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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS

About LEFUMA 20MG TABLET

LEFUMA 20MG TABLET belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

LEFUMA 20MG TABLET contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take LEFUMA 20MG TABLET at the same time every day as prescribed by your doctor. In some cases, LEFUMA 20MG TABLET may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take LEFUMA 20MG TABLET if you are pregnant or planning for pregnancy as LEFUMA 20MG TABLET may cause serious congenital disabilities. LEFUMA 20MG TABLET should not be taken by breastfeeding mothers as it passes into breast milk. LEFUMA 20MG TABLET may cause dizziness, so drive with caution. Avoid consuming alcohol along with LEFUMA 20MG TABLET as it could lead to increased dizziness and liver damage. LEFUMA 20MG TABLET may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

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Whats That

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Non returnable*
COD available

Online payment accepted

Composition

LEFLUNOMIDE-20MG

Manufacturer/Marketer

Wallace Pharmaceutcals Ltd

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of LEFUMA 20MG TABLET

Rheumatoid arthritis, Psoriatic arthritis

Medicinal Benefits

LEFUMA 20MG TABLET belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. LEFUMA 20MG TABLET is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Side Effects of LEFUMA 20MG TABLET

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Directions for Use

Take LEFUMA 20MG TABLET with or without food. Swallow LEFUMA 20MG TABLET as a whole with water; do not crush or chew it.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take LEFUMA 20MG TABLET if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. LEFUMA 20MG TABLET is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking LEFUMA 20MG TABLET if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. LEFUMA 20MG TABLET may cause dizziness, so drive with caution. LEFUMA 20MG TABLET may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Therapeutic Class

ANTIRHEUMATICS

Drug-Drug Interactions

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LeflunomideFludrocortisone
Severe
LeflunomideNaltrexone
Severe

Drug-Drug Interactions

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LeflunomideFludrocortisone
Severe
How does the drug interact with Lefuma 20 mg Tablet 10's:
Taking Fludrocortisone with Lefuma 20 mg Tablet 10's can increase the risk of side effects.

How to manage the interaction:
Co-administration of Lefuma 20 mg Tablet 10's with Fludrocortisone can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you notice infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination - contact your doctor immediately. Do not stop using any medications without a doctor's advice.
LeflunomideNaltrexone
Severe
How does the drug interact with Lefuma 20 mg Tablet 10's:
Taking Lefuma 20 mg Tablet 10's and Naltrexone can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Lefuma 20 mg Tablet 10's and Naltrexone, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideBupropion
Severe
How does the drug interact with Lefuma 20 mg Tablet 10's:
Lefuma 20 mg Tablet 10's can cause liver issues, and combining it with bupropion, can enhance the risk.

How to manage the interaction:
Co-administration of bupropion along with Lefuma 20 mg Tablet 10's can lead to interaction, it can be taken if recommended by a doctor. If you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, or yellowing of the skin or eyes, contact the doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideIdarubicin
Severe
How does the drug interact with Lefuma 20 mg Tablet 10's:
Taking Idarubicin and Lefuma 20 mg Tablet 10's can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Idarubicin can be taken with Lefuma 20 mg Tablet 10's, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
LeflunomideKetoconazole
Severe
How does the drug interact with Lefuma 20 mg Tablet 10's:
Coadministration of Ketoconazole and Lefuma 20 mg Tablet 10's may cause liver injury.

How to manage the interaction:
Although taking Ketoconazole and Lefuma 20 mg Tablet 10's together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
LeflunomideOlaparib
Severe
How does the drug interact with Lefuma 20 mg Tablet 10's:
Taking Lefuma 20 mg Tablet 10's with olaparib may increase the risk of infections.

How to manage the interaction:
Although there is an interaction between Lefuma 20 mg Tablet 10's and olaparib, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideMeloxicam
Severe
How does the drug interact with Lefuma 20 mg Tablet 10's:
When Meloxicam and Lefuma 20 mg Tablet 10's are taken together, can increase the risk of liver damage.

How to manage the interaction:
There may be a possibility of interaction between Lefuma 20 mg Tablet 10's and Meloxicam, but it can be taken if prescribed by a doctor. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
LeflunomideDanazol
Severe
How does the drug interact with Lefuma 20 mg Tablet 10's:
Combining Lefuma 20 mg Tablet 10's with Danazol may increase the risk of liver problems.

How to manage the interaction:
Although taking Danazol and Lefuma 20 mg Tablet 10's together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-coloured urine, liver damage, or bleeding - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideFlurbiprofen
Severe
How does the drug interact with Lefuma 20 mg Tablet 10's:
Using Flurbiprofen with Lefuma 20 mg Tablet 10's can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Flurbiprofen and Lefuma 20 mg Tablet 10's, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact your doctor right away: liver problems, liver disease, unusual liver enzyme levels, fever, chills, joint discomfort, swelling, bruises, skin irritation, itching, loss of appetite, tiredness, feeling sick, throwing up, dark urine, or bleeding. Do not discontinue any medications without first consulting your doctor.
LeflunomideIbrutinib
Severe
How does the drug interact with Lefuma 20 mg Tablet 10's:
Co-administration of Ibrutinib and Lefuma 20 mg Tablet 10's can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Ibrutinib can be taken with Lefuma 20 mg Tablet 10's, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Special Advise

Regular blood tests to monitor your liver function after starting LEFUMA 20MG TABLET, and for every 6-8 weeks are advised.

Author Details

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Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (where the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty in moving and swelling. Patients with rheumatoid arthritis have intense joint pain (especially knee joint) with stiffness. 

Psoriatic arthritis: Psoriatic arthritis is an autoimmune disease characterized by inflammation of the skin (psoriasis) and joints (inflammatory arthritis). It mainly affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

LEFUMA 20MG TABLET Substitute

Substitutes safety advice
  • Lefno-20 Tablet 10's

    26.42per tablet
  • Lefra 20 Tablet 10's

    26.37per tablet
  • Rumalef 20 Tablet 30's

    17.90per tablet
  • Cleft 20 Tablet 10's

    21.83per tablet
  • Lefumide-20 Tablet 10's

    24.03per tablet
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