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  3. Plagril Tablet 10's

Plagril Tablet 10's, Pack of 10 TABLETS
Plagril Tablet 10's, Pack of 10 TABLETS
Plagril Tablet 10's, Pack of 10 TABLETS
Plagril Tablet 10's, Pack of 10 TABLETS
Plagril Tablet 10's, Pack of 10 TABLETS
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Hari Kumar , MBBS
COD available

Online payment accepted

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Whats That

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Composition :

CLOPIDOGREL-75MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Plagril Tablet

Plagril Tablet consists of the anti-platelet drug (blood thinner) primarily taken for the prevention of heart attack or stroke in people at high risk of heart disease. A heart attack generally refers to the blocked flow of blood to the heart because of the blockage of arteries. A heart blockage is most often a build-up of fat, cholesterol and other substances, which form a plaque in the arteries that feed the heart (coronary arteries).

Plagril Tablet belongs to a class of medications called a blood thinner or an antiplatelet medication. Plagril Tablet plays a vital role in preventing the formation of harmful blood clots (plaque) in your veins. It makes your blood flow easy through your veins making it less likely to form a serious blood clot. So, an intake of Plagril Tablet helps prevent blood clots if you have an increased risk of having severe chest pain (unstable angina or heart attack), stroke, peripheral arterial disease (heart problem due to narrowed blood vessels).

The recommended daily dose of Plagril Tablet is 75 mg once daily orally, with or without food. It should be swallowed whole with a glass of water. Do not chew, bite or break it. Your doctor will advise you how often you take your tablets based on your medical condition. In some cases, you may experience nosebleeds, heavier periods, bleeding gums, easy bruising, diarrhoea, stomach pain, indigestion, or heartburn. If the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Stopping a sudden intake of Plagril Tablet may worsen your condition and increase your risk of cardiovascular death, heart attack, and stroke. Let your doctor know if you have any liver, kidney, or heart problems. Plagril Tablet should be taken cautiously in pregnant or breastfeeding women. It should be not given to people with a bleeding disorder (haemophilia), active pathological bleeding, like a peptic ulcer, or bleeding in the brain (intracranial haemorrhage). Do not take Plagril Tablet with aspirin or ibuprofen for pain relief while you are using Plagril Tablet . It may increase the chance of having stomach ulcers or severe gastric bleeding.

Uses of Plagril Tablet

Prevention of heart attack, Prevention of stroke, Prevention of heart related chest pain (angina)

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Plagril Tablet plays a vital role to prevent the formation of harmful blood clots in your blood vessels by making platelets (clotting agents) sticking together. Thus, it helps to reduce the risk of heart attack, stroke, unstable angina (heart related chest pain), peripheral arterial disease (blocked or poor blood flow due to narrowed blood vessels) in heart disease patients and patient who have undergone recent heart surgery with stent.

Storage

Keep Plagril Tablet out of the sight and reach of children.
Side effects of Plagril Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

Drug Warnings

Indigestion medicines known as proton pump inhibitors like omeprazole should be used with caution while taking Plagril Tablet . Prolonged use of Plagril Tablet can cause bleeding problems (like nosebleeds, heavier periods, bleeding gums, and easy bruising). If you are going to have any surgery, discontinue taking Plagril Tablet 5 days before the surgery. Discontinuation of Plagril Tablet might increase the risk of heart attack, stroke, and other risks of cardiovascular events. So, do not stop taking Plagril Tablet of a sudden on your own decision. If you have had any recent stroke or heart attack, stop the intake of Plagril Tablet with painkillers like aspirin or ibuprofen as it can increase your stomach or gastrointestinal bleeding. Purpura (blood leakage under the skin) has been observed with the use of Plagril Tablet including in fatal cases.

Drug-Drug Interactions

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ClopidogrelSelexipag
Critical
ClopidogrelMifepristone
Critical

Drug-Drug Interactions

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ClopidogrelSelexipag
Critical
How does the drug interact with Plagril Tablet:
When Selexipag and Plagril Tablet are taken together, the body's ability to break down Selexipag may be reduced.

How to manage the interaction:
Taking Plagril Tablet with Selexipag is not recommended, please consult your doctor before taking it. They can be taken if prescribed by your doctor.
ClopidogrelMifepristone
Critical
How does the drug interact with Plagril Tablet:
Taking Plagril Tablet together with mifepristone increases the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking Plagril Tablet with mifepristone is not recommended, that would certainly result in interaction, it can be taken if a doctor prescribes it. If you experience prolonged and heavy bleeding, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
ClopidogrelTiclopidine
Severe
How does the drug interact with Plagril Tablet:
Taking Plagril Tablet with ticlopidine can reduced effectiveness of Plagril Tablet.

How to manage the interaction:
Taking Plagril Tablet and Ticlopidine together possibly has an interaction, but you can take these medications together if your doctor has advised it. Do not stop using any medications without talking to your doctor.
ClopidogrelArgatroban
Severe
How does the drug interact with Plagril Tablet:
Taking Plagril Tablet together with argatroban can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Plagril Tablet and Apixaban, they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding, like feeling dizzy or lightheaded, red or black, sticky stools, or severe headaches. Do not discontinue any medications without consulting your doctor.
ClopidogrelTipranavir
Severe
How does the drug interact with Plagril Tablet:
Taking Tipranavir with Plagril Tablet can make the blood-thinning effects of Plagril Tablet stronger.

How to manage the interaction:
Although there is a possible interaction between Plagril Tablet and Tipranavir, you can take these medicines together if prescribed by your doctor. If you notice any bleeding, severe headaches, weakness, or black stools, contact your doctor right away. Do not stop using any medications without talking to your doctor.
ClopidogrelPrasugrel
Severe
How does the drug interact with Plagril Tablet:
Taking Plagril Tablet together with Prasugrel will have an additive effect and increase the risk of bleeding.

