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  3. Xpreza 200 mg Tablet 14's

Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Whats That

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Composition :

AZACITIDINE-200MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Xpreza 200 mg Tablet

Xpreza 200 mg Tablet belongs to the group of anti-cancer medicines called demethylation agents indicated for continued treatment of acute myeloid leukaemia in adults who improved after chemotherapy but could not complete intensive curative therapy. Acute myeloid leukaemia is a type of cancer that forms in the blood-forming cells of the bone marrow.

Xpreza 200 mg Tablet contains Azacitidine, which works by interfering with the growth of cancer cells, which are eventually destroyed by the body. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.
 
In some cases, Xpreza 200 mg Tablet may cause side effects such as nausea, vomiting, diarrhoea, constipation, fatigue and abdominal pain. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
 
Do not use Xpreza 200 mg Tablet if you are pregnant or breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Xpreza 200 mg Tablet . This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Xpreza 200 mg Tablet

Acute myeloid leukaemia

Directions for Use

Take Xpreza 200 mg Tablet with or without food. Swallow the medicine as a whole with water; do not crush or chew it.

Medicinal Benefits

Xpreza 200 mg Tablet belongs to the group of anti-cancer medicines called demethylation agents indicated for continued treatment of adult patients with acute myeloid leukaemia who achieved first complete remission (all signs and symptoms of cancer have disappeared) or complete remission with incomplete blood count recovery following intensive induction chemotherapy and are not able to complete intensive curative therapy. Xpreza 200 mg Tablet contains Azacitidine, a nucleoside metabolic inhibitor which works by interfering with the growth of cancer cells, which are eventually destroyed by the body. It helps the bone marrow in the production of normal blood cells and kills abnormal cells in the bone marrow.

Storage

Keep Xpreza 200 mg Tablet out of reach and sight of children.
Side effects of Xpreza 200 mg Tablet
  • Increased creatinine levels must be corrected immediately with the help of a doctor.
  • Reduce strenuous activities that can lead to muscle breakdown and production of creatinine.
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding tissue.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Avoid smoking and drinking alcohol.
  • Eat a balanced diet rich in fruits, vegetables, whole grains, lean protein, and healthy fats.
  • Opt for lean protein sources like chicken, fish, and turkey.
  • Nourish your body with healthy fats from sources like avocados, olive oil, and fatty fish to support overall well-being.
  • Restrict your consumption of processed foods, sugary beverages, and refined carbs to minimize negative impacts on your health.
  • Adopt a mindful approach to alcohol consumption, opting for moderation to maintain a healthy balance.
  • Engage in moderate exercise like walking, swimming, or yoga.
  • Maintain a healthy weight to alleviate spleen pressure.
  • Refrain from participating in high-risk activities that involve physical collision or intense impact.
  • Ensure your safety while driving by consistently wearing a seatbelt to minimize injury risk.
  • Stay hydrated by drinking plenty of water.
  • Consult your doctor before making diet and lifestyle changes.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.

Drug Warnings

Do not take Xpreza 200 mg Tablet if you are allergic to any of its components or if you are breastfeeding. Inform the doctor if you have liver or kidney problems. Seek medical attention if you experience symptoms of neutropenia/low white blood cells (fever or chills, feeling very tired or weak, body aches, and unusual headache) or thrombocytopenia/low platelet count (unusual bleeding or bruising). Consult the doctor if you are pregnant, plan to become pregnant, or if you plan to father a child.

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical
How does the drug interact with Xpreza 200 mg Tablet:
Taking Yellow fever vaccine with Xpreza 200 mg Tablet can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Xpreza 200 mg Tablet and the Yellow fever vaccine, you can take these medicines together if prescribed by a doctor. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
How does the drug interact with Xpreza 200 mg Tablet:
Taking Xpreza 200 mg Tablet with Natalizumab can raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Xpreza 200 mg Tablet and Natalizumab, but it can be taken if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm(a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, progressive weakness on one side of the body, clumsiness of limbs, disturbance of vision, confusion, or changes in thinking, memory and personality, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Xpreza 200 mg Tablet:
Taking Infliximab with Xpreza 200 mg Tablet can increase the risk or severity of developing infection.

