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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS

About Zigoxin 0.25 mg Tablet 10's

Zigoxin 0.25 mg Tablet 10's belongs to a group of medicines called cardiac glycosides used to treat irregular heartbeats and manage the symptoms of heart failure. Heart failure is a chronic condition in which the heart is unable to pump blood as effectively as it should. Irregular heartbeat is a condition in which your heart beats irregularly, too fast or too slow.

Zigoxin 0.25 mg Tablet 10's contains digoxin, i.e. cardiac glycosides that help to increase the output force of the heart and reduces the rate of heart contractions. Zigoxin 0.25 mg Tablet 10's works on the heart muscle directly and increases the force with which heart muscle contracts with each heartbeat. Thereby, it makes heart efficient in pumping blood around the body and slows down the rate at which heartbeats.

Take Zigoxin 0.25 mg Tablet 10's as prescribed. Your doctor will recommend you how often you take Zigoxin 0.25 mg Tablet 10's based on your medical condition. Some people may experience common side effects like diarrhoea, nausea, vomiting, dizziness, abnormal heartbeat or skin rash. Most of these side effects of Zigoxin 0.25 mg Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are known to be allergic to Zigoxin 0.25 mg Tablet 10's or any other medicines, please tell your doctor. Pregnant or breastfeeding women are advised to consult a doctor before taking the tablet. Regular blood tests are recommended by your doctor while taking Zigoxin 0.25 mg Tablet 10's to monitor the amount of Zigoxin 0.25 mg Tablet 10's in the bloodstream as its toxicity can lead to several forms of heart rhythm disturbances, vomiting, nausea and visual disturbances. If you have beriberi disease caused due to vitamin B1 deficiency, malabsorption syndrome (unable to absorb minerals from food) or any lung or kidney disease, please inform your doctor before taking Zigoxin 0.25 mg Tablet 10's so that the dose may be adjusted or an alternate medicine may be prescribed accordingly. Zigoxin 0.25 mg Tablet 10's has a very narrow therapeutic index. It means small differences in dose of drugs in the body may lead to life-threatening conditions or serious side effects. This makes its use limited and requires close monitoring by doctors like regular electrocardiogram (ECG). So, try not to self-medicate and suggest Zigoxin 0.25 mg Tablet 10's to others.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

DIGOXIN-0.25MG

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Zigoxin 0.25 mg Tablet 10's

Irregular heartbeats, Prevention of heart failure

Medicinal Benefits

Zigoxin 0.25 mg Tablet 10's is a cardiac glycoside that is used to treat heart failure and irregular heartbeats. Zigoxin 0.25 mg Tablet 10's increases the force with which heart muscle contracts with each heartbeat and makes heart efficient in pumping blood around the body. Thus, slows down the rate at which heartbeats and makes heart rate normal. Zigoxin 0.25 mg Tablet 10's improves heart failure symptoms such as exercise capacity and reduces the number of hospitalizations.

Side Effects of Zigoxin 0.25 mg Tablet 10's

  • Feeling confused
  • Dizziness
  • Nausea or vomiting
  • Loss of appetite
  • Diarrhoea
  • Changes in your vision (including blurred vision and not able to look at bright light)

Directions for Use

Tablet: Take it with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.Paediatric solution: Shake the bottle well before use. Check the label for directions and give it with or without food in doses as prescribed by a doctor with the help of a dosing syringe.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are known to be allergic to Zigoxin 0.25 mg Tablet 10's or any other medicines, please tell your doctor. Pregnant or breastfeeding women are advised to consult a doctor before taking the tablet. Avoid intake of alcohol with Zigoxin 0.25 mg Tablet 10's as it may increase the risk of drowsiness. Zigoxin 0.25 mg Tablet 10's may cause vision problems in some people. Make sure you are not affected before driving. Regular blood tests are recommended by your doctor while taking Zigoxin 0.25 mg Tablet 10's to monitor the amount of digoxin in blood as digoxin toxicity can lead to several forms of heart rhythm disturbances, vomiting, nausea and visual disturbances. If you have beriberi disease caused by vitamin B1 deficiency, malabsorption syndrome (unable to absorb minerals from food), thyroid, or any lung or kidney disease, please inform your doctor before taking Zigoxin 0.25 mg Tablet 10's so that the dose may be adjusted or an alternate medicine may be prescribed accordingly. Zigoxin 0.25 mg Tablet 10's has a narrow therapeutic index which makes its use limited and requires close monitoring as small change in dose or blood concentration may lead to severe adverse effects, and overdose may lead to life-threatening reactions.

Therapeutic Class

ANTIARRHYTHMICS

Drug-Drug Interactions

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DigoxinNadolol
Severe
DigoxinGlycopyrronium bromide
Severe

Drug-Drug Interactions

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DigoxinNadolol
Severe
How does the drug interact with Zigoxin 0.25 mg Tablet 10's:
Co-administration of Zigoxin 0.25 mg Tablet 10's and Nadolol may slow down the heart rate and lead to increased side effects.

How to manage the interaction:
If you are supposed to take Zigoxin 0.25 mg Tablet 10's and Nadolol together, a doctor may adjust the dose to safely use both medications. However, if you experience decreased appetite, nausea, vomiting, confusion, diarrhea, seizures, visual changes, overtiredness, irregular heartbeats, and abnormally fast or slow heartbeats, contact a doctor. Do not discontinue the medication without consulting a doctor.
DigoxinGlycopyrronium bromide
Severe
How does the drug interact with Zigoxin 0.25 mg Tablet 10's:
Co-administration of Zigoxin 0.25 mg Tablet 10's and Glycopyrronium bromide may increase the serum concentration of Zigoxin 0.25 mg Tablet 10's and increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Zigoxin 0.25 mg Tablet 10's and Glycopyrronium bromide, you can take these medicines together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, confusion, loss of appetite, nausea, vomiting, diarrhea, change in vision such as blurry or yellow vision, fatigue, and fast or irregular heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DigoxinLapatinib
Severe
How does the drug interact with Zigoxin 0.25 mg Tablet 10's:
Co-administration of Zigoxin 0.25 mg Tablet 10's and Lapatinib may increase the blood levels and effects of Zigoxin 0.25 mg Tablet 10's.

How to manage the interaction:
If you are supposed to take Zigoxin 0.25 mg Tablet 10's and Lapatinib together, a doctor may adjust the dose or monitor more frequently to safely use both medications. If you experience diarrhea, nausea, loss of appetite, vomiting, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, contact a doctor as these may be signs and symptoms of excessive Zigoxin 0.25 mg Tablet 10's levels. Do not discontinue the medication without consulting a doctor.
DigoxinFamotidine
Severe
How does the drug interact with Zigoxin 0.25 mg Tablet 10's:
Co-administration of Zigoxin 0.25 mg Tablet 10's and Famotidine may increase the level or effect of Zigoxin 0.25 mg Tablet 10's.

How to manage the interaction:
Although there is a possible interaction between Zigoxin 0.25 mg Tablet 10's and Famotidine, you can take these medicines together if prescribed by a doctor. Do not discontinue the medication without consulting a doctor.
DigoxinAtazanavir
Severe
How does the drug interact with Zigoxin 0.25 mg Tablet 10's:
Coadministration of Zigoxin 0.25 mg Tablet 10's and Atazanavir may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Zigoxin 0.25 mg Tablet 10's and Atazanavir, you can take these medicines together if prescribed by a doctor. However, if you develop fainting, lightheadedness, sudden dizziness, or irregular heartbeat, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DigoxinSucralfate
Severe
How does the drug interact with Zigoxin 0.25 mg Tablet 10's:
Co-administration of Sucralfate together with Zigoxin 0.25 mg Tablet 10's may decrease the effects of Zigoxin 0.25 mg Tablet 10's.

How to manage the interaction:
If you are supposed to take Zigoxin 0.25 mg Tablet 10's and Sucralfate together, your doctor may adjust the dose to safely use both medications. Do not discontinue the medication without consulting a doctor.
DigoxinCeritinib
Severe
How does the drug interact with Zigoxin 0.25 mg Tablet 10's:
Co-administration of Zigoxin 0.25 mg Tablet 10's and Ceritinib may slow down the heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Zigoxin 0.25 mg Tablet 10's and ceritinib, it can be taken together if prescribed by a doctor. However, if you experience fainting, lightheadedness, sudden dizziness, or irregular heartbeat, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DigoxinBretylium tosilate
Severe
How does the drug interact with Zigoxin 0.25 mg Tablet 10's:
Co-administration of Zigoxin 0.25 mg Tablet 10's and Bretylium tosilate may increase the effect of Zigoxin 0.25 mg Tablet 10's.

How to manage the interaction:
Although taking Bretylium tosilate and Zigoxin 0.25 mg Tablet 10's together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you start feeling sick, throwing up, having seizures, feeling tired, or noticing your heart beating too fast or too slow, it's best to call a doctor right away. Do not discontinue any medications without consulting a doctor.
DigoxinAmiodarone
Severe
How does the drug interact with Zigoxin 0.25 mg Tablet 10's:
Co-administration of Amiodarone with Zigoxin 0.25 mg Tablet 10's can increase Zigoxin 0.25 mg Tablet 10's levels which can lead to severe side effects.

How to manage the interaction:
Taking Amiodarone with Zigoxin 0.25 mg Tablet 10's together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, visual disturbances, slow pulse, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
DigoxinAdenosine
Severe
How does the drug interact with Zigoxin 0.25 mg Tablet 10's:
Co-administration of Adenosine with Zigoxin 0.25 mg Tablet 10's shows additive effects on the heart and may cause abnormal heart rhythms.

How to manage the interaction:
Taking Adenosine with Zigoxin 0.25 mg Tablet 10's together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as dizziness, difficulty in breathing, or chest pain. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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DIGOXIN-0.25MGGrapefruit and Grapefruit Juice
Mild

Drug-Food Interactions

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DIGOXIN-0.25MGGrapefruit and Grapefruit Juice
Mild
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Zigoxin 0.25 mg Tablet 10's with Grapefruit and Grapefruit juice may increase the side effects of Zigoxin 0.25 mg Tablet 10's. Consuming Grapefruit and grapefruit juice should be avoided while taking Zigoxin 0.25 mg Tablet 10's.

Drug-Diseases Interactions

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DIGOXIN-0.25MGOther conduction disorders
Severe
DIGOXIN-0.25MGAbnormalities of heart beat
Severe

Drug-Diseases Interactions

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DIGOXIN-0.25MGOther conduction disorders
Severe
How does the disease interact with Zigoxin 0.25 mg Tablet 10's:
In cases like the Wolff-Parkinson-White syndrome, Zigoxin 0.25 mg Tablet 10's may improve accessory route conduction.

How to manage the interaction:
Zigoxin 0.25 mg Tablet 10's should be used with caution in patients with Wolff-Parkinson-White syndrome (a heart condition that causes rapid heartbeat).
DIGOXIN-0.25MGAbnormalities of heart beat
Severe
How does the disease interact with Zigoxin 0.25 mg Tablet 10's:
Zigoxin 0.25 mg Tablet 10's prolongs the PR interval by slowing sinoatrial and AV conduction. Zigoxin 0.25 mg Tablet 10's therapy can cause severe sinus bradycardia or sinoatrial block in people with preexisting sinus node dysfunction, and it can cause progressive or full heart block in patients with incomplete AV block.

How to manage the interaction:
Zigoxin 0.25 mg Tablet 10's may be administered to patients with complete, stable AV block (an electrical signal that controls your heartbeat is partially or completely blocked) who have congestive heart failure, provided the block was not induced by cardiac glycosides.
DIGOXIN-0.25MGDisorders of mineral metabolism
Severe
How does the disease interact with Zigoxin 0.25 mg Tablet 10's:
Zigoxin 0.25 mg Tablet 10's and calcium have cumulative effects on inotropy. As a result, Zigoxin 0.25 mg Tablet 10's toxicity and dangerous arrhythmias are predisposed in patients with hypercalcemia from any source.

How to manage the interaction:
Hypercalcemia (too much calcium in the blood) should be corrected before starting treatment with Zigoxin 0.25 mg Tablet 10's, and serum calcium levels should be monitored during therapy.
DIGOXIN-0.25MGDisorders of mineral metabolism
Severe
How does the disease interact with Zigoxin 0.25 mg Tablet 10's:
Zigoxin 0.25 mg Tablet 10's and calcium have cumulative effects on inotropy. As a result, Zigoxin 0.25 mg Tablet 10's toxicity and dangerous arrhythmias are predisposed in patients with hypercalcemia from any source.

