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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

Online payment accepted

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Whats That

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Composition

LEFLUNOMIDE-20MG

Manufacturer/Marketer

Ipca Laboratories Ltd

Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Apr-24

for this medicine

About Lefno-20 Tablet 10's

Lefno-20 Tablet 10's belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Lefno-20 Tablet 10's contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Lefno-20 Tablet 10's at the same time every day as prescribed by your doctor. In some cases, Lefno-20 Tablet 10's may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Lefno-20 Tablet 10's if you are pregnant or planning for pregnancy as Lefno-20 Tablet 10's may cause serious congenital disabilities. Lefno-20 Tablet 10's should not be taken by breastfeeding mothers as it passes into breast milk. Lefno-20 Tablet 10's may cause dizziness, so drive with caution. Avoid consuming alcohol along with Lefno-20 Tablet 10's as it could lead to increased dizziness and liver damage. Lefno-20 Tablet 10's may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Lefno-20 Tablet 10's

Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Lefno-20 Tablet 10's with or without food. Swallow Lefno-20 Tablet 10's as a whole with water; do not crush or chew it.

Medicinal Benefits

Lefno-20 Tablet 10's belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Lefno-20 Tablet 10's is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Lefno-20 Tablet 10's

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Drug Warnings

Do not take Lefno-20 Tablet 10's if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Lefno-20 Tablet 10's is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Lefno-20 Tablet 10's if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Lefno-20 Tablet 10's may cause dizziness, so drive with caution. Lefno-20 Tablet 10's may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomidePrednisolone
Severe
LeflunomideAuranofin
Severe

Drug-Drug Interactions

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LeflunomidePrednisolone
Severe
How does the drug interact with Lefno-20 Tablet:
Co-administration of Lefno-20 Tablet with Prednisolone may raise the risk of serious infection.

How to manage the interaction:
Although taking Lefno-20 Tablet and Prednisolone together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in the coughing fluid, weight loss, red or irritated skin, body sores, or discomfort or burning when urinating, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideAuranofin
Severe
How does the drug interact with Lefno-20 Tablet:
Coadministration of Lefno-20 Tablet and auranofin may raise the risk of side effects such as bleeding problems and infections.

How to manage the interaction:
Although there is an interaction between auranofin with Lefno-20 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideAfatinib
Severe
How does the drug interact with Lefno-20 Tablet:
Taking Lefno-20 Tablet with afatinib can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Lefno-20 Tablet and afatinib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomidePomalidomide
Severe
How does the drug interact with Lefno-20 Tablet:
Combining Pomalidomide with Lefno-20 Tablet can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Lefno-20 Tablet and Pomalidomide, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
LeflunomideIndometacin
Severe
How does the drug interact with Lefno-20 Tablet:
Taking Lefno-20 Tablet together with indomethacin may raise the risk of liver damage.

How to manage the interaction:
Although there is an interaction, indomethacin can be taken with Lefno-20 Tablet, if prescribed by the doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult a doctor.
LeflunomideAzacitidine
Severe
How does the drug interact with Lefno-20 Tablet:
Taking azacitidine and Lefno-20 Tablet together may increase the chances of developing severe infections.

How to manage the interaction:
Although there is an interaction between Lefno-20 Tablet and azacitidine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideTizanidine
Severe
How does the drug interact with Lefno-20 Tablet:
Coadministration of tizanidine and Lefno-20 Tablet can increase the risk of liver problems.

How to manage the interaction:
Taking Tizanidine and Lefno-20 Tablet together can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomidePropylthiouracil
Severe
How does the drug interact with Lefno-20 Tablet:
Taking propylthiouracil with Lefno-20 Tablet can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lefno-20 Tablet with Propylthiouracil can possibly result in an interaction, but they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain, unusual bleeding, itching, fatigue, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideKetoconazole
Severe
How does the drug interact with Lefno-20 Tablet:
Coadministration of Ketoconazole and Lefno-20 Tablet may cause liver injury.

How to manage the interaction:
Although taking Ketoconazole and Lefno-20 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
LeflunomideEverolimus
Severe
How does the drug interact with Lefno-20 Tablet:
When everolimus is used with Lefno-20 Tablet, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Lefno-20 Tablet and Everolimus together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Lefno-20 Tablet 10's Substitute

Substitutes safety advice
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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Special Advise

Regular blood tests to monitor your liver function after starting Lefno-20 Tablet 10's, and for every 6-8 weeks are advised.

Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (where the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty in moving and swelling. Patients with rheumatoid arthritis have intense joint pain (especially knee joint) with stiffness. 

Psoriatic arthritis: Psoriatic arthritis is an autoimmune disease characterized by inflammation of the skin (psoriasis) and joints (inflammatory arthritis). It mainly affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

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