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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Medistat 0.5 mg Nasal Spray 5 ml

Medistat 0.5 mg Nasal Spray 5 ml belongs to a class of drugs called benzodiazepines used for the short-term treatment of seizure clusters. Seizure clusters are episodes of elevated seizure activity, defined as two or more seizures occurring within a 24-hour period. They are upsetting situations that can leave you feeling anxious, frustrated, or helpless.

Medistat 0.5 mg Nasal Spray 5 ml contains Midazolam which works by increasing GABA activity (a chemical messenger in the brain). Thus, Medistat 0.5 mg Nasal Spray 5 ml suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

Use Medistat 0.5 mg Nasal Spray 5 ml as prescribed and for the duration as your doctor has prescribed it for you based on your medical condition. Sometimes, it may cause side effects such as headache, drowsiness, runny nose, throat irritation, and nasal discomfort. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Midazolam or any other medicines, please tell your doctor. If you are pregnant, planning for pregnancy or are breastfeeding, please inform your doctor before taking Medistat 0.5 mg Nasal Spray 5 ml. Medistat 0.5 mg Nasal Spray 5 ml is not recommended for children below 12 years as the safety and effectiveness were not established. Avoid consumption of alcohol with Medistat 0.5 mg Nasal Spray 5 ml as it may cause increased drowsiness. Avoid driving or operating machinery until you know how Medistat 0.5 mg Nasal Spray 5 ml affects you. Avoid using Medistat 0.5 mg Nasal Spray 5 ml if you have acute narrow-angle glaucoma (eye problem). Do not take Medistat 0.5 mg Nasal Spray 5 ml with opioids until and unless prescribed by a doctor, as it may increase the risk of breathing problems, severe drowsiness or coma.

rxMedicinePrescription drug

Whats That

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Non returnable*
COD available

Online payment accepted

Composition

MIDAZOLAM-0.5MG

Consume Type

NASAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Medistat 0.5 mg Nasal Spray 5 ml

Seizure clusters (acute repetitive seizures)

Medicinal Benefits

Medistat 0.5 mg Nasal Spray 5 ml contains Midazolam used to treat acute (sudden) repetitive fits. Medistat 0.5 mg Nasal Spray 5 ml increases the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent). Thus, it suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

Side Effects of Medistat 0.5 mg Nasal Spray 5 ml

  • Headache
  • Drowsiness
  • Runny nose
  • Throat irritation
  • Nasal discomfort

Directions for Use

Insert the tip of the bottle into a nostril while closing the other nostril and spray towards the sides of the nostril. Keep your head straight and breathe gently.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

If you are allergic to Midazolam or any other medicines, please tell your doctor. If you are pregnant, planning for pregnancy, or breastfeeding, please inform your doctor before using Medistat 0.5 mg Nasal Spray 5 ml. Medistat 0.5 mg Nasal Spray 5 ml is not recommended for children below 12 years as the safety and effectiveness were not established. Avoid consumption of alcohol with Medistat 0.5 mg Nasal Spray 5 ml as it may cause drowsiness. Avoid driving or operating machinery until you know how Medistat 0.5 mg Nasal Spray 5 ml affects you. Avoid using Medistat 0.5 mg Nasal Spray 5 ml if you have acute narrow-angle glaucoma (eye problem). Do not take Medistat 0.5 mg Nasal Spray 5 ml with opioids until and unless prescribed by a doctor, as it may increase the risk of breathing problems, severe drowsiness or coma. Get medical help immediately if you experience unusually excessive sleepiness or shallow or slowed breathing while using Medistat 0.5 mg Nasal Spray 5 ml.

Therapeutic Class

ANTICONVULSANT

Drug-Drug Interactions

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MidazolamCobicistat
Critical
MidazolamIndinavir
Critical

Drug-Drug Interactions

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MidazolamCobicistat
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Cobicistat and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Cobicistat and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamIndinavir
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Indinavir and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Indinavir and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamAtazanavir
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Atazanavir and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Atazanavir and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamSodium oxybate
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Sodium oxybate and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Sodium oxybate and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamAmprenavir
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Co-administration of Amprenavir and Medistat 0.5 mg Nasal Spray 5 ml may significantly increase the blood levels and effects of Medistat 0.5 mg Nasal Spray 5 ml.

How to manage the interaction:
Although taking Amprenavir along with Medistat 0.5 mg Nasal Spray 5 ml can possibly lead to an interaction, they can be taken if a doctor advices them. In case of increased or prolonged drowsiness and breathing difficulties, consult a doctor. Do not stop using any medications without talking to a doctor.
MidazolamKetoconazole
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Co-administration of Ketoconazole and Medistat 0.5 mg Nasal Spray 5 ml may increase the risk of side effects.

How to manage the interaction:
Although taking Ketoconazole and Medistat 0.5 mg Nasal Spray 5 ml together is not recommended as it may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamIdelalisib
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Idelalisib and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Idelalisib and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamBoceprevir
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Boceprevir and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Boceprevir and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamTelaprevir
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
Telaprevir and Medistat 0.5 mg Nasal Spray 5 ml co-administration may considerably enhance Medistat 0.5 mg Nasal Spray 5 ml blood levels and effects.

How to manage the interaction:
Although taking Telaprevir and Medistat 0.5 mg Nasal Spray 5 ml together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamDelavirdine
Critical
How does the drug interact with Medistat 0.5 mg Nasal Spray 5 ml:
The negative effects of Medistat 0.5 mg Nasal Spray 5 ml and Delavirdine might be increased when used together.

How to manage the interaction:
Taking Medistat 0.5 mg Nasal Spray 5 ml together Delavirdine may cause an interaction. They can, however, be taken if a doctor has prescribed them. Consult a doctor if you have any of the following symptoms: excessive sleepiness, dizziness, confusion, or weak or rapid breathing. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Diet & Lifestyle Advise

  • Do regular exercise and maintain a healthy body weight.
  • Maintain a diet rich in fruits, vegetables and whole grains. Avoid fried foods, high-fat dairy products, pastries and processed foods, as they may worsen anxiety.
  • Follow a regular sleep pattern. Do not take a nap during day time.
  • Avoid watching tv and using mobiles or laptops just before bedtime.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

Yes

Special Advise

  • Do not use Medistat 0.5 mg Nasal Spray 5 ml for more than 1 seizure cluster episode every three days and for more than five seizure cluster episodes per month. Please consult your doctor if you have concerns.

Author Details

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Disease/Condition Glossary

Seizure clusters: Seizure clusters are also known as acute repetitive seizures. These are instances of increased seizure activity, defined as two or more seizures occurring within a 24-hour period. They are stressful circumstances that can leave you feeling nervous, frustrated, or powerless. Stress, sickness with fever, sleep deprivation, missing prescriptions, and the use of alcohol or other non-medical substances are all potential causes of seizure clusters.

Medistat 0.5 mg Nasal Spray 5 ml Substitute

Substitutes safety advice
  • Midaspray 0.5mg Nasal Spray 50 MDI

    6.41per tablet
  • Midacip Nasal Spray 5 ml

    73.71per tablet
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