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Written By aquibnaseer ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Non returnable*
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Composition :

DEFLAZACORT-6MG

Manufacturer/Marketer :

SEIKOMAX HEALTHCARE

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Ostodef-6 Tablet

Ostodef-6 Tablet belongs to the class of medication called steroid primarily used to treat Duchene muscular dystrophy in adults and children above 2 years of age. Autoimmune disease is a health disorder in which the immune system doesn't work normally & is unable to distinguish between a foreign cell & a native cell. This condition results in an immune system that starts to attack native cells & organs, leading to medical problems like Duchenne muscular dystrophy, psoriasis & arthritis, etc.

Ostodef-6 Tablet is an immunosuppressive drug that works by binding to immune system cells and turns off the switches (receptors) that lead to their abnormal functioning or damaging effects. After taking the drug Ostodef-6 Tablet binds to immune cells, resulting in the inhibition of inflammation & autoimmune diseases that occur due to the production of chemicals called cytokines responsible for inflammation. Thus, a Ostodef-6 Tablet class of drugs is beneficial in autoimmune diseases and inflammation that causes harm in various organs, especially in joints in arthritis & skin psoriasis. Ostodef-6 Tablet make organ transplantation possible & treats muscle disorders like Duchenne muscular dystrophy.

Ostodef-6 Tablet is available in both oral tablet and suspension dosage forms. The tablet form of Ostodef-6 Tablet can be taken with or without food and swallowed whole with a water glass. Do not crush, chew or break it. The liquid form of Ostodef-6 Tablet can be taken as advised by your doctor with a measuring cup. Your doctor will recommend how often you take Ostodef-6 Tablet based on your medical condition. Some people may experience nausea, chest pain, vomiting, drowsiness, headache, dizziness, skin rash, tremor, nervousness, diarrhoea and fast heartbeats. Most of these side effects of Ostodef-6 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Do not quit taking deflazacort without consulting your physician. Symptoms such as loss of appetite, a disturbed stomach, vomiting, drowsiness, confusion, headache, fever, joint and muscle pain, peeling skin, and weight loss may be caused by stopping the medication suddenly.

Before starting Ostodef-6 Tablet , please inform your doctor that you are allergic (hypersensitive) to Ostodef-6 Tablet . Extra care is to be taken when a patient has an already existing infection being treated (systemic infection) or has recently had some live virus vaccines. Doctors' consultation is required as Ostodef-6 Tablet is not safe to use during pregnancy. 

Uses of Ostodef-6 Tablet

Duchenne muscular dystrophy (DMD) 

Directions for Use

Tablet: Swallow this tablet whole with a glass of water at the start of a meal or slightly before. Space the doses evenly during the course. Do not chew or crush it. If you cannot swallow the tablet as a whole, you may break the pill into half and take both halves one at a time.Suspension: Measure the suspension in the measuring cup provided with the pack and consume it in the doses as directed by your doctor.

Medicinal Benefits

Ostodef-6 Tablet is beneficial in inflammatory diseases, including asthma, arthritis, and allergies. It is used in the treatment of Duchenne muscular dystrophy (DMD). It raises the amount of glucocorticoid in the body. It works by reducing the formation of inflammatory substances and suppressing immunity to prevent self-damage caused by the immune system (auto-immune reactions occurring in organ transplants, autoimmune diseases, or cancer). Ostodef-6 Tablet is a steroid that interacts with overactive immune cells and slows their activity and decreases the damaging effects they cause in the body. 

Side effects of Ostodef-6 Tablet
  • Eat a balanced diet with proteins, whole grains, fruits, and vegetables; avoid processed foods and excess sugar.
  • Practice physical activity for at least 30 minutes, such as cardio or strength training.
  • Consider intermittent fasting to help with fat reduction.
  • Maintain at least seven hours of sleep to prevent weight gain.
  • Manage stress with yoga, meditation, or deep breathing.
  • Limit alcohol and sugary drinks to reduce fat accumulation.
  • Stay hydrated by drinking plenty of water.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Drink six to eight glasses of water per day to be healthy.
  • Healthy urinary habits can help minimize pollakiuria (frequent urinating).
  • Avoid liquids containing caffeine, artificial sweeteners, and soda, as they might cause bladder discomfort.
  • Add bladder-friendly foods such as omega-3 fatty acids, blueberries, and cranberries.
  • Regular cleansing will help get rid of dead skin cells and stop ingrown hairs.
  • Keep your hormones in balance by managing your stress, eating well and exercising regularly.
  • Shaving, waxing, and bleaching are ways to get rid of extra hair.
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.
  • Limit stimulants like tea, coffee and alcohol.
  • Identify triggers and try managing them.
  • Take a break by scheduling time for yourself.
  • Try creative activities like writing, dancing or painting as it helps release tension.

