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Written By ,
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Non returnable*
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Composition :

TOPIRAMATE-50MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Nextop 50 Tablet

Nextop 50 Tablet belongs to a group of medicines called “antiepileptic (AED)/ anticonvulsant agent' that is primarily indicated in the treatment of epilepsy (Monotherapy and Adjunctive therapy) and It can also be taken to prevent migraine. Epilepsy is a chronic disorder that is responsible for causing unprovoked, recurrent seizures in the body. A seizure is a sudden attack in the brain that makes a person lose control of their actions. Migraine is a mental condition that often causes intense or debilitating headaches with difficulty speaking, nausea, vomiting, and sensitivity to light or sound.

Nextop 50 Tablet is responsible for restoring the balance of neural activity by diminishing the spread of seizure movement in the brain. By controlling the electrical activity of the brain, it controls seizures and relieves the symptoms of migraine. Take Nextop 50 Tablet in an empty stomach without food with one glass of water. Nextop 50 Tablet is only available on prescription. It comes as tablets or capsules intended to be taken by mouth only. Swallow the medication as a whole without crushing or breaking it. Nextop 50 Tablet doses are sometimes advised according to the weight of children so the doctor will change the dose if the child gains or lose weight.

The possible side effects of topiramate include feeling sleepy, dizziness, diarrhoea and feeling sick. Some of the side effects do not even require medical attention and these are usually mild and go away by themselves. Consult with the doctor if any of these side effects continue or get worse with time.

The use of $mame is restricted in persons who are hypersensitive to it, so tell your doctor if you have any allergy to any of the chemical constituents present in this medicine. Tell your doctor if you ever had or already dealing with diarrhoea, glaucoma, metabolic acidosis, lung disease, breathing problems, liver disease, a blood disorder called acute porphyria etc. If a woman is pregnant or planning to pregnant then they should tell their doctor as the use of this medicine during pregnancy may increase the risk of cleft lip and/or cleft palate which is a birth defect in the newborn that may develop during early pregnancy.

Uses of Nextop 50 Tablet

Epilepsy, Migraine

Directions for Use

Tablet: It can be taken irrespective of meals. Swallow the tablet as a whole with a glass of water. Do not chew the tablet. Sprinkle capsule: You may swallow the capsule as a whole or you may open the capsule and sprinkle the entire contents on a teaspoon of soft food. Drink fluids immediately after eating this medicine and food mixture to make sure it is swallowed. Do not store this mixture for later use.

Medicinal Benefits

Nextop 50 Tablet is an antiepileptic (AED) medicine that is used to treat epilepsy in mono or adjunctive therapy and migraine. In Monotherapy epilepsy, Nextop 50 Tablet is suggested for patients above 2 years of age with partial-onset or primary generalized tonic-clonic seizures. In Adjunctive therapy epilepsy, Nextop 50 Tablet is suggested in patients of 2 to 16 years of age with partial-onset seizures or primary generalized tonic-clonic seizures while in patients more than 2 years of age, Nextop 50 Tablet is suggested in patients with seizures associated with Lennox-Gastaut syndrome (LGS). In migraine, Nextop 50 Tablet is suggested for prophylaxis of migraine. Nextop 50 Tablet works by blocking the voltage-dependent sodium and calcium channels and increasing the inhibitory actions of GABA. In epilepsy, Nextop 50 Tablet controls the uncontrolled activity of nerves in the brain and thus prevents or controls seizures. While in migraine, Nextop 50 Tablet tranquilizes the overactive nerve cells in the brain that are responsible for causing migraine.

Storage

Store in a cool and dry place away from sunlight
Side effects of Nextop 50 Tablet
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Managing depression as a side effect of medication: a comprehensive guide.
  • Remember, managing depression as a side effect of medication requires patience, persistence, and collaboration with your healthcare team.
  • Tell your doctor about your depression symptoms to adjust medication.
  • Consult a therapist or counsel for emotional support.
  • Engage in regular exercise to release endorphins (neurotransmitters).
  • Practice stress-reducing techniques like meditation and deep breathing.
  • Build a support network of friends, family, and support groups.
  • Establish a consistent sleep schedule.
  • Eat a nutritious diet rich in fruits, vegetables, and whole grains.
  • Limit or avoid alcohol and recreational substances.
  • Keep a mood journal to track symptoms and progress.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.

