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Composition :

RANOLAZINE-500MG

Manufacturer/Marketer :

Euro Biogenics

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Rolaz-500mg Tablet

Rolaz-500mg Tablet belongs to the class of anti-anginal medications. It is used alone or with other medicines to treat angina pectoris. Angina pectoris is discomfort in the chest or chest pain, which generally occurs due to coronary artery disease (CAD) when an adequate amount of oxygen and blood is not reaching the heart and its muscles. It can also be due to the blockage of the heart's arteries. It helps prevent any further attack of angina by making the heart work more efficiently, and it is used as an add-on to existing treatment in patients whose disease is not adequately controlled by other medicines for angina pectoris, such as beta-blockers or calcium antagonists, or in patients who cannot take these medicines.

The active substance in Rolaz-500mg Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Rolaz-500mg Tablet is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Your doctor will tell you how to take the Rolaz-500mg Tablet based on your medical condition. You may sometimes experience constipation, dizziness, headache, or feeling sick. Most of these side effects of Rolaz-500mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not consume Rolaz-500mg Tablet if you are allergic to any component in this medicine. Rolaz-500mg Tablet should not be stopped even if you feel better for the best results as it prevents any future harm. If you stop taking the Rolaz-500mg Tablet on your own, your chest pain can come back in more severe form. If you plan to get pregnant or are pregnant or breastfeeding, please consult your doctor to avoid any unwanted harm to the baby. Some lifestyle modifications are important for best results when taking Rolaz-500mg Tablet like smoking cessation, decreasing alcohol intake, eating well, regular exercise, and managing stress. Rolaz-500mg Tablet should be taken with caution if you have any liver or kidney problems. Also, inform your doctor if you are taking other medications to avoid unwanted side effects or contraindications.

Uses of Rolaz-500mg Tablet

Angina Pectoris

Directions for Use

Swallow it as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Rolaz-500mg Tablet is prescribed for treating angina. Rolaz-500mg Tablet is an anti-anginal medication used to treat angina pectoris. It reduces sodium ions' flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called ‘sodium-dependent calcium channels’ through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Rolaz-500mg Tablet is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Rolaz-500mg Tablet

  • Constipation
  • Dizziness
  • Headache
  • Feeling sick

Drug Warnings

Rolaz-500mg Tablet should be taken with caution in liver/kidney disease, are pregnant, plan to become pregnant, or are breastfeeding, history of heart disease. Also, grapefruit juice should be avoided while taking Rolaz-500mg Tablet . As a precautionary measure, junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery. Do regular exercise to avoid the feeling of heaviness in the abdomen.

Drug-Drug Interactions

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RanolazineClarithromycin
Critical
RanolazineRitonavir
Critical

Drug-Drug Interactions

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RanolazineClarithromycin
Critical
How does the drug interact with Rolaz-500mg Tablet:
When Rolaz-500mg Tablet and Clarithromycin are taken together, significantly increases the blood levels and effects of Rolaz-500mg Tablet.

How to manage the interaction:
Co-administration of Clarithromycin and Ranozaline can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
RanolazineRitonavir
Critical
How does the drug interact with Rolaz-500mg Tablet:
Taking Ritonavir and Rolaz-500mg Tablet may significantly increase the blood levels and effects of Rolaz-500mg Tablet.

How to manage the interaction:
Co-administration of Rolaz-500mg Tablet with Ritonavir can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any symptoms like feeling lightheaded, fainting, or rapid heartbeats, consult a doctor. Do not stop using any medications without a doctor's advice.
RanolazineNafcillin
Critical
How does the drug interact with Rolaz-500mg Tablet:
When Nafcillin is taken with Rolaz-500mg Tablet, may significantly reduce the blood levels of Rolaz-500mg Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Nafcillin with Rolaz-500mg Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
RanolazineTroglitazone
Critical
How does the drug interact with Rolaz-500mg Tablet:
Co-administration of Troglitazone with Rolaz-500mg Tablet may significantly reduce blood levels of Rolaz-500mg Tablet.

