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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition

LEFLUNOMIDE-20MG

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About DMLEF 20MG TABLET

DMLEF 20MG TABLET belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

DMLEF 20MG TABLET contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take DMLEF 20MG TABLET at the same time every day as prescribed by your doctor. In some cases, DMLEF 20MG TABLET may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take DMLEF 20MG TABLET if you are pregnant or planning for pregnancy as DMLEF 20MG TABLET may cause serious congenital disabilities. DMLEF 20MG TABLET should not be taken by breastfeeding mothers as it passes into breast milk. DMLEF 20MG TABLET may cause dizziness, so drive with caution. Avoid consuming alcohol along with DMLEF 20MG TABLET as it could lead to increased dizziness and liver damage. DMLEF 20MG TABLET may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of DMLEF 20MG TABLET

Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take DMLEF 20MG TABLET with or without food. Swallow DMLEF 20MG TABLET as a whole with water; do not crush or chew it.

Medicinal Benefits

DMLEF 20MG TABLET belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. DMLEF 20MG TABLET is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of DMLEF 20MG TABLET

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Drug Warnings

Do not take DMLEF 20MG TABLET if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. DMLEF 20MG TABLET is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking DMLEF 20MG TABLET if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. DMLEF 20MG TABLET may cause dizziness, so drive with caution. DMLEF 20MG TABLET may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomidePrednisolone
Severe
LeflunomideAuranofin
Severe

Drug-Drug Interactions

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LeflunomidePrednisolone
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Co-administration of DM Lef 20 mg Tablet with Prednisolone may raise the risk of serious infection.

How to manage the interaction:
Although taking DM Lef 20 mg Tablet and Prednisolone together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in the coughing fluid, weight loss, red or irritated skin, body sores, or discomfort or burning when urinating, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideAuranofin
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Coadministration of DM Lef 20 mg Tablet and auranofin may raise the risk of side effects such as bleeding problems and infections.

How to manage the interaction:
Although there is an interaction between auranofin with DM Lef 20 mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideAfatinib
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking DM Lef 20 mg Tablet with afatinib can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between DM Lef 20 mg Tablet and afatinib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomidePomalidomide
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Combining Pomalidomide with DM Lef 20 mg Tablet can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between DM Lef 20 mg Tablet and Pomalidomide, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
LeflunomideIndometacin
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking DM Lef 20 mg Tablet together with indomethacin may raise the risk of liver damage.

How to manage the interaction:
Although there is an interaction, indomethacin can be taken with DM Lef 20 mg Tablet, if prescribed by the doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult a doctor.
LeflunomideAzacitidine
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking azacitidine and DM Lef 20 mg Tablet together may increase the chances of developing severe infections.

How to manage the interaction:
Although there is an interaction between DM Lef 20 mg Tablet and azacitidine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideTizanidine
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Coadministration of tizanidine and DM Lef 20 mg Tablet can increase the risk of liver problems.

How to manage the interaction:
Taking Tizanidine and DM Lef 20 mg Tablet together can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomidePropylthiouracil
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Taking propylthiouracil with DM Lef 20 mg Tablet can increase the risk of liver problems.

How to manage the interaction:
Co-administration of DM Lef 20 mg Tablet with Propylthiouracil can possibly result in an interaction, but they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain, unusual bleeding, itching, fatigue, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideKetoconazole
Severe
How does the drug interact with DM Lef 20 mg Tablet:
Coadministration of Ketoconazole and DM Lef 20 mg Tablet may cause liver injury.

How to manage the interaction:
Although taking Ketoconazole and DM Lef 20 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
LeflunomideEverolimus
Severe
How does the drug interact with DM Lef 20 mg Tablet:
When everolimus is used with DM Lef 20 mg Tablet, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking DM Lef 20 mg Tablet and Everolimus together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

DMLEF 20MG TABLET Substitute

Substitutes safety advice
  • Lefno-20 Tablet 10's

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    26.42per tablet
  • Lefra 20 Tablet 10's

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    26.37per tablet
  • Rumalef 20 Tablet 30's

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    17.90per tablet
  • Cleft 20 Tablet 10's

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    21.83per tablet
  • Lefumide-20 Tablet 10's

    by Others

    24.03per tablet

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Special Advise

Regular blood tests to monitor your liver function after starting DMLEF 20MG TABLET, and for every 6-8 weeks are advised.

Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (where the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty in moving and swelling. Patients with rheumatoid arthritis have intense joint pain (especially knee joint) with stiffness. 

Psoriatic arthritis: Psoriatic arthritis is an autoimmune disease characterized by inflammation of the skin (psoriasis) and joints (inflammatory arthritis). It mainly affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

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