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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sureshvarma D , MPharma
Non returnable*
COD available

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Whats That

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Composition

TOLVAPTAN-15MG

Manufacturer/Marketer

Elixir Pharma

Consume Type

ORAL

Return Policy

Not Returnable

for this medicine

About TLV-15 Tablet 4's

TLV-15 Tablet 4's belongs to a group of medicines called vasopressin V2 receptor antagonist used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Additionally, TLV-15 Tablet 4's is also used to treat autosomal dominant polycystic kidney disease (ADPKD).
 
TLV-15 Tablet 4's contains ‘tolvaptan’ that works by blocking the effect of vasopressin, resulting in decreased water reabsorption, a net increase in free water excretion (aquaresis) and an increase in serum sodium concentrations. This decrease in free water is not associated with an increased excretion of sodium or potassium ions, the increase in serum sodium concentration is solely a result of  increased urine production
 
You are advised to take TLV-15 Tablet 4's for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side-effects such as dizziness, headache, dry mouth, fatigue, diarrhoea, thirst and increased urge to urinate. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
 
Do not take TLV-15 Tablet 4's if you are pregnant as it may cause foetal harm. Consult your doctor before taking TLV-15 Tablet 4's if you are breastfeeding. TLV-15 Tablet 4's is not recommended for children below 18 years as the efficacy and safety have not been established. TLV-15 Tablet 4's may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Inform your doctor about all the medicines you are taking and about your health condition to rule out any unpleasant side-effects.

Uses of TLV-15 Tablet 4's

Hyponatremia (low sodium levels) and autosomal dominant polycystic kidney disease (ADPKD).

Directions for Use

Swallow TLV-15 Tablet 4's as a whole with a glass of water, do not crush, break or chew it.

Medicinal Benefits

TLV-15 Tablet 4's belongs to a group of medicines called vasopressin V2 receptor antagonist. TLV-15 Tablet 4's is used to treat hyponatremia (low levels of sodium) in patients with heart failure, liver disease and hormonal imbalances such as Syndrome of Inappropriate Antidiuretic Hormone (SIADH). Besides this, TLV-15 Tablet 4's is also used to treat autosomal dominant polycystic kidney disease (ADPKD). TLV-15 Tablet 4's works by blocking the effect of vasopressin, a hormone which is involved in the formation of cysts in ADPKD patients. By blocking the effect of vasopressin, TLV-15 Tablet 4's slows down the development of cysts in kidneys and reduces the symptoms of the disease. TLV-15 Tablet 4's antagonises the effect of vasopressin, this results in an increase in free water clearance and decreases urine osmolality due to increased urinary excretion, thereby increases serum sodium concentrations.

Storage

Store in a cool and dry place away from sunlight

Side Effects of TLV-15 Tablet 4's

  • Dizziness
  • Headache
  • Dry mouth
  • Fatigue
  • Weakness
  • Diarrhoea
  • Thirst
  • Increased urge to urinate

Drug Warnings

Do not take TLV-15 Tablet 4's if you are allergic to any of its contents, if you have raised liver enzymes in the blood, very low blood volume, if there is no urine production, if you cannot tell that you are thirsty. Inform your doctor if you have liver disease, difficulty in urination, diabetes, high levels of uric acid, advanced kidney disease or if you have to restrict fluid intake due to certain medical conditions. Do not take TLV-15 Tablet 4's if you are pregnant as it may cause foetal harm. Consult your doctor before taking TLV-15 Tablet 4's if you are breastfeeding. TLV-15 Tablet 4's is not recommended for children below 18 years as efficacy and safety have not been established. TLV-15 Tablet 4's may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. 

Drug-Drug Interactions

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TolvaptanRitonavir
Critical
TolvaptanAtazanavir
Critical

Drug-Drug Interactions

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TolvaptanRitonavir
Critical
How does the drug interact with TLV-15 Tablet:
Taking Ritonavir and TLV-15 Tablet may significantly increase the blood levels of TLV-15 Tablet.

How to manage the interaction:
Taking TLV-15 Tablet with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, fits, contact a doctor. Do not discontinue any medications without consulting a doctor.
TolvaptanAtazanavir
Critical
How does the drug interact with TLV-15 Tablet:
When TLV-15 Tablet and Atazanavir are taken together, may significantly increase the blood levels and effects of TLV-15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between TLV-15 Tablet and Atazanavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanPosaconazole
Critical
How does the drug interact with TLV-15 Tablet:
Taking TLV-15 Tablet and Posaconazole together results in an increase in the levels and effects of TLV-15 Tablet.

