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Reviewed By Sunny S , MBBS
Non returnable*
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Manufacturer/Marketer :

Amazing Research Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pregout Kit

Pregout Kit belongs to a group of gynaecological medications called ‘Abortifacient’ used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. Pregout Kit also works in the second trimester of pregnancy.

Pregout Kit contains two medicines, namely: Mifepristone and Misoprostol. Mifepristone is an anti-hormone (anti-progestogen) that blocks the effects of the progesterone hormone required in women to continue the pregnancy. On the other hand, Misoprostol is a prostaglandin that increases the womb’s (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. Thus, Pregout Kit together cause termination of pregnancy and must be used one after the other for medical abortion.

A medical abortion generally involves 2-3 visits to a doctor or clinic, which includes giving medicines and then confirmation of termination of pregnancy. Following are the schedule involved in medical abortion:

  • Day 1: Medical counselling and examination where doctor instructs to take one tablet of mifepristone (200 mcg)
  • Day 2 to 3: You must return to the hospital/clinic 36 to 48 hours after taking the first dose of mifepristone. Your doctor will tell you about this. The tablet of Misoprostol (800 mcg) will now be given either orally or vaginally.
  • Day 7 to 14: The doctor will confirm and make sure whether the medical abortion has been completed or not. If the abortion is not complete, you might require more follow-up visits.

In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of Pregout Kit subside with time. But if vaginal bleeding does not stop, please visit the doctor immediately, as it requires immediate medical attention.

Pregout Kit should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting Pregout Kit if you have had an ectopic pregnancy (when the womb grows in the fallopian tube), using an intrauterine device, or you are breastfeeding, any bleeding disorder or heart problem. Do not strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.

Uses of Pregout Kit

Medical abortion

Directions for Use

Pregout Kit should be taken in dose and duration as prescribed by your doctor.

Medicinal Benefits

Pregout Kit contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone) needed to maintain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for Pregout Kit to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete. On the other hand, the second medicine is Misoprostol, a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Thus Together Pregout Kit terminates the state of pregnancy. Misoprostol should be taken at least 24-36 hours after taking mifepristone, either orally or vaginally. This is a non-surgical method which is 90% successful.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Pregout Kit if you are allergic to misoprostol and mifepristone, have a heart fitted with an artificial valve, have heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking Pregout Kit in these conditions can cause life-threatening conditions in an individual. Pregout Kit is known to cause sleepiness, so driving or operating machinery should not be done. If you use contraceptive devices like the intrauterine device (IUD), please remove it before taking Pregout Kit. Regular follow-up with the doctor is required for constant monitoring of abortion. If medical termination does not happen or becomes unsuccessful, it should be terminated surgically as it can lead to foetal defects. Your doctor will examine by performing ultrasonography to confirm if the abortion is complete. St John’s Wort (a natural remedy used to treat mild depression) grapefruit juice should not be taken when taking Pregout Kit as it is known to interact.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Pregout Kit:
Taking Pregout Kit with Heparin can increase the risk of negative side effects.

How to manage the interaction:
Taking Heparin with Pregout Kit is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Pregout Kit:
When Tolvaptan is taken with Pregout Kit, it may increase the levels of tolvaptan, which may increase the risk of side effects.

How to manage the interaction:
Taking Tolvaptan and Pregout Kit together is not recommended, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pregout Kit:
When Pregout Kit is taken with Lovastatin, it can increase the risk of side effects including rhabdomyolysis (a condition that causes your muscles to break down (disintegrate), which leads to muscle death).

How to manage the interaction:
Taking Lovastatin with Pregout Kit is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregout Kit:
Using Pregout Kit with Triamcinolone can significantly reduce the effects of triamcinolone.

How to manage the interaction:
Taking Triamcinolone with Pregout Kit is not recommended but can be taken if prescribed by a doctor. However, if you notice any unusual symptoms contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Pregout Kit:
When Pregout Kit is taken with Dabigatran etexilate, it may increase the risk of severe vaginal bleeding in women.

How to manage the interaction:
Taking Pregout Kit with Dabigatran etexilate is not recommended, but it can be taken if prescribed by the doctor. However, if you experience heavy, persistent vaginal bleeding, consult the door. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregout Kit:
Co-administration of Beclomethasone dipropionate with Pregout Kit may make it less effective as a therapy.

