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About Natrilam Tablet

Natrilam Tablet belongs to the class of medication called 'anti-hypertensive drugs', primarily used to treat hypertension (high blood pressure). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the blood vessel's walls. This condition makes the heart work harder in pumping blood to the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack and kidney failure.

Natrilam Tablet consists of Amlodipine and Indapamide.  Amlodipine relaxes blood vessels so that blood passes through them easily, thereby lowering blood pressure. Indapamide inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure. 

The common side effects of Natrilam Tablet include nausea, stomach pain, headache, sleepiness, ankle swelling, flushing (warm sensation in the face, ears, neck, and trunk), palpitations (pounding heartbeat), constipation, muscle pain, and tiredness. Most of these side effects resolve gradually over time and do not usually require medical attention. However, if you notice any side effects that are not manageable, it is advised to consult your doctor.

Try not to stop taking this medicine on your own. Stopping Natrilam Tablet may worsen your condition and increase the risk of a heart attack. Tell your doctor if you are sensitive to Natrilam Tablet , have any kidney/liver diseases, or have heart problems like aortic/mitral stenosis (reduced blood flow from the left atrium to the left ventricle due to narrowing of the mitral valve). Natrilam Tablet is not recommended for use in pregnancy and breastfeeding. Natrilam Tablet may cause dizziness; hence it is advised to drive only when you are alert.

Uses of Natrilam Tablet

High blood pressure (hypertension)

Directions for Use

Swallow this medicine as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Natrilam Tablet is composed of two medicines, namely: Amlodipine and Indapamide. Amlodipine belongs to the class of calcium channel blockers that relaxes blood vessels so that blood passes through them easily, lowering blood pressure. Indapamide is a thiazide diuretic that inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not use Natrilam Tablet if you are allergic to any of its components. Let your doctor know if you have any history of severe kidney or liver diseases, low potassium levels (hypokalaemia), chest pain (angina), poor blood circulation or controlled heart failure, first-degree heart block, diabetes, thyrotoxicosis (a condition caused by an overactive thyroid gland), liver problems and adrenal gland diseases. Let your doctor know if you have anuria (kidneys aren't producing urine), fluid or electrolyte imbalance, lupus erythematosus (an autoimmune inflammatory disease-causing scaly red patches on the skin), gout, abnormal heart rhythms, thyroid disorders or asthma. Consult your doctor if you are pregnant or breastfeeding. Natrilam Tablet can increase the chances of light-headedness, so rise slowly if you are sitting/lying and avoid operating any machine or doing any work that needs mental alertness. Natrilam Tablet is not recommended in people less than 18 years of age.

Drug-Drug Interactions

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IndapamideProtriptyline
Critical
IndapamideDroperidol
Critical

Drug-Drug Interactions

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IndapamideProtriptyline
Critical
How does the drug interact with Natrilam Tablet:
Taking Protriptyline along with Natrilam Tablet can lead to serious heart problems.

How to manage the interaction:
Taking Protriptyline with Natrilam Tablet is not recommended, but can be taken if prescribed by the doctor.
IndapamideDroperidol
Critical
How does the drug interact with Natrilam Tablet:
Taking Droperidol with Natrilam Tablet can lead to severe heart problems.

How to manage the interaction:
Taking Droperidol with Natrilam Tablet is not recommended, but can be taken if prescribed by the doctor.
How does the drug interact with Natrilam Tablet:
Taking Natrilam Tablet with Thioridazine can increase the risk of heart problems.

How to manage the interaction:
Taking Thioridazine with Natrilam Tablet is not recommended, but can be taken if prescribed by the doctor.
AmlodipineDantrolene
Critical
How does the drug interact with Natrilam Tablet:
Using Natrilam Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Natrilam Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
IndapamideAminolevulinic acid
Severe
How does the drug interact with Natrilam Tablet:
Using Aminolevulinic acid with Natrilam Tablet, your skin becomes more sensitive to strong light. This increases your risk of getting a bad sunburn.

How to manage the interaction:
Although taking Natrilam Tablet and Aminolevulinic acid together can cause an interaction, it can be taken if a doctor has suggested it. After treatment, you should wait 48 hours before exposing your eyes, and skin, to any bright lights indoors. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Natrilam Tablet:
Co-administration of Amiodarone together with Natrilam Tablet may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Natrilam Tablet interact, they can be used if prescribed by a doctor. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, painful muscle cramping, get medical attention. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Natrilam Tablet:
Co-administration of Tizanidine with Natrilam Tablet may reduce blood pressure greatly leading to side effects.