Drug Warnings

Nextop 50 Tablet may cause a congenital disability called cleft lip in unborn baby, so the use of this medicine is not allowed in pregnant females. Nextop 50 Tablet may increase the body temperature and reduce sweating, so one should report it to the doctor if they are noticing decreased sweating and hot, dry skin. Nextop 50 Tablet may enhance the level of acid in the blood so one should tell their doctor if they have irregular heartbeats or loss of hunger. Before taking Nextop 50 Tablet , tell the doctor if you have diarrhoea, metabolic acidosis, eye problems, liver disease. Nextop 50 Tablet may affect the working of contraceptives that include the combined pill, vaginal ring, patches,progestogen-only contraceptive pill, and emergency contraception. So, one should tell their doctor if they are using any contraceptives to prevent pregnancy.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Nextop 50 Tablet:
Nextop 50 Tablet can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like clomipramine.

How to manage the interaction:
Although taking Nextop 50 Tablet and Clomipramine together can cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Nextop 50 Tablet:
Coadministration of Nortriptyline with Nextop 50 Tablet might increase the risk or severity of side effects like increased body temperature and decreased sweating. Children are particularly susceptible to this side effect.

How to manage the interaction:
Taking Nortriptyline with Nextop 50 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience decreased sweating, fever, drowsiness, dizziness, lightheadedness, confusion, hallucination, shivering or shaking, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nextop 50 Tablet:
Coadministration of Glycopyrrolate with Nextop 50 Tablet can increase the risk or severity of side effects like increased body temperature and decreased sweating.

How to manage the interaction:
Taking Glycopyrrolate with Nextop 50 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience drowsiness, dizziness, lightheadedness, fever, chills, or decreased sweating, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nextop 50 Tablet:
Co-administration of dexchlorpheniramine with Nextop 50 Tablet can increase the risk of Nextop 50 Tablet side effects like increased body temperature and decreased sweating especially in warm weather.

How to manage the interaction:
Taking Dexchlorpheniramine with Nextop 50 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience decreased sweating, fever, or drowsiness, contact your doctor immediately. Make sure to hydrate yourself during warm weather or after exercise. Do not discontinue any medications without consulting your doctor.
TopiramateOrphenadrine (chloride)
Severe
How does the drug interact with Nextop 50 Tablet:
Nextop 50 Tablet can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with orphenadrine.

How to manage the interaction:
There may be a possibility of interaction between Orphenadrine (chloride) and Nextop 50 Tablet, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
TopiramateAzatadine
Severe
How does the drug interact with Nextop 50 Tablet:
The therapeutic efficacy of Nextop 50 Tablet can be decreased when used in combination with Azatadine.

How to manage the interaction:
Although there is a possible interaction between Nextop 50 Tablet and Azatadine, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Nextop 50 Tablet:
Coadministration of Nextop 50 Tablet with Cyclobenzaprine can increase the risk of developing side effects.

How to manage the interaction:
There may be a possibility of interaction between Cyclobenzaprine and Nextop 50 Tablet, but it can be taken if prescribed by a doctor. However, if you experience fever, excessive sweating, dizziness, or palpitations . Do not stop using any medications without a doctor's advice.
TopiramateBenzatropine
Severe
How does the drug interact with Nextop 50 Tablet:
Nextop 50 Tablet can cause increased body temperature and decreased sweating, and these effects may be worsened when combined with medications like benzatropine.

How to manage the interaction:
Co-administration of Benzatropine with Nextop 50 Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience drowsiness, dizziness, or lightheadedness, consult your doctor immediately. Avoid tasks that need mental attention, such as driving or operating dangerous machinery. Drink plenty of water when it's hot out and while you're exercising, and get medical assistance if you have reduced perspiration or a fever. Do not discontinue any medications without consulting your doctor.
TopiramateMethazolamide
Severe
How does the drug interact with Nextop 50 Tablet:
Combining Nextop 50 Tablet with Methazolamide can increase the risk of negative side effects.

