Amlodipine+indapamide
About
Amlodipine+indapamide belongs to the class of medication called 'anti-hypertensive drugs', primarily used to treat hypertension (high blood pressure). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the blood vessel's walls. This condition makes the heart work harder in pumping blood to the whole body. Hypertension can cause severe health complications, including stroke, heart failure, heart attack and kidney failure.
Amlodipine+indapamide consists of Amlodipine and Indapamide. Amlodipine relaxes blood vessels so that blood passes through them easily, thereby lowering blood pressure. Indapamide inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure.
The common side effects of Amlodipine+indapamide include nausea, stomach pain, headache, sleepiness, ankle swelling, flushing (warm sensation in the face, ears, neck, and trunk), palpitations (pounding heartbeat), constipation, muscle pain, and tiredness. Most of these side effects resolve gradually over time and do not usually require medical attention. However, if you notice any side effects that are not manageable, it is advised to consult your doctor.
Try not to stop taking this medicine on your own. Stopping Amlodipine+indapamide may worsen your condition and increase the risk of a heart attack. Tell your doctor if you are sensitive to Amlodipine+indapamide, have any kidney/liver diseases, or have heart problems like aortic/mitral stenosis (reduced blood flow from the left atrium to the left ventricle due to narrowing of the mitral valve). Amlodipine+indapamide is not recommended for use in pregnancy and breastfeeding. Amlodipine+indapamide may cause dizziness; hence it is advised to drive only when you are alert.
Uses of Amlodipine+indapamide
Medicinal Benefits
Amlodipine+indapamide is composed of two medicines, namely: Amlodipine and Indapamide. Amlodipine belongs to the class of calcium channel blockers that relaxes blood vessels so that blood passes through them easily, lowering blood pressure. Indapamide is a thiazide diuretic that inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure.
Directions for Use
Storage
Side Effects of Amlodipine+indapamide
- Blurred Vision
- Sweating
- Tiredness
- Dehydration
- Constipation
- Dizziness
- Headache
- Nausea
- Cold hands or feet
- Muscle cramps
- Difficulty breathing
- Tightness in the chest
In-Depth Precautions and Warning
Drug Warnings
Do not use Amlodipine+indapamide if you are allergic to any of its components. Let your doctor know if you have any history of severe kidney or liver diseases, low potassium levels (hypokalaemia), chest pain (angina), poor blood circulation or controlled heart failure, first-degree heart block, diabetes, thyrotoxicosis (a condition caused by an overactive thyroid gland), liver problems and adrenal gland diseases. Let your doctor know if you have anuria (kidneys aren't producing urine), fluid or electrolyte imbalance, lupus erythematosus (an autoimmune inflammatory disease-causing scaly red patches on the skin), gout, abnormal heart rhythms, thyroid disorders or asthma. Consult your doctor if you are pregnant or breastfeeding. Amlodipine+indapamide can increase the chances of light-headedness, so rise slowly if you are sitting/lying and avoid operating any machine or doing any work that needs mental alertness. Amlodipine+indapamide is not recommended in people less than 18 years of age.
Drug Interactions
Drug-Drug Interaction: Amlodipine+indapamide may interact with other diuretic medications (hydrochlorothiazide, furosemide, torsemide), anti-hypertensive drugs (chlorthalidone, ramipril, metoprolol, lisinopril, candesartan, baclofen, levodopa, clonidine), drugs treating mental illness (alprazolam, risperidone, amisulpride, pimozide), painkillers (ibuprofen, naproxen), anti-depressants (lithium, duloxetine), Vitamins (vitamin D, cholecalciferol (vitamin D3)), heart-related drugs (amiodarone, digoxin, sotalol), diabetic drugs (insulin glargine, metformin), drugs treating stomach acid (esomeprazole), fits medicine (clonazepam), pain medicine (oxycodone), corticosteroids (prednisone), drugs treating impotence (sildenafil), and multivitamin/minerals.
Drug-Food Interaction: Amlodipine+indapamide may interact or may have decreased effect when used with alcohol and large amounts of orange juice.