How to manage the interaction:
Taking Beclomethasone with Pregout Kit is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Pregout Kit:
Coadministration of Lurasidone with Pregout Kit can increase the levels of Lurasidone which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Lurasidone with Pregout Kit together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any abnormal muscle movements, seizures(fits), high blood sugar, dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Pregout Kit:
Taking Clopidogrel together with Pregout Kit increases the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking clopidogrel with Pregout Kit is not recommended, that would certainly result in interaction, it can be taken if a doctor prescribes it. If you experience prolonged and heavy bleeding, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Pregout Kit:
Combining Pregout Kit and hydrocortisone can reduce the effects of hydrocortisone.

How to manage the interaction:
Taking Hydrocortisone with Pregout Kit is not recommended, consult a doctor before taking it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Pregout Kit:
When Fludrocortisone is taken with Pregout Kit, it can increase the risk of side effects.

How to manage the interaction:
Taking Pregout Kit with Fludrocortisone is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medication without consulting a doctor.

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or grapefruit juice along with Pregout Kit may cause the medication's blood levels to rise to unwanted levels and raise the chance of adverse effects. Avoid taking grapefruit or grapefruit juice along with Pregout Kit as this can raise the chance of adverse effects. However, consult a doctor if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, hypokalemia (low blood potassium), fluid retention, swelling, and high blood pressure.

Diet & Lifestyle Advise

  • Keep your weight under control with body mass index (BMI) 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complication.
  • Avoid chronic stress and physical exercise like running as it might increase vaginal bleeding.
  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • Get an ultrasound done to check if the abortion is done completely to avoid any unwanted complications.
  • Try to include heart-healthy omega 3 fatty acid containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ABORTIFACIENT, CERVICAL RIPENING AGENTS

Pregout Kit Substitute

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Pregout Kit contains Mifepristone and Misoprostol. Mifepristone works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. Misoprostol is a prostaglandin analogue that helps increase uterine contractions and relaxes the cervix. Misoprostol should be taken 24-36 hours after taking mifepristone, either orally or vaginally.

No, Pregout Kit should be taken in the dose and duration as advised by the doctor. Taking it in more than the recommended dose might cause unpleasant side effects like excessive uterine or vaginal bleeding.

No, Pregout Kit is not known to affect any future chances of pregnancy. Pregout Kit is used for medical abortion of early or unwanted pregnancy.

After taking Pregout Kit, you may or may not experience vaginal bleeding, which does not indicate complete abortion. Your doctor will examine with the performing ultrasonography to confirm if the abortion is complete.

Do not take Pregout Kit, if you have a heart fitted with an artificial valve, heart diseases like high blood pressure or high blood cholesterol levels (increased fat in your blood), have asthma, have blood clot problems, have a bleeding disorder, have liver or kidney disease, have anaemia (low haemoglobin) or otherwise malnourished. Taking Pregout Kit in these conditions can cause life-threatening conditions in an individual.

Drug-Drug Interactions Checker List

  • DEXAMETHASONE
  • KETOCONAZOLE
  • ITRACONAZOLE
  • ERYTHROMYCIN
  • RIFAMPICIN
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE
  • CYCLOSPORINE
  • TACROLIMUS
  • SIROLIMUS
  • ERGOTAMINE

Special Advise

  • Get an ultrasound to check whether medical abortion is done completely to avoid unwanted complications.
  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • There might be a possibility of becoming pregnant again immediately after the pregnancy termination is complete. It would be best if you started using contraceptives for at least ten days of taking the mifepristone tablet. It is better to discuss contraceptive options with your doctor.
  • If you are (Rh factor negative), the use of Pregout Kit requires special measures which are taken to prevent Rhesus (Rh) factor sensitisation. So, if you are Rhesus negative, let your doctor know about this before using Pregout Kit.

Disease/Condition Glossary

Medical abortion: It is a procedure in which medicine is used to terminate a pregnancy. It is effectively causing abortion if performed in the first 70 days of pregnancy. Vagina bleeding occurs, and if it does not stop, please inform your doctor as it might require medical supervision. Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (may last up to 30 days), fever, digestive system discomfort fever. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised.

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