How to manage the interaction:
Although there is an interaction between TLV-15 Tablet and Posaconazole, it can be taken if prescribed by a doctor. However, consult a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, or seizures (fits). Do not stop using any medications without a doctor's advice.
TolvaptanIndinavir
Critical
How does the drug interact with TLV-15 Tablet:
When TLV-15 Tablet and Indinavir are taken together, may significantly increase the blood levels and effects of TLV-15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between TLV-15 Tablet and Indinavir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanTelithromycin
Critical
How does the drug interact with TLV-15 Tablet:
When TLV-15 Tablet and Telithromycin are taken together, may significantly increase the blood levels and effects of TLV-15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between TLV-15 Tablet and Telithromycin, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanBoceprevir
Critical
How does the drug interact with TLV-15 Tablet:
Co-administration of Boceprevir and TLV-15 Tablet may significantly increase the blood levels and effects of TLV-15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between TLV-15 Tablet and Boceprevir, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanSaquinavir
Critical
How does the drug interact with TLV-15 Tablet:
When TLV-15 Tablet and Saquinavir are taken together, may significantly increase the blood levels and effects of TLV-15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between TLV-15 Tablet and Saquinavir, but it can be taken if prescribed by a doctor. If you notice any of these signs - like difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanVoriconazole
Critical
How does the drug interact with TLV-15 Tablet:
Co-administration of TLV-15 Tablet together with Voriconazole may significantly increase the blood levels and effects of TLV-15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between TLV-15 Tablet and Voriconazole, but it can be taken if prescribed by a doctor. If you experience difficulty swallowing, trouble speaking, muscle weakness call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanItraconazole
Critical
How does the drug interact with TLV-15 Tablet:
Co-administration of TLV-15 Tablet and Itraconazole may significantly raise TLV-15 Tablet blood levels and effects.

How to manage the interaction:
There may be a possibility of interaction between TLV-15 Tablet and Itraconazole, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
TolvaptanClarithromycin
Critical
How does the drug interact with TLV-15 Tablet:
When TLV-15 Tablet and Clarithromycin are taken together, may significantly increase the blood levels and effects of TLV-15 Tablet.

How to manage the interaction:
There may be a possibility of interaction between TLV-15 Tablet and Clarithromycin, but it can be taken if prescribed by a doctor. If you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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TOLVAPTAN-15MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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TOLVAPTAN-15MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit

How to manage the interaction:
Consuming grapefruit juice while taking TLV-15 Tablet can increase the effects of TLV-15 Tablet. Avoid taking TLV-15 Tablet with grapefruit juice.

Diet & Lifestyle Advise

  • Eat a diet rich in whole grains, vegetables, and fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Manage stress with meditation, yoga, and massage.
  • Drink plenty of fluids.
  • Rehydration beverages that contain electrolytes are also helpful.

Habit Forming

No

Therapeutic Class

CARDIOVASCULAR AGENTS

TLV-15 Tablet 4's Substitute

Substitutes safety advice
  • Natrise Tablet 4's

    by Others

    132.07per tablet
  • Hyponat-O 15 Tablet 10's

    by Others

    67.28per tablet
  • Tolvat 15 Tablet 4's

    by Others

    138.60per tablet
  • Vaptan Tablet 10's

    by AYUR

    90.00per tablet
  • Resodim 15 Tablet 4's

    by Others

    180.68per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

TLV-15 Tablet 4's works by blocking the effect of vasopressin, a hormone which is involved in the formation of cysts in ADPKD patients. By blocking the effect of vasopressin, TLV-15 Tablet 4's slows down the development of cysts in kidneys, reduces the symptoms of the disease, and increases urine production. Thereby increases serum sodium concentrations.

Dry mouth could be a side-effect of TLV-15 Tablet 4's. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Diarrhoea could be a side-effect of TLV-15 Tablet 4's. Drink plenty of fluid to prevent dehydration if you experience diarrhoea. Consult your doctor if you have severe diarrhoea or if you find blood in stools.

TLV-15 Tablet 4's may cause the liver to not work properly. Consult your doctor immediately if you experience nausea, vomiting, fever, loss of appetite, abdominal pain, tiredness, dark urine, jaundice, itching and flu-like symptoms.

TLV-15 Tablet 4's may cause water loss due to increased urine production. This might result in side-effects such as thirst, dry mouth and kidney problems. To prevent this, drink plenty of water regularly. Drink 1-2 glasses of water before going to bed even though you are not thirsty. Special care must be taken in patients with diseases that might reduce fluid intake.

Consult your doctor before taking TLV-15 Tablet 4's if you are diabetic as TLV-15 Tablet 4's might increase the blood sugar levels. Regular monitoring of blood glucose levels while taking TLV-15 Tablet 4's is advised.

Drug-Drug Interactions Checker List

  • CLARITHROMYCIN
  • TELITHROMYCIN
  • SULPHAMETHOXAZOLE+TRIMETHOPRIM
  • KETOCONAZOLE
  • ITRACONAZOLE
  • RITONAVIR
  • INDINAVIR
  • SAQUINAVIR
  • NELFINAVIR
  • NEFAZODONE
  • SPIRONOLACTONE
  • VALSARTAN
  • SACUBITRIL
  • HEPARIN

Special Advise

  • Regular monitoring of liver functioning and electrolyte levels while taking TLV-15 Tablet 4's is advised.
  • Treatment with TLV-15 Tablet 4's should be started and re-started in a hospital or in the presence of a healthcare professional to monitor the sodium levels in your blood closely.

Disease/Condition Glossary

Hyponatremia: Sodium is an important electrolyte that helps in maintaining water balance in and around the cells. It helps in proper nerve, muscle functioning and maintains stable blood pressure levels. Low levels of sodium in the blood are referred to as hyponatremia. Normal levels of sodium are 135-145 milliequivalance per litre. Hyponatremia occurs when the level is below 135mEq/L. Symptoms include weakness, tiredness, nausea, vomiting, headache, irritability, confusion and muscle spasms.

Autosomal Dominant Polycystic Kidney Disease (ADPKD): It is an inherited disorder in which cysts are developed in the kidney. These cysts are non-cancerous sacs that contain a water-like fluid which puts pressure on the surrounding tissues, leading to reduced kidney function. Symptoms include high blood pressure, swollen abdomen, and back or side pain.

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