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  3. Leflunomile 20 Tablet 10's

Leflunomile 20 Tablet 10's, Pack of 10 TABLETS
Leflunomile 20 Tablet 10's, Pack of 10 TABLETS
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Sunny S , MBBS
Non returnable*
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Whats That

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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Steris Healthcare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Leflunomile 20 Tablet

Leflunomile 20 Tablet belongs to the group of medicines called 'anti-rheumatic agents' used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis is an auto-immune disease (the body's immune system attacks its tissue) which leads to joint pain and damage. Psoriatic arthritis is a kind of inflammatory arthritis which occurs in patients with psoriasis (red patches of skin with silvery scales). 

Leflunomile 20 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling. 

Take Leflunomile 20 Tablet at the same time every day as prescribed by your doctor. In some cases, Leflunomile 20 Tablet may cause common side-effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take Leflunomile 20 Tablet if you are pregnant or planning for pregnancy as Leflunomile 20 Tablet may cause serious congenital disabilities. Leflunomile 20 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Leflunomile 20 Tablet may cause dizziness, so drive with caution. Avoid consuming alcohol along with Leflunomile 20 Tablet as it could lead to increased dizziness and liver damage. Leflunomile 20 Tablet may make you more susceptible to infections; consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Uses of Leflunomile 20 Tablet

Rheumatoid arthritis, Psoriatic arthritis

Directions for Use

Take Leflunomile 20 Tablet with or without food. Swallow Leflunomile 20 Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

Leflunomile 20 Tablet belongs to the group of medicines called anti-rheumatic agents used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Leflunomile 20 Tablet is a disease-modifying antirheumatic drug (DMARDs) which inhibits an enzyme called dihydroorotate dehydrogenase and has antiproliferative activity (suppresses the cell growth). Thereby, helps in treating inflammation, redness, and swelling.

Storage

Store in a cool and dry place away from sunlight
Side effects of Leflunomile 20 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.

Drug Warnings

Do not take Leflunomile 20 Tablet if you are allergic to leflunomide, have severe liverkidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections. Leflunomile 20 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age. Talk to your doctor before taking Leflunomile 20 Tablet if you have/had serious infections like interstitial lung disease (inflammation of lungs), tuberculosis (TB), or pneumonia. Leflunomile 20 Tablet may cause dizziness, so drive with caution. Leflunomile 20 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.

Drug-Drug Interactions

verifiedApollotooltip
LeflunomideSimvastatin
Severe
LeflunomideBudesonide
Severe

Drug-Drug Interactions

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LeflunomideSimvastatin
Severe
How does the drug interact with Leflunomile 20 Tablet:
The combined use of Leflunomile 20 Tablet and simvastatin can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Leflunomile 20 Tablet and simvastatin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol and Do not stop using any medications without a doctor's advice.
LeflunomideBudesonide
Severe
How does the drug interact with Leflunomile 20 Tablet:
Taking budesonide with Leflunomile 20 Tablet may raise the risk of severe infections.

How to manage the interaction:
Co-administration of budesonide along with Leflunomile 20 Tablet can lead to an interaction, but it can be taken if recommended by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor. Do not discontinue any medications without consulting the doctor.
LeflunomideMetaxalone
Severe
How does the drug interact with Leflunomile 20 Tablet:
Taking metaxalone with Leflunomile 20 Tablet can cause liver problems.

How to manage the interaction:
Although there is an interaction between Leflunomile 20 Tablet and metaxalone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideMercaptopurine
Severe
How does the drug interact with Leflunomile 20 Tablet:
Co-administration of Mercaptopurine with Leflunomile 20 Tablet can increase the risk of infections and liver problems.

How to manage the interaction:
Although there is an interaction between Leflunomile 20 Tablet and mercaptopurine, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideTizanidine
Severe
How does the drug interact with Leflunomile 20 Tablet:
Coadministration of tizanidine and Leflunomile 20 Tablet can increase the risk of liver problems.

