Domperidone+paracetamol
About
Domperidone+paracetamol is a combination medicine used for the symptomatic treatment of migraine, and any medical condition with concomitant nausea/vomiting and fever/pain. Migraine is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head, eyes, face, and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound.
Domperidone+paracetamol is a combination of two drugs, namely: Domperidone and Paracetamol. Domperidone prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.
Take Domperidone+paracetamol as prescribed. Your doctor will recommend how often you take Domperidone+paracetamol based on your medical condition. Some people may experience some side effects, dry mouth, skin rash, anxiety, diarrhoea, and drowsiness. Most of these side effects of Domperidone+paracetamol do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
You can increase the efficacy of Domperidone+paracetamol by taking a small meal or snacks frequently. Do not take Domperidone+paracetamol if you are allergic to Domperidone+paracetamol and other medicines. If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Domperidone+paracetamol. Inform your doctor if you have heart, kidney, and liver disease. Prolonged intake of Domperidone+paracetamol may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Domperidone+paracetamol, immediately contact your doctor.
Uses of Domperidone+paracetamol
Medicinal Benefits
Domperidone+paracetamol is a combination of two drugs namely; Domperidone and Paracetamol used to treat the vomiting and pain in people with migraines. Domperidone belongs to a class of prokinetic agents that prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting center (chemoreceptor trigger zone –CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Domperidone+paracetamol together used to prevent nausea, vomiting, pain, and fever associated with migraine.
Directions for Use
Storage
Side Effects of Domperidone+paracetamol
- Dry mouth
- Skin rash
- Anxiety
- Diarrhea
- Drowsiness
In-Depth Precautions and Warning
Drug Warnings
Do not take Domperidone+paracetamol if you are allergic to any of its contents or any other medicines, have a history of gastrointestinal bleeding, heart disease, liver/ kidney problem. Prolonged intake of Domperidone+paracetamol may be associated with an increased risk of heart rhythm disorder (arrhythmia) and cardiac arrest (heart attack). So, if you experience heart rhythm disorders like palpitations, trouble in breathing, or loss of consciousness after taking Domperidone+paracetamol, immediately contact your doctor. This risk may be more likely in the elderly (those over 60 years old) or taking a higher dose. If you are pregnant or breastfeeding, inform your doctor before using Domperidone+paracetamol. Avoid consumption of alcohol while using Domperidone+paracetamol as it may increase the side effects and make worse your condition. Domperidone+paracetamol should not be given to children below five years of age. The use of Domperidone+paracetamol is safe in children above five years of age if prescribed by the doctor. Do not exceed dose paracetamol more than 4 gm per day as it can damage your liver.
Drug Interactions
Drug-Drug Interaction: Domperidone+paracetamol interact with medicines used to treat heart problems (amiodarone, dronedarone, quinidine, sotalol, diltiazem, verapamil), antibiotics (erythromycin, clarithromycin, moxifloxacin), gastrointestinal disorder (cisapride, dolasetron), blood thinners (warfarin), vomiting and nausea related pills (metoclopramide), and bile related medicines (cholestyramine),
Drug-Food Interaction: No interaction found.
Drug-Disease interaction: The use of Domperidone+paracetamol is restricted in people with liver disease, a history of gastrointestinal bleeding, or any problem involving the bowels.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
cautionAlcohol consumption with Domperidone+paracetamol may cause sleepiness or an irregular heartbeat.
Pregnancy
cautionThe safety of pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks the benefits outweigh the risks.
Breast Feeding
cautionDomperidone+paracetamol is not usually recommended when breastfeeding, as it passes into breast milk in a small amount. Therefore, it is given to breastfeeding women only if the doctor thinks the benefits outweigh the risks.
Driving
cautionDrive and operate machinery only if you are alert.
Liver
cautionDomperidone+paracetamol to be taken with caution, especially if you have had a history of liver disease/condition. The dose may have to be adjusted by your doctor.
Kidney
cautionDomperidone+paracetamol to be taken with caution, especially if you have had a history of kidney disease/condition. The dose may have to be adjusted by your doctor.
Children
cautionDomperidone+paracetamol should not be given to children below 5 years of age. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing it to children.
Habit Forming
Diet & Lifestyle Advise
- Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over sweet food and include more salty food, especially if you have been vomiting.
- Also, if you like vomiting at a specific time, avoid eating your favorite food at that particular time as your taste for that food may get turned off.
- Include more cool beverages in your food like clear soup, flavored gelatin, carbonated beverages. Also, when you drink with a stray, sip slowly to avoid swallowing air that may lead to gas and acidity.
- Drink after or any other liquid at least 30 minutes after eating food.
- Avoid smoking and alcohol intake.
- Avoid chronic stress as it can raise your migraine pain. Try to enjoy and spending time with your friends to cope with stress and practice mindfulness techniques.
Special Advise
- Prolonged intake of Domperidone+paracetamol can increase the risk of cardiac arrhythmia (irregular heartbeat), so close monitoring of heartbeat is required.
Patients Concern
Disease/Condition Glossary
Migraine: is a neurological condition that can cause severe throbbing pain or a pulsing sensation, usually on one side of the head. People may experience migraine pain in the eyes face and neck. Symptoms may include nausea, vomiting, difficulty speaking, numbness or tingling, and sensitivity to light and sound. Migraine attacks can last for hours to days, and the pain and symptoms can be so severe that it interferes with your daily activities.
FAQs
Domperidone+paracetamol is a combination of drugs namely; Domperidone and Paracetamol. Domperidone is a prokinetic that prevents nausea and vomiting symptoms by blocking certain receptors (like dopamine and serotonin) that stimulate the vomiting centre (chemoreceptor trigger zone - CTZ) located in the brain. It also acts as a prokinetic agent that increases the upper gastrointestinal tract's motility and helps in decreasing the stomach emptying time. Paracetamol is an NSAID that works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes that make another chemical ‘prostaglandins’(PG). These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, lesser PGs are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site. Together, used to prevent nausea, vomiting, pain, and fever associated with migraine.
Talk to your doctor if you do not feel better even after taking Domperidone+paracetamol for 14 days. Do not take Domperidone+paracetamol for longer durations unless prescribed by the doctor.
If you or someone else have taken too much of Domperidone+paracetamol, contact your doctor or nearest hospital casualty department.
It is best to avoid alcohol while taking Domperidone+paracetamol as it can make damage to your liver.
Yes, Domperidone+paracetamol can cause dry mouth. In case you feel excessively thirsty, please increase your fluid intake and do frequent mouth rinses.
