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Written By Veda Maddala , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Composition :

DIGOXIN-0.25MG

Manufacturer/Marketer :

Johnlee Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Lidoxin 0.25mg Tablet

Lidoxin 0.25mg Tablet belongs to a group of medicines called cardiac glycosides used to treat irregular heartbeats and manage the symptoms of heart failure. Heart failure is a chronic condition in which the heart is unable to pump blood as effectively as it should. Irregular heartbeat is a condition in which your heart beats irregularly, too fast or too slow.

Lidoxin 0.25mg Tablet contains digoxin, i.e. cardiac glycosides that help to increase the output force of the heart and reduces the rate of heart contractions. Lidoxin 0.25mg Tablet works on the heart muscle directly and increases the force with which heart muscle contracts with each heartbeat. Thereby, it makes heart efficient in pumping blood around the body and slows down the rate at which heartbeats.

Take Lidoxin 0.25mg Tablet as prescribed. Your doctor will recommend you how often you take Lidoxin 0.25mg Tablet based on your medical condition. Some people may experience common side effects like diarrhoea, nausea, vomiting, dizziness, abnormal heartbeat or skin rash. Most of these side effects of Lidoxin 0.25mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

If you are known to be allergic to Lidoxin 0.25mg Tablet or any other medicines, please tell your doctor. Pregnant or breastfeeding women are advised to consult a doctor before taking the tablet. Regular blood tests are recommended by your doctor while taking Lidoxin 0.25mg Tablet to monitor the amount of Lidoxin 0.25mg Tablet in the bloodstream as its toxicity can lead to several forms of heart rhythm disturbances, vomiting, nausea and visual disturbances. If you have beriberi disease caused due to vitamin B1 deficiency, malabsorption syndrome (unable to absorb minerals from food) or any lung or kidney disease, please inform your doctor before taking Lidoxin 0.25mg Tablet so that the dose may be adjusted or an alternate medicine may be prescribed accordingly. Lidoxin 0.25mg Tablet has a very narrow therapeutic index. It means small differences in dose of drugs in the body may lead to life-threatening conditions or serious side effects. This makes its use limited and requires close monitoring by doctors like regular electrocardiogram (ECG). So, try not to self-medicate and suggest Lidoxin 0.25mg Tablet to others.

Uses of Lidoxin 0.25mg Tablet

Irregular heartbeats, Prevention of heart failure

Directions for Use

Tablet: Take it with or without food as advised by the doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.Paediatric solution: Shake the bottle well before use. Check the label for directions and give it with or without food in doses as prescribed by a doctor with the help of a dosing syringe.

Medicinal Benefits

Lidoxin 0.25mg Tablet is a cardiac glycoside that is used to treat heart failure and irregular heartbeats. Lidoxin 0.25mg Tablet increases the force with which heart muscle contracts with each heartbeat and makes heart efficient in pumping blood around the body. Thus, slows down the rate at which heartbeats and makes heart rate normal. Lidoxin 0.25mg Tablet improves heart failure symptoms such as exercise capacity and reduces the number of hospitalizations.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are known to be allergic to Lidoxin 0.25mg Tablet or any other medicines, please tell your doctor. Pregnant or breastfeeding women are advised to consult a doctor before taking the tablet. Avoid intake of alcohol with Lidoxin 0.25mg Tablet as it may increase the risk of drowsiness. Lidoxin 0.25mg Tablet may cause vision problems in some people. Make sure you are not affected before driving. Regular blood tests are recommended by your doctor while taking Lidoxin 0.25mg Tablet to monitor the amount of digoxin in blood as digoxin toxicity can lead to several forms of heart rhythm disturbances, vomiting, nausea and visual disturbances. If you have beriberi disease caused by vitamin B1 deficiency, malabsorption syndrome (unable to absorb minerals from food), thyroid, or any lung or kidney disease, please inform your doctor before taking Lidoxin 0.25mg Tablet so that the dose may be adjusted or an alternate medicine may be prescribed accordingly. Lidoxin 0.25mg Tablet has a narrow therapeutic index which makes its use limited and requires close monitoring as small change in dose or blood concentration may lead to severe adverse effects, and overdose may lead to life-threatening reactions.

Drug-Drug Interactions

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DigoxinAtazanavir
Severe
DigoxinCeritinib
Severe

Drug-Drug Interactions

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DigoxinAtazanavir
Severe
How does the drug interact with Lidoxin 0.25mg Tablet:
Coadministration of Lidoxin 0.25mg Tablet and Atazanavir may increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Lidoxin 0.25mg Tablet and Atazanavir, you can take these medicines together if prescribed by a doctor. However, if you develop fainting, lightheadedness, sudden dizziness, or irregular heartbeat, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DigoxinCeritinib
Severe
How does the drug interact with Lidoxin 0.25mg Tablet:
Co-administration of Lidoxin 0.25mg Tablet and Ceritinib may slow down the heart rate and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Lidoxin 0.25mg Tablet and ceritinib, it can be taken together if prescribed by a doctor. However, if you experience fainting, lightheadedness, sudden dizziness, or irregular heartbeat, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DigoxinBretylium tosilate
Severe
How does the drug interact with Lidoxin 0.25mg Tablet:
Co-administration of Lidoxin 0.25mg Tablet and Bretylium tosilate may increase the effect of Lidoxin 0.25mg Tablet.

How to manage the interaction:
Although taking Bretylium tosilate and Lidoxin 0.25mg Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you start feeling sick, throwing up, having seizures, feeling tired, or noticing your heart beating too fast or too slow, it's best to call a doctor right away. Do not discontinue any medications without consulting a doctor.
DigoxinAmiodarone
Severe
How does the drug interact with Lidoxin 0.25mg Tablet:
Co-administration of Amiodarone with Lidoxin 0.25mg Tablet can increase Lidoxin 0.25mg Tablet levels which can lead to severe side effects.

How to manage the interaction:
Taking Amiodarone with Lidoxin 0.25mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, visual disturbances, slow pulse, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
DigoxinLapatinib
Severe
How does the drug interact with Lidoxin 0.25mg Tablet:
Co-administration of Lidoxin 0.25mg Tablet and Lapatinib may increase the blood levels and effects of Lidoxin 0.25mg Tablet.

How to manage the interaction:
If you are supposed to take Lidoxin 0.25mg Tablet and Lapatinib together, a doctor may adjust the dose or monitor more frequently to safely use both medications. If you experience diarrhea, nausea, loss of appetite, vomiting, visual disturbances (blurred vision; light halos around objects; green or yellow vision), or an abnormally fast or slow or uneven heartbeat, contact a doctor as these may be signs and symptoms of excessive Lidoxin 0.25mg Tablet levels. Do not discontinue the medication without consulting a doctor.
DigoxinAdenosine
Severe
How does the drug interact with Lidoxin 0.25mg Tablet:
Co-administration of Adenosine with Lidoxin 0.25mg Tablet shows additive effects on the heart and may cause abnormal heart rhythms.

How to manage the interaction:
Taking Adenosine with Lidoxin 0.25mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as dizziness, difficulty in breathing, or chest pain. Do not discontinue any medications without consulting a doctor.
DigoxinSucralfate
Severe
How does the drug interact with Lidoxin 0.25mg Tablet:
Co-administration of Sucralfate together with Lidoxin 0.25mg Tablet may decrease the effects of Lidoxin 0.25mg Tablet.

How to manage the interaction:
If you are supposed to take Lidoxin 0.25mg Tablet and Sucralfate together, your doctor may adjust the dose to safely use both medications. Do not discontinue the medication without consulting a doctor.
DigoxinFingolimod
Severe
How does the drug interact with Lidoxin 0.25mg Tablet:
Co-administration of Fingolimod with Lidoxin 0.25mg Tablet may increase the risk or severity of slowing down of the heart rate.

How to manage the interaction:
Although there is a possible interaction between Lidoxin 0.25mg Tablet and Fingolimod, you can take these medicines together if prescribed by a doctor. It's important to monitor your heart rate and talk to a doctor about any alternative medications that don't interact. If you experience any symptoms like chest pain, shortness of breath, or fainting, it's important to call your doctor right away. Do not discontinue any medications without consulting a doctor.
DigoxinGlycopyrronium bromide
Severe
How does the drug interact with Lidoxin 0.25mg Tablet:
Co-administration of Lidoxin 0.25mg Tablet and Glycopyrronium bromide may increase the serum concentration of Lidoxin 0.25mg Tablet and increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Lidoxin 0.25mg Tablet and Glycopyrronium bromide, you can take these medicines together if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, confusion, loss of appetite, nausea, vomiting, diarrhea, change in vision such as blurry or yellow vision, fatigue, and fast or irregular heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DigoxinCalcium gluconate
Severe
How does the drug interact with Lidoxin 0.25mg Tablet:
Co-administration of Calcium gluconate with Lidoxin 0.25mg Tablet may affect heart rhythm.

How to manage the interaction:
Although there is an interaction, Calcium gluconate can be taken with Lidoxin 0.25mg Tablet if prescribed by the doctor. Consult the prescriber if you experience symptoms of irregular heartbeat, blurred vision, chest tightness, nausea, and seizures. Do not discontinue the medication without consulting a doctor.

Drug-Food Interactions

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DIGOXIN-0.25MGGrapefruit and Grapefruit Juice
Mild

Drug-Food Interactions

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DIGOXIN-0.25MGGrapefruit and Grapefruit Juice
Mild
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Lidoxin 0.25mg Tablet with Grapefruit and Grapefruit juice may increase the side effects of Lidoxin 0.25mg Tablet. Consuming Grapefruit and grapefruit juice should be avoided while taking Lidoxin 0.25mg Tablet.

Diet & Lifestyle Advise

  • Maintain a low salt diet and minimize eating processed foods as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
  • Do the regular exercise as it helps to lower blood pressure and keeps blood vessels and heart in good condition.
  • Quit smoking as smoking increases blood pressure and heart rate.
  • Eat balanced and healthy diet which includes plenty of vegetables, fruits, low fat or fat free products.

Habit Forming

No

Therapeutic Class

ANTIARRHYTHMICS

Lidoxin 0.25mg Tablet Substitute

Substitutes safety advice
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  • Digoxin-0.25 Tablet 10's

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    1.17per tablet
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    1.08per tablet

Author Details

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Drug-Diseases Interactions

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DIGOXIN-0.25MGOther conduction disorders
Severe
DIGOXIN-0.25MGAbnormalities of heart beat
Severe

Drug-Diseases Interactions

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DIGOXIN-0.25MGOther conduction disorders
Severe
How does the disease interact with Lidoxin 0.25mg Tablet:
In cases like the Wolff-Parkinson-White syndrome, Lidoxin 0.25mg Tablet may improve accessory route conduction.

How to manage the interaction:
Lidoxin 0.25mg Tablet should be used with caution in patients with Wolff-Parkinson-White syndrome (a heart condition that causes rapid heartbeat).
DIGOXIN-0.25MGAbnormalities of heart beat
Severe
How does the disease interact with Lidoxin 0.25mg Tablet:
Lidoxin 0.25mg Tablet prolongs the PR interval by slowing sinoatrial and AV conduction. Lidoxin 0.25mg Tablet therapy can cause severe sinus bradycardia or sinoatrial block in people with preexisting sinus node dysfunction, and it can cause progressive or full heart block in patients with incomplete AV block.

How to manage the interaction:
Lidoxin 0.25mg Tablet may be administered to patients with complete, stable AV block (an electrical signal that controls your heartbeat is partially or completely blocked) who have congestive heart failure, provided the block was not induced by cardiac glycosides.
DIGOXIN-0.25MGDisorders of mineral metabolism
Severe
How does the disease interact with Lidoxin 0.25mg Tablet:
Lidoxin 0.25mg Tablet and calcium have cumulative effects on inotropy. As a result, Lidoxin 0.25mg Tablet toxicity and dangerous arrhythmias are predisposed in patients with hypercalcemia from any source.

How to manage the interaction:
Hypercalcemia (too much calcium in the blood) should be corrected before starting treatment with Lidoxin 0.25mg Tablet, and serum calcium levels should be monitored during therapy.
DIGOXIN-0.25MGDisorders of mineral metabolism
Severe
How does the disease interact with Lidoxin 0.25mg Tablet:
Lidoxin 0.25mg Tablet and calcium have cumulative effects on inotropy. As a result, Lidoxin 0.25mg Tablet toxicity and dangerous arrhythmias are predisposed in patients with hypercalcemia from any source.

How to manage the interaction:
Hypercalcemia (too much calcium in the blood) should be corrected before starting treatment with Lidoxin 0.25mg Tablet, and serum calcium levels should be monitored during therapy.
DIGOXIN-0.25MGOther disorders of fluid, electrolyte and acid-base balance
Severe
How does the disease interact with Lidoxin 0.25mg Tablet:
Lidoxin 0.25mg Tablet makes the myocardium more sensitive when potassium and/or magnesium are depleted. Despite Lidoxin 0.25mg Tablet serum drug concentrations, Lidoxin 0.25mg Tablet toxicity may happen in patients with hypokalemia or hypomagnesemia.

How to manage the interaction:
Lidoxin 0.25mg Tablet should be used with caution in patients with or who are at risk of developing potassium and/or magnesium deficiency, including patients on diuretic therapy; those with primary or secondary aldosteronism (may have low potassium levels), severe or prolonged diarrhoea or vomiting, malnutrition; and renal dialysis patients. Electrolyte imbalances may be corrected before starting the treatment.
DIGOXIN-0.25MGThyrotoxicosis [hyperthyroidism]
Moderate
How does the disease interact with Lidoxin 0.25mg Tablet:
Treatment of the underlying illness is the best way to control heart failure and/or atrial arrhythmias brought on by hypermetabolic or hyperdynamic conditions such hyperthyroidism, hypoxia, or arteriovenous shunt.

How to manage the interaction:
Lidoxin 0.25mg Tablet should be used with caution in patients with hyperthyroidism. Your doctor may adjust the dose secondary to changes in the thyroid condition.

FAQs

It may take several weeks for Lidoxin 0.25mg Tablet to show its effect. You are recommended to continue taking Lidoxin 0.25mg Tablet for as long as your doctor prescribes it and do not stop taking Lidoxin 0.25mg Tablet suddenly as it may worsen your heart problems. However, if you experience any difficulty while taking Lidoxin 0.25mg Tablet, please consult your doctor.

Yes, Lidoxin 0.25mg Tablet may cause diarrhoea as a side effect. However, it is not necessary for everyone taking Lidoxin 0.25mg Tablet to experience this side effect. You are recommended to drink plenty of fluids to avoid dehydration. Signs of dehydration include decreased urination or dark, strong-smelling urine. Also, do not take any other medicines to treat diarrhoea without consulting your doctor. If the condition persists or worsen, please consult your doctor.

Yes, Lidoxin 0.25mg Tablet may cause yellow or blurred vision in some people. Therefore, be cautious before driving or using machinery.

No, you can eat normally. However, a balanced and healthy diet are advised for effective results.

You are not recommended to take more than the prescribed dose of Lidoxin 0.25mg Tablet as it may cause Lidoxin 0.25mg Tablet toxicity resulting in symptoms such as vomiting, nausea, loss of appetite, tiredness, dizziness or visual disturbances (more than usual yellow-green). However, if you experience any of these symptoms while taking Lidoxin 0.25mg Tablet, please consult a doctor immediately.

No, you are not recommended to take amiodarone with Lidoxin 0.25mg Tablet as co-administration of these two medicines may increase the levels of Lidoxin 0.25mg Tablet in the blood resulting in Lidoxin 0.25mg Tablet toxicity. However, please consult a doctor before taking other medicines with Lidoxin 0.25mg Tablet so that the dose may be adjusted appropriately.

You are recommended to avoid taking Lidoxin 0.25mg Tablet if you have severe heart problems, have a history of Stokes-Adams attacks (abrupt, short-lived unconsciousness caused by a sudden change in a heartbeat), obstructive cardiomyopathy (enlargement of the heart muscle) and Wolff-Parkinson-White syndrome (extra electrical pathway causes fast heartbeat).

Drug-Drug Interactions Checker List

  • AMIODARONE
  • QUINIDINE
  • ATAZANAVIR
  • SAQUINAVIR
  • CLARITHROMYCIN
  • ITRACONAZOLE
  • ADENOSINE
  • DOLASETRON
  • ARBUTAMINE
  • CERITINIB
  • LAPATINIB
  • FINGOLIMOD
  • FLIBANSERIN
  • CALCIUM CHLORIDE
  • CALCIUM GLUCEPTATE
  • CALCIUM GLUCONATE

Special Advise

  • Regular blood tests are advised while taking Lidoxin 0.25mg Tablet to monitor digoxin levels in the blood, potassium levels and kidney functioning.
  • Low salt diet and regular exercise are recommended along with Lidoxin 0.25mg Tablet for effective results.
  • Regular electrocardiogram (ECG) should be done to see the effect of Lidoxin 0.25mg Tablet on your heartbeat.

Disease/Condition Glossary

Heart failure: It is a chronic condition in which the heart is unable to pump blood as effectively as it should. Heart failure may occur due to certain conditions like high blood pressure, swelling or damage of heart muscle, faulty heart valves or narrow arteries in the heart. Symptoms of heart failure include shortness of breath, tiredness, fast heartbeat and swollen legs.

Arrhythmia (irregular heartbeat) is a condition in which your heart beats irregularly, too fast or too slow. Symptoms of irregular heartbeat include chest pain, shortness of breath, fast or slow heartbeat. 60 to 100 beats per minute is generally considered as normal heart rate.

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