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Reviewed By Sunny S , MBBS
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Composition :

MIFEPRISTONE-25MG

Manufacturer/Marketer :

Koye Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Goefibro-M 25 Tablet

Goefibro-M 25 Tablet belongs to the class of medication called 'progestin antagonist' used in combination with Misoprostol to induce a medical abortion. Goefibro-M 25 Tablet is primarily used to end an early pregnancy (lasting up to 70 days or less than this) or an unwanted pregnancy with medication help.

Goefibro-M 25 Tablet contains Mifepristone, which works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for Goefibro-M 25 Tablet to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete.

Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (which may last up to 30 days), fever, and digestive system discomfort. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised.

Goefibro-M 25 Tablet should be taken in dose and duration as advised by the doctor, preferably with food. It would be best to take it at a fixed time every day. It is a tablet and should be taken orally with a glass of water. In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of Goefibro-M 25 Tablet subside with time. But if your vaginal bleeding does not, please visit the doctor immediately, and it requires immediate medical attention.

Goefibro-M 25 Tablet should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting Goefibro-M 25 Tablet if you have or ever had an ectopic pregnancy (when the fetus grows in the fallopian tube), using an intrauterine device, or if you are breastfeeding, any bleeding disorder or heart problem. Do not do strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.

Uses of Goefibro-M 25 Tablet

Medical abortion

Directions for Use

Goefibro-M 25 Tablet should be taken in dose and duration as prescribed by your doctor. Do not chew or crush it; swallow it as a whole.

Medicinal Benefits

Goefibro-M 25 Tablet contains Mifepristone, which is taken in a regimen with Misoprostol to induce medical abortion or terminate a pregnancy before 70 days. It works by blocking the effect of progesterone (female hormone) needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for Goefibro-M 25 Tablet to show effect.

Storage

Store in a cool and dry place away from sunlight
Side effects of Goefibro-M 25 Tablet
  • Your doctor may reduce your medication dose gradually if you have too much cortisol, while still managing your condition.
  • Try hot baths, massages, and gentle exercises like water aerobics or tai chi to ease aches and pains.
  • Limit sodium and fatty foods to reduce health risks.
  • Consume foods rich in calcium, like dairy, leafy greens, fortified plant milk, and salmon, to support bone health.
  • Include sources of vitamin D in your meals, such as cod liver oil, egg yolks, fortified milk, and fatty fish like swordfish and salmon.
  • Make time for things you enjoy and set limits to avoid getting too tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.

Drug Warnings

Women who have an ectopic pregnancy (a pregnancy outside of the uterus, problems with the adrenal glands (the glands near the kidneys), currently taking corticosteroid therapy (medications), have an allergic reaction to mifepristone, misoprostol or similar drugs, have bleeding problems or taking the blood-thinning drug (warfarin, clopidogrel, aspirin, heparin etc.) should not use Goefibro-M 25 Tablet and contact doctor. After using Goefibro-M 25 Tablet if you start feeling sleepy, do not drive or operate heavy machinery. If you use an intrauterine device (IUD), please remove it before taking the Goefibro-M 25 Tablet . Regular follow-up with the doctor is required for constant monitoring of abortion. If medical termination does not happen or becomes unsuccessful, it should be terminated surgically as it can lead to foetal defects. Your doctor will examine by performing ultrasonography to confirm if the abortion is complete. St John’s Wort (herbal supplements to treat mild depression) and grapefruit juice should not be taken when taking Goefibro-M 25 Tablet as it is known to interact. 

Drug-Drug Interactions

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MifepristoneProtamine
Critical
MifepristoneErgotamine
Critical

Drug-Drug Interactions

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MifepristoneProtamine
Critical
How does the drug interact with Goefibro-M 25 Tablet:
Taking Protamine and Goefibro-M 25 Tablet increases the risk of bleeding in post-abortion patients.

How to manage the interaction:
Taking protamine with Goefibro-M 25 Tablet together results in an interaction, but they can be taken together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
MifepristoneErgotamine
Critical
How does the drug interact with Goefibro-M 25 Tablet:
When Goefibro-M 25 Tablet is taken with Ergotamine, it may increase the blood levels of Ergotamine, which may result in side effects.

How to manage the interaction:
Taking Ergotamine with Goefibro-M 25 Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
MifepristonePrednisolone
Critical
How does the drug interact with Goefibro-M 25 Tablet:
When Goefibro-M 25 Tablet is taken with Prednisolone, the effects of Prednisolone might be considerably reduced, which may be less effective in treating your condition.

How to manage the interaction:
Taking Prednisolone with Goefibro-M 25 Tablet is not recommended, they can be taken together if advised by a doctor. Do not discontinue the medication without consulting a doctor.
MifepristoneFluticasone
Critical
How does the drug interact with Goefibro-M 25 Tablet:
Co-administration of Fluticasone with Goefibro-M 25 Tablet may make Fluticasone less effective as a therapy.

How to manage the interaction:
Taking Fluticasone with Goefibro-M 25 Tablet is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
MifepristoneSimvastatin
Critical
How does the drug interact with Goefibro-M 25 Tablet:
Combining Goefibro-M 25 Tablet with Simvastatin can increase the blood levels of simvastatin, which may increase the risk of side effects.

How to manage the interaction:
Taking Simvastatin with Goefibro-M 25 Tablet is not recommended, but can be taken if prescribed by the doctor. If you experience any symptoms, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
MifepristoneDabigatran etexilate
Critical
How does the drug interact with Goefibro-M 25 Tablet:
When Goefibro-M 25 Tablet is taken with Dabigatran etexilate, it may increase the risk of severe vaginal bleeding in women.

How to manage the interaction:
Taking Goefibro-M 25 Tablet with Dabigatran etexilate is not recommended, but it can be taken if prescribed by the doctor. However, if you experience heavy, persistent vaginal bleeding, consult the door. Do not stop using any medications without talking to a doctor.
MifepristoneLovastatin
Critical
How does the drug interact with Goefibro-M 25 Tablet:
When Goefibro-M 25 Tablet is taken with Lovastatin, it can increase the risk of side effects including rhabdomyolysis (a condition that causes your muscles to break down (disintegrate), which leads to muscle death).

How to manage the interaction:
Taking Lovastatin with Goefibro-M 25 Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
MifepristoneEnoxaparin
Critical
How does the drug interact with Goefibro-M 25 Tablet:
Combining Goefibro-M 25 Tablet with Enoxaparin can increase the risk or severity of side effects of vaginal bleeding.

How to manage the interaction:
Taking Enoxaparin with Goefibro-M 25 Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience prolonged, excessive bleeding, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
MifepristoneFentanyl
Critical
How does the drug interact with Goefibro-M 25 Tablet:
Taking fentanyl and Goefibro-M 25 Tablet may significantly increase the blood levels of fentanyl, which may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Goefibro-M 25 Tablet and fentanyl, they can be taken together if advised by a doctor. Do not stop using any medications without talking to your doctor.
MifepristoneMometasone
Critical
How does the drug interact with Goefibro-M 25 Tablet:
Co-administration of Mometasone with Goefibro-M 25 Tablet may make Mometasone less effective as a therapy.

How to manage the interaction:
Taking Mometasone with Goefibro-M 25 Tablet is generally avoided as it can result in an interaction, it can be taken only when a doctor has advised it. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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MIFEPRISTONE-25MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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MIFEPRISTONE-25MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice may increase the effects of Goefibro-M 25 Tablet. Avoid consumption of grape juice while taking Goefibro-M 25 Tablet. However, if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, swelling, and high blood pressure, consult the doctor.

Diet & Lifestyle Advise

  • Keep your weight under control with a body mass index (BMI) of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.
  • Avoid chronic stress and physical exercise like running, as it might increase vaginal bleeding.
  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • Get an ultrasound to check if the abortion is done completely to avoid unwanted complications.
  • Try to include heart-healthy omega-3 fatty acid-containing foods or drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTIPROGESTERONE

Goefibro-M 25 Tablet Substitute

Substitutes safety advice
  • Fibroease 25mg Tablet 10's

    by AYUR

    68.85per tablet
  • Fibristone 25 Tablet 10's

    by AYUR

    59.27per tablet
  • Fibromif-25mg Tablet 10's

    by AYUR

    37.89per tablet
  • FIBROCEDE-25MG TABLETS 10'S

    by AYUR

    41.76per tablet
  • Fibrobest-M 25 mg Tablet 10's

    by Others

    58.50per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

No, Goefibro-M 25 Tablet should be taken in the dose and duration as advised by the doctor. Taking it in more than the recommended dose might cause unpleasant side effects like excessive uterine bleeding.

No, the Goefibro-M 25 Tablet is not known to affect any future chances of fertility. Goefibro-M 25 Tablet is used for medical abortion.

If you miss a dose of Goefibro-M 25 Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

After taking Goefibro-M 25 Tablet , you may or may not experience vaginal bleeding, which does not indicate complete abortion. Your doctor will examine with the performing ultrasonography to confirm if the abortion is complete.

No, the Goefibro-M 25 Tablet does not affect fertility. Use contraception during sexual intercourse as it may lead to unwanted pregnancy if you are not planning it.

Some of the common side effects of Goefibro-M 25 Tablet are nausea, weakness, fever/chills, vomiting, headache, diarrhoea, and dizziness.

Drug-Drug Interactions Checker List

  • DEXAMETHASONE
  • KETOCONAZOLE
  • ITRACONAZOLE
  • ERYTHROMYCIN
  • RIFAMPICIN
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE
  • CYCLOSPORINE
  • TACROLIMUS
  • SIROLIMUS
  • ERGOTAMINE

Special Advise

  • Goefibro-M 25 Tablet should not be used to end the pregnancy after ten weeks.
  • Contact your doctor immediately if you experience heavy vaginal bleeding after taking this medicine.

Disease/Condition Glossary

Medical abortion: It is a procedure in which medicine is used to end a pregnancy. It is effectively causing abortion if performed in the first 70 days of pregnancy. Vagina bleeding occurs, and if it does not stop, please inform your doctor as it might require medical supervision. Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (which may last up to 30 days), fever, and digestive system discomfort. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised. 

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