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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

About Oxifect 100 mg Injection 50 ml

Oxifect 100 mg Injection 50 ml belongs to the group of medicines called platinum-containing antineoplastic agents used alone or in combination with other anti-cancer medicines to treat cancer of the large bowel/intestine (advanced colon or colorectal cancer). 
 
Oxifect 100 mg Injection 50 ml contains Oxaliplatin, which works by killing the cancer cells. Thereby, it helps treat cancer.
 
In some cases, Oxifect 100 mg Injection 50 ml may cause side effects such as mild nausea, vomiting, diarrhoea, fever, and headache. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with your doctor if any of the side effects persist or worsen.
 
Do not use Oxifect 100 mg Injection 50 ml if you are breastfeeding. Consult a doctor immediately if you become pregnant during treatment with Oxifect 100 mg Injection 50 ml. This medicine is not recommended for children as safety and effectiveness have not been established. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

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Non returnable*
COD available

Online payment accepted

Consume Type

PARENTERAL

Return Policy

3 Days Returnable

Expires on or after

Apr-24

for this medicine

Uses of Oxifect 100 mg Injection 50 ml

Colon and rectal cancer

Medicinal Benefits

Oxifect 100 mg Injection 50 ml contains Oxaliplatin, which belongs to the group of medicines called platinum-containing antineoplastic agents used to treat stage III colon cancer after complete removal of the primary tumour and metastatic cancer of the colon and rectum. It is used in combination with other anti-cancer medicines, such as 5-fluorouracil and folinic acid. Oxifect 100 mg Injection 50 ml works by killing the cancer cells. Thereby, it helps treat cancer. Oxifect 100 mg Injection 50 ml may also be used with other medicines to prevent colon cancer from spreading in patients who have had surgery to remove the tumour.

Side Effects of Oxifect 100 mg Injection 50 ml

  • Mild nausea
  • Vomiting
  • Diarrhoea
  • Headache
  • Peripheral neuropathy
  • Fatigue
  • Back pain
  • Stomach pain

Directions for Use

Oxifect 100 mg Injection 50 ml will be administered by a qualified physician; do not self-administer.

Storage

Store in a cool and dry place away from sunlight

Drug Warnings

Do not use Oxifect 100 mg Injection 50 ml if you are allergic to any of its components, if you are breastfeeding, have a low blood cell count, have severe kidney problems, tingling and numbness in the fingers/toes, and have difficulty performing fragile tasks, such as buttoning clothes. Inform the doctor if you ever suffered an allergic reaction to platinum-containing medicines, have mild/moderate kidney problems, liver problems or abnormal liver function tests during therapy, or heart disorders like prolongation of the QT interval (abnormal electrical signal), an irregular heartbeat, or a family history of heart problems. Seek immediate medical attention if you experience symptoms of an allergic reaction (rash, itching, hives, reddening of the skin, hoarseness, difficulty breathing or swallowing, feeling as if your throat is closing, dizziness, swelling of the lips and tongue, lightheadedness, or fainting), unpleasant sensation in the throat, rhabdomyolysis (muscle pain and swelling), nerve problems (sensitivity to cold temperature or cold objects, pain, tingling or burning sensation), Posterior Reversible Encephalopathy Syndrome (headache, confusion, seizures, vision problems), myelosuppression (chills or shivering, burning or pain on urination, pain on swallowing, sore throat, cough with mucus, persistent diarrhoea), lung problems (shortness of breath, wheezing, cough), or bleeding problems (vomit that looks like coffee grounds or bloody vomit, pink or brown urine, weakness, dizziness, changes in speech, confusion, unexplained bleeding or dark-coloured/tarry stools).

Therapeutic Class

CHEMOTHERAPY

Drug-Drug Interactions

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OxaliplatinZiprasidone
Critical
OxaliplatinAmiodarone
Severe

Drug-Drug Interactions

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OxaliplatinZiprasidone
Critical
How does the drug interact with Oxifect 100 mg Injection 50 ml:
Combining Oxifect 100 mg Injection 50 ml with Ziprasidone can increase the risk of QTc prolongation.