How to manage the interaction:
Hypercalcemia (too much calcium in the blood) should be corrected before starting treatment with Zigoxin 0.25 mg Tablet 10's, and serum calcium levels should be monitored during therapy.
DIGOXIN-0.25MGOther disorders of fluid, electrolyte and acid-base balance
Severe
How does the disease interact with Zigoxin 0.25 mg Tablet 10's:
Zigoxin 0.25 mg Tablet 10's makes the myocardium more sensitive when potassium and/or magnesium are depleted. Despite Zigoxin 0.25 mg Tablet 10's serum drug concentrations, Zigoxin 0.25 mg Tablet 10's toxicity may happen in patients with hypokalemia or hypomagnesemia.

How to manage the interaction:
Zigoxin 0.25 mg Tablet 10's should be used with caution in patients with or who are at risk of developing potassium and/or magnesium deficiency, including patients on diuretic therapy; those with primary or secondary aldosteronism (may have low potassium levels), severe or prolonged diarrhoea or vomiting, malnutrition; and renal dialysis patients. Electrolyte imbalances may be corrected before starting the treatment.
DIGOXIN-0.25MGThyrotoxicosis [hyperthyroidism]
Moderate
How does the disease interact with Zigoxin 0.25 mg Tablet 10's:
Treatment of the underlying illness is the best way to control heart failure and/or atrial arrhythmias brought on by hypermetabolic or hyperdynamic conditions such hyperthyroidism, hypoxia, or arteriovenous shunt.

How to manage the interaction:
Zigoxin 0.25 mg Tablet 10's should be used with caution in patients with hyperthyroidism. Your doctor may adjust the dose secondary to changes in the thyroid condition.

Drug-Drug Interactions Checker List

  • AMIODARONE
  • QUINIDINE
  • ATAZANAVIR
  • SAQUINAVIR
  • CLARITHROMYCIN
  • ITRACONAZOLE
  • ADENOSINE
  • DOLASETRON
  • ARBUTAMINE
  • CERITINIB
  • LAPATINIB
  • FINGOLIMOD
  • FLIBANSERIN
  • CALCIUM CHLORIDE
  • CALCIUM GLUCEPTATE
  • CALCIUM GLUCONATE

Diet & Lifestyle Advise

  • Maintain a low salt diet and minimize eating processed foods as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
  • Do the regular exercise as it helps to lower blood pressure and keeps blood vessels and heart in good condition.
  • Quit smoking as smoking increases blood pressure and heart rate.
  • Eat balanced and healthy diet which includes plenty of vegetables, fruits, low fat or fat free products.

Habit Forming

No

Special Advise

  • Regular blood tests are advised while taking Zigoxin 0.25 mg Tablet 10's to monitor digoxin levels in the blood, potassium levels and kidney functioning.
  • Low salt diet and regular exercise are recommended along with Zigoxin 0.25 mg Tablet 10's for effective results.
  • Regular electrocardiogram (ECG) should be done to see the effect of Zigoxin 0.25 mg Tablet 10's on your heartbeat.

Author Details

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Disease/Condition Glossary

Heart failure: It is a chronic condition in which the heart is unable to pump blood as effectively as it should. Heart failure may occur due to certain conditions like high blood pressure, swelling or damage of heart muscle, faulty heart valves or narrow arteries in the heart. Symptoms of heart failure include shortness of breath, tiredness, fast heartbeat and swollen legs.

Arrhythmia (irregular heartbeat) is a condition in which your heart beats irregularly, too fast or too slow. Symptoms of irregular heartbeat include chest pain, shortness of breath, fast or slow heartbeat. 60 to 100 beats per minute is generally considered as normal heart rate.

Zigoxin 0.25 mg Tablet 10's Substitute

Substitutes safety advice
  • Lanoxin Tablet 10's

    1.31per tablet
  • Dixin 0.25 mg Tablet 10's

    1.31per tablet
  • Digoxin-0.25 Tablet 10's

    1.17per tablet
  • Digon 0.25 mg Tablet 10's

    1.26per tablet
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