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  3. Pregalin D 75/20 Capsule 10's

Written By Lakshmithulasi Yarragunta , Pharm-D (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Not for online sale
Pregalin D 75/20 Capsule 10's, Pack of 10
Pregalin D 75/20 Capsule 10's, Pack of 10
Pregalin D 75/20 Capsule 10's, Pack of 10
Pregalin D 75/20 Capsule 10's, Pack of 10
Non returnable*
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Composition :

DULOXETINE-20MG + PREGABALIN-75MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Pregalin D 75/20 Capsule

Pregalin D 75/20 Capsule belongs to an anticonvulsant class of medicines. It is used in the treatment of diabetic neuropathic pain and fibromyalgia. Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged. Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. Fibromyalgia is a chronic condition with moderate pain and tenderness all over the body resulting in fatigue and trouble sleeping.

Pregalin D 75/20 Capsule is a combination of Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Pregalin D 75/20 Capsule can be taken with or without food or as prescribed by your doctor. Pregalin D 75/20 Capsule may cause certain side effects such as nausea, constipation, headache, dry mouth, increased sweating, loss of appetite, dizziness, and burning sensation. These side effects do not require medical attention and gradually resolve over time. However, if any of these side effects persist, inform your doctor.

Pregalin D 75/20 Capsule should be avoided if you are allergic to it. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, glaucoma (an eye condition), bleeding disorders, or are at risk of hyponatremia (low sodium levels, especially in patients taking diuretics or water pills). If you are pregnant or breastfeeding, inform your doctor before taking this medicine. It is not recommended for use in children and young adults as it increases the risk of suicidal tendencies. 

Uses of Pregalin D 75/20 Capsule

Diabetic Neuropathic Pain, Fibromyalgia

Directions for Use

Take Pregalin D 75/20 Capsule as prescribed by your doctor. Swallow it as a whole with water. It can be taken with or without food. Do not crush, break or chew it.

Medicinal Benefits

Pregalin D 75/20 Capsule contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain. Pregalin D 75/20 Capsule effectively treats neuropathic pain, and improves nerve conduction for proper nerve signal functioning in the body. 

Storage

Keep Pregalin D 75/20 Capsule out of the sight and reach of children.
Side effects of Pregalin D 75/20 Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.

Drug Warnings

Pregalin D 75/20 Capsule should be avoided if you are allergic to any of the components in it. Do not stop taking Pregalin D 75/20 Capsule suddenly without your doctor’s advice, as it may cause withdrawal symptoms like dizziness, tingling sensation, sleep disturbances, restlessness, nausea or vomiting, headache, or excessive sweating. Inform your doctor if you have any liver or kidney disease, seizures (fits), mania, bipolar disorder, or glaucoma (an eye condition). Pregalin D 75/20 Capsule may increase suicidal thoughts, so it is advised to use caution in patients with mania, bipolar disorder or depression. It is not recommended for use in children below 18 years of age as the safety and efficacy of this medicine are not established. Pregnant or breastfeeding mothers should inform the doctor before using Pregalin D 75/20 Capsule .

Drug-Drug Interactions

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DuloxetineEliglustat
Critical
DuloxetineLinezolid
Critical

Drug-Drug Interactions

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DuloxetineEliglustat
Critical
How does the drug interact with Pregalin D 75/20 Capsule:
Coadministration of eliglustat and Pregalin D 75/20 Capsule can significantly increase the blood levels of eliglustat. This may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pregalin D 75/20 Capsule with Eliglustat is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, or weak pulse. Do not discontinue any medications without consulting your doctor.
DuloxetineLinezolid
Critical
How does the drug interact with Pregalin D 75/20 Capsule:
Taking Pregalin D 75/20 Capsule with Linezolid can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Pregalin D 75/20 Capsule with Linezolid is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting a doctor.
DuloxetineProcarbazine
Critical
How does the drug interact with Pregalin D 75/20 Capsule:
Taking Pregalin D 75/20 Capsule with procarbazine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregalin D 75/20 Capsule with Procarbazine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineSelegiline
Critical
How does the drug interact with Pregalin D 75/20 Capsule:
Taking Pregalin D 75/20 Capsule with selegiline may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between Pregalin D 75/20 Capsule and Selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineTranylcypromine
Critical
How does the drug interact with Pregalin D 75/20 Capsule:
Taking Tranylcypromine with Pregalin D 75/20 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Pregalin D 75/20 Capsule is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineSafinamide
Critical
How does the drug interact with Pregalin D 75/20 Capsule:
Coadministration of safinamide with Pregalin D 75/20 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Safinamide with Pregalin D 75/20 Capsule is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
DuloxetineMetoclopramide
Critical
How does the drug interact with Pregalin D 75/20 Capsule:
Coadministration of metoclopramide with Pregalin D 75/20 Capsule increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Metoclopramide with Pregalin D 75/20 Capsule is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
DuloxetinePhenelzine
Critical
How does the drug interact with Pregalin D 75/20 Capsule:
Taking phenelzine with Pregalin D 75/20 Capsule can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Pregalin D 75/20 Capsule with Phenelzine is not recommended, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, blurred vision, pain in the muscles, stomach cramps, nausea, vomiting, and diarrhoea. Do not discontinue any medications without consulting your doctor.
DuloxetineRasagiline
Critical
How does the drug interact with Pregalin D 75/20 Capsule:
Taking Rasagiline with Pregalin D 75/20 Capsule can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Rasagiline and Pregalin D 75/20 Capsule is not recommended as they can possibly result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering, pain in the muscles, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
PregabalinSodium oxybate
Severe
How does the drug interact with Pregalin D 75/20 Capsule:
Using Sodium oxybate together with Pregalin D 75/20 Capsule may increase the risk of side effects.

