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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

DIGOXIN-0.25MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About Dixin 0.25 mg Tablet

Dixin 0.25 mg Tablet belongs to a group of medicines called cardiac glycosides used to treat irregular heartbeats and manage the symptoms of heart failure. Heart failure is a chronic condition in which the heart is unable to pump blood as effectively as it should. Irregular heartbeat is a condition in which your heart beats irregularly, too fast or too slow.

Dixin 0.25 mg Tablet contains digoxin, i.e. cardiac glycosides that help to increase the output force of the heart and reduces the rate of heart contractions. Dixin 0.25 mg Tablet works on the heart muscle directly and increases the force with which heart muscle contracts with each heartbeat. Thereby, it makes heart efficient in pumping blood around the body and slows down the rate at which heartbeats.

Take Dixin 0.25 mg Tablet as prescribed. Your doctor will recommend you how often you take Dixin 0.25 mg Tablet based on your medical condition. Some people may experience common side effects like diarrhoea, nausea, vomiting, dizziness, abnormal heartbeat or skin rash. Most of these side effects of Dixin 0.25 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are known to be allergic to Dixin 0.25 mg Tablet or any other medicines, please tell your doctor. Pregnant or breastfeeding women are advised to consult a doctor before taking the tablet. Regular blood tests are recommended by your doctor while taking Dixin 0.25 mg Tablet to monitor the amount of Dixin 0.25 mg Tablet in the bloodstream as its toxicity can lead to several forms of heart rhythm disturbances, vomiting, nausea and visual disturbances. If you have beriberi disease caused due to vitamin B1 deficiency, malabsorption syndrome (unable to absorb minerals from food) or any lung or kidney disease, please inform your doctor before taking Dixin 0.25 mg Tablet so that the dose may be adjusted or an alternate medicine may be prescribed accordingly. Dixin 0.25 mg Tablet has a very narrow therapeutic index. It means small differences in dose of drugs in the body may lead to life-threatening conditions or serious side effects. This makes its use limited and requires close monitoring by doctors like regular electrocardiogram (ECG). So, try not to self-medicate and suggest Dixin 0.25 mg Tablet to others.

Uses of Dixin 0.25 mg Tablet

Irregular heartbeats, Prevention of heart failure

Directions for Use

Tablet: Take it with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.Paediatric solution: Shake the bottle well before use. Check the label for directions and give it with or without food in doses as prescribed by a doctor with the help of a dosing syringe.

Medicinal Benefits

Dixin 0.25 mg Tablet is a cardiac glycoside that is used to treat heart failure and irregular heartbeats. Dixin 0.25 mg Tablet increases the force with which heart muscle contracts with each heartbeat and makes heart efficient in pumping blood around the body. Thus, slows down the rate at which heartbeats and makes heart rate normal. Dixin 0.25 mg Tablet improves heart failure symptoms such as exercise capacity and reduces the number of hospitalizations.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are known to be allergic to Dixin 0.25 mg Tablet or any other medicines, please tell your doctor. Pregnant or breastfeeding women are advised to consult a doctor before taking the tablet. Avoid intake of alcohol with Dixin 0.25 mg Tablet as it may increase the risk of drowsiness. Dixin 0.25 mg Tablet may cause vision problems in some people. Make sure you are not affected before driving. Regular blood tests are recommended by your doctor while taking Dixin 0.25 mg Tablet to monitor the amount of digoxin in blood as digoxin toxicity can lead to several forms of heart rhythm disturbances, vomiting, nausea and visual disturbances. If you have beriberi disease caused by vitamin B1 deficiency, malabsorption syndrome (unable to absorb minerals from food), thyroid, or any lung or kidney disease, please inform your doctor before taking Dixin 0.25 mg Tablet so that the dose may be adjusted or an alternate medicine may be prescribed accordingly. Dixin 0.25 mg Tablet has a narrow therapeutic index which makes its use limited and requires close monitoring as small change in dose or blood concentration may lead to severe adverse effects, and overdose may lead to life-threatening reactions.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Dixin 0.25 mg Tablet:
Co-administration of Dixin 0.25 mg Tablet and Famotidine may increase the level or effect of Dixin 0.25 mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Dixin 0.25 mg Tablet and Famotidine, you can take these medicines together if prescribed by a doctor. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Dixin 0.25 mg Tablet:
Co-administration of Fingolimod with Dixin 0.25 mg Tablet may increase the risk or severity of slowing down of the heart rate.

