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Reviewed By Sunny S , MBBS
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Composition :

MIFEPRISTONE-25MG

Manufacturer/Marketer :

TTK Healthcare Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Mifiact 25 mg Tablet

Mifiact 25 mg Tablet belongs to the class of medication called 'progestin antagonist' used in combination with Misoprostol to induce a medical abortion. Mifiact 25 mg Tablet is primarily used to end an early pregnancy (lasting up to 70 days or less than this) or an unwanted pregnancy with medication help.

Mifiact 25 mg Tablet contains Mifepristone, which works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for Mifiact 25 mg Tablet to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete.

Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (which may last up to 30 days), fever, and digestive system discomfort. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised.

Mifiact 25 mg Tablet should be taken in dose and duration as advised by the doctor, preferably with food. It would be best to take it at a fixed time every day. It is a tablet and should be taken orally with a glass of water. In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of Mifiact 25 mg Tablet subside with time. But if your vaginal bleeding does not, please visit the doctor immediately, and it requires immediate medical attention.

Mifiact 25 mg Tablet should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting Mifiact 25 mg Tablet if you have or ever had an ectopic pregnancy (when the fetus grows in the fallopian tube), using an intrauterine device, or if you are breastfeeding, any bleeding disorder or heart problem. Do not do strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.

Uses of Mifiact 25 mg Tablet

Medical abortion

Directions for Use

Mifiact 25 mg Tablet should be taken in dose and duration as prescribed by your doctor. Do not chew or crush it; swallow it as a whole.

Medicinal Benefits

Mifiact 25 mg Tablet contains Mifepristone, which is taken in a regimen with Misoprostol to induce medical abortion or terminate a pregnancy before 70 days. It works by blocking the effect of progesterone (female hormone) needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for Mifiact 25 mg Tablet to show effect.

Storage

Store in a cool and dry place away from sunlight

Side Effects of Mifiact 25 mg Tablet

  • Weakness
  • Nausea
  • Uterine cramps
  • Vomiting
  • Diarrhoea
  • Dizziness
  • Infection following abortion
  • Uterine bleeding

Drug Warnings

Women who have an ectopic pregnancy (a pregnancy outside of the uterus, problems with the adrenal glands (the glands near the kidneys), currently taking corticosteroid therapy (medications), have an allergic reaction to mifepristone, misoprostol or similar drugs, have bleeding problems or taking the blood-thinning drug (warfarin, clopidogrel, aspirin, heparin etc.) should not use Mifiact 25 mg Tablet and contact doctor. After using Mifiact 25 mg Tablet if you start feeling sleepy, do not drive or operate heavy machinery. If you use an intrauterine device (IUD), please remove it before taking the Mifiact 25 mg Tablet . Regular follow-up with the doctor is required for constant monitoring of abortion. If medical termination does not happen or becomes unsuccessful, it should be terminated surgically as it can lead to foetal defects. Your doctor will examine by performing ultrasonography to confirm if the abortion is complete. St John’s Wort (herbal supplements to treat mild depression) and grapefruit juice should not be taken when taking Mifiact 25 mg Tablet as it is known to interact. 

Drug-Drug Interactions

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MifepristoneConivaptan
Critical
MifepristoneLovastatin
Critical

Drug-Drug Interactions

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MifepristoneConivaptan
Critical
How does the drug interact with Mifiact 25 mg Tablet:
When Mifiact 25 mg Tablet is taken with Conivaptan, it may increase the risk of negative side effects.

How to manage the interaction:
Taking Mifiact 25 mg Tablet with Conivaptan is not recommended as it leads to an interaction, but it can be taken if prescribed by the doctor. However, if you experience symptoms such as seizures(fits), difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
MifepristoneLovastatin
Critical
How does the drug interact with Mifiact 25 mg Tablet:
When Mifiact 25 mg Tablet is taken with Lovastatin, it can increase the risk of side effects including rhabdomyolysis (a condition that causes your muscles to break down (disintegrate), which leads to muscle death).

How to manage the interaction:
Taking Lovastatin with Mifiact 25 mg Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
MifepristoneDefibrotide
Critical
How does the drug interact with Mifiact 25 mg Tablet:
Co-administration of Mifiact 25 mg Tablet with Defibrotide can increase the risk and severity of vaginal bleeding in women.

How to manage the interaction:
Taking Mifiact 25 mg Tablet with Defibrotide is not recommended, but it can be taken if prescribed by the doctor. However, if you experience excessive, prolonged vaginal bleeding, consult the doctor. Do not stop using any medications without talking to a doctor.
MifepristoneRanolazine
Critical
How does the drug interact with Mifiact 25 mg Tablet:
When Mifiact 25 mg Tablet is taken with Ranolazine, may cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Phenylbutazone with Ranolazine can lead to an interaction. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
MifepristoneApixaban
Critical
How does the drug interact with Mifiact 25 mg Tablet:
Mifiact 25 mg Tablet and Apixaban co-administration have been associated with more severe vaginal bleeding in women.

