Mifegest Kit

Mifegest Kit belongs to a group of gynaecological medications called ‘Abortifacient’ used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. Mifegest Kit also works in the second trimester of pregnancy.

Mifegest Kit contains two medicines, namely: Mifepristone and Misoprostol. Mifepristone is an anti-hormone (anti-progestogen) that blocks the effects of the progesterone hormone required in women to continue the pregnancy. On the other hand, Misoprostol is a prostaglandin that increases the womb’s (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. Thus, Mifegest Kit together cause termination of pregnancy and must be used one after the other for medical abortion.

A medical abortion generally involves 2-3 visits to a doctor or clinic, which includes giving medicines and then confirmation of termination of pregnancy. Following are the schedule involved in medical abortion:

• Day 1: Medical counselling and examination where doctor instructs to take one tablet of mifepristone (200 mcg)
• Day 2 to 3: You must return to the hospital/clinic 36 to 48 hours after taking the first dose of mifepristone. Your doctor will tell you about this. The tablet of Misoprostol (800 mcg) will now be given either orally or vaginally.
• Day 7 to 14: The doctor will confirm and make sure whether the medical abortion has been completed or not. If the abortion is not complete, you might require more follow-up visits.

In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of Mifegest Kit subside with time. But if vaginal bleeding does not stop, please visit the doctor immediately, as it requires immediate medical attention.

Mifegest Kit should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting Mifegest Kit if you have had an ectopic pregnancy (when the womb grows in the fallopian tube), using an intrauterine device, or you are breastfeeding, any bleeding disorder or heart problem. Do not strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.

Mifegest Kit contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone) needed to maintain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for Mifegest Kit to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete. On the other hand, the second medicine is Misoprostol, a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Thus Together Mifegest Kit terminates the state of pregnancy. Misoprostol should be taken at least 24-36 hours after taking mifepristone, either orally or vaginally. This is a non-surgical method which is 90% successful.

• Nausea
• Uterine cramps
• Vomiting
• Diarrhoea
• Dizziness
• Infection following abortion
• Uterine bleeding

Do not take Mifegest Kit if you are allergic to misoprostol and mifepristone, have a heart fitted with an artificial valve, have heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking Mifegest Kit in these conditions can cause life-threatening conditions in an individual. Mifegest Kit is known to cause sleepiness, so driving or operating machinery should not be done. If you use contraceptive devices like the intrauterine device (IUD), please remove it before taking Mifegest Kit. Regular follow-up with the doctor is required for constant monitoring of abortion. If medical termination does not happen or becomes unsuccessful, it should be terminated surgically as it can lead to foetal defects. Your doctor will examine by performing ultrasonography to confirm if the abortion is complete. St John’s Wort (a natural remedy used to treat mild depression) grapefruit juice should not be taken when taking Mifegest Kit as it is known to interact.

Drug-Drug Interactions: Mifegest Kit interacts with corticosteroids (dexamethasone), antifungal (ketoconazole, itraconazole), antibiotics (erythromycin, rifampicin),  anti-epileptic (phenytoin, phenobarbital, carbamazepine), immunosuppressants (cyclosporine, tacrolimus, sirolimus), medicines to treat migraine (ergotamine). So, Mifegest Kit should not be taken along with these drugs.

Drug-Food Interactions: Please tell your doctor about all the Vitamins, herbs, and supplements you are taking as Mifegest Kit may interact with them to produce unpleasant side effects. Also, Mifegest Kit is known to interact with St John’s Wort (a natural remedy used to treat mild depression), and grapefruit juice.

Drug-Disease Interactions: Mifegest Kit should be taken with caution in people who have a bleeding problem, confirmed or suspected ectopic pregnancy, heart problem, liver or kidney disease, vaginal bleeding, porphyria (an inherited blood disease that may cause nervous system or skin problems).

• DEXAMETHASONE
• KETOCONAZOLE
• ITRACONAZOLE
• ERYTHROMYCIN
• RIFAMPICIN
• PHENYTOIN
• PHENOBARBITAL
• CARBAMAZEPINE
• CYCLOSPORINE
• TACROLIMUS
• SIROLIMUS
• ERGOTAMINE

• Keep your weight under control with body mass index (BMI) 19.5-24.9.
• Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
• Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complication.
• Avoid chronic stress and physical exercise like running as it might increase vaginal bleeding.
• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
• Get an ultrasound done to check if the abortion is done completely to avoid any unwanted complications.
• Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

• Get an ultrasound to check whether medical abortion is done completely to avoid unwanted complications.
• Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
• There might be a possibility of becoming pregnant again immediately after the pregnancy termination is complete. It would be best if you started using contraceptives for at least ten days of taking the mifepristone tablet. It is better to discuss contraceptive options with your doctor.
• If you are (Rh factor negative), the use of Mifegest Kit requires special measures which are taken to prevent Rhesus (Rh) factor sensitisation. So, if you are Rhesus negative, let your doctor know about this before using Mifegest Kit.

Medical abortion: It is a procedure in which medicine is used to terminate a pregnancy. It is effectively causing abortion if performed in the first 70 days of pregnancy. Vagina bleeding occurs, and if it does not stop, please inform your doctor as it might require medical supervision. Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (may last up to 30 days), fever, digestive system discomfort fever. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised.