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Written By Urvashi Bharti , MBBS
Reviewed By Sunny S , MBBS

About Grenil Tablet 10's

Grenil Tablet 10's is a combination medicine used for the symptomatic treatment of migraine, and any medical condition with concomitant nausea/vomiting and fever/pain. Migraine is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head, eyes, face, and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.

Grenil Tablet 10's is a combination of two drugs, namely: Domperidone and Paracetamol. Domperidone prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

Take Grenil Tablet 10's as prescribed. Your doctor will recommend how often you take Grenil Tablet 10's based on your medical condition. Some people may experience some side effects, dry mouth, skin rash, anxiety, diarrhoea, and drowsiness. Most of these side effects of Grenil Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

You can increase the efficacy of Grenil Tablet 10's by taking a small meal or snacks frequently. Do not take Grenil Tablet 10's if you are allergic to Grenil Tablet 10's and other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Grenil Tablet 10's. Inform your doctor if you have heart, kidney, and liver disease. Prolonged intake of Grenil Tablet 10's may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Grenil Tablet 10's, immediately contact your doctor.

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Non returnable*
COD available

Online payment accepted

Consume Type

ORAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Grenil Tablet 10's

Migraine

Medicinal Benefits

Grenil Tablet 10's is a combination of two drugs namely; Domperidone and Paracetamol used to treat the vomiting and pain in people with migraines. Domperidone belongs to a class of prokinetic agents that prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting center (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Grenil Tablet 10's together used to prevent nausea, vomiting, pain, and fever associated with migraine.

Side Effects of Grenil Tablet 10's

  • Dry mouth
  • Skin rash
  • Anxiety
  • Diarrhea
  • Drowsiness

Directions for Use

Tablet: Take it on empty stomach or as advised by a doctor. Swallow it as a whole with a glass of water. Do not crush, chew or break it.Suspension: Shake the bottle well before use. Check the label for directions and take it with or without food in doses as prescribed by a doctor with the help of a measuring cup.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not take Grenil Tablet 10's if you are allergic to any of its contents or any other medicines, have a history of gastrointestinal bleeding, heart disease, liver/ kidney problem. Prolonged intake of Grenil Tablet 10's may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). So, if you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Grenil Tablet 10's, immediately contact your doctor. This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you are pregnant or breastfeeding, inform your doctor before using Grenil Tablet 10's. Avoid consumption of alcohol while using Grenil Tablet 10's as it may increase the side effects and make worse your condition. Grenil Tablet 10's should not be given to children below five years of age. The use of Grenil Tablet 10's is safe in children above five years of age if prescribed by the doctor. Do not exceed dose paracetamol more than 4 gm per day as it can damage your liver.

Therapeutic Class

ANTIMIGRAINE AGENTS

Drug-Drug Interactions

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ParacetamolTeriflunomide
Severe
ParacetamolKetamine
Severe

Drug-Drug Interactions

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ParacetamolTeriflunomide
Severe
How does the drug interact with Grenil Tablet 10's:
Co-administration of Teriflunomide with Grenil Tablet 10's may increase the risk or severity of Liver problems.

How to manage the interaction:
Taking Grenil Tablet 10's with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
ParacetamolKetamine
Severe
How does the drug interact with Grenil Tablet 10's:
Co-administration of ketamine and Grenil Tablet 10's may decrease the effectiveness of Ketamine which could result in a higher blood level.

How to manage the interaction:
Although taking Ketamine and Grenil Tablet 10's together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you're feeling very sleepy or having trouble breathing, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
ParacetamolKetoconazole
Severe
How does the drug interact with Grenil Tablet 10's:
Co-administration of Grenil Tablet 10's and Ketoconazole may increase the risk of liver injury.

How to manage the interaction:
Although there is a possible interaction between Grenil Tablet 10's and Ketoconazole, you can take these medicines together if prescribed by a doctor. However, if you have joint pain or swelling, fever, chills, unusual bleeding or bruising, skin rash, itching, over-tiredness, nausea, vomiting, loss of appetite, stomach pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact a doctor immediately as these may be signs and symptoms of liver damage. Do not discontinue the medication without consulting a doctor.
ParacetamolOxazepam
Severe
How does the drug interact with Grenil Tablet 10's:
Co-administration of Grenil Tablet 10's may decrease the excretion rate of Oxazepam which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Oxazepam and Grenil Tablet 10's, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolLeflunomide
Severe
How does the drug interact with Grenil Tablet 10's:
Co-administration of Grenil Tablet 10's and Leflunomide may increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Grenil Tablet 10's and Leflunomide, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ParacetamolValdecoxib
Severe
How does the drug interact with Grenil Tablet 10's:
Co-administration of Grenil Tablet 10's and Valdecoxib may increase the risk or severity of adverse effects.

How to manage the interaction:
Although there is a possible interaction between Grenil Tablet 10's and Valdecoxib, you can take these medicines together if prescribed by a doctor. However, if the side effects worsen, please consult a doctor.
ParacetamolLomitapide
Severe
How does the drug interact with Grenil Tablet 10's:
Co-administration of Lomitapide and Grenil Tablet 10's may increase the risk of severity of liver injury.

How to manage the interaction:
Although there is a possible interaction between Grenil Tablet 10's and Lomitapide, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
ParacetamolMipomersen
Severe
How does the drug interact with Grenil Tablet 10's:
Co-administration of Mipomersen with Grenil Tablet 10's may increase the risk or severity of liver injury.

How to manage the interaction:
There may be a possibility of interaction between Grenil Tablet 10's and Mipomersen, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
DomperidoneKetoconazole
Severe
How does the drug interact with Grenil Tablet 10's:
Coadministration of Grenil Tablet 10's with Ketoconazole can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Grenil Tablet 10's and Ketoconazole together can cause an interaction, it can be taken if a doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneClarithromycin
Severe
How does the drug interact with Grenil Tablet 10's:
Coadministration of Grenil Tablet 10's with Clarithromycin can increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Grenil Tablet 10's and Clarithromycin, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Drug-Drug Interactions Checker List

  • AMIODARONE
  • DRONEDARONE
  • QUINIDINE
  • SOTALOL
  • DILTIAZEM
  • VERAPAMIL
  • ERYTHROMYCIN
  • CLARITHROMYCIN
  • MOXIFLOXACIN
  • CISAPRIDE
  • DOLASETRON
  • WARFARIN
  • METOCLOPRAMIDE
  • CHOLESTYRAMINE

Diet & Lifestyle Advise

  • Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over sweet food and include more salty food, especially if you have been vomiting.
  • Also, if you like vomiting at a specific time, avoid eating your favorite food at that particular time as your taste for that food may get turned off.
  • Include more cool beverages in your food like clear soup, flavored gelatin, carbonated beverages. Also, when you drink with a stray, sip slowly to avoid swallowing air that may lead to gas and acidity.
  • Drink after or any other liquid at least 30 minutes after eating food. 
  • Avoid smoking and alcohol intake.
  • Avoid chronic stress as it can raise your migraine pain. Try to enjoy and spending time with your friends to cope with stress and practice mindfulness techniques.

Habit Forming

No

Special Advise

  • Prolonged intake of Grenil Tablet 10's can increase the risk of cardiac arrhythmia (irregular heartbeat), so close monitoring of heartbeat is required.

Author Details

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Disease/Condition Glossary

Migraine: is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head. People may experience migraine pain in the eyes face and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound. Migraine attacks can last for hours to days, and the pain and symptoms can be so severe that it interferes with your daily activities.

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