How to manage the interaction:
Although taking Plagril Tablet together with Prasugrel may result in interaction, it can be taken if prescribed by a doctor. However, If you experience any unusual bleeding or have other signs of bleeding like feeling dizzy or lightheaded, red or black, sticky stools, or having a severe headache, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
ClopidogrelAcalabrutinib
Severe
How does the drug interact with Plagril Tablet:
Taking Plagril Tablet with acalabrutinib may increase the risk of bleeding.

How to manage the interaction:
There could be a possible interaction between Plagril Tablet and Acalabrutinib, but they can be taken together if your doctor has prescribed them. However, consult your doctor immediately if you experience any unusual bleeding or have other signs of bleeding, like feeling dizzy or lightheaded, red or black, sticky stools, or severe headaches. Do not discontinue any medication without consulting your doctor.
ClopidogrelProtamine
Severe
How does the drug interact with Plagril Tablet:
Taking Protamine with Plagril Tablet can increase the risk of bleeding.

How to manage the interaction:
Taking Protamine with Plagril Tablet together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
ClopidogrelDalteparin
Severe
How does the drug interact with Plagril Tablet:
Using dalteparin together with Plagril Tablet may increase the risk of bleeding.

How to manage the interaction:
There may be a possible interaction between Plagril Tablet and Dalteparin, but they can be taken together if prescribed by your doctor. However, If you experience any unusual bleeding or have other signs of bleeding like feeling dizzy or lightheaded, red or black, sticky stools, or having a headache consult your doctor without any delay. Do not discontinue any medication without consulting your doctor.
ClopidogrelFluconazole
Severe
How does the drug interact with Plagril Tablet:
Co-administration of Plagril Tablet with fluconazole can reduce the effectiveness of Plagril Tablet.

How to manage the interaction:
Plagril Tablet and Fluconazole may interact, but you can take these medications together if a doctor has advised it. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A low cholesterol diet and a regular exercise regime complement treatment with Plagril Tablet effectively.
  • Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.
  • Try to replace most of your saturated fats with unsaturated fats can reduce total cholesterol and LDL cholesterol (bad cholesterol) in a short period.
  • Foods like avocados, olive oil, fatty fish and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.
  • Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.
  • Quit smoking and avoid excessive intake of alcohol.

Side Effects of Plagril Tablet

  • Nosebleeds
  • Heavier periods
  • Bleeding gums
  • Easy bruising
  • Diarrhoea
  • Stomach pain
  • Indigestion or heartburn

Habit Forming

No

Therapeutic Class

ANTICOAGULANTS / ANTITHROMBOTICS. ANTICONVULSANTS

Plagril Tablet Substitute

Substitutes safety advice

Product Substitutes

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Hari Kumar

Reviewed By

Hari Kumar

MBBS

Last Updated

Jul 8, 2025 | 9:29 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Plagril Tablet belongs to a class of medications called a blood thinner or an antiplatelet medication. Plagril Tablet plays a vital role in preventing the formation of harmful blood clots (plaque) in your veins. It makes blood flow easily through your veins, making it less likely to form a serious blood clot. So, an intake of Plagril Tablet helps prevent blood clots if you have an increased risk of having severe chest pain (unstable angina or heart attack), stroke, and peripheral arterial disease (heart problem due to narrowed blood vessels).

Yes, Plagril Tablet causes blood thinning. It works by preventing platelets (a type of blood cells) from sticking together and forming clots.

Please consult your doctor if Plagril Tablet needs to be stopped before undergoing surgery. The doctor might ask you to stop taking Plagril Tablet a few days before surgery to avoid the increased risk of bleeding during the procedure.

Do not take aspirin for pain relief or ibuprofen while you are taking Plagril Tablet unless your doctor says it's OK. They raise the risk of unusual bleeding.

When a blood clot is treated, guidelines recommend that patients take blood thinners for the rest of its life. If they do not, the chance of developing a second clot is 30 to 40 per cent in the next 10 years.

There might be a problem if you are taking herbal therapies with Plagril Tablet especially that affects blood like Ginkgo Biloba and St John's wort plant extract used as antidepressant. Together taking can increase your risk of bleeding. Tell your doctor if you are using any type of herbal supplements before taking Plagril Tablet .

Yes, taking Plagril Tablet can increase the risk of bleeding as it contains aspirin which blood thinner. So, please be very cautious while shaving, cutting fingernails or toenails, or using sharp objects to avoid any bleeding.

Drug-Drug Interactions Checker List

  • WARFARIN
  • ASPIRIN
  • RIVAROXABAN
  • APIXABAN
  • IBUPROFEN
  • CITALOPRAM
  • OMEPRAZOLE

Special Advise

  • As Plagril Tablet tends to increase bleeding, try to avoid injuries, keep away from sharp objects, and inform your doctor if you have peptic ulcers or injuries.

Disease/Condition Glossary

A blood clot can occur in any part of the body that can lead to a heart attack, stroke, and damage to organs (even coma or death). Blood clots can reach your arteries or veins in the organs like the brain, kidney, heart, lungs, and limbs. Conditions like atherosclerosis, diabetes, heart failure, irregular heartbeat (arrhythmia), and obesity/overweight can trigger excessive blood clotting in the brain and heart. On the other hand, deep vein thrombosis (blood clot in veins), peripheral artery disease (narrowed arteries due to fat deposit or blood clot), and atherosclerosis (fat build upon the walls of the arteries) can cause a blood clot in your limbs.

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