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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Whats That

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Composition :

MIDAZOLAM-0.5MG

Manufacturer/Marketer :

Mindneuro Pharma

Consume Type :

NASAL

Return Policy :

Not Returnable

Expires on or after :

About Midazom 0.5 Nasal Spray 50 mdi

Midazom 0.5 Nasal Spray 50 mdi belongs to a class of drugs called benzodiazepines used for the short-term treatment of seizure clusters. Seizure clusters are episodes of elevated seizure activity, defined as two or more seizures occurring within a 24-hour period. They are upsetting situations that can leave you feeling anxious, frustrated, or helpless.

Midazom 0.5 Nasal Spray 50 mdi contains Midazolam which works by increasing GABA activity (a chemical messenger in the brain). Thus, Midazom 0.5 Nasal Spray 50 mdi suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

Use Midazom 0.5 Nasal Spray 50 mdi as prescribed and for the duration as your doctor has prescribed it for you based on your medical condition. Sometimes, it may cause side effects such as headache, drowsiness, runny nose, throat irritation, and nasal discomfort. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Midazolam or any other medicines, please tell your doctor. If you are pregnant, planning for pregnancy or are breastfeeding, please inform your doctor before taking Midazom 0.5 Nasal Spray 50 mdi. Midazom 0.5 Nasal Spray 50 mdi is not recommended for children below 12 years as the safety and effectiveness were not established. Avoid consumption of alcohol with Midazom 0.5 Nasal Spray 50 mdi as it may cause increased drowsiness. Avoid driving or operating machinery until you know how Midazom 0.5 Nasal Spray 50 mdi affects you. Avoid using Midazom 0.5 Nasal Spray 50 mdi if you have acute narrow-angle glaucoma (eye problem). Do not take Midazom 0.5 Nasal Spray 50 mdi with opioids until and unless prescribed by a doctor, as it may increase the risk of breathing problems, severe drowsiness or coma.

Uses of Midazom 0.5 Nasal Spray 50 mdi

Seizure clusters (acute repetitive seizures)

Directions for Use

Insert the tip of the bottle into a nostril while closing the other nostril and spray towards the sides of the nostril. Keep your head straight and breathe gently.

Medicinal Benefits

Midazom 0.5 Nasal Spray 50 mdi contains Midazolam used to treat acute (sudden) repetitive fits. Midazom 0.5 Nasal Spray 50 mdi increases the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent). Thus, it suppresses the excessive and abnormal activity of nerve cells in the brain and controls fits.

Storage

Keep Midazom 0.5 Nasal Spray 50 mdi out of the sight and reach of children.
Side effects of Midazom 0.5 Nasal Spray 50 mdi
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.
  • Contact your physician right away if you suffer from hypoxia symptoms including chest pain, disorientation, or shortness of breath.
  • Your doctor can monitor your progress and modify treatment programs with the help of routine follow-up sessions.
  • Omega-3 supplements may support the transport of oxygen to tissues.
  • Regular exercise improves cardiovascular health and boosts oxygen delivery to tissues.
  • Quit smoking, as it can worsen hypoxia.

Drug Warnings

If you are allergic to Midazolam or any other medicines, please tell your doctor. If you are pregnant, planning for pregnancy, or breastfeeding, please inform your doctor before using Midazom 0.5 Nasal Spray 50 mdi. Midazom 0.5 Nasal Spray 50 mdi is not recommended for children below 12 years as the safety and effectiveness were not established. Avoid consumption of alcohol with Midazom 0.5 Nasal Spray 50 mdi as it may cause drowsiness. Avoid driving or operating machinery until you know how Midazom 0.5 Nasal Spray 50 mdi affects you. Avoid using Midazom 0.5 Nasal Spray 50 mdi if you have acute narrow-angle glaucoma (eye problem). Do not take Midazom 0.5 Nasal Spray 50 mdi with opioids until and unless prescribed by a doctor, as it may increase the risk of breathing problems, severe drowsiness or coma. Get medical help immediately if you experience unusually excessive sleepiness or shallow or slowed breathing while using Midazom 0.5 Nasal Spray 50 mdi.