How to manage the interaction:
Taking Rolaz-500mg Tablet with Troglitazone together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
RanolazineOxcarbazepine
Critical
How does the drug interact with Rolaz-500mg Tablet:
When Rolaz-500mg Tablet is taken with Oxcarbazepine, may significantly reduce the blood levels of Rolaz-500mg Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Oxcarbazepine with Rolaz-500mg Tablet is not recommended as it can lead to an interaction, they can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
RanolazineGrepafloxacin
Critical
How does the drug interact with Rolaz-500mg Tablet:
Co-administration of Grepafloxacin and Rolaz-500mg Tablet may significantly increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Grepafloxacin with Rolaz-500mg Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazineCarbamazepine
Critical
How does the drug interact with Rolaz-500mg Tablet:
Taking Rolaz-500mg Tablet with carbamazepine may significantly reduce the blood levels of Rolaz-500mg Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Rolaz-500mg Tablet with Carbamazepine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
RanolazineGriseofulvin
Critical
How does the drug interact with Rolaz-500mg Tablet:
When Rolaz-500mg Tablet is taken with Griseofulvin, may significantly reduce the blood levels of Rolaz-500mg Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Griseofulvin with Rolaz-500mg Tablet is not recommended, they can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
RanolazineRifampicin
Critical
How does the drug interact with Rolaz-500mg Tablet:
When Rolaz-500mg Tablet is taken with rifampicin, it can reduce the blood levels and effects of Rolaz-500mg Tablet.

How to manage the interaction:
Although there is an interaction between Rolaz-500mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RanolazineCobicistat
Critical
How does the drug interact with Rolaz-500mg Tablet:
When Cobicistat is taken with Rolaz-500mg Tablet, it can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Cobicistat with Rolaz-500mg Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the levels of Rolaz-500mg Tablet, and high blood levels of food can occasionally cause an irregular heart rhythm that may be serious. Grapefruit and grapefruit juice should be avoided while taking Rolaz-500mg Tablet if possible.

Diet & Lifestyle Advise

  • Maintain a healthy lifestyle by exercising regularly, maintaining weight, and eating a healthy diet.
  • If you suffer from kidney or liver disease, please inform your doctor before taking the Rolaz-500mg Tablet .
  • Alcohol consumption along with Rolaz-500mg Tablet should be avoided as it may cause excessive drowsiness and increase muscle pain.
  • As a precautionary measure, junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery.

Habit Forming

No

Therapeutic Class

ANTIANGINALS

Rolaz-500mg Tablet Substitute

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

The active substance in Rolaz-500mg Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Rolaz-500mg Tablet is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

No, Rolaz-500mg Tablet does not stop acute attacks (sudden attacks) of angina, but Rolaz-500mg Tablet helps prevent a new attack.

No, alcohol should not be taken with Rolaz-500mg Tablet as it may lead to unwanted side effects and increase angina attacks.

Yes, smoking (tobacco) decreases the efficacy of Rolaz-500mg Tablet , especially when taken for angina (chest pain), so it should be avoided while taking Rolaz-500mg Tablet .

Yes, Rolaz-500mg Tablet can cause an upset stomach when taken empty stomach. So, to avoid it, Rolaz-500mg Tablet should be taken with a meal for best results.

Yes, Rolaz-500mg Tablet can cause drowsiness. If you feel excessively sleepy, please consult your doctor for better advice.

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • QUINIDINE
  • DOFETILIDE
  • SOTALOL
  • KETOCONAZOLE
  • ITRACONAZOLE

Disease/Condition Glossary

Angina pectoris: Angina pectoris is discomfort in the chest or chest pain that generally occurs due to coronary artery disease (CAD) when you adequate amount of oxygen and blood is not reaching the heart and its muscles. It can also be due to the blockage of the heart's arteries. It helps prevent any further attack of angina by making the heart work more efficiently, but it does not stop an acute attack of angina pectoris.

Side effects of Rolaz-500mg Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
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