How to manage the interaction:
Taking Tizanidine and Leflunomile 20 Tablet together can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideAlefacept
Severe
How does the drug interact with Leflunomile 20 Tablet:
Coadministration of Leflunomile 20 Tablet together with alefacept may raise the risk of severe infections.

How to manage the interaction:
Although there is an interaction between alefacept and Leflunomile 20 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
LeflunomideLenvatinib
Severe
How does the drug interact with Leflunomile 20 Tablet:
Taking Leflunomile 20 Tablet and lenvatinib can increase the risk of liver problems.

How to manage the interaction:
Taking Leflunomile 20 Tablet with Lenvatinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, feeling cold, joint discomfort, swelling, bruising, skin irritation, itching, not feeling hungry, tiredness, feeling sick, stomach ache, dark urine, liver harm, or bleeding. Do not stop using any medications without first talking to your doctor.
LeflunomideCisplatin
Severe
How does the drug interact with Leflunomile 20 Tablet:
Using Leflunomile 20 Tablet together with CISplatin may raise the risk of severe infections.

How to manage the interaction:
Co-administration of Leflunomile 20 Tablet with Cisplatin can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice symptoms like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Other symptoms to look out for include diarrhoea, shortness of breath, weight loss, and pain or burning while urinating." Do not discontinue any medications without consulting your doctor.
LeflunomideErlotinib
Severe
How does the drug interact with Leflunomile 20 Tablet:
When erlotinib is taken with Leflunomile 20 Tablet, it increases the risk of causing liver problems.

How to manage the interaction:
Although there is a possible interaction between Erlotinib and Leflunomile 20 Tablet, you can take these medicines together if advised by your doctor. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, liver damage, or bleeding, it's important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
LeflunomideCabazitaxel
Severe
How does the drug interact with Leflunomile 20 Tablet:
The use of Leflunomile 20 Tablet together with Cabazitaxel may raise the risk of severe infections.

How to manage the interaction:
Taking Cabazitaxel with Leflunomile 20 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like infection, sore throat, diarrhea, muscle pain, weight loss, fever, or difficulty breathing, contact your doctor immediately. If you experience any discomfort or burning while urinating, let your doctor know. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Product Substitutes

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Sunny S

Reviewed By

Sunny S

MBBS

Last Updated

Aug 20, 2024 | 12:51 PM IST

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Drug-Diseases Interactions

verifiedApollotooltip
No Drug - Disease interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Diseases Interactions

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FAQs

Leflunomile 20 Tablet is a disease-modifying antirheumatic drug (DMARD) which stops DNA (genetic material) of the provoked immune system cells required for its survival. Thereby, helps in treating inflammation, redness, and swelling at the damaged site (especially joint).

Leflunomile 20 Tablet may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Leflunomile 20 Tablet . Take Leflunomile 20 Tablet for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, weak immune system and serious infections like pneumonia, or tuberculosis (TB).

Drug-Drug Interactions Checker List

  • IBUPROFEN
  • NAPROXEN
  • ACETAMINOPHEN
  • ASPIRIN
  • DULOXETINE
  • PREDNISONE
  • CELECOXIB
  • AZATHIOPRINE
  • MELOXICAM
  • METHOTREXATE
  • ETANERCEPT
  • ADALIMUMAB
  • ABATACEPT
  • INFLIXIMAB
  • HYDROXYCHLOROQUINE

Special Advise

Regular blood tests to monitor your liver function after starting Leflunomile 20 Tablet , and for every 6-8 weeks are advised.

Disease/Condition Glossary

Rheumatoid arthritis: It is an auto-immune disease (where the body's immune system attacks its tissue) which leads to joint pain and damage. Symptoms of rheumatoid arthritis include pain, inflammation of joints, difficulty in moving and swelling. Patients with rheumatoid arthritis have intense joint pain (especially knee joint) with stiffness. 

Psoriatic arthritis: Psoriatic arthritis is an autoimmune disease characterized by inflammation of the skin (psoriasis) and joints (inflammatory arthritis). It mainly affects large joints in the lower extremities, distal joints of toes and fingers, back and pelvis. Symptoms include inflammation of joints, difficulty moving, swelling, patches of red, scaly skin and pain.

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