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Written By Divya L , PharmaD
Reviewed By Sunny S , MBBS
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Manufacturer/Marketer :

ABS Remedies Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Piogrel AP 75mg/75mg Tablet

Piogrel AP 75mg/75mg Tablet belongs to the class of antiplatelet drugs used for the prevention of heart attack and stroke. A heart attack occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is most often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries). Signs of a heart attack include chest pain, upper body pain, sweating, nausea, fatigue and trouble breathing.

Piogrel AP 75mg/75mg Tablet is composed of two medicines, namely: Aspirin and Clopidogrel. These are blood thinners (anti-platelet) that prevent the formation of a clot in the blood vessels. Aspirin acts as a blood-thinning or anti-platelet agent in a low dose (about 75 mg) to prevent heart attack and stroke. Clopidogrel acts by preventing blood clots if you have severe chest pain (unstable angina or heart attack), stroke, and peripheral arterial disease (heart problem due to narrowed blood vessels). Piogrel AP 75mg/75mg Tablet helps in the free flow of blood, thereby preventing a heart attack, stroke, deep vein thrombosis (blood clot in the vein), and pulmonary embolism (blood clots in the arteries of lungs).

Your doctor will advise you on how often you take your tablets based on your medical condition. The common side effects of Piogrel AP 75mg/75mg Tablet include abdominal pain, indigestion, diarrhoea, easy bruising, and nosebleeds. Piogrel AP 75mg/75mg Tablet is known to cause dizziness and blurry vision, so driving should be avoided. Most of these side effects of Piogrel AP 75mg/75mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Stopping Piogrel AP 75mg/75mg Tablet may worsen your condition and increase the risk of a future heart attack. Let your doctor know if are sensitive to clopidogrel or aspirin, have kidney/liver diseases, bleeding issues (like peptic ulcer, brain haemorrhage), pregnant or planning to become pregnant or breastfeeding. The patient should inform the doctor that they are taking Piogrel AP 75mg/75mg Tablet before any surgery is scheduled or any new medicine is taken. 

Uses of Piogrel AP 75mg/75mg Tablet

Prevention of heart attack and stroke.

Directions for Use

Tablet/capsule: Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Piogrel AP 75mg/75mg Tablet is composed of Aspirin and Clopidogrel, which act as blood thinners (anti-platelet) and prevent the formation of a clot in the blood vessels. Aspirin acts as a blood-thinning or anti-platelet agent in a low dose (about 75 mg) to prevent heart attack and stroke. Clopidogrel acts by preventing blood clots if you have severe chest pain (unstable angina or heart attack), stroke, and peripheral arterial disease (heart problem due to narrowed blood vessels). Piogrel AP 75mg/75mg Tablet helps in the free flow of blood, thereby preventing heart attack, stroke, deep vein thrombosis (blood clot in the vein), and pulmonary embolism (blood clots in the arteries of lungs).

Storage

Keep out of the sight and reach of children.
Side effects of Piogrel AP 75mg/75mg Tablet
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Drug Warnings

You should avoid taking Piogrel AP 75mg/75mg Tablet if you are allergic to Piogrel AP 75mg/75mg Tablet. Let your doctor know if you have a medical condition that is causing bleeding such as a haemophilia, stomach ulcer or bleeding within your head or bowel. Caution is required before giving Piogrel AP 75mg/75mg Tablet to the liver or kidney problems patients. People affected with respiratory problems like asthma, rhinitis or nasal polyps should consult a doctor before intake of Piogrel AP 75mg/75mg Tablet. Piogrel AP 75mg/75mg Tablet is not recommended for the breastfeeding mother as it passes into the breast milk. The safety and effectiveness of Piogrel AP 75mg/75mg Tablet in children less than 12 years of age have not been established. 

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Piogrel AP 75mg/75mg Tablet:
Combining Ketorolac tromethamine with Piogrel AP 75mg/75mg Tablet can increase the risk of adverse effects.

How to manage the interaction:
Taking Piogrel AP 75mg/75mg Tablet with Ketorolac tromethamine is not recommended, as it results in an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor’s advice.
How does the drug interact with Piogrel AP 75mg/75mg Tablet:
Co-administration of Ketorolac and Piogrel AP 75mg/75mg Tablet may increase the risk of side effects.