Drug-Disease Interaction: Let your doctor know if you have any severe kidney or liver diseases, low potassium levels (hypokalaemia), chest pain (angina), poor blood circulation or controlled heart failure, first-degree heart block, diabetes, thyrotoxicosis (a condition caused by an overactive thyroid gland), liver problems, adrenal gland diseases, anuria (kidneys aren't producing urine), fluid or electrolyte imbalance, lupus erythematosus (an autoimmune inflammatory disease-causing scaly red patches on the skin), gout, abnormal heart rhythms, thyroid disorders or asthma.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAlcohol may lower your blood pressure. It would help if you avoid or limit consuming alcohol whilst taking this medicine.
Pregnancy
cautionIndapamide in Amlodipine+indapamide is not recommended during pregnancy. However, seek medical advice before using Amlodipine+indapamide if you plan to conceive or are pregnant.
Breast Feeding
cautionThere are limited studies on how Amlodipine+indapamide affects breastfed infants. However, Indapamide in Amlodipine+indapamide may pass into the breast milk during breastfeeding. Please consult your doctor before using Amlodipine+indapamide if you are a lactating mother.
Driving
cautionAmlodipine+indapamide may cause side effects such as dizziness or tiredness. If you feel dizzy or tired when taking this medicine, do not drive or use any tools or machines.
Liver
cautionLet your doctor know if you have any history of liver diseases before using Amlodipine+indapamide.
Kidney
cautionLet your doctor know if you have any history of kidney diseases before using Amlodipine+indapamide.
Children
unsafeAmlodipine+indapamide is not recommended for use in people below 18 years of age.
Habit Forming
Diet & Lifestyle Advise
- Keep your weight under control with a body mass index (BMI) between 19.5 and 24.9.
- Quit smoking to lower the risk of heart disease.
- Avoid chronic stress, as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress.
- Monitor your blood pressure daily, and if you notice any fluctuations frequently, please get in touch with your doctor immediately.
- Try including heart-healthy omega-3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil that help in lowering your elevated blood pressure.
Special Advise
- Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
- Let your doctor know if you are advised for any blood examinations as diuretics like Indapamide can cause changes in the laboratory parameters like low potassium levels in the blood, low sodium in the blood, low blood pressure, increase in uric acid, increase in blood glucose levels in diabetic patients, increase in calcium levels in the blood, and increase in the liver enzyme levels.
- Let your anaesthetist or medical staff know that you are taking Amlodipine+indapamide since Amlodipine+indapamide can lower blood pressure levels when certain anaesthetic medications are given during any operation or surgery.
- Athletes should be aware that Indapamide in Amlodipine+indapamide gives a positive reaction in doping tests.
Patients Concern
Disease/Condition Glossary
Hypertension: When blood pressure is excessively high, it becomes a chronic problem. Blood pressure is determined by how much blood the heart pumps and how much resistance the arteries provide to the flow of blood. Blood pressure rises, and arteries constrict as the heart pumps more blood. If not treated, uncontrolled blood pressure can cause major cardiac conditions, including heart attack and stroke. Kidney failure and brain damage are two more effects of high blood pressure. Headache, bleeding from the nose, nausea, and chest discomfort are a few signs of hypertension.
FAQs
Amlodipine+indapamide is recommended to use in dose and duration as advised by the doctor. Do not stop taking Amlodipine+indapamide on your own, as it may lead to a sudden rise in blood pressure and increases the risk of heart attack and stroke.
Amlodipine+indapamide can cause dehydration and dry mouth. Drink plenty of fluids and let your doctor know if you develop extreme thirst, muscle weakness or a very dry mouth.
Amlodipine+indapamide can cause dizziness as one of its side effects. If you feel dizzy, try getting up slowly from a sitting or lying position. If your dizziness is severe or unmanageable, please seek medical advice.
It is advised to consult your doctor before taking Amlodipine+indapamide if you have a history of severe kidney or liver diseases, low potassium levels (hypokalaemia), diabetes, gout, abnormal heart rhythms, thyroid disorders and asthma.
It is recommended to consult your doctor since diuretics (water pills) may increase blood sugar levels. Besides this, beta-blockers (blood pressure-lowering agents) can mask hypoglycemia symptoms (low blood sugar).
Even though your blood pressure becomes normal after using Amlodipine+indapamide, it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range.