How to manage the interaction:
Although taking Natrilam Tablet and Tizanidine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you notice any of these signs - feeling dizzy, having a headache, feeling lightheaded, or fainting, Consult a doctor. Do not discontinue any medications without a doctor's advice.
IndapamideDofetilide
Severe
How does the drug interact with Natrilam Tablet:
Co-administration of Natrilam Tablet with Dofetilide can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Natrilam Tablet and Dofetilide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, fainting, shortness of breath, rapid heartbeat, weakness, muscle pain, cramps, nausea, or vomiting, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Natrilam Tablet:
Co-administration of Natrilam Tablet with Pimozide can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Natrilam Tablet and Pimozide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, rapid heartbeat, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Natrilam Tablet:
When Natrilam Tablet and Dronedarone are taken together, the risk of an irregular heart rhythm increases.

How to manage the interaction:
Taking Natrilam Tablet and Dronedarone together can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, rapid heartbeat, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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AMLODIPINE-10MG+INDAPAMIDE-1.5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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AMLODIPINE-10MG+INDAPAMIDE-1.5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Consumption of grapefruit and grapefruit juice along with Indapamide and Amlodipine the levels of Indapamide and Amlodipine in your bloodstream may drop. Avoid consuming a lot of grapefruit and grapefruit juice when using Natrilam Tablet, instead, take it with water. As a result, your body will absorb the drug more easily.

Diet & Lifestyle Advise

  • Keep your weight under control with a body mass index (BMI) between 19.5 and 24.9.
  • Quit smoking to lower the risk of heart disease. 
  • Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress.
  • Monitor your blood pressure daily, and if you notice any fluctuations frequently, please get in touch with your doctor immediately.
  • Try including heart-healthy omega-3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil that help in lowering your elevated blood pressure.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Natrilam Tablet is recommended to use in dose and duration as advised by the doctor. Do not stop taking Natrilam Tablet on your own, as it may lead to a sudden rise in blood pressure and increases the risk of heart attack and stroke.

Natrilam Tablet can cause dehydration and dry mouth. Drink plenty of fluids and let your doctor know if you develop extreme thirst, muscle weakness or a very dry mouth.

Natrilam Tablet can cause dizziness as one of its side effects. If you feel dizzy, try getting up slowly from a sitting or lying position. If your dizziness is severe or unmanageable, please seek medical advice.

It is advised to consult your doctor before taking Natrilam Tablet if you have a history of severe kidney or liver diseases, low potassium levels (hypokalaemia), diabetes, gout, abnormal heart rhythms, thyroid disorders and asthma.

It is recommended to consult your doctor since diuretics (water pills) may increase blood sugar levels. Besides this, beta-blockers (blood pressure-lowering agents) can mask hypoglycemia symptoms (low blood sugar).

Even though your blood pressure becomes normal after using Natrilam Tablet , it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range.

Drug-Drug Interactions Checker List

  • SILDENAFIL
  • OXYCODONE
  • PREDNISONE
  • CLONAZEPAM
  • ESOMEPRAZOLE
  • INSULIN GLARGINE
  • METFORMIN
  • CHOLECALCIFEROL
  • RISPERIDONE
  • DULOXETINE
  • DIGOXIN
  • AMIODARONE
  • LISINOPRIL
  • CANDESARTAN
  • LITHIUM
  • NAPROXEN
  • AMISULPRIDE
  • IBUPROFEN
  • PIMOZIDE
  • ALPRAZOLAM
  • CLONIDINE
  • BACLOFEN
  • LEVODOPA
  • METOPROLOL
  • CHLORTHALIDONE
  • HYDROCHLOROTHIAZIDE
  • FUROSEMIDE
  • TORSEMIDE
  • RAMIPRIL

Special Advise

  • Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
  • Let your doctor know if you are advised for any blood examinations as diuretics like Indapamide can cause changes in the laboratory parameters like low potassium levels in the blood, low sodium in the blood, low blood pressure, increase in uric acid, increase in blood glucose levels in diabetic patients, increase in calcium levels in the blood, and increase in the liver enzyme levels. 
  • Let your anaesthetist or medical staff know that you are taking Natrilam Tablet since Natrilam Tablet  can lower blood pressure levels when certain anaesthetic medications are given during any operation or surgery.
  • Athletes should be aware that Indapamide in Natrilam Tablet gives a positive reaction in doping tests.

Disease/Condition Glossary

Hypertension: When blood pressure is excessively high, it becomes a chronic problem. Blood pressure is determined by how much blood the heart pumps and how much resistance the arteries provide to the flow of blood. Blood pressure rises, and arteries constrict as the heart pumps more blood. If not treated, uncontrolled blood pressure can cause major cardiac conditions, including heart attack and stroke. Kidney failure and brain damage are two more effects of high blood pressure. Headache, bleeding from the nose, nausea, and chest discomfort are a few signs of hypertension.

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