Drug Warnings

Patients with a history of tuberculosis (TB), heart disease or heart failure stomach disorders (gastritis, peptic ulcer), diabetes (including family history), osteoporosis (bone disease), myasthenia gravis (muscle weakness), depression, mental distress, history of muscular problems caused by corticosteroids, kidney & liver dysfunction (including hepatic insufficiency and cirrhosis), should consult a doctor before using Ostodef-6 Tablet .  This medicine is not recommended for children less than 5 years of age, lactating mothers and pregnant women. Avoid going near people who are sick or infected while using Ostodef-6 Tablet . Before taking Ostodef-6 Tablet for at least, 4-6 weeks do not take any live vaccine as it may cause severe allergic reactions. 

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Ostodef-6 Tablet:
Co-administration of Ostodef-6 Tablet and Desmopressin may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Although co- administration of Daflazacort with Desmopression can possibly lead to an interaction, it can be taken in case a doctor advices you. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty in concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, or sudden weight gain. Do not stop using any medications without consulting a doctor.
How does the drug interact with Ostodef-6 Tablet:
Coadministration of Ostodef-6 Tablet and itraconazole may significantly raise Ostodef-6 Tablet blood levels.

How to manage the interaction:
Despite the possibility of an interaction, Ostodef-6 Tablet and itraconazole can be used if a doctor so prescribes. Consult a doctor if you have swelling, electrolyte imbalances, high blood pressure, high blood sugar, muscle weakness, mood swings, acne, stretch marks, easy bruising, menstrual irregularities, or excessive facial or body hair growth. Never stop taking any medications without talking to a doctor.
How does the drug interact with Ostodef-6 Tablet:
Using Deferasirox together with Ostodef-6 Tablet may increase the risk of gastric and intestinal ulcers and bleeding.

How to manage the interaction:
Co-administration of Deferasirox with Ostodef-6 Tablet can result in an interaction, but it can be taken if your doctor has advised it. If you have any symptoms like stomach pain, dizziness, loss of appetite, nausea, vomiting, or black or tarry stools, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Ostodef-6 Tablet:
Coadministration of Indinavir with Ostodef-6 Tablet can increase the levels of Ostodef-6 Tablet in the body.

How to manage the interaction:
Taking Erythromycin with Indinavir together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like high blood pressure, high blood glucose, muscle weakness, mood swings, acne, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and increased body fat, sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DeflazacortAmprenavir
Severe
How does the drug interact with Ostodef-6 Tablet:
Coadministration of Amprenavir with Ostodef-6 Tablet can increase the levels of Ostodef-6 Tablet in the body.

How to manage the interaction:
Taking Amprenavir with Ostodef-6 Tablet together can result in an interaction. It can be taken if your doctor has advised it. However, if you experience symptoms like muscle weakness, excessive growth of facial or body hair, sudden dizziness, lightheadedness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ostodef-6 Tablet:
Aprepitant may significantly raise the blood levels of Ostodef-6 Tablet. This may lead to increased side effects.

How to manage the interaction:
Taking Aprepitant with Ostodef-6 Tablet together can result in an interaction, but it can be taken if your doctor has advised it. Consult a physician if you notice any signs of swelling, diarrhoea, muscle cramps, muscle weakness, depression, back pain, or excessive facial or body hair growth. Without consulting a doctor, never stop taking medicines.
How does the drug interact with Ostodef-6 Tablet:
Co-administration of Baricitinib with Ostodef-6 Tablet may increase the risk of infections.

How to manage the interaction:
Although there is an interaction, Baricitinib can be taken with Ostodef-6 Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, red or irritated skin, body sores, discomfort or burning while urinating, severe abdominal pain, nausea, or vomiting, consult a doctor. Do not discontinue any medication without a doctor's advice.
How does the drug interact with Ostodef-6 Tablet:
Taking Nevirapine with Ostodef-6 Tablet may significantly reduce the blood levels of Ostodef-6 Tablet, which may make the medication less effective in treating the condition.