How to manage the interaction:
Although there is a possible interaction between Methazolamide and Nextop 50 Tablet, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include problems with your body's acid levels, not feeling hungry, an irregular heartbeat, breathing fast, kidney stones, weak bones, decreased sweating, feeling too hot, drinking more fluids than usual, or having stomach pain. Don't hesitate to reach out to your doctor if you experience any of these. Do not stop using any medications without a doctor's advice.
How does the drug interact with Nextop 50 Tablet:
Using Tolterodine with Nextop 50 Tablet can increase body temperature and decreased sweating.

How to manage the interaction:
Although there is an interaction between Tolterodine and Nextop 50 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sleepiness, dizziness, or lightheadedness. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a balanced diet that consists of good fats, proteins, carbohydrates, vegetables, and fruit which helps the body and brain to work properly and keep a person healthy and energetic.
  • Fatigue is one of the primary reasons that trigger seizures in the body, so sleeping properly can help in relaxing the brain.
  • One should avoid the consumption of alcohol as it can trigger seizures in patients. Even one or two glasses can trigger epilepsy and worsen the side effects of Nextop 50 Tablet .
  • Keep yourself happy and avoid taking emotional stress as stress causes seizures. Persons who maintain healthy stress levels have reported that they have responded well to the medicine.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Seizures can happen when the brain cells are not working properly or working faster than normal. Nextop 50 Tablet slows down these electrical signals to stop seizures.

No, you should take rest after taking this medicine as this medicine affects the thinking ability and vision of a person so avoid doing any task that requires mental alertness.

Nextop 50 Tablet acts by decreasing the spread of seizure activity in the brain. It also restores the normal balance of neurons which in turn calms the brain. In epilepsy, cells present in the brain talk to each other by generating electric signals. When these cells fail to work properly or working faster than normal then it causes seizures. Nextop 50 Tablet slows down these electrical signals and thus prevents or controls seizures. While in migraine, Nextop 50 Tablet tranquilizes the overactive nerve cells in the brain that are responsible for causing migraine.

Yes, the use of Nextop 50 Tablet is safe for long time use if suggested by the doctor.

Yes, Nextop 50 Tablet may affect the working of contraceptives that include the combined pill, vaginal ring, patches,progestogen-only contraceptive pill, and emergency contraception. Tell your doctor if you are using any type of contraceptives as the doctor may suggest using different types of contraceptives or combined hormonal contraceptives.

No, Nextop 50 Tablet does not affect fertility.

Generally, one should avoid consuming alcohol while taking Nextop 50 Tablet as it may make a person feel sleepy or tired and can cause seizures in some people with epilepsy.

Drug-Drug Interactions Checker List

  • METFORMIN
  • GLIBENCLAMIDE
  • PIOGLITAZONE
  • VENLAFAXINE
  • AMITRIPTYLINE
  • DILTIAZEM
  • HYDROCHLOROTHIAZIDE
  • PROPRANOLOL
  • RISPERIDONE

Disease/Condition Glossary

Epilepsy: It is a neurological disorder in which brain activity becomes abnormal characterized by intense electrical bursts in the brain (seizures). When these bursts happen in one part of the brain it is called a partial seizure while if these bursts occur in the complete brain it is called a generalized seizure. Sometimes, a person starts experiencing the symptoms before starting of seizure that includes a sudden feeling of fear, dizziness, changes in vision, shakiness in arms and legs, and headache. While the symptoms that occur during a seizure include losing consciousness, characterized by confusion, uncontrollable muscle spasms, falling, biting tongue, sudden, rapid eye movements, unusual noises, such as grunting, sudden mood changes, etc.

Migraine: It is a mild to severe headache that starts as a dull ache in the region around the eye. It usually lasts a few hours up to several days and gets worst with the movement. The possible warning signs that can start before the occurrence of migraine include visual changes, unusual tiredness, tingling in an arm or leg. A person facing migraine may also face mild to severe pain in the head, pulsing, throbbing pain in the head, sensitivity to sound and light, vomiting, and Nausea.

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