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Reviewed By Sunny S , MBBS
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Consume Type

ORAL

Return Policy

Not Returnable

Expires on or after

Jan-27

for this medicine

About MEFI 25 TABLETS

MEFI 25 TABLETS belongs to the class of medication called 'progestin antagonist' used in combination with Misoprostol to induce a medical abortion. MEFI 25 TABLETS is primarily used to end an early pregnancy (lasting up to 70 days or less than this) or an unwanted pregnancy with medication help.

MEFI 25 TABLETS contains Mifepristone, which works by blocking the effect of progesterone (female hormone), which is needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for MEFI 25 TABLETS to show effect. Once it starts acting, you will experience uterine bleeding. But no uterine bleeding does not mean that the abortion is complete.

Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (which may last up to 30 days), fever, and digestive system discomfort. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised.

MEFI 25 TABLETS should be taken in dose and duration as advised by the doctor, preferably with food. It would be best to take it at a fixed time every day. It is a tablet and should be taken orally with a glass of water. In some cases, you may experience nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Most of these side effects of MEFI 25 TABLETS subside with time. But if your vaginal bleeding does not, please visit the doctor immediately, and it requires immediate medical attention.

MEFI 25 TABLETS should not be stopped abruptly without consulting the doctor as it may lead to incomplete abortion. Inform your doctor before starting MEFI 25 TABLETS if you have or ever had an ectopic pregnancy (when the fetus grows in the fallopian tube), using an intrauterine device, or if you are breastfeeding, any bleeding disorder or heart problem. Do not do strenuous activities like running, heavy exercise, or driving to avoid excessive bleeding. The doctor will also check with ultrasound if the absorption is complete as no bleeding does not mean that abortion is complete.

Uses of MEFI 25 TABLETS

Medical abortion

Directions for Use

MEFI 25 TABLETS should be taken in dose and duration as prescribed by your doctor. Do not chew or crush it; swallow it as a whole.

Medicinal Benefits

MEFI 25 TABLETS contains Mifepristone, which is taken in a regimen with Misoprostol to induce medical abortion or terminate a pregnancy before 70 days. It works by blocking the effect of progesterone (female hormone) needed to sustain a pregnancy. In the absence of progesterone, the lining of the uterus breaks down as it does every month during the menstrual cycle, and the growth of pregnancy is stopped. It takes approximately 24-48 hours for MEFI 25 TABLETS to show effect.

Storage

Store in a cool and dry place away from sunlight

Side Effects of MEFI 25 TABLETS

  • Weakness
  • Nausea
  • Uterine cramps
  • Vomiting
  • Diarrhoea
  • Dizziness
  • Infection following abortion
  • Uterine bleeding

Drug Warnings

Women who have an ectopic pregnancy (a pregnancy outside of the uterus, problems with the adrenal glands (the glands near the kidneys), currently taking corticosteroid therapy (medications), have an allergic reaction to mifepristone, misoprostol or similar drugs, have bleeding problems or taking the blood-thinning drug (warfarin, clopidogrel, aspirin, heparin etc.) should not use MEFI 25 TABLETS and contact doctor. After using MEFI 25 TABLETS if you start feeling sleepy, do not drive or operate heavy machinery. If you use an intrauterine device (IUD), please remove it before taking the MEFI 25 TABLETS . Regular follow-up with the doctor is required for constant monitoring of abortion. If medical termination does not happen or becomes unsuccessful, it should be terminated surgically as it can lead to foetal defects. Your doctor will examine by performing ultrasonography to confirm if the abortion is complete. St John’s Wort (herbal supplements to treat mild depression) and grapefruit juice should not be taken when taking MEFI 25 TABLETS as it is known to interact. 

Drug-Drug Interactions

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MifepristonePrasugrel
Critical
MifepristoneLurasidone
Critical

Drug-Drug Interactions

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MifepristonePrasugrel
Critical
How does the drug interact with Mefi 25 Tablets:
Co-administration of Mefi 25 Tablets with Prasugrel can increase the chance of experiencing vaginal bleeding in women.

How to manage the interaction:
Taking Prasugrel with Mefi 25 Tablets can lead to an interaction, but it can be taken if a doctor has prescribed it. However, if you experience prolonged, heavy bleeding, consult a doctor immediately. Do not discontinue the medication without consulting a doctor.
MifepristoneLurasidone
Critical
How does the drug interact with Mefi 25 Tablets:
Coadministration of Lurasidone with Mefi 25 Tablets can increase the levels of Lurasidone which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Lurasidone with Mefi 25 Tablets together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any abnormal muscle movements, seizures(fits), high blood sugar, dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
MifepristoneConivaptan
Critical
How does the drug interact with Mefi 25 Tablets:
When Mefi 25 Tablets is taken with Conivaptan, it may increase the risk of negative side effects.

How to manage the interaction:
Taking Mefi 25 Tablets with Conivaptan is not recommended as it leads to an interaction, but it can be taken if prescribed by the doctor. However, if you experience symptoms such as seizures(fits), difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
MifepristoneTriamcinolone
Critical
How does the drug interact with Mefi 25 Tablets:
Using Mefi 25 Tablets with Triamcinolone can significantly reduce the effects of triamcinolone.