How to manage the interaction:
Taking Ketorolac with Piogrel AP 75mg/75mg Tablet is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience unusual bleeding or bruising, dizziness, tarry stools, coughing up or vomiting fresh or dried blood, severe headache and weakness. Do not stop using any medications without talking to a doctor.
How does the drug interact with Piogrel AP 75mg/75mg Tablet:
Taking Piogrel AP 75mg/75mg Tablet together with mifepristone increases the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking Piogrel AP 75mg/75mg Tablet with mifepristone is not recommended, that would certainly result in interaction, it can be taken if a doctor prescribes it. If you experience prolonged and heavy bleeding, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Piogrel AP 75mg/75mg Tablet:
When Selexipag and Piogrel AP 75mg/75mg Tablet are taken together, the body's ability to break down Selexipag may be reduced.

How to manage the interaction:
Taking Piogrel AP 75mg/75mg Tablet with Selexipag is not recommended, please consult your doctor before taking it. They can be taken if prescribed by your doctor.
How does the drug interact with Piogrel AP 75mg/75mg Tablet:
Co-administration of methotrexate with Piogrel AP 75mg/75mg Tablet can increase the levels and side effects of methotrexate.

How to manage the interaction:
Although there is a possible interaction between Piogrel AP 75mg/75mg Tablet and methotrexate, you can take these medicines together if prescribed by a doctor. However, consult a doctor if you experience symptoms such as nausea, vomiting, diarrhea, sore throat, chills, fever, rash, unusual bruising or bleeding, pale skin, dark urine, swelling of the legs and hands, breathing difficulty. Do not stop using any medications without consulting a doctor.
AspirinDefibrotide
Severe
How does the drug interact with Piogrel AP 75mg/75mg Tablet:
Coadministration of Piogrel AP 75mg/75mg Tablet with Defibrotide may increase the risk of bleeding.

How to manage the interaction:
Taking Piogrel AP 75mg/75mg Tablet with Defibrotide together can result in an interaction, but it can be taken if a doctor has advised it. It is important to closely monitor your body for any signs of bleeding issues. If you notice any symptoms like bleeding, bruising, dizziness, severe headache, weakness, or vomiting, it is recommended to contact a doctor right away. Regular check-ups and tests will help ensure your safety and well-being. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Piogrel AP 75mg/75mg Tablet:
Combined use of Piogrel AP 75mg/75mg Tablet with ramucirumab may result in gut ulcers and bleeding.

How to manage the interaction:
There may be a possibility of interaction between Piogrel AP 75mg/75mg Tablet and Ramucirumab, but it can be taken if prescribed by a doctor. However, if you notice unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without a doctor's advice.
AspirinEdoxaban
Severe
How does the drug interact with Piogrel AP 75mg/75mg Tablet:
When edoxaban is used with Piogrel AP 75mg/75mg Tablet, the risk of bleeding may increase.

How to manage the interaction:
Although there is a possible interaction between Piogrel AP 75mg/75mg Tablet and edoxaban, you can take these medicines together if prescribed by a doctor. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Piogrel AP 75mg/75mg Tablet:
Using Piogrel AP 75mg/75mg Tablet together with deflazacort may increase the risk of gastric and intestinal ulcers, bleeding and perforation.

How to manage the interaction:
Co-administration of Piogrel AP 75mg/75mg Tablet with Deflazacort can result in an interaction, but it can be taken if a doctor has advised it. If you have any symptoms unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Piogrel AP 75mg/75mg Tablet:
Taking Piogrel AP 75mg/75mg Tablet with ibuprofen may impair the efficacy of Piogrel AP 75mg/75mg Tablet and increase the risk of developing stomach ulcers and bleeding.

How to manage the interaction:
Although there is a possible interaction between Piogrel AP 75mg/75mg Tablet and ibuprofen, you can take these medicines together if prescribed by a doctor. However, if you experience severe stomach discomfort, bloating, sudden dizziness or lightheadedness, nausea, vomiting (particularly with blood), loss of appetite, and/or black, tarry stools, contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals. Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Piogrel AP 75mg/75mg Tablet.
  • Keep your cholesterol and triglyceride levels under control.
  • Eat at regular intervals, and maintain a healthy diet that includes fresh fruits, and vegetables.
  • Limit alcohol intake since it raises blood pressure and increases the risk of heart diseases.
  • Keep a check on your weight and exercise regularly to keep your heart healthy.
  • Your doctor also guides you on how to notice and manage the early symptoms of detecting heart diseases. 