How to manage the interaction:
Taking Oxifect 100 mg Injection 50 ml with Ziprasidone is not recommended, please consult your doctor before taking it.
OxaliplatinAmiodarone
Severe
How does the drug interact with Oxifect 100 mg Injection 50 ml:
Coadministration of Amiodarone together with Oxifect 100 mg Injection 50 ml may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Oxifect 100 mg Injection 50 ml interact, they can be used if prescribed by a doctor. If you have cardiac problems or electrolyte imbalances, you may be at greater risk. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical attention. Do not discontinue any medications without consulting a doctor.
OxaliplatinCladribine
Severe
How does the drug interact with Oxifect 100 mg Injection 50 ml:
Combining Cladribine with Oxifect 100 mg Injection 50 ml can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Oxifect 100 mg Injection 50 ml and Cladribine, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
OxaliplatinEfavirenz
Severe
How does the drug interact with Oxifect 100 mg Injection 50 ml:
Taking Oxifect 100 mg Injection 50 ml with Efavirenz can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Oxifect 100 mg Injection 50 ml with Efavirenz together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OxaliplatinGatifloxacin
Severe
How does the drug interact with Oxifect 100 mg Injection 50 ml:
Taking Oxifect 100 mg Injection 50 ml with Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Oxifect 100 mg Injection 50 ml with Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OxaliplatinClozapine
Severe
How does the drug interact with Oxifect 100 mg Injection 50 ml:
Co-administration of Oxifect 100 mg Injection 50 ml with Clozapine can increase the risk of neutropenia (low white blood count).

How to manage the interaction:
Although taking Oxifect 100 mg Injection 50 ml and Clozapine together can evidently cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without talking to a doctor.
OxaliplatinEscitalopram
Severe
How does the drug interact with Oxifect 100 mg Injection 50 ml:
Combining Oxifect 100 mg Injection 50 ml with Escitalopram can increase the risk of QTc prolongation.

How to manage the interaction:
Although there is a possible interaction between Oxifect 100 mg Injection 50 ml and Escitalopram, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
OxaliplatinNilotinib
Severe
How does the drug interact with Oxifect 100 mg Injection 50 ml:
Combining Oxifect 100 mg Injection 50 ml and nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Oxifect 100 mg Injection 50 ml and nilotinib together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
OxaliplatinThalidomide
Severe
How does the drug interact with Oxifect 100 mg Injection 50 ml:
Taking thalidomide together with Oxifect 100 mg Injection 50 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Oxifect 100 mg Injection 50 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
OxaliplatinHydroxychloroquine
Severe
How does the drug interact with Oxifect 100 mg Injection 50 ml:
The combined use of Oxifect 100 mg Injection 50 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of oxalipatin and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Habit Forming

No

Special Advise

  • Women must use reliable contraception during treatment and for nine months after receiving the last dose.
  • Male patients are advised not to father a child during treatment and for six months after the last dose. Use effective contraception during this time.
  • If you are due to undergo any surgery, including dental surgery, inform the doctor/dentist that you are on treatment with Oxifect 100 mg Injection 50 ml.
  • Avoid eating or drinking anything that is colder than room temperature for five days after receiving each dose of Oxifect 100 mg Injection 50 ml. To reduce side effects caused by cold temperature-cover yourself with a blanket while getting treatment with Oxifect 100 mg Injection 50 ml, wear warm clothing in cold weather at all times, cover your mouth and nose with a scarf and wear gloves whilst touching cold objects. Drink fluid at room/warm temperature and always drink through a straw. Avoid using ice and AC, touching cold metals, and breathing deeply when exposed to cold air.

Disease/Condition Glossary

Colon and rectal cancer: It is a cancer of the colon or rectum. Colorectal cancer is the growth of cells that form in the lower end of the digestive tract. Most of these cancers begin as polyps (non-cancerous growths). Symptoms may include abdominal discomfort, blood in the stool, and changes in bowel habits like constipation or diarrhoea.

Oxifect 100 mg Injection 50 ml Substitute

Substitutes safety advice
  • Oxitan Vail 50Ml

    by AYUR

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  • OXITAN 100MG INJECTION 50ML

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  • Soxplat 100 mg Injection 1's

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  • Oxoplan 100 Injection 1's

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  • Dacotin Rtu-100 Injection 20 ml

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