How to manage the interaction:
Although there is a possible interaction between Dixin 0.25 mg Tablet and Fingolimod, you can take these medicines together if prescribed by a doctor. It's important to monitor your heart rate and talk to a doctor about any alternative medications that don't interact. If you experience any symptoms like chest pain, shortness of breath, or fainting, it's important to call your doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dixin 0.25 mg Tablet:
Co-administration of Dixin 0.25 mg Tablet and Ceritinib may slow down the heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Dixin 0.25 mg Tablet and ceritinib, it can be taken together if prescribed by a doctor. However, if you experience fainting, lightheadedness, sudden dizziness, or irregular heartbeat, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Dixin 0.25 mg Tablet:
Co-administration of Amiodarone with Dixin 0.25 mg Tablet can increase Dixin 0.25 mg Tablet levels which can lead to severe side effects.

How to manage the interaction:
Taking Amiodarone with Dixin 0.25 mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, visual disturbances, slow pulse, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
DigoxinNadolol
Severe
How does the drug interact with Dixin 0.25 mg Tablet:
Co-administration of Dixin 0.25 mg Tablet and Nadolol may slow down the heart rate and lead to increased side effects.

How to manage the interaction:
If you are supposed to take Dixin 0.25 mg Tablet and Nadolol together, a doctor may adjust the dose to safely use both medications. However, if you experience decreased appetite, nausea, vomiting, confusion, diarrhea, seizures, visual changes, overtiredness, irregular heartbeats, and abnormally fast or slow heartbeats, contact a doctor. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Dixin 0.25 mg Tablet:
Co-administration of Adenosine with Dixin 0.25 mg Tablet shows additive effects on the heart and may cause abnormal heart rhythms.

How to manage the interaction:
Taking Adenosine with Dixin 0.25 mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as dizziness, difficulty in breathing, or chest pain. Do not discontinue any medications without consulting a doctor.
DigoxinDolasetron
Severe
How does the drug interact with Dixin 0.25 mg Tablet:
Co-administration of Dixin 0.25 mg Tablet with Dolasetron can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Dixin 0.25 mg Tablet with Dolasetron can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these risk factors or if you experience symptoms like an irregular heartbeat, dizziness, fainting, or a fast or irregular heartbeat, it is important to call a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Dixin 0.25 mg Tablet:
Co-administration of Calcium carbonate and Dixin 0.25 mg Tablet may increase the calcium levels may increase the effects of Dixin 0.25 mg Tablet

How to manage the interaction:
Although there is an interaction, Calcium carbonate can be taken with Dixin 0.25 mg Tablet if prescribed by the doctor. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Dixin 0.25 mg Tablet:
Co-administration of Dixin 0.25 mg Tablet and Glycopyrronium bromide may increase the serum concentration of Dixin 0.25 mg Tablet and increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Dixin 0.25 mg Tablet and Glycopyrronium bromide, you can take these medicines together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, confusion, loss of appetite, nausea, vomiting, diarrhea, change in vision such as blurry or yellow vision, fatigue, and fast or irregular heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Dixin 0.25 mg Tablet:
Co-administration of Sucralfate together with Dixin 0.25 mg Tablet may decrease the effects of Dixin 0.25 mg Tablet.

How to manage the interaction:
If you are supposed to take Dixin 0.25 mg Tablet and Sucralfate together, your doctor may adjust the dose to safely use both medications. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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DIGOXIN-0.25MGGrapefruit and Grapefruit Juice
Mild

Drug-Food Interactions

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DIGOXIN-0.25MGGrapefruit and Grapefruit Juice
Mild
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Dixin 0.25 mg Tablet with Grapefruit and Grapefruit juice may increase the side effects of Dixin 0.25 mg Tablet. Consuming Grapefruit and grapefruit juice should be avoided while taking Dixin 0.25 mg Tablet.