Side Effects of Piogrel AP 75mg/75mg Tablet

  • Abdominal pain
  • Indigestion
  • Diarrhoea
  • Easy bruising
  • Nosebleeds
  • Increased bleeding tendency

Habit Forming

No

Therapeutic Class

PLATELET AGGREGATION INHIBITOR

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Piogrel AP 75mg/75mg Tablet consists Aspirin and Clopidogrel. Aspirin acts as a blood-thinning or anti-platelet agent in a low dose to prevent heart attack and stroke. Clopidogrel acts by preventing blood clots if you have severe chest pain (unstable angina or heart attack), stroke, and peripheral arterial disease (heart problem due to narrowed blood vessels).

Please consult your doctor if Piogrel AP 75mg/75mg Tablet needs to be discontinued before undergoing surgery. The doctor might ask you to stop taking Piogrel AP 75mg/75mg Tablet a few days before surgery since it can cause an increased risk of bleeding during surgery.

Piogrel AP 75mg/75mg Tablet consists of Aspirin and Clopidogrel. These are blood-thinning agents and can increase the risk of bleeding. It is advised to be cautious during your daily activities like shaving, cutting fingernails or using sharp objects. Also, please consult your doctor beforehand if you undergo any surgery.

Piogrel AP 75mg/75mg Tablet is generally safe to take for a long time. It works best if you take it for many months or even years. If you're at risk of getting a stomach ulcer, your doctor may prescribe a medicine to treat ulcer, while you're taking Piogrel AP 75mg/75mg Tablet.

Drug-Drug Interactions Checker List

  • WARFARIN
  • HEPARIN
  • FLUOXETINE
  • LITHIUM
  • GLIBENCLAMIDE
  • REPAGLINIDE
  • METHOTREXATE
  • VALPROATE
  • PHENYTOIN
  • IBUPROFEN
  • OMEPRAZOLE
  • FLUCONAZOLE
  • RITONAVIR
  • COBICISTAT
  • PROBENECID

Special Advise

Let your doctor know that you are using Piogrel AP 75mg/75mg Tablet if you have a scheduled surgery since this medicine may increase the risk of bleeding.

Disease/Condition Glossary

A blood clot is a clump or aggregation of blood that changes from a liquid to a gel-like state. Clotting is a natural process that prevents you from losing too much blood in an accident, trauma, surgery or cut. When a clot forms inside the veins, it won’t always dissolve on its own and can become even life-threatening situation.

Stroke: When our brain does not get sufficient oxygen and blood supply, it starts dying within a few minutes leading to a heart attack or stroke.

Heart attack: It occurs when a blood clot blocks the blood flow to the heart. This blockage of arteries is most often an accumulation of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries). During a heart attack (myocardial infarction), the blood supply which nourishes the heart with oxygen is cut off. This causes the heart muscle to die. Signs of a heart attack include chest pain, upper body pain, sweating, nausea, fatigue and trouble breathing.

Have a query?

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Alcohol

Caution

Avoid consuming alcohol since it may worsen the side effects like dizziness and increased blood pressure.

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Pregnancy

Caution

Piogrel AP 75mg/75mg Tablet is not recommended to use during pregnancy since it may affect the foetus. Please consult your doctor if you are planning to become pregnant or already pregnant before starting Piogrel AP 75mg/75mg Tablet.

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Breast Feeding

Caution

There is limited data on how Piogrel AP 75mg/75mg Tablet affects breastfeeding. Please consult your doctor before starting Piogrel AP 75mg/75mg Tablet.

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Driving

Caution

Do not drive or operate machinery if you experience dizziness or drowsiness while using Piogrel AP 75mg/75mg Tablet. Piogrel AP 75mg/75mg Tablet can also sometimes cause blurry vision, hence avoid driving in such situations. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Let your doctor know if you have any history of liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Piogrel AP 75mg/75mg Tablet.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Piogrel AP 75mg/75mg Tablet.

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Children

Caution

Piogrel AP 75mg/75mg Tablet is not recommended for children below the age of 16 years. The safety and efficacy of Piogrel AP 75mg/75mg Tablet have not been established in children.

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