How to manage the interaction:
Taking Apixaban with Mifiact 25 mg Tablet together is not generally recommended as it may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience persistent, excessive bleeding, consult the doctor. Without consulting a doctor, never stop taking any medication.
MifepristoneHydrocortisone
Critical
How does the drug interact with Mifiact 25 mg Tablet:
Combining Mifiact 25 mg Tablet and hydrocortisone can reduce the effects of hydrocortisone.

How to manage the interaction:
Taking Hydrocortisone with Mifiact 25 mg Tablet is not recommended, consult a doctor before taking it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
MifepristoneSirolimus
Critical
How does the drug interact with Mifiact 25 mg Tablet:
Coadministration of Sirolimus with Mifiact 25 mg Tablet can increase the levels of Sirolimus in the blood, which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Sirolimus with Mifiact 25 mg Tablet is not recommended, they can be taken together if a doctor advises. However, contact a doctor if you experience any symptoms like back pain · difficulty falling asleep or staying asleep, fever, headache, joint pain, rash, stomach pain, constipation, or diarrhea. Do not stop taking any medications without consulting a doctor.
MifepristonePrednisolone
Critical
How does the drug interact with Mifiact 25 mg Tablet:
When Mifiact 25 mg Tablet is taken with Prednisolone, the effects of Prednisolone might be considerably reduced, which may be less effective in treating your condition.

How to manage the interaction:
Taking Prednisolone with Mifiact 25 mg Tablet is not recommended, they can be taken together if advised by a doctor. Do not discontinue the medication without consulting a doctor.
MifepristoneTacrolimus
Critical
How does the drug interact with Mifiact 25 mg Tablet:
Taking tacrolimus with Mifiact 25 mg Tablet may significantly increase the blood levels of tacrolimus, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Tacrolimus with Mifiact 25 mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
MifepristoneTriamcinolone
Critical
How does the drug interact with Mifiact 25 mg Tablet:
Using Mifiact 25 mg Tablet with Triamcinolone can significantly reduce the effects of triamcinolone.

How to manage the interaction:
Taking Triamcinolone with Mifiact 25 mg Tablet is not recommended but can be taken if prescribed by a doctor. However, if you notice any unusual symptoms contact a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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MIFEPRISTONE-25MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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MIFEPRISTONE-25MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice may increase the effects of Mifiact 25 mg Tablet. Avoid consumption of grape juice while taking Mifiact 25 mg Tablet. However, if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, swelling, and high blood pressure, consult the doctor.

Diet & Lifestyle Advise

  • Keep your weight under control with a body mass index (BMI) of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.
  • Avoid chronic stress and physical exercise like running, as it might increase vaginal bleeding.
  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • Get an ultrasound to check if the abortion is done completely to avoid unwanted complications.
  • Try to include heart-healthy omega-3 fatty acid-containing foods or drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTIPROGESTERONE

Mifiact 25 mg Tablet Substitute

Substitutes safety advice
  • Mymefi 25 Tablet 10's

    by Others

    56.30per tablet
  • MEFI 25 TABLETS 10'S

    by AYUR

    50.58per tablet
  • Mifeone 25mg Softgel Capsule 14's

    by AYUR

    56.44per tablet
  • Mifebase 25 Tablet 10's

    by Others

    19.17per tablet
  • Mifinox 25 Tablet 10's

    by Others

    47.70per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

No, Mifiact 25 mg Tablet should be taken in the dose and duration as advised by the doctor. Taking it in more than the recommended dose might cause unpleasant side effects like excessive uterine bleeding.

No, the Mifiact 25 mg Tablet is not known to affect any future chances of fertility. Mifiact 25 mg Tablet is used for medical abortion.

If you miss a dose of Mifiact 25 mg Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

After taking Mifiact 25 mg Tablet , you may or may not experience vaginal bleeding, which does not indicate complete abortion. Your doctor will examine with the performing ultrasonography to confirm if the abortion is complete.

No, the Mifiact 25 mg Tablet does not affect fertility. Use contraception during sexual intercourse as it may lead to unwanted pregnancy if you are not planning it.

Some of the common side effects of Mifiact 25 mg Tablet are nausea, weakness, fever/chills, vomiting, headache, diarrhoea, and dizziness.

Drug-Drug Interactions Checker List

  • DEXAMETHASONE
  • KETOCONAZOLE
  • ITRACONAZOLE
  • ERYTHROMYCIN
  • RIFAMPICIN
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE
  • CYCLOSPORINE
  • TACROLIMUS
  • SIROLIMUS
  • ERGOTAMINE

Special Advise

  • Mifiact 25 mg Tablet should not be used to end the pregnancy after ten weeks.
  • Contact your doctor immediately if you experience heavy vaginal bleeding after taking this medicine.

Disease/Condition Glossary

Medical abortion: It is a procedure in which medicine is used to end a pregnancy. It is effectively causing abortion if performed in the first 70 days of pregnancy. Vagina bleeding occurs, and if it does not stop, please inform your doctor as it might require medical supervision. Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (which may last up to 30 days), fever, and digestive system discomfort. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised. 

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