Diet & Lifestyle Advise

  • Maintain a low salt diet and minimize eating processed foods as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
  • Do the regular exercise as it helps to lower blood pressure and keeps blood vessels and heart in good condition.
  • Quit smoking as smoking increases blood pressure and heart rate.
  • Eat balanced and healthy diet which includes plenty of vegetables, fruits, low fat or fat free products.

Habit Forming

No

Therapeutic Class

ANTIARRHYTHMICS

Dixin 0.25 mg Tablet Substitute

Substitutes safety advice
  • Lanoxin Tablet 10's

    by Others

    1.31per tablet
  • Digoxin-0.25 Tablet 10's

    by Others

    1.17per tablet
  • Digon 0.25 mg Tablet 10's

    by Others

    1.26per tablet
  • Geoxin 0.25mg Tablet

    by Others

    0.90per tablet
  • Digover Tablet 10's

    by Others

    1.45per tablet

Author Details

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Drug-Diseases Interactions

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DIGOXIN-0.25MGOther conduction disorders
Severe
DIGOXIN-0.25MGAbnormalities of heart beat
Severe

Drug-Diseases Interactions

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DIGOXIN-0.25MGOther conduction disorders
Severe
How does the disease interact with Dixin 0.25 mg Tablet:
In cases like the Wolff-Parkinson-White syndrome, Dixin 0.25 mg Tablet may improve accessory route conduction.

How to manage the interaction:
Dixin 0.25 mg Tablet should be used with caution in patients with Wolff-Parkinson-White syndrome (a heart condition that causes rapid heartbeat).
DIGOXIN-0.25MGAbnormalities of heart beat
Severe
How does the disease interact with Dixin 0.25 mg Tablet:
Dixin 0.25 mg Tablet prolongs the PR interval by slowing sinoatrial and AV conduction. Dixin 0.25 mg Tablet therapy can cause severe sinus bradycardia or sinoatrial block in people with preexisting sinus node dysfunction, and it can cause progressive or full heart block in patients with incomplete AV block.

How to manage the interaction:
Dixin 0.25 mg Tablet may be administered to patients with complete, stable AV block (an electrical signal that controls your heartbeat is partially or completely blocked) who have congestive heart failure, provided the block was not induced by cardiac glycosides.
DIGOXIN-0.25MGDisorders of mineral metabolism
Severe
How does the disease interact with Dixin 0.25 mg Tablet:
Dixin 0.25 mg Tablet and calcium have cumulative effects on inotropy. As a result, Dixin 0.25 mg Tablet toxicity and dangerous arrhythmias are predisposed in patients with hypercalcemia from any source.

How to manage the interaction:
Hypercalcemia (too much calcium in the blood) should be corrected before starting treatment with Dixin 0.25 mg Tablet, and serum calcium levels should be monitored during therapy.
DIGOXIN-0.25MGDisorders of mineral metabolism
Severe
How does the disease interact with Dixin 0.25 mg Tablet:
Dixin 0.25 mg Tablet and calcium have cumulative effects on inotropy. As a result, Dixin 0.25 mg Tablet toxicity and dangerous arrhythmias are predisposed in patients with hypercalcemia from any source.

How to manage the interaction:
Hypercalcemia (too much calcium in the blood) should be corrected before starting treatment with Dixin 0.25 mg Tablet, and serum calcium levels should be monitored during therapy.
DIGOXIN-0.25MGOther disorders of fluid, electrolyte and acid-base balance
Severe
How does the disease interact with Dixin 0.25 mg Tablet:
Dixin 0.25 mg Tablet makes the myocardium more sensitive when potassium and/or magnesium are depleted. Despite Dixin 0.25 mg Tablet serum drug concentrations, Dixin 0.25 mg Tablet toxicity may happen in patients with hypokalemia or hypomagnesemia.

How to manage the interaction:
Dixin 0.25 mg Tablet should be used with caution in patients with or who are at risk of developing potassium and/or magnesium deficiency, including patients on diuretic therapy; those with primary or secondary aldosteronism (may have low potassium levels), severe or prolonged diarrhoea or vomiting, malnutrition; and renal dialysis patients. Electrolyte imbalances may be corrected before starting the treatment.
DIGOXIN-0.25MGThyrotoxicosis [hyperthyroidism]
Moderate
How does the disease interact with Dixin 0.25 mg Tablet:
Treatment of the underlying illness is the best way to control heart failure and/or atrial arrhythmias brought on by hypermetabolic or hyperdynamic conditions such hyperthyroidism, hypoxia, or arteriovenous shunt.

