Noculi Oral Solution 450 ml is indicated for the treatment of renal tubular acidosis and kidney stones due to low citric acid levels or high uric acid. Kidney stones are small, hard deposits made up of calcium, phosphate and other minerals/acid salts that stick together in concentrated urine. Renal tubular acidosis is a condition in which the kidneys fail to excrete acids into the urine, this causes the blood to remain too acidic.
 
Noculi Oral Solution 450 ml is a combination of two drugs, namely: Magnesium citrate and Potassium citrate. Noculi Oral Solution 450 ml raises the urinary pH, potassium, magnesium and citric acid levels; this prevents the crystallisation, growth and accumulation of stone-forming salts.
 
You are advised to take Noculi Oral Solution 450 ml for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects such as abdominal discomfort, diarrhoea, nausea, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
 
Consult your doctor before taking Noculi Oral Solution 450 ml if you are pregnant or breastfeeding. Noculi Oral Solution 450 ml is not recommended for children as safety and effectiveness have not been established. It is not known if alcohol interacts with Noculi Oral Solution 450 ml, so please consult a doctor. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Noculi Oral Solution 450 ml is a combination of two drugs, namely: Magnesium citrate and Potassium citrate. Noculi Oral Solution 450 ml is indicated for the treatment of renal tubular acidosis with calcium stones, uric acid lithiasis with or without calcium stone, hypocitraturic calcium oxalate nephrolithiasis (kidney stones). Noculi Oral Solution 450 ml raises the urinary pH, potassium, magnesium and citric acid levels; this prevents the crystallisation, growth and accumulation of stone-forming salts. 

• Abdominal discomfort
• Diarrhoea
• Vomiting
• Nausea

Do not take Noculi Oral Solution 450 ml if you are allergic to any of its components; if you have hyperkalaemia (high levels of potassium), delayed gastric emptying, intestinal obstruction, peptic ulcers, urinary tract infection, or renal insufficiency. Inform your doctor if you have gastrointestinal lesions. If you experience severe vomiting, gastrointestinal bleeding or abdominal pain, stop taking Noculi Oral Solution 450 ml and consult a doctor immediately. Noculi Oral Solution 450 ml is not recommended for children as safety and effectiveness have not been established. Consult your doctor before taking Noculi Oral Solution 450 ml if you are pregnant or breastfeeding. 

Drug-Drug Interactions: Noculi Oral Solution 450 ml may interact with diuretics (triamterene, spironolactone, amiloride) and anticholinergic drugs.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor if you have hyperkalaemia (high levels of potassium), delayed gastric emptying, intestinal obstruction, peptic ulcers, urinary tract infection, or renal insufficiency.

• TRIAMTERENE
• SPIRONOLACTONE
• AMILORIDE

• Drink plenty of fluids as they help in flushing out excess minerals.
• Limit salt intake. High amounts of salt can increase the risk of kidney stones.
• Maintain a healthy weight by exercising regularly.
• Avoid foods rich in oxalates such as spinach, nuts, okra, dates, avocado, hot chocolate, cocoa, baked potato, french fries, and cereals as they might increase the risk of oxalate stones.
• Try maintaining optimum levels of calcium in the body as too little or high calcium can lead to kidney stones.

Kidney stones: Nephrolithiasis, also known as kidney stones, is a disease affecting the urinary tract. Kidney stones are small, hard deposits made up of calcium, phosphate and other minerals/acid salts that stick together in concentrated urine. They are the common cause of blood in urine and can be painful when passing through the urinary tract. Symptoms include severe pain, usually in one side of the abdomen and nausea. 

Renal tubular acidosis: It is a condition that involves the accumulation of acid in the body due to the failure of the kidneys to acidify the urine appropriately. The kidneys fail to excrete acids into the urine, which causes the blood to remain too acidic. If not treated, it could lead to kidney stones, bone disease, kidney disease or failure.