maintain a low-fat diet and eat foods rich in vitamin C, such as bell peppers, spinach, parsley and berries, which help in healing faster.
Opt for food and drinks high in Omega 3 fatty acids to get relief from pain, swelling, and inflammation. Omega 3 fatty acid-enriched foods include flaxseeds, walnut, soybean oil, salmon, and tuna if you prefer non-veg.
Eat more fibre-rich foods such as fruits and vegetables.
Eat smaller meals all day.
Drink small amounts of water throughout the day.
If you are intolerant to lactose, lower your intake of milk.
Avoid intake of foods high in sugar and fat and processed foods, as these may cause inflammation.
Try to avoid alcohol as it can affect your stomach and intestine and also limits the absorption of the important nutrients required by your body.

Side Effects of Mesacol 1 gm Suppository

Diarrhoea
Stomach pain
Headache
Nausea

Habit Forming

No

Therapeutic Class

ANTI- INFLAMMATORY AGENTS

Mesacol 1 gm Suppository Substitute

Pentasa 1 gm Suppository 7's

by AYUR

₹101.26per tablet

Vegaz 1 gm Suppository 7's

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Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:34 AM IST

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Drug-Diseases Interactions

No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

How does Mesacol 1 gm Suppository work?

Mesacol 1 gm Suppository contains Mesalazine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves symptoms such as stomach pain or bleeding.

Does Mesacol 1 gm Suppository cause diarrhoea?

Mesacol 1 gm Suppository may cause diarrhoea as a common side effect. However, if the condition persists or worsens with fever, watery stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while using Mesacol 1 gm Suppository to prevent dehydration.

Can I take Mesacol 1 gm Suppository with aspirin?

You are not recommended to take Mesacol 1 gm Suppository with aspirin as co-administration of these two medicines may increase the risk of kidney problems. However, please consult your doctor before taking Mesacol 1 gm Suppository with other medicines.

Can i stop using Mesacol 1 gm Suppository on my own?

No, you are not recommended to stop using Mesacol 1 gm Suppository suddenly as it may cause recurring symptoms. Therefore, use Mesacol 1 gm Suppository for as long as your doctor has prescribed it and if you experience any difficulty while using Mesacol 1 gm Suppository, please consult your doctor.

Drug-Drug Interactions Checker List

ASPIRIN
IBUPROFEN
AZATHIOPRINE

Disease/Condition Glossary

Ulcerative colitis: It is a type of chronic inflammatory bowel disease that causes inflammation of the lining of the large intestine (colon) and produces ulcers on the lining of the colon, which may cause bleeding and discharge of pus and mucus. The common symptoms include bloody stools, stomach pain, rectal pain, diarrhoea, fever or weight loss. Additionally, it may cause other problems such as joint pain or swelling, mouth sores, skin problems, decreased appetite or nausea. The factors involved in causing ulcerative colitis include immune disorders and environmental factors like viruses, bacteria or antigens, which may trigger the immune system and genes inherited from the parent.

Ulcerative proctitis: It is a condition in which ulcerative colitis solely affects the rear channel (rectum).