How to manage the interaction:
Although taking Pregalin D 75/20 Capsule with Sodium oxybate together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult the doctor. For at least six hours after taking sodium oxybate, avoid operating machinery or engaging in potentially dangerous activities. Also, be careful when getting up from a sitting or lying down posture. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercise regularly, which helps in reducing pain.
  • Rest well, and get enough sleep.
  • Always take a warm bath, as it can be soothing.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improves coping skills.

Side Effects of Pregalin D 75/20 Capsule

  • Burning sensation
  • Drowsiness
  • Nausea
  • Constipation
  • Headache
  • Dry mouth
  • Increased sweating
  • Loss of appetite

Habit Forming

Yes

Therapeutic Class

ANTICONVULSANT

Pregalin D 75/20 Capsule Substitute

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Author Details

Lakshmithulasi YarraguntaDoctor badge

Written By

Lakshmithulasi Yarragunta

Pharm-D (PB)

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 8, 2025 | 9:48 AM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Pregalin D 75/20 Capsule contains Pregabalin and Duloxetine. Pregabalin belongs to an anticonvulsant class of drugs, whereas Duloxetine is a selective serotonin reuptake (SSRI) inhibitor. This medicine mainly works by increasing the chemical messengers in the brain responsible for regulating pain.

Do not stop using Pregalin D 75/20 Capsule suddenly as it can cause withdrawal symptoms. Your doctor will gradually reduce the dose based on your clinical condition.

Seek medical attention immediately if you notice any depressive thoughts while using Pregalin D 75/20 Capsule . Your doctor may change the dose or medicine to treat your condition.

Neuropathic pain/ peripheral neuropathy is pain that occurs when the nervous system is not working properly or is damaged.

Drug-Drug Interactions Checker List

  • TRAMADOL
  • FLUOXETINE
  • MOCLOBEMIDE
  • VENLAFAXINE
  • AMITRIPTYLINE

Special Advise

  • Do not stop taking Pregalin D 75/20 Capsule suddenly, as it may cause withdrawal symptoms.
  • Do frequent blood tests to check your fasting blood glucose, HbA1c, and total cholesterol (TC) levels to reduce any serious side effects.

Disease/Condition Glossary

Diabetic Neuropathy: Diabetic neuropathic pain/diabetic neuropathy is a condition causing moderate to severe pain due to damage of nerves in the thigh, hip, buttock and leg regions. Symptoms may include tingling, shooting pain, burning, or even an electric shock sensation. It mainly occurs in patients suffering from Type II Diabetes.

Fibromyalgia: It is a chronic condition with moderate pain and tenderness of the muscle all over the body. It mainly occurs due to physical or psychological stress. Symptoms may include fatigue, tiredness, trouble sleeping, anxiety, headache and depression.

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Alcohol

Unsafe

Avoid alcohol consumption during treatment with $nmae as it may increase the risk of serious side effects and worsen your health.

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Pregnancy

Caution

If you are pregnant, especially in the last trimester or planning pregnancy, inform your doctor before taking Pregalin D 75/20 Capsule . It may cause foetal abnormalities if taken in the last trimester of pregnancy. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before taking Pregalin D 75/20 Capsule . Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Pregalin D 75/20 Capsule may cause drowsiness. Hence, avoid driving vehicles or operating machines after taking Pregalin D 75/20 Capsule .

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Liver

Caution

If you have liver conditions, inform your doctor before taking Pregalin D 75/20 Capsule . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have kidney conditions, inform your doctor before taking Pregalin D 75/20 Capsule . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Pregalin D 75/20 Capsule is not recommended for children below 18 years as the safety and efficacy of use for this medicine are not established. Please seek medical advice for more information.

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