Drug-Drug Interactions

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MidazolamAmprenavir
Critical

Drug-Drug Interactions

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How does the drug interact with Midazom 0.5 Nasal Spray 50 mdi:
Atazanavir and Midazom 0.5 Nasal Spray 50 mdi co-administration may considerably enhance Midazom 0.5 Nasal Spray 50 mdi blood levels and effects.

How to manage the interaction:
Although taking Atazanavir and Midazom 0.5 Nasal Spray 50 mdi together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamAmprenavir
Critical
How does the drug interact with Midazom 0.5 Nasal Spray 50 mdi:
Co-administration of Amprenavir and Midazom 0.5 Nasal Spray 50 mdi may significantly increase the blood levels and effects of Midazom 0.5 Nasal Spray 50 mdi.

How to manage the interaction:
Although taking Amprenavir along with Midazom 0.5 Nasal Spray 50 mdi can possibly lead to an interaction, they can be taken if a doctor advices them. In case of increased or prolonged drowsiness and breathing difficulties, consult a doctor. Do not stop using any medications without talking to a doctor.
MidazolamIdelalisib
Critical
How does the drug interact with Midazom 0.5 Nasal Spray 50 mdi:
Idelalisib and Midazom 0.5 Nasal Spray 50 mdi co-administration may considerably enhance Midazom 0.5 Nasal Spray 50 mdi blood levels and effects.

How to manage the interaction:
Although taking Idelalisib and Midazom 0.5 Nasal Spray 50 mdi together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamSodium oxybate
Critical
How does the drug interact with Midazom 0.5 Nasal Spray 50 mdi:
Sodium oxybate and Midazom 0.5 Nasal Spray 50 mdi co-administration may considerably enhance Midazom 0.5 Nasal Spray 50 mdi blood levels and effects.

How to manage the interaction:
Although taking Sodium oxybate and Midazom 0.5 Nasal Spray 50 mdi together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Midazom 0.5 Nasal Spray 50 mdi:
Indinavir and Midazom 0.5 Nasal Spray 50 mdi co-administration may considerably enhance Midazom 0.5 Nasal Spray 50 mdi blood levels and effects.

How to manage the interaction:
Although taking Indinavir and Midazom 0.5 Nasal Spray 50 mdi together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamBoceprevir
Critical
How does the drug interact with Midazom 0.5 Nasal Spray 50 mdi:
Boceprevir and Midazom 0.5 Nasal Spray 50 mdi co-administration may considerably enhance Midazom 0.5 Nasal Spray 50 mdi blood levels and effects.

How to manage the interaction:
Although taking Boceprevir and Midazom 0.5 Nasal Spray 50 mdi together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Midazom 0.5 Nasal Spray 50 mdi:
Taking ceritinib and Midazom 0.5 Nasal Spray 50 mdi may significantly increase the blood levels and effects of Midazom 0.5 Nasal Spray 50 mdi.

How to manage the interaction:
Although taking ceritinib and Midazom 0.5 Nasal Spray 50 mdi together may result in an interaction, they can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
MidazolamDelavirdine
Critical
How does the drug interact with Midazom 0.5 Nasal Spray 50 mdi:
The negative effects of Midazom 0.5 Nasal Spray 50 mdi and Delavirdine might be increased when used together.

How to manage the interaction:
Taking Midazom 0.5 Nasal Spray 50 mdi together Delavirdine may cause an interaction. They can, however, be taken if a doctor has prescribed them. Consult a doctor if you have any of the following symptoms: excessive sleepiness, dizziness, confusion, or weak or rapid breathing. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Midazom 0.5 Nasal Spray 50 mdi:
Co-administration of Ketoconazole and Midazom 0.5 Nasal Spray 50 mdi may increase the risk of side effects.

How to manage the interaction:
Although taking Ketoconazole and Midazom 0.5 Nasal Spray 50 mdi together is not recommended as it may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
MidazolamCobicistat
Critical
How does the drug interact with Midazom 0.5 Nasal Spray 50 mdi:
Cobicistat and Midazom 0.5 Nasal Spray 50 mdi co-administration may considerably enhance Midazom 0.5 Nasal Spray 50 mdi blood levels and effects.