How to manage the interaction:
Although taking Xpreza 200 mg Tablet and Infliximab together can cause an interaction, it can be taken if a doctor has suggested it. If you experience symptoms like fever, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, and pain or burning during urination, it is recommended to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Xpreza 200 mg Tablet:
Taking baricitinib and Xpreza 200 mg Tablet can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Xpreza 200 mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Xpreza 200 mg Tablet:
Taking Xpreza 200 mg Tablet and leflunomide together may increase the chances of developing severe infections.

How to manage the interaction:
Although there is an interaction between leflunomide and Xpreza 200 mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Xpreza 200 mg Tablet:
The use of cladribine with Xpreza 200 mg Tablet can increase the risk of infections.

How to manage the interaction:
Taking Xpreza 200 mg Tablet with Cladribine together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience a fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Xpreza 200 mg Tablet:
The use of fingolimod in conjunction with Xpreza 200 mg Tablet may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Xpreza 200 mg Tablet with Fingolimod can possibly result in an interaction, but it can be taken if your doctor has advised it. However, Consult a doctor immediately if you have a fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Xpreza 200 mg Tablet:
Taking Xpreza 200 mg Tablet with Teriflunomide can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Xpreza 200 mg Tablet and Teriflunomide together can cause an interaction, it can be taken if a doctor has suggested it. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not stop using any medications without talking to a doctor.
How does the drug interact with Xpreza 200 mg Tablet:
Taking Xpreza 200 mg Tablet with tofacitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Xpreza 200 mg Tablet and Tofacitinib, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not discontinue any medications without consulting a doctor.
AzacitidineBCG vaccine
Severe
How does the drug interact with Xpreza 200 mg Tablet:
Taking BCG vaccine with Xpreza 200 mg Tablet can increase the risk of infection.

How to manage the interaction:
Co-administration of Xpreza 200 mg Tablet with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly as it helps maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Side Effects of Xpreza 200 mg Tablet

  • Nausea
  • Vomiting
  • Diarrhoea
  • Constipation
  • Dizziness
  • Fatigue
  • Abdominal pain
  • Decreased appetite
  • Arthralgia (joint pain)

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Xpreza 200 mg Tablet works by helping bone marrow in the production of normal blood cells and killing abnormal cells in the bone marrow.

Xpreza 200 mg Tablet may affect fertility in men and women. Consult the doctor if you have any concerns.

The doctor will prescribe anti-nausea medicine to help prevent nausea and vomiting during treatment with Xpreza 200 mg Tablet . Take the anti-nausea medicine 30 minutes before each dose of Xpreza 200 mg Tablet or as the doctor advises.

If you vomit after taking a dose Xpreza 200 mg Tablet , avoid taking another dose on the same day. Take the next dose at the regular time the next day. Talk to the doctor if you have any concerns.

Special Advise

  • If you are a female, you should take a pregnancy test prior to the start of the treatment. Use reliable contraception to prevent pregnancy during treatment and for 6 months after the last dose.
  • Male patients with partners of reproductive potential should use effective contraception during treatment and for 3 months after stopping the treatment.
  • If the powder from the medicine comes in contact with your skin, wash the area well with soap and water immediately.
  • If the powder from the medicine comes in contact with mucous membranes (eyes or mouth), flush the area with water immediately.

Disease/Condition Glossary

Acute myeloid leukaemia: Acute myeloid leukaemia, also called acute myelogenous leukaemia or acute nonlymphocytic leukaemia, is the cancer of blood and bone marrow with excess immature white blood cells. Symptoms include fever, recurrent infections, fatigue, and easy bruising.

Have a query?

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Alcohol

Consult your doctor

It is not known if alcohol affects Xpreza 200 mg Tablet . Please consult your doctor.

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Pregnancy

Unsafe

Xpreza 200 mg Tablet can harm the unborn baby. Avoid becoming pregnant during treatment with Xpreza 200 mg Tablet . Consult the doctor immediately if you become pregnant during treatment with Xpreza 200 mg Tablet .

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Breast Feeding

Unsafe

Avoid breastfeeding during treatment with Xpreza 200 mg Tablet and for one week after the last dose.

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Driving

Consult your doctor

It is unknown if Xpreza 200 mg Tablet affects your ability to drive. Drive only if you are alert.

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Liver

Caution

If you have a history of liver disease, inform your doctor before taking Xpreza 200 mg Tablet .

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before taking Xpreza 200 mg Tablet .

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Children

Unsafe

Xpreza 200 mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

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