How to manage the interaction:
Taking Triamcinolone with Mefi 25 Tablets is not recommended but can be taken if prescribed by a doctor. However, if you notice any unusual symptoms contact a doctor. Do not discontinue any medications without consulting a doctor.
MifepristoneMidazolam
Critical
How does the drug interact with Mefi 25 Tablets:
Co-administration of Mefi 25 Tablets and Midazolam may significantly increase Midazolam blood levels and effects, which increases the risk of side effects.

How to manage the interaction:
Although taking Mefi 25 Tablets and Midazolam together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MifepristonePrednisolone
Critical
How does the drug interact with Mefi 25 Tablets:
When Mefi 25 Tablets is taken with Prednisolone, the effects of Prednisolone might be considerably reduced, which may be less effective in treating your condition.

How to manage the interaction:
Taking Prednisolone with Mefi 25 Tablets is not recommended, they can be taken together if advised by a doctor. Do not discontinue the medication without consulting a doctor.
MifepristoneDabigatran etexilate
Critical
How does the drug interact with Mefi 25 Tablets:
When Mefi 25 Tablets is taken with Dabigatran etexilate, it may increase the risk of severe vaginal bleeding in women.

How to manage the interaction:
Taking Mefi 25 Tablets with Dabigatran etexilate is not recommended, but it can be taken if prescribed by the doctor. However, if you experience heavy, persistent vaginal bleeding, consult the door. Do not stop using any medications without talking to a doctor.
MifepristoneFluticasone
Critical
How does the drug interact with Mefi 25 Tablets:
Co-administration of Fluticasone with Mefi 25 Tablets may make Fluticasone less effective as a therapy.

How to manage the interaction:
Taking Fluticasone with Mefi 25 Tablets is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
MifepristoneDihydroergotamine
Critical
How does the drug interact with Mefi 25 Tablets:
When Mefi 25 Tablets is taken with Dihydroergotamine, it may increase the risk of side effects.

How to manage the interaction:
Taking Dihydroergotamine with Mefi 25 Tablets is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
MifepristoneRanolazine
Critical
How does the drug interact with Mefi 25 Tablets:
When Mefi 25 Tablets is taken with Ranolazine, may cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Phenylbutazone with Ranolazine can lead to an interaction. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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MIFEPRISTONE-25MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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MIFEPRISTONE-25MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice may increase the effects of Mefi 25 Tablets. Avoid consumption of grape juice while taking Mefi 25 Tablets. However, if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, swelling, and high blood pressure, consult the doctor.

Diet & Lifestyle Advise

  • Keep your weight under control with a body mass index (BMI) of 19.5-24.9.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Quitting smoking and not drinking alcohol is the best strategy to lower the risk of any complications.
  • Avoid chronic stress and physical exercise like running, as it might increase vaginal bleeding.
  • Monitor your blood pressure daily and if there is too much fluctuation, then immediately contact your doctor.
  • Get an ultrasound to check if the abortion is done completely to avoid unwanted complications.
  • Try to include heart-healthy omega-3 fatty acid-containing foods or drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTIPROGESTERONE

MEFI 25 TABLETS Substitute

Substitutes safety advice
  • Goefibro-M 25 Tablet 10's

    by AYUR

    49.32per tablet
  • Fibroease 25mg Tablet 10's

    by AYUR

    68.85per tablet
  • Fibristone 25 Tablet 10's

    by AYUR

    59.27per tablet
  • Fibromif-25mg Tablet 10's

    by AYUR

    37.89per tablet
  • FIBROCEDE-25MG TABLETS 10'S

    by AYUR

    41.76per tablet

Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • DEXAMETHASONE
  • KETOCONAZOLE
  • ITRACONAZOLE
  • ERYTHROMYCIN
  • RIFAMPICIN
  • PHENYTOIN
  • PHENOBARBITAL
  • CARBAMAZEPINE
  • CYCLOSPORINE
  • TACROLIMUS
  • SIROLIMUS
  • ERGOTAMINE

Key Ingredients

Mifepristone.

Special Advise

  • MEFI 25 TABLETS should not be used to end the pregnancy after ten weeks.
  • Contact your doctor immediately if you experience heavy vaginal bleeding after taking this medicine.

Disease/Condition Glossary

Medical abortion: It is a procedure in which medicine is used to end a pregnancy. It is effectively causing abortion if performed in the first 70 days of pregnancy. Vagina bleeding occurs, and if it does not stop, please inform your doctor as it might require medical supervision. Having a medical abortion is a very emotional decision. You should be mentally prepared for all the risks a surgical absorption could lead to, like incomplete abortion, heavy and prolonged bleeding (which may last up to 30 days), fever, and digestive system discomfort. Also, if the medication does not work, it can lead to an unwanted ongoing pregnancy, leading to fetal defects. So, to avoid any complications, keep in regular touch with your doctor and do as advised. 

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