How to manage the interaction:
Although taking Cobicistat and Midazom 0.5 Nasal Spray 50 mdi together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do regular exercise and maintain a healthy body weight.
  • Maintain a diet rich in fruits, vegetables and whole grains. Avoid fried foods, high-fat dairy products, pastries and processed foods, as they may worsen anxiety.
  • Follow a regular sleep pattern. Do not take a nap during day time.
  • Avoid watching tv and using mobiles or laptops just before bedtime.
  • Avoid consumption of alcohol as it may increase drowsiness.

Side Effects of Midazom 0.5 Nasal Spray 50 mdi

  • Headache
  • Drowsiness
  • Runny nose
  • Throat irritation
  • Nasal discomfort

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Midazom 0.5 Nasal Spray 50 mdi contains Midazolam, which works by increasing the activity of GABA (a chemical messenger in the brain that acts as a natural nerve-calming agent). Thereby preventing fits by stabilizing the electrical activity of nerve cells in the brain.

If the seizure cluster continues after 10 minutes of the first dose, you can use the second dose of Midazom 0.5 Nasal Spray 50 mdi if advised by your doctor. However, the second dose should be given in the other nostril. Do not use more than two doses to treat a seizure cluster.

You are not recommended to take Midazom 0.5 Nasal Spray 50 mdi with opioids, alcohol or other central nervous system depressants as it may cause breathing problems, severe drowsiness or coma. Therefore, please consult your doctor before taking Midazom 0.5 Nasal Spray 50 mdi with any other medicines.

You are not recommended to stop using Midazom 0.5 Nasal Spray 50 mdi suddenly without consulting your doctor as it may cause withdrawal symptoms such as hallucinations, nervousness, shaking, muscle pain or cramps. Therefore, use Midazom 0.5 Nasal Spray 50 mdi for as long as your doctor has prescribed it, and if you experience any difficulty while using Midazom 0.5 Nasal Spray 50 mdi, please consult your doctor so that the dose may be reduced gradually.

Yes, Midazom 0.5 Nasal Spray 50 mdi may cause physical dependence if used for prolonged periods. Therefore, use Midazom 0.5 Nasal Spray 50 mdi only in the dose and for the duration as advised by your doctor.

Special Advise

  • Do not use Midazom 0.5 Nasal Spray 50 mdi for more than 1 seizure cluster episode every three days and for more than five seizure cluster episodes per month. Please consult your doctor if you have concerns.

Disease/Condition Glossary

Seizure clusters: Seizure clusters are also known as acute repetitive seizures. These are instances of increased seizure activity, defined as two or more seizures occurring within a 24-hour period. They are stressful circumstances that can leave you feeling nervous, frustrated, or powerless. Stress, sickness with fever, sleep deprivation, missing prescriptions, and the use of alcohol or other non-medical substances are all potential causes of seizure clusters.

Have a query?

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Alcohol

Unsafe

Avoid consumption of alcohol with Midazom 0.5 Nasal Spray 50 mdi as it may increase drowsiness.

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Pregnancy

Caution

If you are pregnant or planning for pregnancy, inform your doctor before using Midazom 0.5 Nasal Spray 50 mdi. Babies born to mothers receiving Midazom 0.5 Nasal Spray 50 mdi late in pregnancy may be at risk of feeding or breathing problems, withdrawal symptoms or dangerously low body temperature.

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Breast Feeding

Caution

Midazom 0.5 Nasal Spray 50 mdi may be excreted in breast milk and may harm your baby. Therefore, discuss with your doctor the best way to feed your baby if you use Midazom 0.5 Nasal Spray 50 mdi.

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Driving

Caution

Avoid driving or operating machinery until you know how Midazom 0.5 Nasal Spray 50 mdi affects you.

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Liver

Consult your doctor

If you have liver problems, consult your doctor before using Midazom 0.5 Nasal Spray 50 mdi.

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Kidney

Consult your doctor

If you have kidney diseases/conditions, consult your doctor before using Midazom 0.5 Nasal Spray 50 mdi.

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Children

Unsafe

Midazom 0.5 Nasal Spray 50 mdi is not recommended for children below 12 years as the safety and effectiveness were not established.

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