How to manage the interaction:
Dixin 0.25 mg Tablet should be used with caution in patients with hyperthyroidism. Your doctor may adjust the dose secondary to changes in the thyroid condition.

FAQs

It may take several weeks for Dixin 0.25 mg Tablet to show its effect. You are recommended to continue taking Dixin 0.25 mg Tablet for as long as your doctor prescribes it and do not stop taking Dixin 0.25 mg Tablet suddenly as it may worsen your heart problems. However, if you experience any difficulty while taking Dixin 0.25 mg Tablet , please consult your doctor.

Yes, Dixin 0.25 mg Tablet may cause diarrhoea as a side effect. However, it is not necessary for everyone taking Dixin 0.25 mg Tablet to experience this side effect. You are recommended to drink plenty of fluids to avoid dehydration. Signs of dehydration include decreased urination or dark, strong-smelling urine. Also, do not take any other medicines to treat diarrhoea without consulting your doctor. If the condition persists or worsen, please consult your doctor.

Yes, Dixin 0.25 mg Tablet may cause yellow or blurred vision in some people. Therefore, be cautious before driving or using machinery.

No, you can eat normally. However, a balanced and healthy diet are advised for effective results.

You are not recommended to take more than the prescribed dose of Dixin 0.25 mg Tablet as it may cause Dixin 0.25 mg Tablet toxicity resulting in symptoms such as vomiting, nausea, loss of appetite, tiredness, dizziness or visual disturbances (more than usual yellow-green). However, if you experience any of these symptoms while taking Dixin 0.25 mg Tablet , please consult a doctor immediately.

No, you are not recommended to take amiodarone with Dixin 0.25 mg Tablet as co-administration of these two medicines may increase the levels of Dixin 0.25 mg Tablet in the blood resulting in Dixin 0.25 mg Tablet toxicity. However, please consult a doctor before taking other medicines with Dixin 0.25 mg Tablet so that the dose may be adjusted appropriately.

You are recommended to avoid taking Dixin 0.25 mg Tablet if you have severe heart problems, have a history of Stokes-Adams attacks (abrupt, short-lived unconsciousness caused by a sudden change in a heartbeat), obstructive cardiomyopathy (enlargement of the heart muscle) and Wolff-Parkinson-White syndrome (extra electrical pathway causes fast heartbeat).

Drug-Drug Interactions Checker List

  • AMIODARONE
  • QUINIDINE
  • ATAZANAVIR
  • SAQUINAVIR
  • CLARITHROMYCIN
  • ITRACONAZOLE
  • ADENOSINE
  • DOLASETRON
  • ARBUTAMINE
  • CERITINIB
  • LAPATINIB
  • FINGOLIMOD
  • FLIBANSERIN
  • CALCIUM CHLORIDE
  • CALCIUM GLUCEPTATE
  • CALCIUM GLUCONATE

Special Advise

  • Regular blood tests are advised while taking Dixin 0.25 mg Tablet to monitor digoxin levels in the blood, potassium levels and kidney functioning.
  • Low salt diet and regular exercise are recommended along with Dixin 0.25 mg Tablet for effective results.
  • Regular electrocardiogram (ECG) should be done to see the effect of Dixin 0.25 mg Tablet on your heartbeat.

Disease/Condition Glossary

Heart failure: It is a chronic condition in which the heart is unable to pump blood as effectively as it should. Heart failure may occur due to certain conditions like high blood pressure, swelling or damage of heart muscle, faulty heart valves or narrow arteries in the heart. Symptoms of heart failure include shortness of breath, tiredness, fast heartbeat and swollen legs.

Arrhythmia (irregular heartbeat) is a condition in which your heart beats irregularly, too fast or too slow. Symptoms of irregular heartbeat include chest pain, shortness of breath, fast or slow heartbeat. 60 to 100 beats per minute is generally considered as normal heart rate.

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