How to manage the interaction:
Although using Nevirapine and Ostodef-6 Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
DeflazacortCertolizumab
Severe
How does the drug interact with Ostodef-6 Tablet:
Co-administration of Ostodef-6 Tablet with Certolizumab may increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Ostodef-6 Tablet and Certolizumab, you can take these medicines together if prescribed by your doctor. If you have any of the symptoms like fever, chills, diarrhea, sore throat, muscle pain, and pain or burning when you urinate, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Ostodef-6 Tablet:
Coadministration of Voriconazole with Ostodef-6 Tablet can increase the levels of Ostodef-6 Tablet in the body, which increases risk/severity of side effects.

How to manage the interaction:
Taking Voriconazole with Ostodef-6 Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, shortness of breath, rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

A patient needs to take extra care of hygiene & stay away from places/people believed to be a cause of infection as this drug affects a patient's immune system & thus proper care is to be taken.

 

Side Effects of Ostodef-6 Tablet

Most of the side effects of Ostodef-6 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Common side effects include upper respiratory tract infection, excessive abdominal fat, runny or stuffy nose, skin redness, irritability, abdominal discomfort or pain, irregular behaviour, fever, back pain, acne, nausea, restlessness, nosebleeds and stretch marks.

Habit Forming

No

Therapeutic Class

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Not recommended in mild allergies. Ostodef-6 Tablet is recommended only on consulting a doctor as Ostodef-6 Tablet is a strong medicine that produces considerable side effects & thus used only in moderate to severe cases.

It is not recommended to stop by a patient himself/herself, especially by a patient undergoing organ transplantation as it may worsen the situation.

It is not recommended to be taken Ostodef-6 Tablet with alcohol as it may cause stomach bleeding.

No its is not recommended to be used in seasonal allergy or mild cases. Only on doctors consultation, Ostodef-6 Tablet may be used in extreme cases of seasonal allergy.

You should not use Ostodef-6 Tablet if you have taken live vaccines of mumps, measles, rubella (MMR), polio, rotavirus, yellow fever, typhoid, nasal flu (influenza), varicella (chickenpox), and zoster (shingles). Do not take Ostodef-6 Tablet if you have a compromised immune system, eye problems or weak bones.

Drug-Drug Interactions Checker List

  • RIFAMPICIN
  • RIFABUTIN
  • CARBAMAZEPINE
  • PHENOBARBITONE
  • PHENYTOIN
  • PRIMIDONE

Special Advise

  • While taking Ostodef-6 Tablet and for at least 4-6 weeks before you start taking it. If you are taking Ostodef-6 Tablet , so do not receive a 'live' vaccine or you could develop a serious infection.  
  • Do not eat grapefruit or drink grapefruit juice while taking this medication as grapefruit has interaction with Ostodef-6 Tablet .
  • Regular eye check-ups, bone mineral test and liver function test is suggested while using Ostodef-6 Tablet . 

Disease/Condition Glossary

Autoimmune disease: These are a group of disorders in which the immune system doesn't work properly due to various genetic & environmental reasons that starts attacking normal cells, producing various chemicals resulting in unwanted and hazardous effects in patients. The overactive immune system leads to various symptoms that affect day to day life and promote diseases like arthritis, muscular weakness. The immune system can also damage the organ, which has been transplanted to the patient from another person due to having different blood groups/antigens of donor patients organ. The immune system considers it a foreign harmful body, leading to complications after transplanting an organ like a kidney, liver, or heart. 

Have a query?

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Alcohol

Caution

The effect of taking both alcohol and Ostodef-6 Tablet may lead to bleeding & ulcers in the stomach. Doctors' consultation is recommended.

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Pregnancy

Unsafe

Not recommended in pregnant females.Ostodef-6 Tablet crosses the placenta and doses equivalent to >40 mg prednisolone daily increase the risk of fetal and neonatal damage.

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Breast Feeding

Caution

No adverse effect is reported yet it is advised to have doctors' consultation by breastfeeding mothers.

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Driving

Unsafe

A patient may experience muscle weakness/feeling tired. Do not drive and do not use tools or machines while using this drug.

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Liver

Caution

If you've ever had hepatitis B or if you are a carrier of hepatitis B, using Ostodef-6 Tablet can cause this virus to become active or get worse. You may need frequent liver function tests. If you need surgery, tell the surgeon ahead of time that you are using Ostodef-6 Tablet .

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Kidney

Caution

Before using Ostodef-6 Tablet by a kidney patient it is recommended to have a doctors consultation. It may affect the kidney in a few cases.

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Children

Unsafe

Ostodef-6 Tablet is not recommended for children below 5 years of age. Children between 5-10 years of age should consult a doctor before using Ostodef-6 Tablet .

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