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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
COD available

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Whats That

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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Meddox Formulations

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About LEF 20 mg Tablet 10's

LEF 20 mg Tablet 10's belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

LEF 20 mg Tablet 10's contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take LEF 20 mg Tablet 10's at the same time every day as prescribed by your doctor. In some cases, LEF 20 mg Tablet 10's may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take LEF 20 mg Tablet 10's if you are pregnant or planning for pregnancy as LEF 20 mg Tablet 10's may cause serious congenital disabilities. LEF 20 mg Tablet 10's should not be taken by breastfeeding mothers as it passes into breast milk. LEF 20 mg Tablet 10's may cause dizziness, so drive with caution. Avoid consuming alcohol along with LEF 20 mg Tablet 10's as it could lead to increased dizziness and liver damage. LEF 20 mg Tablet 10's may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of LEF 20 mg Tablet 10's

Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take LEF 20 mg Tablet 10's with or without food. Swallow LEF 20 mg Tablet 10's as a whole with water; do not crush or chew it.

Medicinal Benefits

LEF 20 mg Tablet 10's belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. LEF 20 mg Tablet 10's is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Storage

Store in a cool and dry place away from sunlight

Side Effects of LEF 20 mg Tablet 10's

  • Diarrhoea
  • Nausea
  • Stomach pain
  • Indigestion
  • Rash
  • Hair loss

Drug Warnings

Do not take LEF 20 mg Tablet 10's if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. LEF 20 mg Tablet 10's is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking LEF 20 mg Tablet 10's if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. LEF 20 mg Tablet 10's may cause dizziness, so drive with caution. LEF 20 mg Tablet 10's may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

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LeflunomideTamoxifen
Severe
LeflunomideTemozolomide
Severe

Drug-Drug Interactions

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LeflunomideTamoxifen
Severe
How does the drug interact with LEF 20 mg Tablet:
Taking LEF 20 mg Tablet with tamoxifen affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking tamoxifen and LEF 20 mg Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideTemozolomide
Severe
How does the drug interact with LEF 20 mg Tablet:
Taking Temozolomide with LEF 20 mg Tablet can increase the risk of infections.

How to manage the interaction:
Although taking temozolomide and LEF 20 mg Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, pain or burning during urination, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting a doctor.
LeflunomideCaspofungin
Severe
How does the drug interact with LEF 20 mg Tablet:
LEF 20 mg Tablet can cause liver problems, and combining it with other drugs, such as binimetinib, can raise the risk.

How to manage the interaction:
There may be a possibility of interaction between LEF 20 mg Tablet and Caspofungin, but it can be taken if prescribed by a doctor. If you have any of these symptoms, contact your doctor right away. These symptoms include liver problems, fever, rash, itching, loss of appetite, dark urine, stomach pain, unusual bleeding or bruising, feeling tired, and yellowing of the skin or eyes. Do not stop using any medications without a doctor's advice.
LeflunomideAcitretin
Severe
How does the drug interact with LEF 20 mg Tablet:
Coadministration of Acitretin with LEF 20 mg Tablet may increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Acitretin and LEF 20 mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideBrigatinib
Severe
How does the drug interact with LEF 20 mg Tablet:
Brigatinib can cause higher levels of LEF 20 mg Tablet in the blood by reducing its excretion.

How to manage the interaction:
There may be a possibility of interaction between LEF 20 mg Tablet and Brigatinib, but it can be taken if prescribed by a doctor. If you notice symptoms like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Other symptoms to look out for include diarrhea, shortness of breath, weight loss, and pain or burning while urinating." Do not discontinue any medications without consulting your doctor.
LeflunomideErlotinib
Severe
How does the drug interact with LEF 20 mg Tablet:
When erlotinib is taken with LEF 20 mg Tablet, it increases the risk of causing liver problems.

How to manage the interaction:
Although there is a possible interaction between Erlotinib and LEF 20 mg Tablet, you can take these medicines together if advised by your doctor. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, liver damage, or bleeding, it's important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
LeflunomideCerivastatin
Severe
How does the drug interact with LEF 20 mg Tablet:
LEF 20 mg Tablet can cause liver problems, and combining it with other drugs, such as Cerivastatin, can raise the risk.

How to manage the interaction:
Although there is a possible interaction between LEF 20 mg Tablet and Cerivastatin, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms - fever, joint pain, rash, or stomach pain, contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideTofacitinib
Severe
How does the drug interact with LEF 20 mg Tablet:
Taking tofacitinib with LEF 20 mg Tablet can increase the risk of infections.

How to manage the interaction:
Although there is an interaction between LEF 20 mg Tablet and tofacitinib together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideMycophenolate Mofetil
Severe
How does the drug interact with LEF 20 mg Tablet:
Using LEF 20 mg Tablet together with mycophenolate mofetil may increase the risk of developing serious infections.

How to manage the interaction:
Although taking Mycophenolate Mofetil and LEF 20 mg Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination call a doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideAcarbose
Severe
How does the drug interact with LEF 20 mg Tablet:
Co-administration of acarbose with LEF 20 mg Tablet may increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between acarbose and LEF 20 mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

LEF 20 mg Tablet 10's Substitute

Substitutes safety advice
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Author Details

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Drug-Diseases Interactions

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No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

LEF 20 mg Tablet 10's is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

LEF 20 mg Tablet 10's may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of LEF 20 mg Tablet 10's. Take LEF 20 mg Tablet 10's for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Special Advise

Regular blood tests to monitor your liver function after starting LEF 20 mg Tablet 10's, and for every 6-8 weeks are advised.

Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (where the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty in moving and swelling. Patients with rheumatoid arthritis have intense joint pain (especially knee joint) with stiffness. 

Psoriatic arthritis: Psoriatic arthritis is an autoimmune disease characterized by inflammation of the skin (psoriasis) and joints (inflammatory arthritis). It mainly affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

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